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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278PROSITE-ProRule annotation1
Active sitei470PROSITE-ProRule annotation1
Active sitei529PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERineucr-CBPYA Carboxypeptidase_S10
MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:NCU00477
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 3, Linkage Group III

Organism-specific databases

EuPathDBiFungiDB:NCU00477

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040745918 – 137By similarityAdd BLAST120
ChainiPRO_0000407460138 – 554Carboxypeptidase Y homolog AAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ7RXW8

Structurei

3D structure databases

ProteinModelPortaliQ7RXW8
SMRiQ7RXW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000198296
InParanoidiQ7RXW8
KOiK13289
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RXW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISASTVLL GAASAASAAS FQNQAQHVLA DNFHKAHDAV KPVADSFAHT
60 70 80 90 100
TLESFEEAFN GMNSQAKALW DEIKLLVPEN AFDKPTWFSK PKAAKRRKDW
110 120 130 140 150
DHVVKGADVQ KLWVKGADGE KHREVGGQLD NFNLRVKSVD PSKLGVDKVK
160 170 180 190 200
QYSGYLDDEE NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKKL RVVSNEYAWN NNASVIFLDQ PVNVGYSYSG NAVSNTVAAG
260 270 280 290 300
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKDRNIN
310 320 330 340 350
LKSVLIGNGL TDPLTQYEHY RPMACGEGGY PAVLSESECR SMDNALPRCQ
360 370 380 390 400
SLIRNCYESG SVWSCVPAAI YCNNQFIGPY QRTGQNVYDI RGKCEDDSNL
410 420 430 440 450
CYSALGWISD YLNQKDVMDA LGVEVEGYES CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPGILKEI PVLIYAGDAD FICNWLGNKA WSEALEWPGK NGFNKAELED
510 520 530 540 550
LSLPKADKEY GKVKSSGNFT FMQIYQAGHM VPMDQPENSL DFLNRWLGGE

WFEQ
Length:554
Mass (Da):62,153
Last modified:December 15, 2003 - v1
Checksum:i77DFFCEBCCF91249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002238 Genomic DNA Translation: EAA27560.1
RefSeqiXP_956796.1, XM_951703.3

Genome annotation databases

EnsemblFungiiEAA27560; EAA27560; NCU00477
GeneIDi3872943
KEGGincr:NCU00477

Similar proteinsi

Entry informationi

Entry nameiCBPYA_NEUCR
AccessioniPrimary (citable) accession number: Q7RXW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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