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Reviewed, UniProtKB/Swiss-Prot Q7RYU8 (HAT1_NEUCR)

Last modified February 9, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone acetyltransferase type B catalytic subunit
    EC=2.3.1.48
Gene names
Name: hat-1
ORF Names: NCU06472
OrganismNeurospora crassa [Complete proteome]
Taxonomic identifier5141 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

histone acetylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: EC

protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Histone acetyltransferase type B catalytic subunit
PRO_0000227726

Sequences

Sequence LengthMass (Da)Tools
Q7RYU8-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: D2DCF7829D6855D7

FASTA50857,696
        10         20         30         40         50         60 
MSGDDDWWTS SNEALLVSLV TPSDTGVKTL DTFHPEYTNN IFGEKEQIFG YKGLRINLQY 

        70         80         90        100        110        120 
NASDMLPNLK VSYKKKYQPT ADEEALDINE VLSEFLPEIA FQKQSDFETR LKSIPDNWTP 

       130        140        150        160        170        180 
PGTLVTSFTN KDGEYEVYSG KITDPAVKQL LNRIQILVPF FVDGGTPIDM EDPDVDRWTI 

       190        200        210        220        230        240 
YFLYNKRPLL NQPDKFSYHF AGYSTLYRYY AFQPPAESES KTPTDTPTFS VDGDFDLDTL 

       250        260        270        280        290        300 
PCRTRISQFI IIPPFQQKGL GSRLYSIIYQ QYLKHEPTIE LTVEDPNEAF DDMRDLADLA 

       310        320        330        340        350        360 
FLSKQPEFQA LKIDTSVEIP EEGKAPSNIV DQAAWEACRK KFKIVPRQFA RVLEMYLMSQ 

       370        380        390        400        410        420 
LPESVRPGLG APEDEDYEEQ SGRSKSKGHE KALPKPTPED EHTYRLWMML VKRRLYVHNR 

       430        440        450        460        470        480 
DALGQLELKE RREELAKVFA GVEFDYARLL IKAEEQGKLA QADGETAGDQ VPATPSAANG 

       490        500 
KRKLDEVEQA EGTAAASSKK AKVESGHA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABX02000027 Genomic DNA. Translation: EAA28127.1.
RefSeqXP_957363.1.

3D structure databases

SMRQ7RYU8. Positions 3-361.
ModBaseSearch...

Genome annotation databases

GeneID3873462.
KEGGncr:NCU06472.
NMPDRfig|5141.1.peg.4260.

Phylogenomic databases

eggNOGfuNOG05412.
OrthoDBEOG9CG1RQ.
PhylomeDBQ7RYU8.

Enzyme and pathway databases

BRENDA2.3.1.48. 266.

Family and domain databases

InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_NEUCR
AccessionPrimary (citable) accession number: Q7RYU8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents