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Protein

Ovochymase-1

Gene

OVCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Charge relay systemBy similarity1
Metal bindingi116CalciumBy similarity1
Active sitei139Charge relay systemBy similarity1
Active sitei237Charge relay systemBy similarity1
Active sitei615Charge relay systemBy similarity1
Active sitei664Charge relay systemBy similarity1
Active sitei763Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.322.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovochymase-1 (EC:3.4.21.-)
Gene namesi
Name:OVCH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:23080. OVCH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910581.

Polymorphism and mutation databases

BioMutaiOVCH1.
DMDMi118573093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000026117923 – 46Activation peptideBy similarityAdd BLAST24
ChainiPRO_000026118047 – 1134Ovochymase-1Add BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi72 ↔ 88By similarity
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi173 ↔ 243By similarity
Disulfide bondi204 ↔ 222By similarity
Disulfide bondi233 ↔ 262By similarity
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi341 ↔ 373By similarity
Disulfide bondi419 ↔ 446By similarity
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi473 ↔ 494By similarity
Glycosylationi507N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi600 ↔ 616By similarity
Disulfide bondi698 ↔ 769By similarity
Disulfide bondi729 ↔ 747By similarity
Disulfide bondi759 ↔ 788By similarity
Disulfide bondi846 ↔ 873By similarity
Glycosylationi1106N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ7RTY7.
PeptideAtlasiQ7RTY7.
PRIDEiQ7RTY7.

PTM databases

iPTMnetiQ7RTY7.
PhosphoSitePlusiQ7RTY7.

Expressioni

Gene expression databases

BgeeiENSG00000187950.
CleanExiHS_OVCH1.
ExpressionAtlasiQ7RTY7. baseline and differential.

Organism-specific databases

HPAiHPA040253.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326708.

Structurei

3D structure databases

ProteinModelPortaliQ7RTY7.
SMRiQ7RTY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 296Peptidase S1 1PROSITE-ProRule annotationAdd BLAST259
Domaini284 – 410CUB 1PROSITE-ProRule annotationAdd BLAST127
Domaini419 – 531CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini575 – 812Peptidase S1 2PROSITE-ProRule annotationAdd BLAST238
Domaini846 – 957CUB 3PROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 3 CUB domains.PROSITE-ProRule annotation
Contains 2 peptidase S1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000172098.
InParanoidiQ7RTY7.
KOiK01362.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ7RTY7.
TreeFamiTF318987.

Family and domain databases

CDDicd00041. CUB. 3 hits.
cd00190. Tryp_SPc. 2 hits.
Gene3Di2.60.120.290. 4 hits.
InterProiIPR000859. CUB_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 4 hits.
SSF50494. SSF50494. 2 hits.
PROSITEiPS01180. CUB. 3 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLASAGLL LLLVIGHPRS LGLKCGIRMV NMKSKEPAVG SRFFSRISSW
60 70 80 90 100
RNSTVTGHPW QVSLKSDEHH FCGGSLIQED RVVTAAHCLD SLSEKQLKNI
110 120 130 140 150
TVTSGEYSLF QKDKQEQNIP VSKIITHPEY NSREYMSPDI ALLYLKHKVK
160 170 180 190 200
FGNAVQPICL PDSDDKVEPG ILCLSSGWGK ISKTSEYSNV LQEMELPIMD
210 220 230 240 250
DRACNTVLKS MNLPPLGRTM LCAGFPDWGM DACQGDSGGP LVCRRGGGIW
260 270 280 290 300
ILAGITSWVA GCAGGSVPVR NNHVKASLGI FSKVSELMDF ITQNLFTGLD
310 320 330 340 350
RGQPLSKVGS RYITKALSSV QEVNGSQRGK GILDMEKQVG CDHDYVSLRS
360 370 380 390 400
SSGVLFNQRS LMEDDGKQNK RVCGKILPSP LLAETSEAMV PFVSDTEDSG
410 420 430 440 450
SGFELTVTAV QKSEAGSGCG SLAILVEEGT NHSAKYPDLY PSNIRCHWFI
460 470 480 490 500
CAPEKHIIKL TFEDFAVKFS PNCIYDAVVI YGDSEEKHKL AKLCGMLTIT
510 520 530 540 550
SIFSSSNMTV IYFKSDGKNR LQGFKARFTI LPSESLNKFE PKLPPQNNPV
560 570 580 590 600
STVKAILHDV CGIPPFSPQW LSRRIAGGEE ACPHCWPWQV GLRFLGDYQC
610 620 630 640 650
GGAIINPVWI LTAAHCVQLK NNPLSWTIIA GDHDRNLKES TEQVRRAKHI
660 670 680 690 700
IVHEDFNTLS YDSDIALIQL SSPLEYNSVV RPVCLPHSAE PLFSSEICAV
710 720 730 740 750
TGWGSISADG GLASRLQQIQ VHVLEREVCE HTYYSAHPGG ITEKMICAGF
760 770 780 790 800
AASGEKDFCQ GDSGGPLVCR HENGPFVLYG IVSWGAGCVQ PWKPGVFARV
810 820 830 840 850
MIFLDWIQSK INGPASLQTN NKCKTLKQQL PPPTPSPDSA SWPGCCSEAE
860 870 880 890 900
LEKPRGFFPT PRYLLDYRGR LECSWVLRVS PSSMAKFTIE YLSLLGSPVC
910 920 930 940 950
QDSVLIIYEE RHSKRKTAGG LHGRRLYSMT FMSPGPLVRV TFHALVRGAF
960 970 980 990 1000
GISYIDLKVL GPKDSKITRL SQSSNREHLV PCEDVLLTKP EGIMQIPRNS
1010 1020 1030 1040 1050
HRTTMGCQWR LVAPLNHIIQ LNIINFPMKP TTFVCHGHLR VYEGFGPGKK
1060 1070 1080 1090 1100
LIASFAGTLA MILTKDILKR EKLNFINTYI MHIWENSVYD NVRSVGKRKQ
1110 1120 1130
KKFASNLSYS MEAEKSRIQV PADLVPAKGS LSGS
Length:1,134
Mass (Da):125,066
Last modified:November 28, 2006 - v2
Checksum:i87F935BCCB773B16
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029089133R → C.Corresponds to variant rs10843438dbSNPEnsembl.1
Natural variantiVAR_029090228W → G.Corresponds to variant rs967181dbSNPEnsembl.1
Natural variantiVAR_029091330K → E.Corresponds to variant rs3847680dbSNPEnsembl.1
Natural variantiVAR_029092444I → T.Corresponds to variant rs7975356dbSNPEnsembl.1
Natural variantiVAR_057159557L → V.Corresponds to variant rs35183403dbSNPEnsembl.1
Natural variantiVAR_029093672S → F.Corresponds to variant rs11050243dbSNPEnsembl.1
Natural variantiVAR_029094754G → R.Corresponds to variant rs12305672dbSNPEnsembl.1
Natural variantiVAR_029095881P → A.Corresponds to variant rs1347570dbSNPEnsembl.1
Natural variantiVAR_029096934P → S.Corresponds to variant rs7967676dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012151 Genomic DNA. No translation available.
BN000128 mRNA. Translation: CAD67579.1.
RefSeqiNP_899234.2. NM_183378.2.
UniGeneiHs.674588.

Genome annotation databases

EnsembliENST00000318184; ENSP00000326708; ENSG00000187950.
GeneIDi341350.
KEGGihsa:341350.
UCSCiuc001rix.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012151 Genomic DNA. No translation available.
BN000128 mRNA. Translation: CAD67579.1.
RefSeqiNP_899234.2. NM_183378.2.
UniGeneiHs.674588.

3D structure databases

ProteinModelPortaliQ7RTY7.
SMRiQ7RTY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326708.

Protein family/group databases

MEROPSiS01.322.

PTM databases

iPTMnetiQ7RTY7.
PhosphoSitePlusiQ7RTY7.

Polymorphism and mutation databases

BioMutaiOVCH1.
DMDMi118573093.

Proteomic databases

PaxDbiQ7RTY7.
PeptideAtlasiQ7RTY7.
PRIDEiQ7RTY7.

Protocols and materials databases

DNASUi341350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318184; ENSP00000326708; ENSG00000187950.
GeneIDi341350.
KEGGihsa:341350.
UCSCiuc001rix.2. human.

Organism-specific databases

CTDi341350.
GeneCardsiOVCH1.
HGNCiHGNC:23080. OVCH1.
HPAiHPA040253.
neXtProtiNX_Q7RTY7.
PharmGKBiPA134910581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000172098.
InParanoidiQ7RTY7.
KOiK01362.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ7RTY7.
TreeFamiTF318987.

Miscellaneous databases

GenomeRNAii341350.
PROiQ7RTY7.

Gene expression databases

BgeeiENSG00000187950.
CleanExiHS_OVCH1.
ExpressionAtlasiQ7RTY7. baseline and differential.

Family and domain databases

CDDicd00041. CUB. 3 hits.
cd00190. Tryp_SPc. 2 hits.
Gene3Di2.60.120.290. 4 hits.
InterProiIPR000859. CUB_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 4 hits.
SSF50494. SSF50494. 2 hits.
PROSITEiPS01180. CUB. 3 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOVCH1_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.