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Q7S2S0

- Q7S2S0_NEUCR

UniProt

Q7S2S0 - Q7S2S0_NEUCR

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Protein

DNA ligase

Gene

NCU09706

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: RefGenome
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. lagging strand elongation Source: RefGenome
  6. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCU09706Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 7, Linkage Group VII

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU09706.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ7S2S0.
KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7S2S0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPAKKRKL NSGTKQSFSV PSRGLEYFFA KQKQNGASKE PSPLPKESDS
60 70 80 90 100
QPAQQGSSEE HLNDEELARK LQAEWDAEAR ASSTPRENDV RSQDVAVSTT
110 120 130 140 150
EPVDTDGVEP TNESNPQTVT APPKADRPKG KNTLSLSSAA ATEDQASASI
160 170 180 190 200
PLDESPLTFN PSKYIPQLQE SWATDGGDAS YALLIRCFVL VSSTTSRIKI
210 220 230 240 250
VDTLVNCVRL LIEGDPSSLL PAVWLATNAI SPPYVSMELG LGGSAISKAL
260 270 280 290 300
KQVCGLDNRS LKALNDKLGD PGDVAFEAKK KQSFTLRKPK PLTIKGVFQS
310 320 330 340 350
LVKISKTQGQ GSGDAKQRIV DKLLQDARGG EESRYVVRTL CQHLRIGAVK
360 370 380 390 400
TTMLIALARA FLLSKPPGAN IPTKDPNQLA KLKKEELAEV YAKAEEIVKA
410 420 430 440 450
SYARHPDYND LVPVLLETGV SEELLVRCGL TLHIPLRPML GGITRDLSEM
460 470 480 490 500
LSRLQGRDFA CEYKYDGQRA QIHCDDRGVV SIFSRHLELM TDKYPDLVAL
510 520 530 540 550
VPKIRGEDVQ SFIMEGEVVA VDRATGELKN FQTLTNRARK DVAIGAITID
560 570 580 590 600
VCLFAFDLMY LNGQPLLNRS FRERRDMLRS LFMEIPHHFT WVKSIDATSQ
610 620 630 640 650
ESEIVLEFFK SAVDSKCEGI MVKILDNLPE LEAPGPDDST DPIIPTELVA
660 670 680 690 700
TSSDAVAVSV SAKKSLKGMG KGNHAETKAP SDTPNPNSNE KKQSRRKPLL
710 720 730 740 750
ATYEPDKRLD SWLKVKKDYI GTSAGVDTLD LIPIAAWHGT GRKAKWWSPI
760 770 780 790 800
LLAVRNEETG SLEAVCKCMS GFTDSFYKAN REVYDKDGSF SSDGEPKNVH
810 820 830 840 850
VAKPGFVEYA GGNPDVWFEP QEVWEVAFAD ITISPTYTAA IGLVREDKGL
860 870 880 890 900
SLRFPRFLRK REDKGIEEAS TSDFLAGLWR KQEVKAPAPP PVEGGREIDE
910
AGLENEDEDD DEYEDGE
Length:917
Mass (Da):100,830
Last modified:January 22, 2014 - v3
Checksum:i7D7C32E31BC6A9B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002242 Genomic DNA. Translation: EAA29709.3.
RefSeqiXP_958945.2. XM_953852.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000009526; EFNCRP00000009508; EFNCRG00000009507.
GeneIDi3875111.
KEGGincr:NCU09706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002242 Genomic DNA. Translation: EAA29709.3 .
RefSeqi XP_958945.2. XM_953852.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09706.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000009526 ; EFNCRP00000009508 ; EFNCRG00000009507 .
GeneIDi 3875111.
KEGGi ncr:NCU09706.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036006.
InParanoidi Q7S2S0.
KOi K10747.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7S2S0_NEUCR
AccessioniPrimary (citable) accession number: Q7S2S0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 22, 2014
Last modified: October 29, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3