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Protein

DNA ligase

Gene

NCU09706

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCU09706Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU09706.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ7S2S0.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7S2S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPAKKRKL NSGTKQSFSV PSRGLEYFFA KQKQNGASKE PSPLPKESDS
60 70 80 90 100
QPAQQGSSEE HLNDEELARK LQAEWDAEAR ASSTPRENDV RSQDVAVSTT
110 120 130 140 150
EPVDTDGVEP TNESNPQTVT APPKADRPKG KNTLSLSSAA ATEDQASASI
160 170 180 190 200
PLDESPLTFN PSKYIPQLQE SWATDGGDAS YALLIRCFVL VSSTTSRIKI
210 220 230 240 250
VDTLVNCVRL LIEGDPSSLL PAVWLATNAI SPPYVSMELG LGGSAISKAL
260 270 280 290 300
KQVCGLDNRS LKALNDKLGD PGDVAFEAKK KQSFTLRKPK PLTIKGVFQS
310 320 330 340 350
LVKISKTQGQ GSGDAKQRIV DKLLQDARGG EESRYVVRTL CQHLRIGAVK
360 370 380 390 400
TTMLIALARA FLLSKPPGAN IPTKDPNQLA KLKKEELAEV YAKAEEIVKA
410 420 430 440 450
SYARHPDYND LVPVLLETGV SEELLVRCGL TLHIPLRPML GGITRDLSEM
460 470 480 490 500
LSRLQGRDFA CEYKYDGQRA QIHCDDRGVV SIFSRHLELM TDKYPDLVAL
510 520 530 540 550
VPKIRGEDVQ SFIMEGEVVA VDRATGELKN FQTLTNRARK DVAIGAITID
560 570 580 590 600
VCLFAFDLMY LNGQPLLNRS FRERRDMLRS LFMEIPHHFT WVKSIDATSQ
610 620 630 640 650
ESEIVLEFFK SAVDSKCEGI MVKILDNLPE LEAPGPDDST DPIIPTELVA
660 670 680 690 700
TSSDAVAVSV SAKKSLKGMG KGNHAETKAP SDTPNPNSNE KKQSRRKPLL
710 720 730 740 750
ATYEPDKRLD SWLKVKKDYI GTSAGVDTLD LIPIAAWHGT GRKAKWWSPI
760 770 780 790 800
LLAVRNEETG SLEAVCKCMS GFTDSFYKAN REVYDKDGSF SSDGEPKNVH
810 820 830 840 850
VAKPGFVEYA GGNPDVWFEP QEVWEVAFAD ITISPTYTAA IGLVREDKGL
860 870 880 890 900
SLRFPRFLRK REDKGIEEAS TSDFLAGLWR KQEVKAPAPP PVEGGREIDE
910
AGLENEDEDD DEYEDGE
Length:917
Mass (Da):100,830
Last modified:January 22, 2014 - v3
Checksum:i7D7C32E31BC6A9B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002242 Genomic DNA. Translation: EAA29709.3.
RefSeqiXP_958945.3. XM_953852.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000009526; EFNCRP00000009508; EFNCRG00000009507.
GeneIDi3875111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002242 Genomic DNA. Translation: EAA29709.3.
RefSeqiXP_958945.3. XM_953852.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000009526; EFNCRP00000009508; EFNCRG00000009507.
GeneIDi3875111.

Organism-specific databases

EuPathDBiFungiDB:NCU09706.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ7S2S0.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7S2S0_NEUCR
AccessioniPrimary (citable) accession number: Q7S2S0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: January 22, 2014
Last modified: July 22, 2015
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.