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Q7RVY5

- HEM1_NEUCR

UniProt

Q7RVY5 - HEM1_NEUCR

Protein

5-aminolevulinate synthase, mitochondrial

Gene

hem-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei155 – 1551SubstrateBy similarity
    Binding sitei268 – 2681SubstrateBy similarity
    Binding sitei287 – 2871SubstrateBy similarity
    Binding sitei320 – 3201Pyridoxal phosphateBy similarity
    Binding sitei348 – 3481Pyridoxal phosphateBy similarity
    Binding sitei388 – 3881Pyridoxal phosphateBy similarity
    Active sitei391 – 3911By similarity
    Binding sitei420 – 4201Pyridoxal phosphateBy similarity
    Binding sitei421 – 4211Pyridoxal phosphateBy similarity
    Binding sitei506 – 5061SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hem-1
    ORF Names:NCU06189
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6969MitochondrionSequence AnalysisAdd
    BLAST
    Chaini70 – 6295605-aminolevulinate synthase, mitochondrialPRO_0000001242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei391 – 3911N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU06189.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RVY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiKLAQYPK.
    OrthoDBiEOG7HHX1P.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7RVY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSVLRQSKA VCPFMKKATA SSLRAMTTAA RPAASPCGGA ISKLQVLAHR    50
    CPVMGKAMAV QSARTGGRAS AAPASFVHKA KLHTGRPREA QAVEGVFTGQ 100
    KAGLPPHPPV KPTTATAANP SPAACTVSGN FGTKFNYEKF YENELEKKHK 150
    DKSYRYFNNI NRLAKDFPRA HMATKEEKVA VWCANDYLGM GRNKHVLEAM 200
    HTTLDEYGAG AGGTRNISGH NKHAVELENS LAKLHATDAA LVFSSCYVAN 250
    DATLATLGSK LPDCVILSDS LNHASMIQGI RHSGAKKIIF KHNDVEDLEK 300
    KLAALPLHIP KIIAFESVYS MCGSIGPIEK FCDLAEKYGA ITFNDEVHAV 350
    GMYGPHGAGV AEHLDWEAHQ RGETKGTIAD RIDIYSGTLG KAYGCVGGYI 400
    AGSAKLVDTI RSLAPGFIFT TTLPPAVMAG ARAAIEYQMS YDGDRRLQQL 450
    HTRAVKEALA DRDIPVIPNP SHIIPILVGN AELAKKASDK LLNDHQIYVQ 500
    SINYPTVPVG QERLRITPTP GHTKQFRDHL VAALDSIWTE LGIKRTSDWA 550
    AEGGFIGVGE AEAEPVAPLW TDEQLGIADA VAELRAQASD EKKGVINQLL 600
    ESVALEQERE ALNAAEEVAD AAKAAAASA 629
    Length:629
    Mass (Da):67,447
    Last modified:December 4, 2007 - v2
    Checksum:i01FA359E33FFEF00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33765.2.
    RefSeqiXP_963001.2. XM_957908.2.
    UniGeneiNcr.24732.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000006022; EFNCRP00000006015; EFNCRG00000006012.
    GeneIDi3879149.
    KEGGincr:NCU06189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002238 Genomic DNA. Translation: EAA33765.2 .
    RefSeqi XP_963001.2. XM_957908.2.
    UniGenei Ncr.24732.

    3D structure databases

    ProteinModelPortali Q7RVY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU06189.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000006022 ; EFNCRP00000006015 ; EFNCRG00000006012 .
    GeneIDi 3879149.
    KEGGi ncr:NCU06189.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi KLAQYPK.
    OrthoDBi EOG7HHX1P.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiHEM1_NEUCR
    AccessioniPrimary (citable) accession number: Q7RVY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3