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Protein

Ovochymase-1

Gene

OVCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Charge relay systemBy similarity
Metal bindingi116 – 1161CalciumBy similarity
Active sitei139 – 1391Charge relay systemBy similarity
Active sitei237 – 2371Charge relay systemBy similarity
Active sitei615 – 6151Charge relay systemBy similarity
Active sitei664 – 6641Charge relay systemBy similarity
Active sitei763 – 7631Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.322.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovochymase-1 (EC:3.4.21.-)
Gene namesi
Name:OVCH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:23080. OVCH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910581.

Polymorphism and mutation databases

BioMutaiOVCH1.
DMDMi118573093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 4624Activation peptideBy similarityPRO_0000261179Add
BLAST
Chaini47 – 11341088Ovochymase-1PRO_0000261180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi72 ↔ 88By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi173 ↔ 243By similarity
Disulfide bondi204 ↔ 222By similarity
Disulfide bondi233 ↔ 262By similarity
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi341 ↔ 373By similarity
Disulfide bondi419 ↔ 446By similarity
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi473 ↔ 494By similarity
Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi600 ↔ 616By similarity
Disulfide bondi698 ↔ 769By similarity
Disulfide bondi729 ↔ 747By similarity
Disulfide bondi759 ↔ 788By similarity
Disulfide bondi846 ↔ 873By similarity
Glycosylationi1106 – 11061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ7RTY7.
PeptideAtlasiQ7RTY7.
PRIDEiQ7RTY7.

PTM databases

iPTMnetiQ7RTY7.
PhosphoSiteiQ7RTY7.

Expressioni

Gene expression databases

BgeeiENSG00000187950.
CleanExiHS_OVCH1.
ExpressionAtlasiQ7RTY7. baseline and differential.

Organism-specific databases

HPAiHPA040253.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326708.

Structurei

3D structure databases

ProteinModelPortaliQ7RTY7.
SMRiQ7RTY7. Positions 17-295, 333-813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 296259Peptidase S1 1PROSITE-ProRule annotationAdd
BLAST
Domaini284 – 410127CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini419 – 531113CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini575 – 812238Peptidase S1 2PROSITE-ProRule annotationAdd
BLAST
Domaini846 – 957112CUB 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 3 CUB domains.PROSITE-ProRule annotation
Contains 2 peptidase S1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000172098.
InParanoidiQ7RTY7.
KOiK01362.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ7RTY7.
TreeFamiTF318987.

Family and domain databases

CDDicd00190. Tryp_SPc. 2 hits.
Gene3Di2.60.120.290. 4 hits.
InterProiIPR000859. CUB_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 4 hits.
SSF50494. SSF50494. 2 hits.
PROSITEiPS01180. CUB. 3 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLASAGLL LLLVIGHPRS LGLKCGIRMV NMKSKEPAVG SRFFSRISSW
60 70 80 90 100
RNSTVTGHPW QVSLKSDEHH FCGGSLIQED RVVTAAHCLD SLSEKQLKNI
110 120 130 140 150
TVTSGEYSLF QKDKQEQNIP VSKIITHPEY NSREYMSPDI ALLYLKHKVK
160 170 180 190 200
FGNAVQPICL PDSDDKVEPG ILCLSSGWGK ISKTSEYSNV LQEMELPIMD
210 220 230 240 250
DRACNTVLKS MNLPPLGRTM LCAGFPDWGM DACQGDSGGP LVCRRGGGIW
260 270 280 290 300
ILAGITSWVA GCAGGSVPVR NNHVKASLGI FSKVSELMDF ITQNLFTGLD
310 320 330 340 350
RGQPLSKVGS RYITKALSSV QEVNGSQRGK GILDMEKQVG CDHDYVSLRS
360 370 380 390 400
SSGVLFNQRS LMEDDGKQNK RVCGKILPSP LLAETSEAMV PFVSDTEDSG
410 420 430 440 450
SGFELTVTAV QKSEAGSGCG SLAILVEEGT NHSAKYPDLY PSNIRCHWFI
460 470 480 490 500
CAPEKHIIKL TFEDFAVKFS PNCIYDAVVI YGDSEEKHKL AKLCGMLTIT
510 520 530 540 550
SIFSSSNMTV IYFKSDGKNR LQGFKARFTI LPSESLNKFE PKLPPQNNPV
560 570 580 590 600
STVKAILHDV CGIPPFSPQW LSRRIAGGEE ACPHCWPWQV GLRFLGDYQC
610 620 630 640 650
GGAIINPVWI LTAAHCVQLK NNPLSWTIIA GDHDRNLKES TEQVRRAKHI
660 670 680 690 700
IVHEDFNTLS YDSDIALIQL SSPLEYNSVV RPVCLPHSAE PLFSSEICAV
710 720 730 740 750
TGWGSISADG GLASRLQQIQ VHVLEREVCE HTYYSAHPGG ITEKMICAGF
760 770 780 790 800
AASGEKDFCQ GDSGGPLVCR HENGPFVLYG IVSWGAGCVQ PWKPGVFARV
810 820 830 840 850
MIFLDWIQSK INGPASLQTN NKCKTLKQQL PPPTPSPDSA SWPGCCSEAE
860 870 880 890 900
LEKPRGFFPT PRYLLDYRGR LECSWVLRVS PSSMAKFTIE YLSLLGSPVC
910 920 930 940 950
QDSVLIIYEE RHSKRKTAGG LHGRRLYSMT FMSPGPLVRV TFHALVRGAF
960 970 980 990 1000
GISYIDLKVL GPKDSKITRL SQSSNREHLV PCEDVLLTKP EGIMQIPRNS
1010 1020 1030 1040 1050
HRTTMGCQWR LVAPLNHIIQ LNIINFPMKP TTFVCHGHLR VYEGFGPGKK
1060 1070 1080 1090 1100
LIASFAGTLA MILTKDILKR EKLNFINTYI MHIWENSVYD NVRSVGKRKQ
1110 1120 1130
KKFASNLSYS MEAEKSRIQV PADLVPAKGS LSGS
Length:1,134
Mass (Da):125,066
Last modified:November 28, 2006 - v2
Checksum:i87F935BCCB773B16
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331R → C.
Corresponds to variant rs10843438 [ dbSNP | Ensembl ].
VAR_029089
Natural varianti228 – 2281W → G.
Corresponds to variant rs967181 [ dbSNP | Ensembl ].
VAR_029090
Natural varianti330 – 3301K → E.
Corresponds to variant rs3847680 [ dbSNP | Ensembl ].
VAR_029091
Natural varianti444 – 4441I → T.
Corresponds to variant rs7975356 [ dbSNP | Ensembl ].
VAR_029092
Natural varianti557 – 5571L → V.
Corresponds to variant rs35183403 [ dbSNP | Ensembl ].
VAR_057159
Natural varianti672 – 6721S → F.
Corresponds to variant rs11050243 [ dbSNP | Ensembl ].
VAR_029093
Natural varianti754 – 7541G → R.
Corresponds to variant rs12305672 [ dbSNP | Ensembl ].
VAR_029094
Natural varianti881 – 8811P → A.
Corresponds to variant rs1347570 [ dbSNP | Ensembl ].
VAR_029095
Natural varianti934 – 9341P → S.
Corresponds to variant rs7967676 [ dbSNP | Ensembl ].
VAR_029096

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012151 Genomic DNA. No translation available.
BN000128 mRNA. Translation: CAD67579.1.
RefSeqiNP_899234.2. NM_183378.2.
UniGeneiHs.674588.

Genome annotation databases

EnsembliENST00000318184; ENSP00000326708; ENSG00000187950.
GeneIDi341350.
KEGGihsa:341350.
UCSCiuc001rix.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012151 Genomic DNA. No translation available.
BN000128 mRNA. Translation: CAD67579.1.
RefSeqiNP_899234.2. NM_183378.2.
UniGeneiHs.674588.

3D structure databases

ProteinModelPortaliQ7RTY7.
SMRiQ7RTY7. Positions 17-295, 333-813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326708.

Protein family/group databases

MEROPSiS01.322.

PTM databases

iPTMnetiQ7RTY7.
PhosphoSiteiQ7RTY7.

Polymorphism and mutation databases

BioMutaiOVCH1.
DMDMi118573093.

Proteomic databases

PaxDbiQ7RTY7.
PeptideAtlasiQ7RTY7.
PRIDEiQ7RTY7.

Protocols and materials databases

DNASUi341350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318184; ENSP00000326708; ENSG00000187950.
GeneIDi341350.
KEGGihsa:341350.
UCSCiuc001rix.2. human.

Organism-specific databases

CTDi341350.
GeneCardsiOVCH1.
HGNCiHGNC:23080. OVCH1.
HPAiHPA040253.
neXtProtiNX_Q7RTY7.
PharmGKBiPA134910581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000172098.
InParanoidiQ7RTY7.
KOiK01362.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ7RTY7.
TreeFamiTF318987.

Miscellaneous databases

GenomeRNAii341350.
PROiQ7RTY7.

Gene expression databases

BgeeiENSG00000187950.
CleanExiHS_OVCH1.
ExpressionAtlasiQ7RTY7. baseline and differential.

Family and domain databases

CDDicd00190. Tryp_SPc. 2 hits.
Gene3Di2.60.120.290. 4 hits.
InterProiIPR000859. CUB_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00089. Trypsin. 2 hits.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00020. Tryp_SPc. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 4 hits.
SSF50494. SSF50494. 2 hits.
PROSITEiPS01180. CUB. 3 hits.
PS50240. TRYPSIN_DOM. 2 hits.
PS00134. TRYPSIN_HIS. 2 hits.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOVCH1_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.