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Protein

DNA ligase

Gene

NCU06481

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: GO_Central

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: GO_Central
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. lagging strand elongation Source: GO_Central
  6. nucleotide-excision repair Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCU06481Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: GO_Central
  2. mitochondrion Source: GO_Central
  3. nucleus Source: GO_Central
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU06481.1.

Structurei

3D structure databases

ProteinModelPortaliQ7RYJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ7RYJ3.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKQQQTLG KFFGKADAPA GGKQQTKLSF GTKATSTTSS KTKEEPKKDE
60 70 80 90 100
IAGEDGGHEE VEKKVEEMKI KDKSPAKTGR GRGRPAKGKE VAKEVAKEKS
110 120 130 140 150
SAEEDEDVME VVEEVKEETG NKKKRSRSPT TKSPKSKKAK TEEDSEDVAP
160 170 180 190 200
ASKRSRRSRK VVEDDEDETM EDVPASSAPV KEEKSKKAAS PKPALKKKSS
210 220 230 240 250
SPAPVEKAND AEASSASASE IEAEEEDEDE KTEAVAKEAR KVIQTTLATK
260 270 280 290 300
VKDPYPDWKA GEPVPYAALC TTFSLIEQTR KRLLIMEYCS LFLRQVLRLT
310 320 330 340 350
PDDLLPTVLL MINKLAPDYA GIELGIGESL IMKAIGETTG RSIAVVKNDQ
360 370 380 390 400
KEIGDLGLVA VKSRSKQPTM FKPKPLTIRG VHKGLMDIAT TMTGTGAQQK
410 420 430 440 450
KVDGIKKLLS AADANSTGKV DITKDKGGPS EAKFIVRFLE GKLRLGLAEK
460 470 480 490 500
SVIVSLAQAM IAHEFAQKGK IPSESDFSKA ESILKTVYSE LPSYDVIIPA
510 520 530 540 550
MLQHGIMNLR EHCKLRPGVP LKPMLANPTK AITEVLDRFE GQTFTCEYKY
560 570 580 590 600
DGERAQIHYV AKDVPKSEGD LSQVASKDTG KGVAAIFSRN SEDLSQKYPD
610 620 630 640 650
VLAKLPTWVK EGTKSFVLDC ESVAWDTVDK KVLPFQQLMT RKKKDVKLED
660 670 680 690 700
VKVKVCVFAF DLLYLNGQAV VEKSLRERRE LLREAFKPVE GEFAFATSMD
710 720 730 740 750
GQELDEIQSF LDESVKAGCE GLMVKMLDGA ESGYEPSKRS RNWLKIKKDY
760 770 780 790 800
LAGIGDSLDL VVLGAYHGKG KRTSVFGAFL LACYNPSTDT YETVCNIGTG
810 820 830 840 850
FSDEVLQELH SSLSPIIIDR PKPFYAHSSG GQHQPDVWFE PKYVWEVKTA
860 870 880 890 900
DLTLSPRYKA GMKEGVDPSG EKGISLRFPR FIKVRDDKKP DEATTSRMVA
910 920
EMYRKQESVG KNKGPAVDDN FEY
Length:923
Mass (Da):101,799
Last modified:December 15, 2003 - v1
Checksum:iCE1A00706465A807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA27885.1.
RefSeqiXP_957121.1. XM_952028.1.
UniGeneiNcr.25681.

Genome annotation databases

EnsemblFungiiEFNCRT00000006215; EFNCRP00000006207; EFNCRG00000006204.
GeneIDi3873294.
KEGGincr:NCU06481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA27885.1.
RefSeqiXP_957121.1. XM_952028.1.
UniGeneiNcr.25681.

3D structure databases

ProteinModelPortaliQ7RYJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.NCU06481.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000006215; EFNCRP00000006207; EFNCRG00000006204.
GeneIDi3873294.
KEGGincr:NCU06481.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiQ7RYJ3.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987Imported.

Entry informationi

Entry nameiQ7RYJ3_NEUCR
AccessioniPrimary (citable) accession number: Q7RYJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: February 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.