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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

tpc-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:tpc-1
ORF Names:NCU07384
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU07384

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei96 – 112Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei190 – 209Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei221 – 238Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei293 – 310Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204701 – 333Mitochondrial thiamine pyrophosphate carrier 1Add BLAST333

Structurei

3D structure databases

ProteinModelPortaliQ7S2H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 115Solcar 1Add BLAST104
Repeati129 – 215Solcar 2Add BLAST87
Repeati222 – 318Solcar 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726
InParanoidiQ7S2H8
KOiK15108
OMAiWKGNVPA
OrthoDBiEOG092C3KDM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q7S2H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKAERLKD EGSRLQVTAA GATAGLISRF VIAPLDVVKI RLQLQHHSLS
60 70 80 90 100
DPLLHQRRAE IIGGGPVYKG TLPTIRHILR TEGLTGLWKG NIPAELLYVS
110 120 130 140 150
YAAVQFTTYR SITQFLQAAF PKDQNKQLPP SVESFIAGAS AGGVATAVTY
160 170 180 190 200
PLDLLRTRFA AQGVERVYPS LVQALKTIYA SEGVTGYFRG LGPGLAQIIP
210 220 230 240 250
YMGTFFCVYE TLRPRLSKLE LPYSSGSAVA GVLASVMAKT GTFPLDLVRK
260 270 280 290 300
RIQVQGPTRG MYVHKNIPVY DGGMVKTVAT IVRREGVRGL YRGLTVSLFK
310 320 330
AAPASAVTMW TYERALKLYI RLGAAGPGRK EGV
Length:333
Mass (Da):36,097
Last modified:December 15, 2003 - v1
Checksum:i91123E0FFB22CED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002236 Genomic DNA Translation: EAA29641.1
RefSeqiXP_958877.1, XM_953784.3

Genome annotation databases

EnsemblFungiiEAA29641; EAA29641; NCU07384
GeneIDi3875015
KEGGincr:NCU07384

Similar proteinsi

Entry informationi

Entry nameiTPC1_NEUCR
AccessioniPrimary (citable) accession number: Q7S2H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 15, 2003
Last modified: January 31, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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