Q7S2S0 (Q7S2S0_NEUCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

ORF Names:

NCU09706 EMBL EAA29709.2

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	853 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW lagging strand elongation Inferred from Biological aspect of Ancestor. Source: RefGenome nucleotide-excision repair Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	chromosome Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7S2S0 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 85484A9B6A4D0FEE	FASTA	853	94,126
	10 20 30 40 50 60 MSSPAKKRKL NSGTKQSFSV PSRGLEYFFA KQKQNGASKE PSPLPKESDS QPAQQGSSEE 70 80 90 100 110 120 HLNDEELARK LQAEWDAEAR ASSTPRENDV RSQDVAVSTT EPVDTDGVEP TNESNPQTVT 130 140 150 160 170 180 APPKADRPKG KNTLSLSSAA ATEDQASASI PLDESPLTFN PSKYIPQLQE SWATDGGDAS 190 200 210 220 230 240 YALLIRCFVL VSSTTSRIKI VDTLVNCVRL LIEGDPSSLL PAVWLATNAI SPPSLKALND 250 260 270 280 290 300 KLGDPGDVAF EAKKKQSFTL RKPKPLTIKG VFQSLVKISK TQGQGSGDAK QRIVDKLLQD 310 320 330 340 350 360 ARGGEESRYV VRTLCQHLKK EELAEVYAKA EEIVKASYAR HPDYNDLVPV LLETGVSEEL 370 380 390 400 410 420 LVRCGLTLHI PLRPMLGGIT RDLSEMLSRL QGRDFACEYK YDGQRAQIHC DDRGVVSIFS 430 440 450 460 470 480 RHLELMTDKY PDLVALVPKI RGEDVQSFIM EGEVVAVDRA TGELKNFQTL TNRARKDVAI 490 500 510 520 530 540 GAITIDVCLF AFDLMYLNGQ PLLNRSFRER RDMLRSLFME IPHHFTWVKS IDATSQESEI 550 560 570 580 590 600 VLEFFKSAVD SKCEGIMVKI LDNLPELEAP GPDDSTDPII PTELVATSSD AVAVSVSAKK 610 620 630 640 650 660 SLKGMGKGNH AETKAPSDTP NPNSNEKKQS RRKPLLATYE PDKRLDSWLK VKKDYIGTSA 670 680 690 700 710 720 GVDTLDLIPI AAWHGTGRKA KWWSPILLAV RNEETGSLEA VCKCMSGFTD SFYKANREVY 730 740 750 760 770 780 DKDGSFSSDG EPKNVHVAKP GFVEYAGGNP DVWFEPQEVW EVAFADITIS PTYTAAIGLV 790 800 810 820 830 840 REDKGLSLRF PRFLRKREDK GIEEASTSDF LAGLWRKQEV KAPAPPPVEG GREIDEAGLE 850 NEDEDDDEYE DGE

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000084 Genomic DNA. Translation: EAA29709.2.
RefSeq	XP_958945.2. XM_953852.2.
3D structure databases
ProteinModelPortal	Q7S2S0.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU09706.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000009526; EFNCRP00000009508; EFNCRG00000009507.
GeneID	3875111.
KEGG	ncr:NCU09706.
Phylogenomic databases
eggNOG	COG1793.
HOGENOM	HOG000036006.
KO	K10747.
OMA	MSGFTDS.
OrthoDB	EOG4SFDF2.
Family and domain databases
Gene3D	1.10.3260.10. 3 hits. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7S2S0_NEUCR

Accession

Primary (citable) accession number: Q7S2S0

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	October 23, 2007
Last modified:	April 3, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)