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Q7RVA8 (KPYK_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Alternative name(s):
Acetate-requiring protein 8
Gene names
Name:ace-8
Synonyms:pyk1
ORF Names:NCU06075
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Pyruvate kinase
PRO_0000112115

Sites

Metal binding641Potassium By similarity
Metal binding661Potassium By similarity
Metal binding971Potassium By similarity
Metal binding981Potassium; via carbonyl oxygen By similarity
Metal binding2551Magnesium Potential
Metal binding2791Magnesium By similarity
Binding site621Substrate By similarity
Binding site2781Substrate; via amide nitrogen By similarity
Binding site2791Substrate; via amide nitrogen By similarity
Binding site3111Substrate By similarity
Binding site3501ADP Potential
Site2531Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7RVA8 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 0193D192F0CBA18B

FASTA52757,870
        10         20         30         40         50         60 
MAATALDHLS LGGKIQWLAQ LNTEFQPARE FRRTSIICTI GPKTNSVEAI NKLRDAGLNV 

        70         80         90        100        110        120 
VRMNFSHGSY EYHQSVIDNA RQAEKVHPGR PIAIALDTKG PEIRTGNTKN DEDIPISAGT 

       130        140        150        160        170        180 
ILNITTDEKY KDECTIEHMY VDYVNITKVI APGRIIYVDD GVLAFEVLEI VDDKTIKVKA 

       190        200        210        220        230        240 
RNNGYISSRK GVNLPNTDVD LPALSEKDKA DLRFGVKNKV DMVFASFIRR GQDIKDIREV 

       250        260        270        280        290        300 
LGEDGKQIQI IAKIENRQGL NNFAEILAET DGVMVARGDL GIEIPAAEVF AAQKKIIAMC 

       310        320        330        340        350        360 
NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK GAYPTEAVRE 

       370        380        390        400        410        420 
MSEAVLKAEN TIPYVSHFEE LCSLAKRPVS IVESCAMASV RASLDLNAAA ILVLSTSGES 

       430        440        450        460        470        480 
ARLISKYRPV CPIIMITRND SASRYAHLYR GVYPFLFPES KPDFSKVNWQ EDVDRRIKWG 

       490        500        510        520 
LSHGIGLKVL NEGETVVVVQ GWKGGMGNTN TFRIVKADVN HLGLGQP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM002242 Genomic DNA. Translation: ESA41917.1.
CM002242 Genomic DNA. Translation: ESA41918.1.
RefSeqXP_001728254.1. XM_001728202.1.
XP_959838.1. XM_954745.2.
UniGeneNcr.20447.

3D structure databases

ProteinModelPortalQ7RVA8.
SMRQ7RVA8. Positions 30-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06075.1.

Proteomic databases

PRIDEQ7RVA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000005490; EFNCRP00000005484; EFNCRG00000005481.
EFNCRT00000005491; EFNCRP00000005485; EFNCRG00000005481.
GeneID3875985.
KEGGncr:NCU06075.

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021559.
KOK00873.
OMAHADHQRS.
OrthoDBEOG7M6DJC.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_NEUCR
AccessionPrimary (citable) accession number: Q7RVA8
Secondary accession number(s): A7UWL6, V5IKJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways