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Q7RXQ8 (HIS4_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

EC=5.3.1.16
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:his-7
Synonyms:his6
ORF Names:NCU00150
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the HisA/HisF family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2572571-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
PRO_0000141960

Sequences

Sequence LengthMass (Da)Tools
Q7RXQ8 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: CE92E61296EF5BC8

FASTA25728,142
        10         20         30         40         50         60 
MTRFRPCIDL HAGQVKQIVG GTLDSATSEL RTNFVSPHPP AYFAKLYRDN DLSGAHVIML 

        70         80         90        100        110        120 
GPGNKEAALE SLKAWPGGLQ VGGGITDANA REWVEAGAEK VIITSYLFPN GKFSQSHLDA 

       130        140        150        160        170        180 
VLAALDGDKS KLVIDLSCRR QGDDRWFVAM NKWQTITDME VSEESIKALE PYCSEFLIHA 

       190        200        210        220        230        240 
ADNEGLQKGI DEKLVQRLSE WCSIPVTYAG GGRNLEDLET VKRLSGGKVD LTIGSALDCF 

       250 
GGKGVTLQEC VEWNRRQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002238 Genomic DNA. Translation: ESA43286.1.
CM002238 Genomic DNA. Translation: ESA43287.1.
RefSeqXP_956663.1. XM_951570.1.
UniGeneNcr.17464.

3D structure databases

ProteinModelPortalQ7RXQ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU00150.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000000077; EFNCRP00000000077; EFNCRG00000000077.
GeneID3872810.
KEGGncr:NCU00150.

Phylogenomic databases

eggNOGCOG0106.
HOGENOMHOG000172261.
KOK01814.
OrthoDBEOG7ZWDC9.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERPTHR21169. PTHR21169. 1 hit.
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02129. hisA_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_NEUCR
AccessionPrimary (citable) accession number: Q7RXQ8
Secondary accession number(s): U9W340
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 15, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways