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Q7S2W6 (IF6_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 6

Short name=eIF-6
Gene names
Name:tif-6
Synonyms:tif6
ORF Names:NCU09004
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export By similarity. HAMAP-Rule MF_03132

Subunit structure

Monomer. Associates with the 60S ribosomal subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleusnucleolus By similarity. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity. HAMAP-Rule MF_03132

Post-translational modification

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export By similarity. HAMAP-Rule MF_03132

Sequence similarities

Belongs to the eIF-6 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
Ribosome biogenesis
   Cellular componentCytoplasm
Nucleus
   Molecular functionInitiation factor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmature ribosome assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionribosome binding

Inferred from electronic annotation. Source: InterPro

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Eukaryotic translation initiation factor 6 HAMAP-Rule MF_03132
PRO_0000402109

Amino acid modifications

Modified residue1741Phosphoserine; by CK1 By similarity
Modified residue1751Phosphoserine; by CK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7S2W6 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 542A2C7CDB7AEB68

FASTA24626,514
        10         20         30         40         50         60 
MAVRAQFENS NEVGVFSTLT NSYALVAVGA SENFYSVFEA ELQDVIPICR TTIAGTRIIG 

        70         80         90        100        110        120 
RLTAGNRKGL LVPTTTSDQE LQHLRNSLPD DVRIQRIEER LSALGNVIVC NDHTALIHPD 

       130        140        150        160        170        180 
LERETEEIIA DVLGVEVFRQ TIADNVLVGS YMALSNQGGL VHPKTSIQDQ DELSSLLQVP 

       190        200        210        220        230        240 
LVAGSVNRGS NVIGGGMVVN DWMAVTGLDT TAPELSVIES VFRLGEGAAP GQINSSLKDT 


MVESFY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002238 Genomic DNA. Translation: EAA29796.1.
RefSeqXP_959032.1. XM_953939.2.
UniGeneNcr.15820.

3D structure databases

ProteinModelPortalQ7S2W6.
SMRQ7S2W6. Positions 1-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU09004.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000008959; EFNCRP00000008941; EFNCRG00000008945.
GeneID3875154.
KEGGncr:NCU09004.

Phylogenomic databases

eggNOGCOG1976.
HOGENOMHOG000230605.
KOK03264.
OMANDWCAFT.
OrthoDBEOG7TTQKB.

Family and domain databases

HAMAPMF_00032. eIF_6.
InterProIPR002769. eIF6.
[Graphical view]
PANTHERPTHR10784. PTHR10784. 1 hit.
PfamPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFPIRSF006413. IF-6. 1 hit.
SMARTSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsTIGR00323. eIF-6. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF6_NEUCR
AccessionPrimary (citable) accession number: Q7S2W6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries