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Q7RVA8

- KPYK_NEUCR

UniProt

Q7RVA8 - KPYK_NEUCR

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Protein
Pyruvate kinase
Gene
ace-8, pyk1, NCU06075
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Metal bindingi64 – 641Potassium By similarity
Metal bindingi66 – 661Potassium By similarity
Metal bindingi97 – 971Potassium By similarity
Metal bindingi98 – 981Potassium; via carbonyl oxygen By similarity
Sitei253 – 2531Transition state stabilizer By similarity
Metal bindingi255 – 2551Magnesium Reviewed prediction
Binding sitei278 – 2781Substrate; via amide nitrogen By similarity
Metal bindingi279 – 2791Magnesium By similarity
Binding sitei279 – 2791Substrate; via amide nitrogen By similarity
Binding sitei311 – 3111Substrate By similarity
Binding sitei350 – 3501ADP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Alternative name(s):
Acetate-requiring protein 8
Gene namesi
Name:ace-8
Synonyms:pyk1
ORF Names:NCU06075
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 7, Linkage Group VII

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Pyruvate kinase
PRO_0000112115Add
BLAST

Proteomic databases

PRIDEiQ7RVA8.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi5141.NCU06075.1.

Structurei

3D structure databases

ProteinModelPortaliQ7RVA8.
SMRiQ7RVA8. Positions 30-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiHADHQRS.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RVA8-1 [UniParc]FASTAAdd to Basket

« Hide

MAATALDHLS LGGKIQWLAQ LNTEFQPARE FRRTSIICTI GPKTNSVEAI    50
NKLRDAGLNV VRMNFSHGSY EYHQSVIDNA RQAEKVHPGR PIAIALDTKG 100
PEIRTGNTKN DEDIPISAGT ILNITTDEKY KDECTIEHMY VDYVNITKVI 150
APGRIIYVDD GVLAFEVLEI VDDKTIKVKA RNNGYISSRK GVNLPNTDVD 200
LPALSEKDKA DLRFGVKNKV DMVFASFIRR GQDIKDIREV LGEDGKQIQI 250
IAKIENRQGL NNFAEILAET DGVMVARGDL GIEIPAAEVF AAQKKIIAMC 300
NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD CVMLSGETAK 350
GAYPTEAVRE MSEAVLKAEN TIPYVSHFEE LCSLAKRPVS IVESCAMASV 400
RASLDLNAAA ILVLSTSGES ARLISKYRPV CPIIMITRND SASRYAHLYR 450
GVYPFLFPES KPDFSKVNWQ EDVDRRIKWG LSHGIGLKVL NEGETVVVVQ 500
GWKGGMGNTN TFRIVKADVN HLGLGQP 527
Length:527
Mass (Da):57,870
Last modified:December 15, 2003 - v1
Checksum:i0193D192F0CBA18B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002242 Genomic DNA. Translation: ESA41917.1.
CM002242 Genomic DNA. Translation: ESA41918.1.
RefSeqiXP_001728254.1. XM_001728202.1.
XP_959838.1. XM_954745.2.
UniGeneiNcr.20447.

Genome annotation databases

EnsemblFungiiEFNCRT00000005490; EFNCRP00000005484; EFNCRG00000005481.
EFNCRT00000005491; EFNCRP00000005485; EFNCRG00000005481.
GeneIDi3875985.
KEGGincr:NCU06075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM002242 Genomic DNA. Translation: ESA41917.1 .
CM002242 Genomic DNA. Translation: ESA41918.1 .
RefSeqi XP_001728254.1. XM_001728202.1.
XP_959838.1. XM_954745.2.
UniGenei Ncr.20447.

3D structure databases

ProteinModelPortali Q7RVA8.
SMRi Q7RVA8. Positions 30-514.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU06075.1.

Proteomic databases

PRIDEi Q7RVA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000005490 ; EFNCRP00000005484 ; EFNCRG00000005481 .
EFNCRT00000005491 ; EFNCRP00000005485 ; EFNCRG00000005481 .
GeneIDi 3875985.
KEGGi ncr:NCU06075.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi HADHQRS.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiKPYK_NEUCR
AccessioniPrimary (citable) accession number: Q7RVA8
Secondary accession number(s): A7UWL6, V5IKJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 15, 2003
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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