Q7RTY9 (PRS41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative serine protease 41
EC=3.4.21.-

Alternative name(s):
Testis serine protease 1
Short name=TESSP-1

Gene names

Name:	PRSS41
Synonyms:	TESSP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Note: Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular organelle Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 54	35	Potential		PRO_0000345420
	Chain	55 – 299	245	Putative serine protease 41		PRO_5000095968
	Propeptide	300 – 318	19	Removed in mature form Potential		PRO_0000345421
Regions
	Domain	55 – 297	243	Peptidase S1
	Compositional bias	38 – 41	4	Poly-Gly
Sites
	Active site	95	1	Charge relay system By similarity
	Active site	147	1	Charge relay system By similarity
	Active site	249	1	Charge relay system By similarity
Amino acid modifications
	Lipidation	299	1	GPI-anchor amidated serine By similarity
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	284	1	N-linked (GlcNAc...) Potential
	Disulfide bond	80 ↔ 96		By similarity
	Disulfide bond	181 ↔ 255		By similarity
	Disulfide bond	215 ↔ 234		By similarity
	Disulfide bond	245 ↔ 273		By similarity
Natural variations
	Natural variant	286	1	S → G. Ref.3		VAR_064369

Sequences

	Sequence		Length	Mass (Da)
	Q7RTY9 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: D792213630CF15C3	FASTA	318	35,078
	10 20 30 40 50 60 MGARGALLLA LLLARAGLGK PGELGALQAG PGAARRPGGG GREEACGHRE IHALVAGGVE 70 80 90 100 110 120 SARGRWPWQA SLRLRRRHRC GGSLLSRRWV LSAAHCFQKH YYPSEWTVQL GELTSRPTPW 130 140 150 160 170 180 NLRAYSSRYK VQDIIVNPDA LGVLRNDIAL LRLASSVTYN AYIQPICIES STFNFVHRPD 190 200 210 220 230 240 CWVTGWGLIS PSGTPLPPPY NLREAQVTIL NNTRCNYLFE QPSSRSMIWD SMFCAGAEDG 250 260 270 280 290 300 SVDTCKGDSG GPLVCDKDGL WYQVGIVSWG MDCGQPNRPG VYTNISVYFH WIRRVMSHST 310 PRPNPSQLLL LLALLWAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human and mouse proteases: a comparative genomic approach." Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	"A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24." Corbett M.A., Bahlo M., Jolly L., Afawi Z., Gardner A.E., Oliver K.L., Tan S., Coffey A., Mulley J.C., Dibbens L.M., Simri W., Shalata A., Kivity S., Jackson G.D., Berkovic S.F., Gecz J. Am. J. Hum. Genet. 87:371-375(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLY-286.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC092117 Genomic DNA. No translation available. BN000124 mRNA. Translation: CAD67575.1.
IPI	IPI00373824.
RefSeq	NP_001128558.1. NM_001135086.1.
UniGene	Hs.647401.
3D structure databases
HSSP	HSSP built from PDB template 1RTF based on UniProtKB P00750.
ProteinModelPortal	Q7RTY9.
ModBase	Search...
Protein family/group databases
MEROPS	S01.327.
Polymorphism databases
DMDM	74759056.
Proteomic databases
PRIDE	Q7RTY9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	360226.
KEGG	hsa:360226.
UCSC	uc010uwi.2. human.
Organism-specific databases
CTD	360226.
GeneCards	GC16P002854.
HGNC	HGNC:30715. PRSS41.
neXtProt	NX_Q7RTY9.
PharmGKB	PA165450634.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG013304.
InParanoid	Q7RTY9.
PhylomeDB	Q7RTY9.
Gene expression databases
Genevestigator	Q7RTY9.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	360226.
NextBio	100094.

Entry information

Entry name

PRS41_HUMAN

Accession

Primary (citable) accession number: Q7RTY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.