Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7RTY1

- MOT9_HUMAN

UniProt

Q7RTY1 - MOT9_HUMAN

Protein

Monocarboxylate transporter 9

Gene

SLC16A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. urate metabolic process Source: BHF-UCL

    Keywords - Biological processi

    Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.13.16. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 9
    Short name:
    MCT 9
    Alternative name(s):
    Solute carrier family 16 member 9
    Gene namesi
    Name:SLC16A9
    Synonyms:C10orf36, MCT9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23520. SLC16A9.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Monocarboxylate transporter 9PRO_0000289332Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTY1.
    PRIDEiQ7RTY1.

    PTM databases

    PhosphoSiteiQ7RTY1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7RTY1.
    BgeeiQ7RTY1.
    CleanExiHS_SLC16A9.
    GenevestigatoriQ7RTY1.

    Organism-specific databases

    HPAiHPA049286.

    Interactioni

    Protein-protein interaction databases

    BioGridi128664. 1 interaction.
    STRINGi9606.ENSP00000298215.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini34 – 5219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 796ExtracellularSequence Analysis
    Topological domaini101 – 1011CytoplasmicSequence Analysis
    Topological domaini123 – 13614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini158 – 1636CytoplasmicSequence Analysis
    Topological domaini185 – 304120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 34116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini363 – 3719ExtracellularSequence Analysis
    Topological domaini393 – 3975CytoplasmicSequence Analysis
    Topological domaini419 – 43214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini454 – 4618CytoplasmicSequence Analysis
    Topological domaini483 – 50927ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000113632.
    HOVERGENiHBG097515.
    InParanoidiQ7RTY1.
    KOiK08186.
    OMAiATLIIMG.
    OrthoDBiEOG7TMZRG.
    PhylomeDBiQ7RTY1.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RTY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK    50
    TAWVGSLASG VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP 100
    NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDDRRGLAL GLISTGSSVG 150
    LFIYAALQRM LVEFYGLDGC LLIVGALALN ILACGSLMRP LQSSDCPLPK 200
    KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI TLANGDWKQD 250
    SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL 300
    FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG 350
    IMTAVGKLLL GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL 400
    LSGILGFLTG NWSIFPYVTT KTVGIEKLAH AYGILMFFAG LGNSLGPPIV 450
    GWFYDWTQTY DIAFYFSGFC VLLGGFILLL AALPSWDTCN KQLPKPAPTT 500
    FLYKVASNV 509
    Length:509
    Mass (Da):55,794
    Last modified:December 15, 2003 - v1
    Checksum:i716D56D969B1B0A8
    GO

    Sequence cautioni

    The sequence BAD18743.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti203 – 2031A → V.
    Corresponds to variant rs56370926 [ dbSNP | Ensembl ].
    VAR_062149
    Natural varianti258 – 2581T → K.
    Corresponds to variant rs2242206 [ dbSNP | Ensembl ].
    VAR_032619
    Natural varianti461 – 4611D → E.
    Corresponds to variant rs11006655 [ dbSNP | Ensembl ].
    VAR_032620

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125791 mRNA. Translation: BAC86293.1.
    AK172758 mRNA. Translation: BAD18743.1. Different initiation.
    BC126238 mRNA. Translation: AAI26239.1.
    BC130567 mRNA. Translation: AAI30568.1.
    AL122071 mRNA. Translation: CAB59247.1.
    BN000144 mRNA. Translation: CAD80155.1.
    CCDSiCCDS7256.1.
    PIRiT34552.
    RefSeqiNP_919274.1. NM_194298.2.
    UniGeneiHs.499709.

    Genome annotation databases

    EnsembliENST00000395347; ENSP00000378756; ENSG00000165449.
    ENST00000395348; ENSP00000378757; ENSG00000165449.
    GeneIDi220963.
    KEGGihsa:220963.
    UCSCiuc010qig.1. human.

    Polymorphism databases

    DMDMi74723223.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125791 mRNA. Translation: BAC86293.1 .
    AK172758 mRNA. Translation: BAD18743.1 . Different initiation.
    BC126238 mRNA. Translation: AAI26239.1 .
    BC130567 mRNA. Translation: AAI30568.1 .
    AL122071 mRNA. Translation: CAB59247.1 .
    BN000144 mRNA. Translation: CAD80155.1 .
    CCDSi CCDS7256.1.
    PIRi T34552.
    RefSeqi NP_919274.1. NM_194298.2.
    UniGenei Hs.499709.

    3D structure databases

    ProteinModelPortali Q7RTY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128664. 1 interaction.
    STRINGi 9606.ENSP00000298215.

    Protein family/group databases

    TCDBi 2.A.1.13.16. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q7RTY1.

    Polymorphism databases

    DMDMi 74723223.

    Proteomic databases

    PaxDbi Q7RTY1.
    PRIDEi Q7RTY1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395347 ; ENSP00000378756 ; ENSG00000165449 .
    ENST00000395348 ; ENSP00000378757 ; ENSG00000165449 .
    GeneIDi 220963.
    KEGGi hsa:220963.
    UCSCi uc010qig.1. human.

    Organism-specific databases

    CTDi 220963.
    GeneCardsi GC10M061410.
    HGNCi HGNC:23520. SLC16A9.
    HPAi HPA049286.
    neXtProti NX_Q7RTY1.
    PharmGKBi PA134991247.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000113632.
    HOVERGENi HBG097515.
    InParanoidi Q7RTY1.
    KOi K08186.
    OMAi ATLIIMG.
    OrthoDBi EOG7TMZRG.
    PhylomeDBi Q7RTY1.
    TreeFami TF313792.

    Miscellaneous databases

    ChiTaRSi SLC16A9. human.
    GeneWikii SLC16A9.
    GenomeRNAii 220963.
    NextBioi 91108.
    PROi Q7RTY1.

    Gene expression databases

    ArrayExpressi Q7RTY1.
    Bgeei Q7RTY1.
    CleanExi HS_SLC16A9.
    Genevestigatori Q7RTY1.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-509.
      Tissue: Testis.
    4. "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
      Halestrap A.P., Meredith D.
      Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMOT9_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTY1
    Secondary accession number(s): Q6ZMI2, Q9UFH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3