Reviewed, UniProtKB/Swiss-Prot Q7RX99 (ATG1_NEUCR)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg-1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg-1
ORF Names:	NCU00188

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	932 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 932	932	Serine/threonine-protein kinase atg-1		PRO_0000085649
Regions
	Domain	24 – 329	306	Protein kinase
	Nucleotide binding	30 – 38	9	ATP By similarity
Sites
	Active site	167	1	Proton acceptor By similarity
	Binding site	53	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7RX99-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 399DBDEABF6500EF	FASTA	932	102,663
	10 20 30 40 50 60 MSDRTSASSS SRRTKQNYDA IGSFVIDQEI GKGSFAKVYL GRHKVTGALV AVKSVELARL 70 80 90 100 110 120 NKKLKENLYG EIQILKTLRH PHIVALHDCV ESSTHINLIM EYCELGDLSL FIKKRDKLIT 130 140 150 160 170 180 NPYTHDLARK YPVYPNAGLN EVVTRHFLKQ LASALQFLRA GDFVHRDVKP QNLLLLPSPH 190 200 210 220 230 240 MMANNKTAKH IMSGSYDSFT PAAGLASAPM LKLADFGFAR VLPSTSLAET LCGSPLYMAP 250 260 270 280 290 300 EILRYEKYDA KADLWSVGTV LYEMVTGRPP FKASNHVELL RKIESSGDVI KFTRESVVSQ 310 320 330 340 350 360 EMKGLIRALL KKNPVERISF EDLFNHPVVT EPIPGLVEDD IPKPPRRRSL KEERPVSRAE 370 380 390 400 410 420 DSLVPSRKQS LRKDLADREG APQTAGPSSP KPRRSSPLAT PNEPVEISKP NYFQIPPRED 430 440 450 460 470 480 RLSYSPRKEA ADGLGIKRPQ VQPSTSAPTR PSSYVDRRHR SSNASLRAPV REANPPPNDV 490 500 510 520 530 540 TRTKPRGMGT KPMTEEERAA QDIAFERDYV LVDKKHLEVN ALADQISMYP QQPQSPKSAQ 550 560 570 580 590 600 IVRRATQQGS PTSTSGAVPS PPSRALQLAQ GHSRQGSYDK ALGTSPSKAT SVISKAIQDA 610 620 630 640 650 660 SLRLFGFKYA PHLLSKGPSP VPMYNPFPTY PAPNTPTGLI SDGKQGTPVD EDSRVAQCIE 670 680 690 700 710 720 DHATRSDVVY GFAEVKYKQL VPLAPSMDHG LGGAPIEKSA EEDGLTAEAI VSLSEEALVL 730 740 750 760 770 780 YVKALTLLAK SMDIASLWWS RKNKVESTNS ITSAARDSAN SEALALRING AVQWIRSRFN 790 800 810 820 830 840 EVLEKAEIVR LKLAEAQKRL PEDHPSHPNN HANDSTALNS LSTVGVFLSE GISAERLMYD 850 860 870 880 890 900 RAIEMSRAAA INEIANEDLP GCEISYITAI RMLEAVLDQD DDHLPKRKVS GASKEEKTGA 910 920 930 NELSDEMNNE DKQVVQNGEP TSVLVQNKAS LY

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AABX02000001 Genomic DNA. Translation: EAA27175.1.
RefSeq	XP_956411.1.
3D structure databases
HSSP	HSSP built from PDB template 1NY3 based on UniProtKB P49137.
ModBase	Search...
Genome annotation databases
GeneID	3872551.
KEGG	ncr:NCU00188.
NMPDR	fig|5141.1.peg.207.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_NEUCR

Accession

Primary (citable) accession number: Q7RX99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 15, 2003
Last modified:	November 25, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)