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Q7RTZ2

- U17L1_HUMAN

UniProt

Q7RTZ2 - U17L1_HUMAN

Protein

Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 1

Gene

USP17L1P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891NucleophilePROSITE-ProRule annotation
    Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.078.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 1 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 17-like protein 1
    Ubiquitin thioesterase 17-like protein 1
    Ubiquitin-specific-processing protease 17-like protein 1
    Gene namesi
    Name:USP17L1P
    Synonyms:USP17L, USP17L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:37182. USP17L1P.

    Subcellular locationi

    Nucleus By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 1PRO_0000253963Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTZ2.
    PRIDEiQ7RTZ2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ7RTZ2.

    Organism-specific databases

    HPAiHPA045642.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTZ2.
    SMRiQ7RTZ2. Positions 49-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 375296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000144638.
    HOVERGENiHBG007129.
    InParanoidiQ7RTZ2.
    PhylomeDBiQ7RTZ2.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RTZ2-1 [UniParc]FASTAAdd to Basket

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    MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD    50
    LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY 100
    TLPLANYMLS REHSQTCQRP KCCMLCTMQA HITWALHSPG HVIQPSQALA 150
    AGFHRGKQED VHEFLMFTVD AMKKACLPGH KQVDHHCKDT TLIHQIFGGC 200
    WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL VKPEELNGEN 250
    AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC 300
    LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEVQWYKMD 350
    DAEVTVCSII SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD 400
    RRAKQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF 450
    NVGKVEGTLP PNALVIHQSK YKCGMKNHHP EQQSSLLNLS STTRTDQESM 500
    NTGTLASLQG RTRRAKGKNK HSKRALLVCQ 530
    Length:530
    Mass (Da):59,590
    Last modified:December 15, 2003 - v1
    Checksum:i5CCFDA6582338353
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228730 Genomic DNA. No translation available.
    BN000116 Genomic DNA. Translation: CAD66056.1.
    RefSeqiNP_001243802.1. NM_001256873.1.
    UniGeneiHs.653091.

    Genome annotation databases

    GeneIDi401447.
    KEGGihsa:401447.
    UCSCiuc031taa.1. human.

    Polymorphism databases

    DMDMi74723224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228730 Genomic DNA. No translation available.
    BN000116 Genomic DNA. Translation: CAD66056.1 .
    RefSeqi NP_001243802.1. NM_001256873.1.
    UniGenei Hs.653091.

    3D structure databases

    ProteinModelPortali Q7RTZ2.
    SMRi Q7RTZ2. Positions 49-372.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.078.

    Polymorphism databases

    DMDMi 74723224.

    Proteomic databases

    PaxDbi Q7RTZ2.
    PRIDEi Q7RTZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 401447.
    KEGGi hsa:401447.
    UCSCi uc031taa.1. human.

    Organism-specific databases

    CTDi 401447.
    GeneCardsi GC08P007190.
    HGNCi HGNC:37182. USP17L1P.
    HPAi HPA045642.
    neXtProti NX_Q7RTZ2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000144638.
    HOVERGENi HBG007129.
    InParanoidi Q7RTZ2.
    PhylomeDBi Q7RTZ2.

    Miscellaneous databases

    GenomeRNAii 401447.
    NextBioi 106844.

    Gene expression databases

    Genevestigatori Q7RTZ2.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Human and mouse proteases: a comparative genomic approach."
      Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.
      Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
      Burrows J.F., McGrattan M.J., Johnston J.A.
      Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    4. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
      Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
      BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiU17L1_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated
    The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3