Q7RYL6 (AMPP1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	ampp
ORF Names:	NCU00112

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Probable Xaa-Pro aminopeptidase P		PRO_0000411799
Sites
	Metal binding	411	1	Manganese 2 By similarity
	Metal binding	422	1	Manganese 1 By similarity
	Metal binding	422	1	Manganese 2 By similarity
	Metal binding	520	1	Manganese 1 By similarity
	Metal binding	534	1	Manganese 1 By similarity
	Metal binding	534	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7RYL6 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: E092E3DEE18F6B73	FASTA	614	67,872
	10 20 30 40 50 60 MTVNTTDRLA ALRSLMKERN VDIYVVPSED SHASEYIAEC DARRAFISGF TGSAGTAVVT 70 80 90 100 110 120 LDKAALATDG RYFNQASKQL DENWHLLKTG LQDVPTWQEW TADESAGGKS VGIDPTLISP 130 140 150 160 170 180 AVADKLDGDI KKHGGAGLKA INENLVDLVW GDSRPPRPSE PVFLLGAKYS GKGTAEKLTN 190 200 210 220 230 240 LRKELEKKKA AAFVVSMLDE VAWLFNLRGN DITYNPVFFS YAIVTKDSAT LYVDESKLND 250 260 270 280 290 300 EVKQYLAENG TGIKPYNDLF KDTEILANAA KSTSESDKPT KYLVSNKASW ALKLALGGEK 310 320 330 340 350 360 HVDEVRSPIG DAKAIKNETE LEGMRRCHIR DGAALIKYFA WLEDQLINKK AKLDEVEAAD 370 380 390 400 410 420 QLEQFRSEQA DFVGLSFDTI SSTGPNGAII HYKPERGACS VIDPDAIYLC DSGAQFCDGT 430 440 450 460 470 480 TDVTRTLHFG QPTDAERKSY TLVLKGNIAL DTAVFPKGTS GFALDALARQ FLWKYGLDYR 490 500 510 520 530 540 HGTGHGVGSF LNVHEGPIGI GTRKAYIDVP LAPGNVLSIE PGYYEDGNYG IRIENLAIVR 550 560 570 580 590 600 EVKTEHQFGD KPYLGFEHVT MVPYCRKLID ESLLTQEEKD WLNKSNEEIR KNMAGYFDGD 610 QLTTEWLLRE TSPF

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000001 Genomic DNA. Translation: EAA28000.1.
RefSeq	XP_957236.1. XM_952143.1.
UniGene	Ncr.15444.
3D structure databases
ProteinModelPortal	Q7RYL6.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU00112.1.
Protein family/group databases
MEROPS	M24.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000000161; EFNCRP00000000161; EFNCRG00000000161.
GeneID	3873358.
KEGG	ncr:NCU00112.
Phylogenomic databases
eggNOG	COG0006.
HOGENOM	HOG000255713.
KO	K01262.
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_NEUCR

Accession

Primary (citable) accession number: Q7RYL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program