Reviewed, UniProtKB/Swiss-Prot Q7RTZ2 (U17L1_HUMAN)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 1
    EC=3.1.2.15
Alternative name(s):
    Ubiquitin thioesterase 17-like protein 1
    Ubiquitin-specific-processing protease 17-like protein 1
    Deubiquitinating enzyme 17-like protein 1

Gene names

Name:	USP17L1
Synonyms:	USP17L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates By similarity.
Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. UniProtKB Q9H9J4
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the peptidase C19 family. USP17 subfamily.
Caution	The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.

Ontologies

Keywords
Biological process	Apoptosis Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Ubiquitin carboxyl-terminal hydrolase 17-like protein 1		PRO_0000253963
Sites
	Active site	89	1	By similarity UniProtKB Q9H9J4
	Active site	325	1	By similarity UniProtKB Q9H9J4
	Active site	334	1	By similarity UniProtKB Q9H9J4

Sequences

	Sequence		Length	Mass (Da)
	Q7RTZ2-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 5CCFDA6582338353	FASTA	530	59,590
	10 20 30 40 50 60 MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR 70 80 90 100 110 120 QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TLPLANYMLS REHSQTCQRP 130 140 150 160 170 180 KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED VHEFLMFTVD AMKKACLPGH 190 200 210 220 230 240 KQVDHHCKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL 250 260 270 280 290 300 VKPEELNGEN AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC 310 320 330 340 350 360 LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEVQWYKMD DAEVTVCSII 370 380 390 400 410 420 SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRAKQGELKR DHPCLQAPEL 430 440 450 460 470 480 DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVGKVEGTLP PNALVIHQSK YKCGMKNHHP 490 500 510 520 530 EQQSSLLNLS STTRTDQESM NTGTLASLQG RTRRAKGKNK HSKRALLVCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human and mouse proteases: a comparative genomic approach." Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Nat. Rev. Genet. 4:544-558(2003) [PubMed: 12838346] [Abstract] Cited for: IDENTIFICATION.
[3]	"The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence." Burrows J.F., McGrattan M.J., Johnston J.A. Genomics 85:524-529(2005) [PubMed: 15780755] [Abstract] Cited for: NOMENCLATURE.
[4]	"Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability." Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H. BMC Genomics 7:292-292(2006) [PubMed: 17109758] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF228730 Genomic DNA. No translation available. BN000116 Genomic DNA. Translation: CAD66056.1.
IPI	IPI00394951.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q7RTZ2.
Genome annotation databases
Ensembl	ENSG00000206033. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC08P007180.
H-InvDB	HIX0034676. HIX0058593. HIX0058594.
Phylogenomic databases
HOVERGEN	Q7RTZ2.
Enzyme and pathway databases
BRENDA	3.1.2.15. 247.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. False negative. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

U17L1_HUMAN

Accession

Primary (citable) accession number: Q7RTZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 15, 2003
Last modified:	July 7, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)