Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Helicase swr-1

Gene

crf1-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi970 – 977ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase swr-1 (EC:3.6.4.12)
Alternative name(s):
Chromatin remodeling factor 1-1
Gene namesi
Name:crf1-1
Synonyms:swr1
ORF Names:NCU09993
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU09993.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743711 – 1845Helicase swr-1Add BLAST1845

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7S133.
SMRiQ7S133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 493HSAPROSITE-ProRule annotationAdd BLAST76
Domaini957 – 1122Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1510 – 1660Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1073 – 1076DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 51Thr-richAdd BLAST50
Compositional biasi246 – 292Pro-richAdd BLAST47

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186095.
InParanoidiQ7S133.
KOiK11681.
OMAiHEVWGPH.
OrthoDBiEOG092C1YH4.

Family and domain databases

InterProiView protein in InterPro
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7S133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTMMTDSGT ASDSGAGLVD STRNDTTTTT TTTTTPGDND ADDDNTNGTT
60 70 80 90 100
TGHHDNNETD NNSKSYSSTH HVPAIDNTST TNANDNEDAA GFLDRDQSPL
110 120 130 140 150
SSISSPLSEP DNFEFDTEPI PSILSPKSTT SDNHARDGET PELDEDGQPP
160 170 180 190 200
AKRRRVRETT PHNHSRKPKP ESPPWKKFEA EGPTTIITED GRRKSGRVNP
210 220 230 240 250
VLLGMKPSDK KVTRKAIQTS PVSNKSSAST SRKPAPASSS NSKHAPAKMP
260 270 280 290 300
PPPPPPKAPA RKSATTHETR PSASRSRRRS PSPRRPATPP KPAAVGTRRS
310 320 330 340 350
TRQALAHSRA SYDDGQLSPG ASRATPRIKL KVRPPLTVIP LVHPNQANVR
360 370 380 390 400
PKLGPTFEEY FARAHEIPVE EGGQHIPDEE PKYTDEMALQ DAKVILRVEK
410 420 430 440 450
EVEPGGLLAP DRCSAFEPEA EEEPPRQWAH LDHLTKAMTN FRKLMYREQQ
460 470 480 490 500
LHMQAAKRIA IACEAEWRRR NPQPKTAEEI ELEEMEASKA KWRQVIRAFA
510 520 530 540 550
GTWENVRVEV NRRRLVEWEA EEQRRVKAAL NQAVNLSEQK LQQRQAQVDG
560 570 580 590 600
DEITDEDEDE DDEDLASGMP SVMGDEKESD EHSDQGSDEM SDENDEDEDE
610 620 630 640 650
DNMSSSEDDD KKSTASDEGL TQEELRAKYA NLPTLGTTDE TEETTKDVEM
660 670 680 690 700
ADAPAAMDGS VANDDDTSDE SVDMDDDLGS SEESDDDEEE EEDDEEEEES
710 720 730 740 750
DDEPAGLLGL FFGKSELKKL KEEAVTEEPS VEPAGDVEMT DASAALRPEL
760 770 780 790 800
QVNGHAHEAP ITNGTHTNEQ LASSQTEGAD DEVSLLVIPN DEIAAENTQT
810 820 830 840 850
AAEPGSGVVE KDFLTNDSSL KYPNEIVQSE NQTLPAKESV EAGGDLPMVD
860 870 880 890 900
APSTDDLQRE TAAAPSLEAP PNTRHDSQET VAATDMQSQS QTQSPKTTDT
910 920 930 940 950
KPTDVDTPHS ELAVSVQKPD SRQSSPQPTT PTVKTEIPFL LRGTLREYQH
960 970 980 990 1000
HGLDWLAGLY ANNTNGILAD EMGLGKTIQT IALLAHLACH HEVWGPHLVI
1010 1020 1030 1040 1050
VPTSVMLNWE MEFKKWCPGF KILTYYGNQE ERKRKRQGWN NDDVWNVCIT
1060 1070 1080 1090 1100
SYQMVLQDQQ VFRRRRWHYM ILDEAHNIKN FKSQRWQTLL GFNTQARLLL
1110 1120 1130 1140 1150
TGTPLQNNLT ELWSLLYFLA PPENGEGGFV DLTEFHNWFA RPESQILESG
1160 1170 1180 1190 1200
REQLDDEARA IIAKLHKVLR PYLLRRLKAD VEKQMPAKYE HVEFCRLSKR
1210 1220 1230 1240 1250
QRELYDGFLS RADTRETLQS GNYMSIINCL MQLRKVCNHP DLFVDRPIMT
1260 1270 1280 1290 1300
SFRMSRSVPA DYEWKEKFIR NRLLATKPMT TVNLSFLNMI PTEYEDLSKT
1310 1320 1330 1340 1350
HTDRIAQLSS HRILLDLREA QKVRANNAYT ALDPSSVKSN LVYLESAARW
1360 1370 1380 1390 1400
GRFEELQHCV YINALRRQQR PIYGKRLTEF LTLDTHLRPY KPRPRVPAKI
1410 1420 1430 1440 1450
MSWFEEDSFL LHNAIPTLQQ RAESMEMTIT KFACVTPAVV TGPEMNRFLL
1460 1470 1480 1490 1500
GERGIQLFED LDLKLSAPVK YAPYMPPQPP PDPWHEARMR LTIQFPDKRL
1510 1520 1530 1540 1550
LQYDCGKLQA LDKLLRKLQA GGHRALIFTQ MTKVLDILEQ FLNIHGHKYL
1560 1570 1580 1590 1600
RLDGATKVEQ RQILTDRFNH DPRILCFILS TRSGGLGINL TGADTVIFYD
1610 1620 1630 1640 1650
QDWNPAMDKQ CQDRCHRIGQ TRDVHIYRLV SEHTIEANIL RKASQKQMLD
1660 1670 1680 1690 1700
DVVIQEGEFT TDYFNRLSVR DVLGSNGEVI ASNEDDVAAN LAMDRVLGGP
1710 1720 1730 1740 1750
STTGAGGYDG TADGGGGASQ PPVRNVGRVL EMAEDREDVD AAKAAEKEIM
1760 1770 1780 1790 1800
QDEADFGEAG STRPGTPGDG LADLDGQLLG GEENKEVEDE VIEYNAWGER
1810 1820 1830 1840
MHTIDEYMLG FMAKALEGTP LELPRDRKKG RDRNRNRKGK DSRKR
Length:1,845
Mass (Da):206,953
Last modified:December 15, 2003 - v1
Checksum:i4E19DC989ACFEE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002242 Genomic DNA. Translation: EAA29066.1.
RefSeqiXP_958302.1. XM_953209.2.

Genome annotation databases

EnsemblFungiiEAA29066; EAA29066; NCU09993.
GeneIDi3874449.
KEGGincr:NCU09993.

Similar proteinsi

Entry informationi

Entry nameiSWR1_NEUCR
AccessioniPrimary (citable) accession number: Q7S133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 15, 2003
Last modified: July 5, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families