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Q7S2W6

- IF6_NEUCR

UniProt

Q7S2W6 - IF6_NEUCR

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Protein
Eukaryotic translation initiation factor 6
Gene
tif-6, tif6, NCU09004
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity.UniRule annotation

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mature ribosome assembly Source: UniProtKB-HAMAP
  2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
  3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6
Short name:
eIF-6
Gene namesi
Name:tif-6
Synonyms:tif6
ORF Names:NCU09004
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleolus By similarity
Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Eukaryotic translation initiation factor 6UniRule annotation
PRO_0000402109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741Phosphoserine; by CK1 By similarity
Modified residuei175 – 1751Phosphoserine; by CK1 By similarity

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit By similarity.

Protein-protein interaction databases

STRINGi5141.NCU09004.1.

Structurei

3D structure databases

ProteinModelPortaliQ7S2W6.
SMRiQ7S2W6. Positions 1-224.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.

Phylogenomic databases

eggNOGiCOG1976.
HOGENOMiHOG000230605.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7TTQKB.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7S2W6-1 [UniParc]FASTAAdd to Basket

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MAVRAQFENS NEVGVFSTLT NSYALVAVGA SENFYSVFEA ELQDVIPICR    50
TTIAGTRIIG RLTAGNRKGL LVPTTTSDQE LQHLRNSLPD DVRIQRIEER 100
LSALGNVIVC NDHTALIHPD LERETEEIIA DVLGVEVFRQ TIADNVLVGS 150
YMALSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVIGGGMVVN 200
DWMAVTGLDT TAPELSVIES VFRLGEGAAP GQINSSLKDT MVESFY 246
Length:246
Mass (Da):26,514
Last modified:December 15, 2003 - v1
Checksum:i542A2C7CDB7AEB68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA29796.1.
RefSeqiXP_959032.1. XM_953939.2.
UniGeneiNcr.15820.

Genome annotation databases

EnsemblFungiiEFNCRT00000008959; EFNCRP00000008941; EFNCRG00000008945.
GeneIDi3875154.
KEGGincr:NCU09004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA29796.1 .
RefSeqi XP_959032.1. XM_953939.2.
UniGenei Ncr.15820.

3D structure databases

ProteinModelPortali Q7S2W6.
SMRi Q7S2W6. Positions 1-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09004.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000008959 ; EFNCRP00000008941 ; EFNCRG00000008945 .
GeneIDi 3875154.
KEGGi ncr:NCU09004.

Phylogenomic databases

eggNOGi COG1976.
HOGENOMi HOG000230605.
KOi K03264.
OMAi NDWCAFT.
OrthoDBi EOG7TTQKB.

Family and domain databases

HAMAPi MF_00032. eIF_6.
InterProi IPR002769. eIF6.
[Graphical view ]
PANTHERi PTHR10784. PTHR10784. 1 hit.
Pfami PF01912. eIF-6. 1 hit.
[Graphical view ]
PIRSFi PIRSF006413. IF-6. 1 hit.
SMARTi SM00654. eIF6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00323. eIF-6. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiIF6_NEUCR
AccessioniPrimary (citable) accession number: Q7S2W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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