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Protein

Monocarboxylate transporter 9

Gene

SLC16A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • urate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.16. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 9
Short name:
MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene namesi
Name:SLC16A9
Synonyms:C10orf36, MCT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23520. SLC16A9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 509CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi220963.
OpenTargetsiENSG00000165449.
PharmGKBiPA134991247.

Polymorphism and mutation databases

BioMutaiSLC16A9.
DMDMi74723223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002893321 – 509Monocarboxylate transporter 9Add BLAST509

Proteomic databases

EPDiQ7RTY1.
PaxDbiQ7RTY1.
PeptideAtlasiQ7RTY1.
PRIDEiQ7RTY1.

PTM databases

iPTMnetiQ7RTY1.
PhosphoSitePlusiQ7RTY1.

Expressioni

Gene expression databases

BgeeiENSG00000165449.
CleanExiHS_SLC16A9.
GenevisibleiQ7RTY1. HS.

Organism-specific databases

HPAiHPA049286.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4A2Q142403EBI-10232636,EBI-73473
KLC4Q9NSK03EBI-10232636,EBI-949319
MRPL11Q9Y3B73EBI-10232636,EBI-5453723

Protein-protein interaction databases

BioGridi128664. 4 interactors.
IntActiQ7RTY1. 4 interactors.
STRINGi9606.ENSP00000378756.

Structurei

3D structure databases

ProteinModelPortaliQ7RTY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7RTY1.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG091G04XL.
PhylomeDBiQ7RTY1.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030767. MCT9.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF158. PTHR11360:SF158. 2 hits.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK
60 70 80 90 100
TAWVGSLASG VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP
110 120 130 140 150
NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDDRRGLAL GLISTGSSVG
160 170 180 190 200
LFIYAALQRM LVEFYGLDGC LLIVGALALN ILACGSLMRP LQSSDCPLPK
210 220 230 240 250
KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI TLANGDWKQD
260 270 280 290 300
SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
310 320 330 340 350
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG
360 370 380 390 400
IMTAVGKLLL GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL
410 420 430 440 450
LSGILGFLTG NWSIFPYVTT KTVGIEKLAH AYGILMFFAG LGNSLGPPIV
460 470 480 490 500
GWFYDWTQTY DIAFYFSGFC VLLGGFILLL AALPSWDTCN KQLPKPAPTT

FLYKVASNV
Length:509
Mass (Da):55,794
Last modified:December 15, 2003 - v1
Checksum:i716D56D969B1B0A8
GO

Sequence cautioni

The sequence BAD18743 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062149203A → V.Corresponds to variant rs56370926dbSNPEnsembl.1
Natural variantiVAR_032619258T → K.Corresponds to variant rs2242206dbSNPEnsembl.1
Natural variantiVAR_032620461D → E.Corresponds to variant rs11006655dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA. Translation: BAC86293.1.
AK172758 mRNA. Translation: BAD18743.1. Different initiation.
BC126238 mRNA. Translation: AAI26239.1.
BC130567 mRNA. Translation: AAI30568.1.
AL122071 mRNA. Translation: CAB59247.1.
BN000144 mRNA. Translation: CAD80155.1.
CCDSiCCDS7256.1.
PIRiT34552.
RefSeqiNP_001310910.1. NM_001323981.1.
NP_919274.1. NM_194298.2.
XP_016871373.1. XM_017015884.1.
UniGeneiHs.499709.

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449.
ENST00000395348; ENSP00000378757; ENSG00000165449.
GeneIDi220963.
KEGGihsa:220963.
UCSCiuc010qig.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA. Translation: BAC86293.1.
AK172758 mRNA. Translation: BAD18743.1. Different initiation.
BC126238 mRNA. Translation: AAI26239.1.
BC130567 mRNA. Translation: AAI30568.1.
AL122071 mRNA. Translation: CAB59247.1.
BN000144 mRNA. Translation: CAD80155.1.
CCDSiCCDS7256.1.
PIRiT34552.
RefSeqiNP_001310910.1. NM_001323981.1.
NP_919274.1. NM_194298.2.
XP_016871373.1. XM_017015884.1.
UniGeneiHs.499709.

3D structure databases

ProteinModelPortaliQ7RTY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128664. 4 interactors.
IntActiQ7RTY1. 4 interactors.
STRINGi9606.ENSP00000378756.

Protein family/group databases

TCDBi2.A.1.13.16. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ7RTY1.
PhosphoSitePlusiQ7RTY1.

Polymorphism and mutation databases

BioMutaiSLC16A9.
DMDMi74723223.

Proteomic databases

EPDiQ7RTY1.
PaxDbiQ7RTY1.
PeptideAtlasiQ7RTY1.
PRIDEiQ7RTY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449.
ENST00000395348; ENSP00000378757; ENSG00000165449.
GeneIDi220963.
KEGGihsa:220963.
UCSCiuc010qig.2. human.

Organism-specific databases

CTDi220963.
DisGeNETi220963.
GeneCardsiSLC16A9.
HGNCiHGNC:23520. SLC16A9.
HPAiHPA049286.
neXtProtiNX_Q7RTY1.
OpenTargetsiENSG00000165449.
PharmGKBiPA134991247.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7RTY1.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG091G04XL.
PhylomeDBiQ7RTY1.
TreeFamiTF313792.

Miscellaneous databases

ChiTaRSiSLC16A9. human.
GeneWikiiSLC16A9.
GenomeRNAii220963.
PROiQ7RTY1.

Gene expression databases

BgeeiENSG00000165449.
CleanExiHS_SLC16A9.
GenevisibleiQ7RTY1. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030767. MCT9.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF158. PTHR11360:SF158. 2 hits.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT9_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY1
Secondary accession number(s): Q6ZMI2, Q9UFH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.