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Q7S2W6

- IF6_NEUCR

UniProt

Q7S2W6 - IF6_NEUCR

Protein

Eukaryotic translation initiation factor 6

Gene

tif-6

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

    GO - Molecular functioni

    1. ribosomal large subunit binding Source: UniProtKB-HAMAP
    2. ribosome binding Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mature ribosome assembly Source: UniProtKB-HAMAP
    2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
    3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 6UniRule annotation
    Short name:
    eIF-6UniRule annotation
    Gene namesi
    Name:tif-6
    Synonyms:tif6
    ORF Names:NCU09004
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleusnucleolus UniRule annotation
    Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Eukaryotic translation initiation factor 6PRO_0000402109Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotation
    Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotation

    Post-translational modificationi

    Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi5141.NCU09004.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7S2W6.
    SMRiQ7S2W6. Positions 1-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-6 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1976.
    HOGENOMiHOG000230605.
    KOiK03264.
    OMAiNDWCAFT.
    OrthoDBiEOG7TTQKB.

    Family and domain databases

    HAMAPiMF_00032. eIF_6.
    InterProiIPR002769. eIF6.
    [Graphical view]
    PANTHERiPTHR10784. PTHR10784. 1 hit.
    PfamiPF01912. eIF-6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006413. IF-6. 1 hit.
    SMARTiSM00654. eIF6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00323. eIF-6. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7S2W6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRAQFENS NEVGVFSTLT NSYALVAVGA SENFYSVFEA ELQDVIPICR    50
    TTIAGTRIIG RLTAGNRKGL LVPTTTSDQE LQHLRNSLPD DVRIQRIEER 100
    LSALGNVIVC NDHTALIHPD LERETEEIIA DVLGVEVFRQ TIADNVLVGS 150
    YMALSNQGGL VHPKTSIQDQ DELSSLLQVP LVAGSVNRGS NVIGGGMVVN 200
    DWMAVTGLDT TAPELSVIES VFRLGEGAAP GQINSSLKDT MVESFY 246
    Length:246
    Mass (Da):26,514
    Last modified:December 15, 2003 - v1
    Checksum:i542A2C7CDB7AEB68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA29796.1.
    RefSeqiXP_959032.1. XM_953939.2.
    UniGeneiNcr.15820.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000008959; EFNCRP00000008941; EFNCRG00000008945.
    GeneIDi3875154.
    KEGGincr:NCU09004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA29796.1 .
    RefSeqi XP_959032.1. XM_953939.2.
    UniGenei Ncr.15820.

    3D structure databases

    ProteinModelPortali Q7S2W6.
    SMRi Q7S2W6. Positions 1-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU09004.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000008959 ; EFNCRP00000008941 ; EFNCRG00000008945 .
    GeneIDi 3875154.
    KEGGi ncr:NCU09004.

    Phylogenomic databases

    eggNOGi COG1976.
    HOGENOMi HOG000230605.
    KOi K03264.
    OMAi NDWCAFT.
    OrthoDBi EOG7TTQKB.

    Family and domain databases

    HAMAPi MF_00032. eIF_6.
    InterProi IPR002769. eIF6.
    [Graphical view ]
    PANTHERi PTHR10784. PTHR10784. 1 hit.
    Pfami PF01912. eIF-6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006413. IF-6. 1 hit.
    SMARTi SM00654. eIF6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00323. eIF-6. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiIF6_NEUCR
    AccessioniPrimary (citable) accession number: Q7S2W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3