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Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei284Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat-1
ORF Names:NCU06472
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU06472

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277261 – 508Histone acetyltransferase type B catalytic subunitAdd BLAST508

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei178Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ7RYU8
SMRiQ7RYU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 46Interaction with histone H4 N-terminusBy similarity3
Regioni207 – 209Interaction with histone H4 N-terminusBy similarity3
Regioni249 – 251Acetyl-CoA bindingBy similarity3
Regioni256 – 262Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

HOGENOMiHOG000164382
InParanoidiQ7RYU8
KOiK11303
OMAiMAHQIFG
OrthoDBiEOG092C3YYH

Family and domain databases

Gene3Di3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RYU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDDDWWTS SNEALLVSLV TPSDTGVKTL DTFHPEYTNN IFGEKEQIFG
60 70 80 90 100
YKGLRINLQY NASDMLPNLK VSYKKKYQPT ADEEALDINE VLSEFLPEIA
110 120 130 140 150
FQKQSDFETR LKSIPDNWTP PGTLVTSFTN KDGEYEVYSG KITDPAVKQL
160 170 180 190 200
LNRIQILVPF FVDGGTPIDM EDPDVDRWTI YFLYNKRPLL NQPDKFSYHF
210 220 230 240 250
AGYSTLYRYY AFQPPAESES KTPTDTPTFS VDGDFDLDTL PCRTRISQFI
260 270 280 290 300
IIPPFQQKGL GSRLYSIIYQ QYLKHEPTIE LTVEDPNEAF DDMRDLADLA
310 320 330 340 350
FLSKQPEFQA LKIDTSVEIP EEGKAPSNIV DQAAWEACRK KFKIVPRQFA
360 370 380 390 400
RVLEMYLMSQ LPESVRPGLG APEDEDYEEQ SGRSKSKGHE KALPKPTPED
410 420 430 440 450
EHTYRLWMML VKRRLYVHNR DALGQLELKE RREELAKVFA GVEFDYARLL
460 470 480 490 500
IKAEEQGKLA QADGETAGDQ VPATPSAANG KRKLDEVEQA EGTAAASSKK

AKVESGHA
Length:508
Mass (Da):57,696
Last modified:December 15, 2003 - v1
Checksum:iD2DCF7829D6855D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA Translation: EAA28127.1
RefSeqiXP_957363.1, XM_952270.3

Genome annotation databases

EnsemblFungiiEAA28127; EAA28127; NCU06472
GeneIDi3873462
KEGGincr:NCU06472

Entry informationi

Entry nameiHAT1_NEUCR
AccessioniPrimary (citable) accession number: Q7RYU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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