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Q7RYJ3

- Q7RYJ3_NEUCR

UniProt

Q7RYJ3 - Q7RYJ3_NEUCR

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Protein
DNA ligase
Gene
NCU06481
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. DNA ligation Source: RefGenome
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. lagging strand elongation Source: RefGenome
  5. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCU06481Imported
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)Imported
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. mitochondrion Source: RefGenome
  3. nucleus Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU06481.1.

Structurei

3D structure databases

ProteinModelPortaliQ7RYJ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
KOiK10747.
OMAiMVKMLEG.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RYJ3-1 [UniParc]FASTAAdd to Basket

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MPPKQQQTLG KFFGKADAPA GGKQQTKLSF GTKATSTTSS KTKEEPKKDE    50
IAGEDGGHEE VEKKVEEMKI KDKSPAKTGR GRGRPAKGKE VAKEVAKEKS 100
SAEEDEDVME VVEEVKEETG NKKKRSRSPT TKSPKSKKAK TEEDSEDVAP 150
ASKRSRRSRK VVEDDEDETM EDVPASSAPV KEEKSKKAAS PKPALKKKSS 200
SPAPVEKAND AEASSASASE IEAEEEDEDE KTEAVAKEAR KVIQTTLATK 250
VKDPYPDWKA GEPVPYAALC TTFSLIEQTR KRLLIMEYCS LFLRQVLRLT 300
PDDLLPTVLL MINKLAPDYA GIELGIGESL IMKAIGETTG RSIAVVKNDQ 350
KEIGDLGLVA VKSRSKQPTM FKPKPLTIRG VHKGLMDIAT TMTGTGAQQK 400
KVDGIKKLLS AADANSTGKV DITKDKGGPS EAKFIVRFLE GKLRLGLAEK 450
SVIVSLAQAM IAHEFAQKGK IPSESDFSKA ESILKTVYSE LPSYDVIIPA 500
MLQHGIMNLR EHCKLRPGVP LKPMLANPTK AITEVLDRFE GQTFTCEYKY 550
DGERAQIHYV AKDVPKSEGD LSQVASKDTG KGVAAIFSRN SEDLSQKYPD 600
VLAKLPTWVK EGTKSFVLDC ESVAWDTVDK KVLPFQQLMT RKKKDVKLED 650
VKVKVCVFAF DLLYLNGQAV VEKSLRERRE LLREAFKPVE GEFAFATSMD 700
GQELDEIQSF LDESVKAGCE GLMVKMLDGA ESGYEPSKRS RNWLKIKKDY 750
LAGIGDSLDL VVLGAYHGKG KRTSVFGAFL LACYNPSTDT YETVCNIGTG 800
FSDEVLQELH SSLSPIIIDR PKPFYAHSSG GQHQPDVWFE PKYVWEVKTA 850
DLTLSPRYKA GMKEGVDPSG EKGISLRFPR FIKVRDDKKP DEATTSRMVA 900
EMYRKQESVG KNKGPAVDDN FEY 923
Length:923
Mass (Da):101,799
Last modified:December 15, 2003 - v1
Checksum:iCE1A00706465A807
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA27885.1.
RefSeqiXP_957121.1. XM_952028.1.
UniGeneiNcr.25681.

Genome annotation databases

EnsemblFungiiEFNCRT00000006215; EFNCRP00000006207; EFNCRG00000006204.
GeneIDi3873294.
KEGGincr:NCU06481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002238 Genomic DNA. Translation: EAA27885.1 .
RefSeqi XP_957121.1. XM_952028.1.
UniGenei Ncr.25681.

3D structure databases

ProteinModelPortali Q7RYJ3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU06481.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006215 ; EFNCRP00000006207 ; EFNCRG00000006204 .
GeneIDi 3873294.
KEGGi ncr:NCU06481.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036006.
KOi K10747.
OMAi MVKMLEG.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiQ7RYJ3_NEUCR
AccessioniPrimary (citable) accession number: Q7RYJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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