Q7RYU8 (HAT1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B catalytic subunit
EC=2.3.1.48

Gene names

Name:	hat-1
ORF Names:	NCU06472

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the HAT1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell histone acetyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Histone acetyltransferase type B catalytic subunit		PRO_0000227726

Sequences

	Sequence		Length	Mass (Da)
	Q7RYU8 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: D2DCF7829D6855D7	FASTA	508	57,696
	10 20 30 40 50 60 MSGDDDWWTS SNEALLVSLV TPSDTGVKTL DTFHPEYTNN IFGEKEQIFG YKGLRINLQY 70 80 90 100 110 120 NASDMLPNLK VSYKKKYQPT ADEEALDINE VLSEFLPEIA FQKQSDFETR LKSIPDNWTP 130 140 150 160 170 180 PGTLVTSFTN KDGEYEVYSG KITDPAVKQL LNRIQILVPF FVDGGTPIDM EDPDVDRWTI 190 200 210 220 230 240 YFLYNKRPLL NQPDKFSYHF AGYSTLYRYY AFQPPAESES KTPTDTPTFS VDGDFDLDTL 250 260 270 280 290 300 PCRTRISQFI IIPPFQQKGL GSRLYSIIYQ QYLKHEPTIE LTVEDPNEAF DDMRDLADLA 310 320 330 340 350 360 FLSKQPEFQA LKIDTSVEIP EEGKAPSNIV DQAAWEACRK KFKIVPRQFA RVLEMYLMSQ 370 380 390 400 410 420 LPESVRPGLG APEDEDYEEQ SGRSKSKGHE KALPKPTPED EHTYRLWMML VKRRLYVHNR 430 440 450 460 470 480 DALGQLELKE RREELAKVFA GVEFDYARLL IKAEEQGKLA QADGETAGDQ VPATPSAANG 490 500 KRKLDEVEQA EGTAAASSKK AKVESGHA

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000027 Genomic DNA. Translation: EAA28127.1.
RefSeq	XP_957363.1. XM_952270.2.
UniGene	Ncr.16687.
3D structure databases
ProteinModelPortal	Q7RYU8.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU06472.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000006218; EFNCRP00000006210; EFNCRG00000006207.
GeneID	3873462.
KEGG	ncr:NCU06472.
Phylogenomic databases
eggNOG	NOG326277.
HOGENOM	HOG000164382.
KO	K11303.
OMA	ETIYGYE.
OrthoDB	EOG4WHCV7.
Family and domain databases
Gene3D	1.10.10.390. 1 hit. 3.40.630.30. 1 hit. 3.90.360.10. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. IPR013523. Hist_AcTrfase_HAT1_C. [Graphical view]
PANTHER	PTHR12046. PTHR12046. 1 hit.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HAT1_NEUCR

Accession

Primary (citable) accession number: Q7RYU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program