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Q7RVA8

- KPYK_NEUCR

UniProt

Q7RVA8 - KPYK_NEUCR

Protein

Pyruvate kinase

Gene

ace-8

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621SubstrateBy similarity
    Metal bindingi64 – 641PotassiumBy similarity
    Metal bindingi66 – 661PotassiumBy similarity
    Metal bindingi97 – 971PotassiumBy similarity
    Metal bindingi98 – 981Potassium; via carbonyl oxygenBy similarity
    Sitei253 – 2531Transition state stabilizerBy similarity
    Metal bindingi255 – 2551MagnesiumSequence Analysis
    Binding sitei278 – 2781Substrate; via amide nitrogenBy similarity
    Metal bindingi279 – 2791MagnesiumBy similarity
    Binding sitei279 – 2791Substrate; via amide nitrogenBy similarity
    Binding sitei311 – 3111SubstrateBy similarity
    Binding sitei350 – 3501ADPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Alternative name(s):
    Acetate-requiring protein 8
    Gene namesi
    Name:ace-8
    Synonyms:pyk1
    ORF Names:NCU06075
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 7, Linkage Group VII

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Pyruvate kinasePRO_0000112115Add
    BLAST

    Proteomic databases

    PRIDEiQ7RVA8.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi5141.NCU06075.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RVA8.
    SMRiQ7RVA8. Positions 30-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    HOGENOMiHOG000021559.
    KOiK00873.
    OMAiHADHQRS.
    OrthoDBiEOG7M6DJC.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RVA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATALDHLS LGGKIQWLAQ LNTEFQPARE FRRTSIICTI GPKTNSVEAI    50
    NKLRDAGLNV VRMNFSHGSY EYHQSVIDNA RQAEKVHPGR PIAIALDTKG 100
    PEIRTGNTKN DEDIPISAGT ILNITTDEKY KDECTIEHMY VDYVNITKVI 150
    APGRIIYVDD GVLAFEVLEI VDDKTIKVKA RNNGYISSRK GVNLPNTDVD 200
    LPALSEKDKA DLRFGVKNKV DMVFASFIRR GQDIKDIREV LGEDGKQIQI 250
    IAKIENRQGL NNFAEILAET DGVMVARGDL GIEIPAAEVF AAQKKIIAMC 300
    NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK 350
    GAYPTEAVRE MSEAVLKAEN TIPYVSHFEE LCSLAKRPVS IVESCAMASV 400
    RASLDLNAAA ILVLSTSGES ARLISKYRPV CPIIMITRND SASRYAHLYR 450
    GVYPFLFPES KPDFSKVNWQ EDVDRRIKWG LSHGIGLKVL NEGETVVVVQ 500
    GWKGGMGNTN TFRIVKADVN HLGLGQP 527
    Length:527
    Mass (Da):57,870
    Last modified:December 15, 2003 - v1
    Checksum:i0193D192F0CBA18B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002242 Genomic DNA. Translation: ESA41917.1.
    CM002242 Genomic DNA. Translation: ESA41918.1.
    RefSeqiXP_001728254.1. XM_001728202.1.
    XP_959838.1. XM_954745.2.
    UniGeneiNcr.20447.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000005490; EFNCRP00000005484; EFNCRG00000005481.
    EFNCRT00000005491; EFNCRP00000005485; EFNCRG00000005481.
    GeneIDi3875985.
    KEGGincr:NCU06075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM002242 Genomic DNA. Translation: ESA41917.1 .
    CM002242 Genomic DNA. Translation: ESA41918.1 .
    RefSeqi XP_001728254.1. XM_001728202.1.
    XP_959838.1. XM_954745.2.
    UniGenei Ncr.20447.

    3D structure databases

    ProteinModelPortali Q7RVA8.
    SMRi Q7RVA8. Positions 30-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU06075.1.

    Proteomic databases

    PRIDEi Q7RVA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000005490 ; EFNCRP00000005484 ; EFNCRG00000005481 .
    EFNCRT00000005491 ; EFNCRP00000005485 ; EFNCRG00000005481 .
    GeneIDi 3875985.
    KEGGi ncr:NCU06075.

    Phylogenomic databases

    eggNOGi COG0469.
    HOGENOMi HOG000021559.
    KOi K00873.
    OMAi HADHQRS.
    OrthoDBi EOG7M6DJC.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiKPYK_NEUCR
    AccessioniPrimary (citable) accession number: Q7RVA8
    Secondary accession number(s): A7UWL6, V5IKJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3