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Protein

DNA ligase

Gene

NCU06481

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCU06481Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU06481

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliQ7RYJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini648 – 785DNA_LIGASE_A3InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006
InParanoidiQ7RYJ3
KOiK10747
OMAiWIKYKRD
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKQQQTLG KFFGKADAPA GGKQQTKLSF GTKATSTTSS KTKEEPKKDE
60 70 80 90 100
IAGEDGGHEE VEKKVEEMKI KDKSPAKTGR GRGRPAKGKE VAKEVAKEKS
110 120 130 140 150
SAEEDEDVME VVEEVKEETG NKKKRSRSPT TKSPKSKKAK TEEDSEDVAP
160 170 180 190 200
ASKRSRRSRK VVEDDEDETM EDVPASSAPV KEEKSKKAAS PKPALKKKSS
210 220 230 240 250
SPAPVEKAND AEASSASASE IEAEEEDEDE KTEAVAKEAR KVIQTTLATK
260 270 280 290 300
VKDPYPDWKA GEPVPYAALC TTFSLIEQTR KRLLIMEYCS LFLRQVLRLT
310 320 330 340 350
PDDLLPTVLL MINKLAPDYA GIELGIGESL IMKAIGETTG RSIAVVKNDQ
360 370 380 390 400
KEIGDLGLVA VKSRSKQPTM FKPKPLTIRG VHKGLMDIAT TMTGTGAQQK
410 420 430 440 450
KVDGIKKLLS AADANSTGKV DITKDKGGPS EAKFIVRFLE GKLRLGLAEK
460 470 480 490 500
SVIVSLAQAM IAHEFAQKGK IPSESDFSKA ESILKTVYSE LPSYDVIIPA
510 520 530 540 550
MLQHGIMNLR EHCKLRPGVP LKPMLANPTK AITEVLDRFE GQTFTCEYKY
560 570 580 590 600
DGERAQIHYV AKDVPKSEGD LSQVASKDTG KGVAAIFSRN SEDLSQKYPD
610 620 630 640 650
VLAKLPTWVK EGTKSFVLDC ESVAWDTVDK KVLPFQQLMT RKKKDVKLED
660 670 680 690 700
VKVKVCVFAF DLLYLNGQAV VEKSLRERRE LLREAFKPVE GEFAFATSMD
710 720 730 740 750
GQELDEIQSF LDESVKAGCE GLMVKMLDGA ESGYEPSKRS RNWLKIKKDY
760 770 780 790 800
LAGIGDSLDL VVLGAYHGKG KRTSVFGAFL LACYNPSTDT YETVCNIGTG
810 820 830 840 850
FSDEVLQELH SSLSPIIIDR PKPFYAHSSG GQHQPDVWFE PKYVWEVKTA
860 870 880 890 900
DLTLSPRYKA GMKEGVDPSG EKGISLRFPR FIKVRDDKKP DEATTSRMVA
910 920
EMYRKQESVG KNKGPAVDDN FEY
Length:923
Mass (Da):101,799
Last modified:December 15, 2003 - v1
Checksum:iCE1A00706465A807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA Translation: EAA27885.1
RefSeqiXP_957121.1, XM_952028.2

Genome annotation databases

EnsemblFungiiEAA27885; EAA27885; NCU06481
GeneIDi3873294
KEGGincr:NCU06481

Similar proteinsi

Entry informationi

Entry nameiQ7RYJ3_NEUCR
AccessioniPrimary (citable) accession number: Q7RYJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health