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Q7RVY5 (HEM1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-aminolevulinate synthase, mitochondrial

EC=2.3.1.37
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene names
Name:hem-1
ORF Names:NCU06189
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function5-aminolevulinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6969Mitochondrion Potential
Chain70 – 6295605-aminolevulinate synthase, mitochondrial
PRO_0000001242

Sites

Active site3911 By similarity
Binding site1551Substrate By similarity
Binding site2681Substrate By similarity
Binding site2871Substrate By similarity
Binding site3201Pyridoxal phosphate By similarity
Binding site3481Pyridoxal phosphate By similarity
Binding site3881Pyridoxal phosphate By similarity
Binding site4201Pyridoxal phosphate By similarity
Binding site4211Pyridoxal phosphate By similarity
Binding site5061Substrate By similarity

Amino acid modifications

Modified residue3911N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7RVY5 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 01FA359E33FFEF00

FASTA62967,447
        10         20         30         40         50         60 
MDSVLRQSKA VCPFMKKATA SSLRAMTTAA RPAASPCGGA ISKLQVLAHR CPVMGKAMAV 

        70         80         90        100        110        120 
QSARTGGRAS AAPASFVHKA KLHTGRPREA QAVEGVFTGQ KAGLPPHPPV KPTTATAANP 

       130        140        150        160        170        180 
SPAACTVSGN FGTKFNYEKF YENELEKKHK DKSYRYFNNI NRLAKDFPRA HMATKEEKVA 

       190        200        210        220        230        240 
VWCANDYLGM GRNKHVLEAM HTTLDEYGAG AGGTRNISGH NKHAVELENS LAKLHATDAA 

       250        260        270        280        290        300 
LVFSSCYVAN DATLATLGSK LPDCVILSDS LNHASMIQGI RHSGAKKIIF KHNDVEDLEK 

       310        320        330        340        350        360 
KLAALPLHIP KIIAFESVYS MCGSIGPIEK FCDLAEKYGA ITFNDEVHAV GMYGPHGAGV 

       370        380        390        400        410        420 
AEHLDWEAHQ RGETKGTIAD RIDIYSGTLG KAYGCVGGYI AGSAKLVDTI RSLAPGFIFT 

       430        440        450        460        470        480 
TTLPPAVMAG ARAAIEYQMS YDGDRRLQQL HTRAVKEALA DRDIPVIPNP SHIIPILVGN 

       490        500        510        520        530        540 
AELAKKASDK LLNDHQIYVQ SINYPTVPVG QERLRITPTP GHTKQFRDHL VAALDSIWTE 

       550        560        570        580        590        600 
LGIKRTSDWA AEGGFIGVGE AEAEPVAPLW TDEQLGIADA VAELRAQASD EKKGVINQLL 

       610        620 
ESVALEQERE ALNAAEEVAD AAKAAAASA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002238 Genomic DNA. Translation: EAA33765.2.
RefSeqXP_963001.2. XM_957908.2.
UniGeneNcr.24732.

3D structure databases

ProteinModelPortalQ7RVY5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06189.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006022; EFNCRP00000006015; EFNCRG00000006012.
GeneID3879149.
KEGGncr:NCU06189.

Phylogenomic databases

eggNOGCOG0156.
HOGENOMHOG000221020.
KOK00643.
OMAKLAQYPK.
OrthoDBEOG7HHX1P.

Enzyme and pathway databases

UniPathwayUPA00251; UER00375.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01821. 5aminolev_synth. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM1_NEUCR
AccessionPrimary (citable) accession number: Q7RVY5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 4, 2007
Last modified: February 19, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways