Q7RTY8 (TMPS7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protease serine 7
EC=3.4.21.-

Alternative name(s):
Matriptase-3

Gene names

Name:

TMPRSS7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	843 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position By similarity.
Subunit structure	Forms a heterodimer with SERPINA5.
Subcellular location	Cell membrane; Single-pass type II membrane protein By similarity.
Tissue specificity	Expressed in brain, ovary, testis, salivary gland, trachea and lung. Ref.5
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 3 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Contains 1 SEA domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro serine-type peptidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7RTY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on similarity to mouse ortholog.

Isoform 2 (identifier: Q7RTY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     166-166: Missing.
     231-243: Missing.

Isoform 3 (identifier: Q7RTY8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-271: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 843	843	Transmembrane protease serine 7		PRO_0000027859
Regions
	Topological domain	1 – 76	76	Cytoplasmic Potential
	Transmembrane	77 – 97	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	98 – 843	746	Extracellular Potential
	Domain	101 – 222	122	SEA
	Domain	247 – 360	114	CUB 1
	Domain	365 – 481	117	CUB 2
	Domain	483 – 519	37	LDL-receptor class A 1
	Domain	517 – 554	38	LDL-receptor class A 2
	Domain	558 – 595	38	LDL-receptor class A 3
	Domain	606 – 840	235	Peptidase S1
Sites
	Active site	646	1	Charge relay system By similarity
	Active site	694	1	Charge relay system By similarity
	Active site	790	1	Charge relay system By similarity
Amino acid modifications
	Disulfide bond	247 ↔ 273		By similarity
	Disulfide bond	299 ↔ 322		By similarity
	Disulfide bond	365 ↔ 396		By similarity
	Disulfide bond	484 ↔ 496		By similarity
	Disulfide bond	491 ↔ 509		By similarity
	Disulfide bond	503 ↔ 518		By similarity
	Disulfide bond	525 ↔ 544		By similarity
	Disulfide bond	538 ↔ 553		By similarity
	Disulfide bond	559 ↔ 571		By similarity
	Disulfide bond	566 ↔ 585		By similarity
	Disulfide bond	579 ↔ 594		By similarity
	Disulfide bond	631 ↔ 647		By similarity
	Disulfide bond	730 ↔ 796		By similarity
	Disulfide bond	762 ↔ 775		By similarity
Natural variations
	Alternative sequence	1 – 271	271	Missing in isoform 3.		VSP_040771
	Alternative sequence	1 – 112	112	Missing in isoform 2.		VSP_040772
	Alternative sequence	166	1	Missing in isoform 2.		VSP_040773
	Alternative sequence	231 – 243	13	Missing in isoform 2.		VSP_040774
Experimental info
	Sequence conflict	816	1	S → C in BAD18401. Ref.2
	Sequence conflict	816	1	S → C in AAI17323. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 8D97E984FD87934C	FASTA	843	94,415
	10 20 30 40 50 60 MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP 70 80 90 100 110 120 KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE 130 140 150 160 170 180 FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV 190 200 210 220 230 240 FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST 250 260 270 280 290 300 IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV 310 320 330 340 350 360 TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI 370 380 390 400 410 420 PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK 430 440 450 460 470 480 KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI 490 500 510 520 530 540 SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG 550 560 570 580 590 600 FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS 610 620 630 640 650 660 SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT 670 680 690 700 710 720 AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT 730 740 750 760 770 780 GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS 790 800 810 820 830 840 GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP SLL
	Isoform 2 [UniParc]. Checksum: 95151028202683C8	FASTA	717	80,354
	10 20 30 40 50 60 MFRITNIEFL PEYRQKESRE FLSVSRTVQQ VINLVYTTSA FSKFYEQSVV ADVSNNKGGL 70 80 90 100 110 120 LVHFWIVFVM PRAKGHIFCE DCVAAILKDS IQTSIINRTS VGSLQGLAVD MDSVVLNDKG 130 140 150 160 170 180 CSQYFYAEHL SLHYPLEISA ASGRLMCHFK LVAIVGYLIR LSIKSIQIEA DNCVTDSLTI 190 200 210 220 230 240 YDSLLPIRSS ILYRICEPTR TLMSFVSTNN LMLVTFKSPH IRRLSGIRAY FEVIPEQKCE 250 260 270 280 290 300 NTVLVKDITG FEGKISSPYY PSYYPPKCKC TWKFQTSLST LGIALKFYNY SITKKSMKGC 310 320 330 340 350 360 EHGWWEINEH MYCGSYMDHQ TIFRVPSPLV HIQLQCSSRL SDKPLLAEYG SYNISQPCPV 370 380 390 400 410 420 GSFRCSSGLC VPQAQRCDGV NDCFDESDEL FCVSPQPACN TSSFRQHGPL ICDGFRDCEN 430 440 450 460 470 480 GRDEQNCTQS IPCNNRTFKC GNDICFRKQN AKCDGTVDCP DGSDEEGCTC SRSSSALHRI 490 500 510 520 530 540 IGGTDTLEGG WPWQVSLHFV GSAYCGASVI SREWLLSAAH CFHGNRLSDP TPWTAHLGMY 550 560 570 580 590 600 VQGNAKFVSP VRRIVVHEYY NSQTFDYDIA LLQLSIAWPE TLKQLIQPIC IPPTGQRVRS 610 620 630 640 650 660 GEKCWVTGWG RRHEADNKGS LVLQQAEVEL IDQTLCVSTY GIITSRMLCA GIMSGKRDAC 670 680 690 700 710 KGDSGGPLSC RRKSDGKWIL TGIVSWGHGS GRPNFPGVYT RVSNFVPWIH KYVPSLL
	Isoform 3 [UniParc]. Checksum: 0458CBFB987EA285	FASTA	572	64,025
	10 20 30 40 50 60 MCHFKLVAIV GYLIRLSIKS IQIEADNCVT DSLTIYDSLL PIRSSILYRI CEPTRTLMSF 70 80 90 100 110 120 VSTNNLMLVT FKSPHIRRLS GIRAYFEVIP EQKCENTVLV KDITGFEGKI SSPYYPSYYP 130 140 150 160 170 180 PKCKCTWKFQ TSLSTLGIAL KFYNYSITKK SMKGCEHGWW EINEHMYCGS YMDHQTIFRV 190 200 210 220 230 240 PSPLVHIQLQ CSSRLSDKPL LAEYGSYNIS QPCPVGSFRC SSGLCVPQAQ RCDGVNDCFD 250 260 270 280 290 300 ESDELFCVSP QPACNTSSFR QHGPLICDGF RDCENGRDEQ NCTQSIPCNN RTFKCGNDIC 310 320 330 340 350 360 FRKQNAKCDG TVDCPDGSDE EGCTCSRSSS ALHRIIGGTD TLEGGWPWQV SLHFVGSAYC 370 380 390 400 410 420 GASVISREWL LSAAHCFHGN RLSDPTPWTA HLGMYVQGNA KFVSPVRRIV VHEYYNSQTF 430 440 450 460 470 480 DYDIALLQLS IAWPETLKQL IQPICIPPTG QRVRSGEKCW VTGWGRRHEA DNKGSLVLQQ 490 500 510 520 530 540 AEVELIDQTL CVSTYGIITS RMLCAGIMSG KRDACKGDSG GPLSCRRKSD GKWILTGIVS 550 560 570 WGHGSGRPNF PGVYTRVSNF VPWIHKYVPS LL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Teratocarcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Human and mouse proteases: a comparative genomic approach." Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Nat. Rev. Genet. 4:544-558(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity." Szabo R., Netzel-Arnett S., Hobson J.P., Antalis T.M., Bugge T.H. Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, HETERODIMER WITH SERPINA5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC015778 Genomic DNA. No translation available. AC024887 Genomic DNA. No translation available. AK131211 mRNA. Translation: BAD18401.1. BC117322 mRNA. Translation: AAI17323.1. BN000125 mRNA. Translation: CAD67577.1.
IPI	IPI00915469. IPI00940406. IPI00941864.
RefSeq	NP_001036040.2. NM_001042575.2.
UniGene	Hs.435490.
3D structure databases
ProteinModelPortal	Q7RTY8.
SMR	Q7RTY8. Positions 481-839.
ModBase	Search...
PTM databases
PhosphoSite	Q7RTY8.
Polymorphism databases
DMDM	218511859.
Proteomic databases
PaxDb	Q7RTY8.
PRIDE	Q7RTY8.
Protocols and materials databases
DNASU	344805.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000419127; ENSP00000411645; ENSG00000176040. ENST00000452346; ENSP00000398236; ENSG00000176040.
GeneID	344805.
KEGG	hsa:344805.
UCSC	uc010hqb.2. human. uc011bhr.1. human.
Organism-specific databases
CTD	344805.
GeneCards	GC03P111753.
HGNC	HGNC:30846. TMPRSS7.
HPA	HPA040630.
neXtProt	NX_Q7RTY8.
PharmGKB	PA134928796.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000136851.
HOVERGEN	HBG108591.
InParanoid	Q7RTY8.
KO	K09638.
OMA	LVHFWIV.
Gene expression databases
ArrayExpress	Q7RTY8.
Bgee	Q7RTY8.
CleanEx	HS_TMPRSS7.
Genevestigator	Q7RTY8.
Family and domain databases
Gene3D	2.60.120.290. 2 hits. 4.10.400.10. 2 hits.
InterPro	IPR000859. CUB_dom. IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR000082. SEA. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00431. CUB. 2 hits. PF00057. Ldl_recept_a. 2 hits. PF01390. SEA. 1 hit. PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00042. CUB. 1 hit. SM00192. LDLa. 3 hits. SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF49854. CUB. 2 hits. SSF57424. LDL_rcpt_classA_cys-rich. 3 hits. SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS01180. CUB. 2 hits. PS01209. LDLRA_1. 1 hit. PS50068. LDLRA_2. 2 hits. PS50024. SEA. False negative. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	344805.
NextBio	98762.

Entry information

Entry name

TMPS7_HUMAN

Accession

Primary (citable) accession number: Q7RTY8
Secondary accession number(s): C9J8P7, E9PAS3, Q17RH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.