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Q7RZA5 (MTAP_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Short name=MTAPase
Gene names
ORF Names:NCU03963, NCU03963.1
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_03155

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_03155

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_03155

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_03155

Subcellular location

Cytoplasm By similarity. Nucleus By similarity HAMAP-Rule MF_03155.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_03155
PRO_0000415131

Regions

Region62 – 632Phosphate binding By similarity
Region95 – 962Phosphate binding By similarity
Region221 – 2233Substrate binding By similarity

Sites

Binding site201Phosphate By similarity
Binding site1971Substrate; via amide nitrogen By similarity
Binding site1981Phosphate By similarity
Site1791Important for substrate specificity By similarity
Site2351Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7RZA5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: B041C35866DF28D0

FASTA31033,720
        10         20         30         40         50         60 
MENLPTTYDG PVHIAVIGGT GLSKLEGYVP VAALNPTTPW GSPSSPLMIF EHNGHAVAFL 

        70         80         90        100        110        120 
ARHGLYHQLA PHEVPARANI AALRSIGVRT IIAFSAVGSL REEIKPMDFV IPDQIIDRTK 

       130        140        150        160        170        180 
GIRPFTFYEG GVVGHVGFAD PFDAGLAQVV EKCASAMKGD GVVLHNKGTI ICMEGPAFST 

       190        200        210        220        230        240 
RAESHMYRSW GGSVINMSAL PEAKLAREAE LAYQMICMAT DYDCWRDEAG EDVDVAMVMK 

       250        260        270        280        290        300 
YMAANGENAK HLVGAVLDEL LKQDNSDLVL AKKWQGSAQG AVKFMTKPEG RDPEAMKRVE 

       310 
FLFPGFWEQN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002241 Genomic DNA. Translation: EAA28366.1.
RefSeqXP_957602.1. XM_952509.2.
UniGeneNcr.19060.

3D structure databases

ProteinModelPortalQ7RZA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03963.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000003734; EFNCRP00000003734; EFNCRG00000003730.
GeneID3873724.
KEGGncr:NCU03963.

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000228986.
KOK00772.
OMAMTNHTEA.
OrthoDBEOG77DJGM.

Enzyme and pathway databases

UniPathwayUPA00904; UER00873.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTAP_NEUCR
AccessionPrimary (citable) accession number: Q7RZA5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways