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Protein

Iron-sulfur clusters transporter atm1, mitochondrial

Gene

fes-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei406Glutathione; via amide nitrogenBy similarity1
Binding sitei458ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi482 – 493ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter atm1, mitochondrial
Alternative name(s):
Iron-sulfur protein 4
Gene namesi
Name:fes-4
Synonyms:atm1
ORF Names:NCU05029
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 5, Linkage Group VI

Organism-specific databases

EuPathDBiFungiDB:NCU05029.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 123Mitochondrial matrixBy similarityAdd BLAST105
Transmembranei124 – 145HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini146 – 168Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei169 – 192HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini193 – 241Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei242 – 265HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini266Mitochondrial intermembraneBy similarity1
Transmembranei267 – 287HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini288 – 353Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei354 – 372HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini373 – 387Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei388 – 409HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini410 – 716Mitochondrial matrixBy similarityAdd BLAST307

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000025544819 – 716Iron-sulfur clusters transporter atm1, mitochondrialAdd BLAST698

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7RX59.
SMRiQ7RX59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 414ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini449 – 690ABC transporterPROSITE-ProRule annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 297Glutathione bindingBy similarity5
Regioni356 – 359Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ7RX59.
KOiK05663.
OrthoDBiEOG092C3H79.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RX59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSIKLSTM ATSLHRAHGT SALLRRPRLW APRLSSIHAT PTIANLRASF
60 70 80 90 100
TTSSPRLFAP NGSAKDESKP AVSTVPKTTG RGPSDPLAAI DKTAQEQRKA
110 120 130 140 150
DWAIMKEMSK YLWPKGSWGD KARVLLAIGL LVGGKVLNVQ VPFYFREIVD
160 170 180 190 200
SLNIDFSTTG GSVTAVAGAM ILGYGAARVG AVVSQELRNA VFASVAQKAI
210 220 230 240 250
RKVARNTFEH LLNLDLSFHL SKQTGGLTRA IDRGTKGISF LLTSMVFHIV
260 270 280 290 300
PTALEISMVC GILTYNFGWQ YAALTALTMV SYTAFTILTT AWRTKFRRQA
310 320 330 340 350
NAADNKASTI AVDSLINYEA VKYFNNEAYE VGRYDKALAQ YEKNSIKVAT
360 370 380 390 400
SLAFLNSGQN IIFSSALTVM MYMGAHGVAT GQLTVGDLVL INQLVFQLSV
410 420 430 440 450
PLNFLGSVYR ELRQSLLDME TLFNLQKVNV TIKEQPNAKP LTLTRGGEIE
460 470 480 490 500
FKDVTFGYHP ESPILRDLSL TIPAGKKVAI VGPSGCGKST LLRLLFRFYD
510 520 530 540 550
PQKGAIYIDG QDIRSVTLES LRRAIGVVPQ DTPLFNDTVE HNIRYGNLSA
560 570 580 590 600
TPEQVIEAAK AAHIHEKIIS WRDGYNTKVG ERGLMISGGE KQRLAVSRLI
610 620 630 640 650
LKDPPLLFFD EATSALDTHT EQALMENINA ILKGLGQKGE KKTSLFVAHR
660 670 680 690 700
LRTIYDSDLI IVLKEGRVAE QGTHRELMER NGVYAQLWRA QEMLMTEEGE
710
VSKKGEKEEV GEKKEA
Length:716
Mass (Da):78,758
Last modified:December 15, 2003 - v1
Checksum:i88819137DAB13D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002241 Genomic DNA. Translation: EAA27101.3.
RefSeqiXP_956337.3. XM_951244.3.

Genome annotation databases

EnsemblFungiiEAA27101; EAA27101; NCU05029.
GeneIDi3872484.
KEGGincr:NCU05029.

Similar proteinsi

Entry informationi

Entry nameiATM1_NEUCR
AccessioniPrimary (citable) accession number: Q7RX59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 15, 2003
Last modified: April 12, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families