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Q7RTY1 (MOT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 9
Short name=MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene names
Name:SLC16A9
Synonyms:C10orf36, MCT9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Sequence caution

The sequence BAD18743.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processurate metabolic process

Inferred from mutant phenotype PubMed 19503597. Source: BHF-UCL

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Monocarboxylate transporter 9
PRO_0000289332

Regions

Topological domain1 – 1212Extracellular Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5219Cytoplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 796Extracellular Potential
Transmembrane80 – 10021Helical; Potential
Topological domain1011Cytoplasmic Potential
Transmembrane102 – 12221Helical; Potential
Topological domain123 – 13614Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1636Cytoplasmic Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 304120Extracellular Potential
Transmembrane305 – 32521Helical; Potential
Topological domain326 – 34116Cytoplasmic Potential
Transmembrane342 – 36221Helical; Potential
Topological domain363 – 3719Extracellular Potential
Transmembrane372 – 39221Helical; Potential
Topological domain393 – 3975Cytoplasmic Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 43214Extracellular Potential
Transmembrane433 – 45321Helical; Potential
Topological domain454 – 4618Cytoplasmic Potential
Transmembrane462 – 48221Helical; Potential
Topological domain483 – 50927Extracellular Potential

Natural variations

Natural variant2031A → V.
Corresponds to variant rs56370926 [ dbSNP | Ensembl ].
VAR_062149
Natural variant2581T → K.
Corresponds to variant rs2242206 [ dbSNP | Ensembl ].
VAR_032619
Natural variant4611D → E.
Corresponds to variant rs11006655 [ dbSNP | Ensembl ].
VAR_032620

Sequences

Sequence LengthMass (Da)Tools
Q7RTY1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 716D56D969B1B0A8

FASTA50955,794
        10         20         30         40         50         60 
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK TAWVGSLASG 

        70         80         90        100        110        120 
VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP NIYFLFFSYG IVVGLGCGLL 

       130        140        150        160        170        180 
YTATVTITCQ YFDDRRGLAL GLISTGSSVG LFIYAALQRM LVEFYGLDGC LLIVGALALN 

       190        200        210        220        230        240 
ILACGSLMRP LQSSDCPLPK KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI 

       250        260        270        280        290        300 
TLANGDWKQD SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL 

       310        320        330        340        350        360 
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG IMTAVGKLLL 

       370        380        390        400        410        420 
GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL LSGILGFLTG NWSIFPYVTT 

       430        440        450        460        470        480 
KTVGIEKLAH AYGILMFFAG LGNSLGPPIV GWFYDWTQTY DIAFYFSGFC VLLGGFILLL 

       490        500 
AALPSWDTCN KQLPKPAPTT FLYKVASNV

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-509.
Tissue: Testis.
[4]"The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
Halestrap A.P., Meredith D.
Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK125791 mRNA. Translation: BAC86293.1.
AK172758 mRNA. Translation: BAD18743.1. Different initiation.
BC126238 mRNA. Translation: AAI26239.1.
BC130567 mRNA. Translation: AAI30568.1.
AL122071 mRNA. Translation: CAB59247.1.
BN000144 mRNA. Translation: CAD80155.1.
IPIIPI00375582.
PIRT34552.
RefSeqNP_919274.1. NM_194298.2.
UniGeneHs.499709.

3D structure databases

ProteinModelPortalQ7RTY1.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298215.

PTM databases

PhosphoSiteQ7RTY1.

Polymorphism databases

DMDM74723223.

Proteomic databases

PaxDbQ7RTY1.
PRIDEQ7RTY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395347; ENSP00000378756; ENSG00000165449.
ENST00000395348; ENSP00000378757; ENSG00000165449.
GeneID220963.
KEGGhsa:220963.
UCSCuc010qig.1. human.

Organism-specific databases

CTD220963.
GeneCardsGC10M061410.
HGNCHGNC:23520. SLC16A9.
HPAHPA049286.
neXtProtNX_Q7RTY1.
PharmGKBPA134991247.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000113632.
HOVERGENHBG097515.
InParanoidQ7RTY1.
KOK08186.
OMAMSAEIFP.
OrthoDBEOG4R23TK.
PhylomeDBQ7RTY1.

Gene expression databases

ArrayExpressQ7RTY1.
BgeeQ7RTY1.
CleanExHS_SLC16A9.
GenevestigatorQ7RTY1.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC16A9. human.
GenomeRNAi220963.
NextBio91108.

Entry information

Entry nameMOT9_HUMAN
AccessionPrimary (citable) accession number: Q7RTY1
Secondary accession number(s): Q6ZMI2, Q9UFH8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents