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Protein

Monocarboxylate transporter 9

Gene

SLC16A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity).By similarity

GO - Molecular functioni

  1. monocarboxylic acid transmembrane transporter activity Source: GO_Central
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transmembrane transport Source: GO_Central
  2. monocarboxylic acid transport Source: GOC
  3. urate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.16. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 9
Short name:
MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene namesi
Name:SLC16A9
Synonyms:C10orf36, MCT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23520. SLC16A9.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 796ExtracellularSequence Analysis
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Topological domaini101 – 1011CytoplasmicSequence Analysis
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Topological domaini123 – 13614ExtracellularSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 1636CytoplasmicSequence Analysis
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 304120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Topological domaini326 – 34116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 3719ExtracellularSequence Analysis
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Topological domaini393 – 3975CytoplasmicSequence Analysis
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 43214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence AnalysisAdd
BLAST
Topological domaini454 – 4618CytoplasmicSequence Analysis
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 50927ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Monocarboxylate transporter 9PRO_0000289332Add
BLAST

Proteomic databases

PaxDbiQ7RTY1.
PRIDEiQ7RTY1.

PTM databases

PhosphoSiteiQ7RTY1.

Expressioni

Gene expression databases

BgeeiQ7RTY1.
CleanExiHS_SLC16A9.
GenevestigatoriQ7RTY1.

Organism-specific databases

HPAiHPA049286.

Interactioni

Protein-protein interaction databases

BioGridi128664. 5 interactions.
STRINGi9606.ENSP00000298215.

Structurei

3D structure databases

ProteinModelPortaliQ7RTY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7RTY1.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7RTY1.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK
60 70 80 90 100
TAWVGSLASG VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP
110 120 130 140 150
NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDDRRGLAL GLISTGSSVG
160 170 180 190 200
LFIYAALQRM LVEFYGLDGC LLIVGALALN ILACGSLMRP LQSSDCPLPK
210 220 230 240 250
KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI TLANGDWKQD
260 270 280 290 300
SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
310 320 330 340 350
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG
360 370 380 390 400
IMTAVGKLLL GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL
410 420 430 440 450
LSGILGFLTG NWSIFPYVTT KTVGIEKLAH AYGILMFFAG LGNSLGPPIV
460 470 480 490 500
GWFYDWTQTY DIAFYFSGFC VLLGGFILLL AALPSWDTCN KQLPKPAPTT

FLYKVASNV
Length:509
Mass (Da):55,794
Last modified:December 15, 2003 - v1
Checksum:i716D56D969B1B0A8
GO

Sequence cautioni

The sequence BAD18743.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031A → V.
Corresponds to variant rs56370926 [ dbSNP | Ensembl ].
VAR_062149
Natural varianti258 – 2581T → K.
Corresponds to variant rs2242206 [ dbSNP | Ensembl ].
VAR_032619
Natural varianti461 – 4611D → E.
Corresponds to variant rs11006655 [ dbSNP | Ensembl ].
VAR_032620

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA. Translation: BAC86293.1.
AK172758 mRNA. Translation: BAD18743.1. Different initiation.
BC126238 mRNA. Translation: AAI26239.1.
BC130567 mRNA. Translation: AAI30568.1.
AL122071 mRNA. Translation: CAB59247.1.
BN000144 mRNA. Translation: CAD80155.1.
CCDSiCCDS7256.1.
PIRiT34552.
RefSeqiNP_919274.1. NM_194298.2.
UniGeneiHs.499709.

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449.
ENST00000395348; ENSP00000378757; ENSG00000165449.
GeneIDi220963.
KEGGihsa:220963.
UCSCiuc010qig.1. human.

Polymorphism databases

DMDMi74723223.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125791 mRNA. Translation: BAC86293.1.
AK172758 mRNA. Translation: BAD18743.1. Different initiation.
BC126238 mRNA. Translation: AAI26239.1.
BC130567 mRNA. Translation: AAI30568.1.
AL122071 mRNA. Translation: CAB59247.1.
BN000144 mRNA. Translation: CAD80155.1.
CCDSiCCDS7256.1.
PIRiT34552.
RefSeqiNP_919274.1. NM_194298.2.
UniGeneiHs.499709.

3D structure databases

ProteinModelPortaliQ7RTY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128664. 5 interactions.
STRINGi9606.ENSP00000298215.

Protein family/group databases

TCDBi2.A.1.13.16. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ7RTY1.

Polymorphism databases

DMDMi74723223.

Proteomic databases

PaxDbiQ7RTY1.
PRIDEiQ7RTY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395347; ENSP00000378756; ENSG00000165449.
ENST00000395348; ENSP00000378757; ENSG00000165449.
GeneIDi220963.
KEGGihsa:220963.
UCSCiuc010qig.1. human.

Organism-specific databases

CTDi220963.
GeneCardsiGC10M061410.
HGNCiHGNC:23520. SLC16A9.
HPAiHPA049286.
neXtProtiNX_Q7RTY1.
PharmGKBiPA134991247.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7RTY1.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7RTY1.
TreeFamiTF313792.

Miscellaneous databases

ChiTaRSiSLC16A9. human.
GeneWikiiSLC16A9.
GenomeRNAii220963.
NextBioi91108.
PROiQ7RTY1.

Gene expression databases

BgeeiQ7RTY1.
CleanExiHS_SLC16A9.
GenevestigatoriQ7RTY1.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-509.
    Tissue: Testis.
  4. "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
    Halestrap A.P., Meredith D.
    Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMOT9_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY1
Secondary accession number(s): Q6ZMI2, Q9UFH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.