Q7S2W6 (IF6_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 6
Short name=eIF-6

Gene names

Name:	tif-6
Synonyms:	tif6
ORF Names:	NCU09004

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity. HAMAP-Rule MF_03132
Subunit structure	Monomer. Associates with the 60S ribosomal subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus › nucleolus By similarity. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.
Post-translational modification	Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity. HAMAP-Rule MF_03132
Sequence similarities	Belongs to the eIF-6 family.

Ontologies

Keywords
Biological process	Protein biosynthesis Ribosome biogenesis
Cellular component	Cytoplasm Nucleus
Molecular function	Initiation factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mature ribosome assembly Inferred from electronic annotation. Source: HAMAP ribosomal large subunit biogenesis Inferred from electronic annotation. Source: HAMAP ribosomal subunit export from nucleus Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribosomal large subunit binding Inferred from electronic annotation. Source: HAMAP ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Eukaryotic translation initiation factor 6 HAMAP-Rule MF_03132		PRO_0000402109
Amino acid modifications
	Modified residue	174	1	Phosphoserine; by CK1 By similarity
	Modified residue	175	1	Phosphoserine; by CK1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7S2W6 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 542A2C7CDB7AEB68	FASTA	246	26,514
	10 20 30 40 50 60 MAVRAQFENS NEVGVFSTLT NSYALVAVGA SENFYSVFEA ELQDVIPICR TTIAGTRIIG 70 80 90 100 110 120 RLTAGNRKGL LVPTTTSDQE LQHLRNSLPD DVRIQRIEER LSALGNVIVC NDHTALIHPD 130 140 150 160 170 180 LERETEEIIA DVLGVEVFRQ TIADNVLVGS YMALSNQGGL VHPKTSIQDQ DELSSLLQVP 190 200 210 220 230 240 LVAGSVNRGS NVIGGGMVVN DWMAVTGLDT TAPELSVIES VFRLGEGAAP GQINSSLKDT MVESFY

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000067 Genomic DNA. Translation: EAA29796.1.
RefSeq	XP_959032.1. XM_953939.2.
UniGene	Ncr.15820.
3D structure databases
HSSP	HSSP built from PDB template 1G62 based on UniProtKB Q12522.
ProteinModelPortal	Q7S2W6.
SMR	Q7S2W6. Positions 1-224.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU09004.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000008959; EFNCRP00000008941; EFNCRG00000008945.
GeneID	3875154.
KEGG	ncr:NCU09004.
Phylogenomic databases
eggNOG	COG1976.
HOGENOM	HOG000230605.
KO	K03264.
OMA	QFENSNE.
OrthoDB	EOG4M951G.
Family and domain databases
HAMAP	MF_00032. eIF-6.
InterPro	IPR002769. eIF6. [Graphical view]
PANTHER	PTHR10784. PTHR10784. 1 hit.
Pfam	PF01912. eIF-6. 1 hit. [Graphical view]
PIRSF	PIRSF006413. IF-6. 1 hit.
SMART	SM00654. eIF6. 1 hit. [Graphical view]
TIGRFAMs	TIGR00323. eIF-6. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF6_NEUCR

Accession

Primary (citable) accession number: Q7S2W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program