Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278PROSITE-ProRule annotation1
Active sitei470PROSITE-ProRule annotation1
Active sitei529PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERineucr-CBPYA. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:NCU00477
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU00477.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040745918 – 137By similarityAdd BLAST120
ChainiPRO_0000407460138 – 554Carboxypeptidase Y homolog AAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ7RXW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000198296.
InParanoidiQ7RXW8.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RXW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISASTVLL GAASAASAAS FQNQAQHVLA DNFHKAHDAV KPVADSFAHT
60 70 80 90 100
TLESFEEAFN GMNSQAKALW DEIKLLVPEN AFDKPTWFSK PKAAKRRKDW
110 120 130 140 150
DHVVKGADVQ KLWVKGADGE KHREVGGQLD NFNLRVKSVD PSKLGVDKVK
160 170 180 190 200
QYSGYLDDEE NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKKL RVVSNEYAWN NNASVIFLDQ PVNVGYSYSG NAVSNTVAAG
260 270 280 290 300
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKDRNIN
310 320 330 340 350
LKSVLIGNGL TDPLTQYEHY RPMACGEGGY PAVLSESECR SMDNALPRCQ
360 370 380 390 400
SLIRNCYESG SVWSCVPAAI YCNNQFIGPY QRTGQNVYDI RGKCEDDSNL
410 420 430 440 450
CYSALGWISD YLNQKDVMDA LGVEVEGYES CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPGILKEI PVLIYAGDAD FICNWLGNKA WSEALEWPGK NGFNKAELED
510 520 530 540 550
LSLPKADKEY GKVKSSGNFT FMQIYQAGHM VPMDQPENSL DFLNRWLGGE

WFEQ
Length:554
Mass (Da):62,153
Last modified:December 15, 2003 - v1
Checksum:i77DFFCEBCCF91249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA27560.1.
RefSeqiXP_956796.1. XM_951703.3.

Genome annotation databases

EnsemblFungiiEAA27560; EAA27560; NCU00477.
GeneIDi3872943.
KEGGincr:NCU00477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA. Translation: EAA27560.1.
RefSeqiXP_956796.1. XM_951703.3.

3D structure databases

ProteinModelPortaliQ7RXW8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERineucr-CBPYA. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA27560; EAA27560; NCU00477.
GeneIDi3872943.
KEGGincr:NCU00477.

Organism-specific databases

EuPathDBiFungiDB:NCU00477.

Phylogenomic databases

HOGENOMiHOG000198296.
InParanoidiQ7RXW8.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_NEUCR
AccessioniPrimary (citable) accession number: Q7RXW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.