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Protein

Serine/threonine-protein kinase tel1

Gene

mus-21

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tel1 (EC:2.7.11.1)
Alternative name(s):
ATM homolog
DNA-damage checkpoint kinase tel1
Telomere length regulation protein 1
Gene namesi
Name:mus-21
Synonyms:tel1
ORF Names:NCU00274
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU00274.

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

  • Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29392939Serine/threonine-protein kinase tel1PRO_0000227705Add
BLAST

Interactioni

Subunit structurei

Associates with DNA double-strand breaks.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7RZT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1869 – 2471603FATPROSITE-ProRule annotationAdd
BLAST
Domaini2603 – 2906304PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2907 – 293933FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ7RZT9.
KOiK04728.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 5 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RZT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPATETVDF KKLIVTLNGK TITGRTSALK SLISYFKGDE TGSQAESHSQ
60 70 80 90 100
KLFDDKTYHY VYEALFTCAL TEKADYFSCL KSSKSDSVRN SCVKRLEGCA
110 120 130 140 150
EALRLAVQHG AYKIKRKTAT AIADHITQTL LDSDDNFFEP LLKGYVKVLS
160 170 180 190 200
AFLNIQVNVE NLAAFGGEKW ESSIDLCLNA ISRFLEAAEH DSGTSVRASP
210 220 230 240 250
APGTPATSRA GSVGPLSASV QVNGQLAIEF LACVKALTSA SNAPVLRRAK
260 270 280 290 300
RISQLVLRLL TLRHIKLGEL QRDSFSILNN ILVRVQTESI ALTNTITTAL
310 320 330 340 350
VPVLSHCWQP RSLSRDAMST SLKDEMLKTL YGIHLYLESL LREATDDKLL
360 370 380 390 400
QDTEDLLDSL WSEYSRRDDK TRLQLGDVTF SAMQLHPDHP LTMVFGLRPY
410 420 430 440 450
HLAGEQNWAL LENIALLEIV YAKNSQRDRQ HLEDEPDKPR KRRRVIGSSN
460 470 480 490 500
RIHQKLMSQD PAVQLTALQL IPFLSALKHP SLEEVKGALV DLSQFISAKQ
510 520 530 540 550
GLVASWAMIA CSSLAAHKTS RDPSLSAMWK QAWHIGIRSL SLPSTSRSAC
560 570 580 590 600
VLLNWILKAK LLSDHEIAGD VNQIITTADI SGPAMLVDSA PVLMLTLLRI
610 620 630 640 650
RNAIFPNASQ STSSHVIRWV FLKWNPCESA YASVHGVHAA PVDLINLLRA
660 670 680 690 700
CYEMPPLRMN TSLTVFDGPV AQFRAVQKQR HAMLRYLLLL EDEAPPEDSH
710 720 730 740 750
KATSTDQPKR EEIRAADSSS SHSAKRLILE LLFPKLDELL QMVELWHKRG
760 770 780 790 800
ESDSAAPVST DRLVSVASTC IVGAFIMPEL VGLNSSMSRD LEKTVFGIVE
810 820 830 840 850
GMIKAIAESP QSEDFFNLVL EVSAPYIPTL GEAELTHFKR EEPYALRLFA
860 870 880 890 900
TVSNSLLEKT RRESPTDSDP ASMDLDDEFD SQETRKSTTA GKRFLSRRDI
910 920 930 940 950
TLKHTPEAFY LDTSLRLHLL RIIRADDGEL GRVPDPIVDH LLELSDEDLL
960 970 980 990 1000
SCRLFMQELF ASDVVTPVDL AIRMIERIAA TISNNQYTCC EAAMCTVMDI
1010 1020 1030 1040 1050
MEGFITMWTD EELEISNLVG DIYDHLIKRA LPNNSLSSTA QIWFSRLLFR
1060 1070 1080 1090 1100
LLEVNPMFAS QVLKLPSTRS TLLTILRDAP MDVKFFIGIN LPRIFGMHVL
1110 1120 1130 1140 1150
QTHDDIIVEI LEVLPGEGME GIAFRLFVLA ELACKWPTLL RRCAYHIFET
1160 1170 1180 1190 1200
PGKNQTSASH ATSCLKRVSR CLNLSSPQEL FTIFAPQILY TWLAIDSIDE
1210 1220 1230 1240 1250
IPYSIFGFSN LAELLSKSQS EAVGIMIMRG HETDARELAK TLKLSIQELV
1260 1270 1280 1290 1300
TQNFSKIVAY SIAQDSSLPN EVTGESRVRR IIGAEPYSSN IILNFADILA
1310 1320 1330 1340 1350
IFFEICDQEY PIEDSFRKDA ANFAYAADIM DKIKAFGHLD TMLPPNQQPS
1360 1370 1380 1390 1400
YKAKFLKRQI LHLVKRTNYE LHDIWTPALV VFVARKLLNT IHPALGPLHA
1410 1420 1430 1440 1450
CSVLRKIRVL ICLAGDTALY GYPLEMLLHS LRAFVVDPEC ADDALGITQY
1460 1470 1480 1490 1500
LITEGSDHLI RFPSFLAGYA LSCLADLRVF LESSQSSTTQ ESQFKATKSK
1510 1520 1530 1540 1550
AQLFHAWFSK YLANYTTNAW KDKTQKEAFE AITQSAANIR VMGNAEKGTH
1560 1570 1580 1590 1600
ESKLLLEILK DWGRQHQLLN GPARSVALSI LCGSFNVPPP SRLDVIQSDE
1610 1620 1630 1640 1650
EALAHGAAVW MSCGSKKLSS EYLAWAGRVI GRSYAASGDV PPELLRESRL
1660 1670 1680 1690 1700
QEYRKKSPVN FDFMESEEAL LSLIEALTAS SDGFRAGLAE AALRVAVSDA
1710 1720 1730 1740 1750
LHENDRPLIT ACQKSLSESL LVASEWGELR IPRSDRFSVE HPNETEIFSA
1760 1770 1780 1790 1800
EFLESPEWAQ QLTTLLAQSV PGSVALRVLP PILTKVKGFA EQAFPFIVHN
1810 1820 1830 1840 1850
VLEYELDQTQ GMKQKLSEAL KEWLTSTSPA ARDNQKLLIN TILYLRTQAN
1860 1870 1880 1890 1900
PNETSIADRL HWLEVNFSIA AAAATRCGMY KVALLFAELA STEITRQSRR
1910 1920 1930 1940 1950
SSAIQGLGDT SEILLDIFEN IDDPDAYYGL TQDASLSTVL ARLEYENDGT
1960 1970 1980 1990 2000
KSLAFRGAQY DSHLRRRDVA SQQDGQALIK ALSSLGLAGL SNSLLQTQQS
2010 2020 2030 2040 2050
LDGSSTSLDS TFITARRLEI WNLPAPAATE NWAVTVYKAY QSMHQASDIN
2060 2070 2080 2090 2100
MVRSAVHDGL TKTLKHLTGK SLNTLTLRHQ LGALATLAEL DDVLNTGDLS
2110 2120 2130 2140 2150
ELNGIIEDFQ ARSKWMMSGQ YDDVSRILSC RETTLSLWSQ RHNLRPARLT
2160 2170 2180 2190 2200
PANARLAQIR GMLVSSDIYR FHRATQETLN LSTTLTDLIR PSEQMGLAVD
2210 2220 2230 2240 2250
AAIRMETANS LWDQGEMISS IRMLQNIDKE SPLEKQTVPV SRSDLLSKIG
2260 2270 2280 2290 2300
YQVSVARLES PDTIQKNYLE PALKELKGKS EGKEAGRVYH QFAMFCDEQL
2310 2320 2330 2340 2350
QNPDGLEDLA RLQNLERGKN DEVTQLKALI ASTRDSQLKN KYSSHLSKAK
2360 2370 2380 2390 2400
QWLDLDQQEL RRVEQTRSEF VRLSLQNYLL SLAASDEYNN DALRFTALWL
2410 2420 2430 2440 2450
ECSEDDMVNE VVKRYLSKVP TRKFAPLINQ LSSRLQHQEG LFQITLIGLV
2460 2470 2480 2490 2500
YSICLDHPYH GMYQIWSGVK ARSIKNDEVA LSRQKATDKI ARAIKKSGAS
2510 2520 2530 2540 2550
AAKIYLAINA TSKVYHNLAM DRDAKKYKAG HKMNIKDSKA GLEFLAAFAE
2560 2570 2580 2590 2600
FPIPPPTMQM PLLASCDYSQ VPMIVKFEPQ MSIASGVSAP KIITAIGSDG
2610 2620 2630 2640 2650
RQYKQLVKGG NDDLRQDAIM EQVFAAVSEL LKHHRATRQR NLGIRTYKVL
2660 2670 2680 2690 2700
PLTETTGVIE FVSNTIPLHE YLMPAHEIYY PKDLKGSHCR KEIMNAQSKS
2710 2720 2730 2740 2750
VDTRVAVYRK VTERFHPVMR YFFMEWFPDP DEWFARRTAY TRTTAAISML
2760 2770 2780 2790 2800
GHVLGLGDRH GHNILLDTKT GEVVHIDLGV AFELGRILPV PELVPFRLTR
2810 2820 2830 2840 2850
DIVDGMGITK TEGVFRRCCE FTLDALREET YSIMTILDVL RYDPLYSWSM
2860 2870 2880 2890 2900
SPLRMARLQN VRVGAGEDDV VEAEDERRAG DKKSTKNLNE PSEADRALEV
2910 2920 2930
VRKKLSKTLS VMATVNDLIN QATDERNLAV LFCGWAAYA
Length:2,939
Mass (Da):328,696
Last modified:December 4, 2007 - v2
Checksum:iA20726A7FE66C920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA28509.3.
RefSeqiXP_957745.3. XM_952652.3.

Genome annotation databases

EnsemblFungiiEFNCRT00000000181; EFNCRP00000000181; EFNCRG00000000181.
GeneIDi3873915.
KEGGincr:NCU00274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA28509.3.
RefSeqiXP_957745.3. XM_952652.3.

3D structure databases

ProteinModelPortaliQ7RZT9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000000181; EFNCRP00000000181; EFNCRG00000000181.
GeneIDi3873915.
KEGGincr:NCU00274.

Organism-specific databases

EuPathDBiFungiDB:NCU00274.

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ7RZT9.
KOiK04728.
OrthoDBiEOG7ZWD92.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 5 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiATM_NEUCR
AccessioniPrimary (citable) accession number: Q7RZT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 4, 2007
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.