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Reviewed, UniProtKB/Swiss-Prot Q7RXL1 (NCB5R_NEUCR)

Last modified June 16, 2009. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-cytochrome b5 reductase 1
    EC=1.6.2.2
Alternative name(s):
    Microsomal cytochrome b reductase
Gene names
Name: cbr-1
ORF Names: NCU00216
OrganismNeurospora crassa [Complete proteome]
Taxonomic identifier5141 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes By similarity.

Catalytic activity

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactor

FAD By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310NADH-cytochrome b5 reductase 1
PRO_0000330160

Regions

Transmembrane33 – 5018 Potential
Domain61 – 169109FAD-binding FR-type
Nucleotide binding149 – 16416FAD By similarity
Nucleotide binding175 – 20935FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7RXL1-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: AD00607089CF7B40

FASTA31034,001
        10         20         30         40         50         60 
MSEESLLERK YFDGIYIPAG LLVFGTVIVK KEWTLYAALA ALILGAIKYF RMLPKKVLKP 

        70         80         90        100        110        120 
AVFQEFELKE KTIISHNVAI YRFKLPTPDS VLGLPIGQHI SIGAAIEQPD GSTKEIVRSY 

       130        140        150        160        170        180 
TPISGDHQPG YFDLLIKSYP TGNISKHMAS LQVGQTIRVK GPKGAFVYTP NMVRHFGMVA 

       190        200        210        220        230        240 
GGTGITPMLQ VIRAIVRGRA AGDRTEVDLI FANVTAQDIL LKEDLDALVA QDKGIRVHYV 

       250        260        270        280        290        300 
LDRPPEGWTG GVGFVTQEMV EKLLPKPASD VKILLCGPPP MISGLKKATE ALGFQKARPV 

       310 
SKLEDQVFAF 

« Hide

Cross-references

Sequence databases

AABX02000001 Genomic DNA. Translation: EAA27365.1.
RefSeqXP_956601.1.

3D structure databases

HSSPHSSP built from PDB template 1CNF based on UniProtKB P17571.
ModBaseSearch...

Genome annotation databases

GeneID3872748.
KEGGncr:NCU00216.
NMPDRfig|5141.1.peg.235.

Family and domain databases

InterProIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd.
IPR001433. OxRdtase_FAD/NAD_bd.
[Graphical view]
PfamPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSPR00406. CYTB5RDTASE.
PR00371. FPNCR.
PROSITEPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCB5R_NEUCR
AccessionPrimary (citable) accession number: Q7RXL1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents