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Q7RYU8

- HAT1_NEUCR

UniProt

Q7RYU8 - HAT1_NEUCR

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei178 – 1781Interaction with histone H4 N-terminusBy similarity
Active sitei284 – 2841Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat-1
ORF Names:NCU06472
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Histone acetyltransferase type B catalytic subunitPRO_0000227726Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail.By similarity

Protein-protein interaction databases

STRINGi5141.NCU06472.1.

Structurei

3D structure databases

ProteinModelPortaliQ7RYU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 463Interaction with histone H4 N-terminusBy similarity
Regioni207 – 2093Interaction with histone H4 N-terminusBy similarity
Regioni249 – 2513Acetyl-CoA bindingBy similarity
Regioni256 – 2627Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000164382.
InParanoidiQ7RYU8.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7RYU8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGDDDWWTS SNEALLVSLV TPSDTGVKTL DTFHPEYTNN IFGEKEQIFG
60 70 80 90 100
YKGLRINLQY NASDMLPNLK VSYKKKYQPT ADEEALDINE VLSEFLPEIA
110 120 130 140 150
FQKQSDFETR LKSIPDNWTP PGTLVTSFTN KDGEYEVYSG KITDPAVKQL
160 170 180 190 200
LNRIQILVPF FVDGGTPIDM EDPDVDRWTI YFLYNKRPLL NQPDKFSYHF
210 220 230 240 250
AGYSTLYRYY AFQPPAESES KTPTDTPTFS VDGDFDLDTL PCRTRISQFI
260 270 280 290 300
IIPPFQQKGL GSRLYSIIYQ QYLKHEPTIE LTVEDPNEAF DDMRDLADLA
310 320 330 340 350
FLSKQPEFQA LKIDTSVEIP EEGKAPSNIV DQAAWEACRK KFKIVPRQFA
360 370 380 390 400
RVLEMYLMSQ LPESVRPGLG APEDEDYEEQ SGRSKSKGHE KALPKPTPED
410 420 430 440 450
EHTYRLWMML VKRRLYVHNR DALGQLELKE RREELAKVFA GVEFDYARLL
460 470 480 490 500
IKAEEQGKLA QADGETAGDQ VPATPSAANG KRKLDEVEQA EGTAAASSKK

AKVESGHA
Length:508
Mass (Da):57,696
Last modified:December 15, 2003 - v1
Checksum:iD2DCF7829D6855D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA28127.1.
RefSeqiXP_957363.1. XM_952270.2.
UniGeneiNcr.16687.

Genome annotation databases

EnsemblFungiiEFNCRT00000006218; EFNCRP00000006210; EFNCRG00000006207.
GeneIDi3873462.
KEGGincr:NCU06472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA28127.1 .
RefSeqi XP_957363.1. XM_952270.2.
UniGenei Ncr.16687.

3D structure databases

ProteinModelPortali Q7RYU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU06472.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006218 ; EFNCRP00000006210 ; EFNCRG00000006207 .
GeneIDi 3873462.
KEGGi ncr:NCU06472.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000164382.
InParanoidi Q7RYU8.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiHAT1_NEUCR
AccessioniPrimary (citable) accession number: Q7RYU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3