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Q7S2S0

- Q7S2S0_NEUCR

UniProt

Q7S2S0 - Q7S2S0_NEUCR

Protein

DNA ligase

Gene

NCU09706

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (22 Jan 2014)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome

    GO - Biological processi

    1. DNA ligation Source: RefGenome
    2. DNA ligation involved in DNA repair Source: InterPro
    3. DNA recombination Source: UniProtKB-KW
    4. lagging strand elongation Source: RefGenome
    5. nucleotide-excision repair Source: RefGenome

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:NCU09706Imported
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 7, Linkage Group VII

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome
    2. nucleus Source: RefGenome

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU09706.1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036006.
    KOiK10747.
    OrthoDBiEOG7TXKRG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7S2S0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPAKKRKL NSGTKQSFSV PSRGLEYFFA KQKQNGASKE PSPLPKESDS    50
    QPAQQGSSEE HLNDEELARK LQAEWDAEAR ASSTPRENDV RSQDVAVSTT 100
    EPVDTDGVEP TNESNPQTVT APPKADRPKG KNTLSLSSAA ATEDQASASI 150
    PLDESPLTFN PSKYIPQLQE SWATDGGDAS YALLIRCFVL VSSTTSRIKI 200
    VDTLVNCVRL LIEGDPSSLL PAVWLATNAI SPPYVSMELG LGGSAISKAL 250
    KQVCGLDNRS LKALNDKLGD PGDVAFEAKK KQSFTLRKPK PLTIKGVFQS 300
    LVKISKTQGQ GSGDAKQRIV DKLLQDARGG EESRYVVRTL CQHLRIGAVK 350
    TTMLIALARA FLLSKPPGAN IPTKDPNQLA KLKKEELAEV YAKAEEIVKA 400
    SYARHPDYND LVPVLLETGV SEELLVRCGL TLHIPLRPML GGITRDLSEM 450
    LSRLQGRDFA CEYKYDGQRA QIHCDDRGVV SIFSRHLELM TDKYPDLVAL 500
    VPKIRGEDVQ SFIMEGEVVA VDRATGELKN FQTLTNRARK DVAIGAITID 550
    VCLFAFDLMY LNGQPLLNRS FRERRDMLRS LFMEIPHHFT WVKSIDATSQ 600
    ESEIVLEFFK SAVDSKCEGI MVKILDNLPE LEAPGPDDST DPIIPTELVA 650
    TSSDAVAVSV SAKKSLKGMG KGNHAETKAP SDTPNPNSNE KKQSRRKPLL 700
    ATYEPDKRLD SWLKVKKDYI GTSAGVDTLD LIPIAAWHGT GRKAKWWSPI 750
    LLAVRNEETG SLEAVCKCMS GFTDSFYKAN REVYDKDGSF SSDGEPKNVH 800
    VAKPGFVEYA GGNPDVWFEP QEVWEVAFAD ITISPTYTAA IGLVREDKGL 850
    SLRFPRFLRK REDKGIEEAS TSDFLAGLWR KQEVKAPAPP PVEGGREIDE 900
    AGLENEDEDD DEYEDGE 917
    Length:917
    Mass (Da):100,830
    Last modified:January 22, 2014 - v3
    Checksum:i7D7C32E31BC6A9B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002242 Genomic DNA. Translation: EAA29709.3.
    RefSeqiXP_958945.2. XM_953852.2.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000009526; EFNCRP00000009508; EFNCRG00000009507.
    GeneIDi3875111.
    KEGGincr:NCU09706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002242 Genomic DNA. Translation: EAA29709.3 .
    RefSeqi XP_958945.2. XM_953852.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU09706.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000009526 ; EFNCRP00000009508 ; EFNCRG00000009507 .
    GeneIDi 3875111.
    KEGGi ncr:NCU09706.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036006.
    KOi K10747.
    OrthoDBi EOG7TXKRG.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

    Entry informationi

    Entry nameiQ7S2S0_NEUCR
    AccessioniPrimary (citable) accession number: Q7S2S0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 15, 2003
    Last sequence update: January 22, 2014
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3