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Reviewed, UniProtKB/Swiss-Prot Q7RVA8 (KPYK_NEUCR)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyruvate kinase
      Short name=PK
    EC=2.7.1.40
Gene names
Name: pyk-1
ORF Names: NCU06075
OrganismNeurospora crassa [Complete proteome]
Taxonomic identifier5141 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Pyruvate kinase
PRO_0000112115

Sites

Active site2531 By similarity
Metal binding2551Magnesium Potential
Metal binding2761Magnesium Potential
Metal binding2771Magnesium Potential
Binding site3501ADP Potential

Sequences

Sequence LengthMass (Da)Tools
Q7RVA8-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 0193D192F0CBA18B

FASTA52757,870
        10         20         30         40         50         60 
MAATALDHLS LGGKIQWLAQ LNTEFQPARE FRRTSIICTI GPKTNSVEAI NKLRDAGLNV 

        70         80         90        100        110        120 
VRMNFSHGSY EYHQSVIDNA RQAEKVHPGR PIAIALDTKG PEIRTGNTKN DEDIPISAGT 

       130        140        150        160        170        180 
ILNITTDEKY KDECTIEHMY VDYVNITKVI APGRIIYVDD GVLAFEVLEI VDDKTIKVKA 

       190        200        210        220        230        240 
RNNGYISSRK GVNLPNTDVD LPALSEKDKA DLRFGVKNKV DMVFASFIRR GQDIKDIREV 

       250        260        270        280        290        300 
LGEDGKQIQI IAKIENRQGL NNFAEILAET DGVMVARGDL GIEIPAAEVF AAQKKIIAMC 

       310        320        330        340        350        360 
NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK GAYPTEAVRE 

       370        380        390        400        410        420 
MSEAVLKAEN TIPYVSHFEE LCSLAKRPVS IVESCAMASV RASLDLNAAA ILVLSTSGES 

       430        440        450        460        470        480 
ARLISKYRPV CPIIMITRND SASRYAHLYR GVYPFLFPES KPDFSKVNWQ EDVDRRIKWG 

       490        500        510        520 
LSHGIGLKVL NEGETVVVVQ GWKGGMGNTN TFRIVKADVN HLGLGQP 

« Hide

Cross-references

Sequence databases

AABX02000021 Genomic DNA. Translation: EAA30602.1.
RefSeqXP_959838.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3875985.
NMPDRfig|5141.1.peg.3863.

Enzyme and pathway databases

BRENDA2.7.1.40. 266.

Family and domain databases

InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase_cat.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
[Graphical view]
Gene3DG3DSA:3.20.20.60. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
G3DSA:3.40.1380.20. Pyrv_Knase_a/b. 1 hit.
PANTHERPTHR11817. Pyruvate_kinase. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
ProDomPD001009. Pyruvate_kinase. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_NEUCR
AccessionPrimary (citable) accession number: Q7RVA8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 15, 2003
Last modified: June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents