Q7RYE7 (GAL7_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	gal-7
ORF Names:	G21B4.010, NCU04460

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Galactose-1-phosphate uridylyltransferase		PRO_0000169890
Sites
	Active site	207	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	126	1	Zinc By similarity
	Metal binding	205	1	Zinc By similarity
	Metal binding	223	1	Iron By similarity
	Metal binding	323	1	Iron By similarity
	Metal binding	340	1	Iron By similarity
	Metal binding	342	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7RYE7 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: F7716BC5E28B4335	FASTA	392	44,890
	10 20 30 40 50 60 MTDKVLDDIS HRRYNPLNGS WLLVSPHRTK RPWQGQQEAP ALNKLPEYDP QCYLCPGNKR 70 80 90 100 110 120 AQGDSNPHYK NTFAFVNDYS AVKEEQQEYH PRKDAAGDGD DDIASLLLQA QPATGRCYVL 130 140 150 160 170 180 TFSAKHDTTL ADMSATEIVP VIETWTRIYA SHLSASHPLR DAAARSLSEI PPNPDGEVEP 190 200 210 220 230 240 AKKQQLRYMQ IFENKGAAMG CSNPHPHCQI WTTSTLPEEP GKELAQMTKY HREHKGRHLL 250 260 270 280 290 300 EDYVKVEMAK GERVVWQNDG FLVVCPWWAV WPFEVLVIAK RHVRALVELT SEERLQFAEA 310 320 330 340 350 360 VQEVTRRYDN LFETNFPYSS GIHQAPLDCT EEEAETSWFH MHFYPPLLRS ATVRKFLVGY 370 380 390 ELMAEPQRDI TPEQAAARLR DCGGELYRKS LQ

References

[1]

"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

[2]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908808 Genomic DNA. Translation: CAF05986.1. AABX02000020 Genomic DNA. Translation: EAA27793.1.
RefSeq	XP_957029.1. XM_951936.1.
UniGene	Ncr.15127.
3D structure databases
ProteinModelPortal	Q7RYE7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7RYE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000005239; EFNCRP00000005235; EFNCRG00000005232.
GeneID	3873213.
KEGG	ncr:NCU04460.
NMPDR	fig|5141.1.peg.1746.
Phylogenomic databases
eggNOG	fuNOG06817.
GeneTree	EFGT00050000004427.
OMA	GIHQAPL.
OrthoDB	EOG45QMP2.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
KO	K00965.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
SUPFAM	SSF54197. His_triad-like_motif. 2 hits.
TIGRFAMs	TIGR00209. GalT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_NEUCR

Accession

Primary (citable) accession number: Q7RYE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	December 15, 2003
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program