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Protein

Monocarboxylate transporter 13

Gene

SLC16A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.1.13.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 13
Short name:
MCT 13
Alternative name(s):
Solute carrier family 16 member 13
Gene namesi
Name:SLC16A13
Synonyms:MCT13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000174327.6.
HGNCiHGNC:31037. SLC16A13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 426CytoplasmicCuratedAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125853

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi201232.
MIMi125853. phenotype.
OpenTargetsiENSG00000174327.
PharmGKBiPA134991782.

Polymorphism and mutation databases

BioMutaiSLC16A13.
DMDMi74723222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871871 – 426Monocarboxylate transporter 13Add BLAST426

Proteomic databases

PaxDbiQ7RTY0.
PeptideAtlasiQ7RTY0.
PRIDEiQ7RTY0.

PTM databases

iPTMnetiQ7RTY0.
PhosphoSitePlusiQ7RTY0.

Expressioni

Gene expression databases

BgeeiENSG00000174327.
CleanExiHS_SLC16A13.

Organism-specific databases

HPAiHPA065245.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952734EBI-12243266,EBI-748961

Protein-protein interaction databases

BioGridi128373. 2 interactors.
IntActiQ7RTY0. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ7RTY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVT. Eukaryota.
ENOG4111K3V. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG106552.
InParanoidiQ7RTY0.
KOiK08189.
OMAiAGYFVCG.
OrthoDBiEOG091G05SW.
PhylomeDBiQ7RTY0.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR011701. MFS.
IPR020846. MFS_dom.
IPR036259. MFS_trans_sf.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7RTY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRTEPPDG GWGWVVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA
60 70 80 90 100
RVSWIASIGI AVQQFGSPVG SALSTKFGPR PVVMTGGILA ALGMLLASFA
110 120 130 140 150
TSLTHLYLSI GLLSGSGWAL TFAPTLACLS CYFSRRRSLA TGLALTGVGL
160 170 180 190 200
SSFTFAPFFQ WLLSHYAWRG SLLLVSALSL HLVACGALLR PPSLAEDPAV
210 220 230 240 250
GGPRAQLTSL LHHGPFLRYT VALTLINTGY FIPYLHLVAH LQDLDWDPLP
260 270 280 290 300
AAFLLSVVAI SDLVGRVVSG WLGDAVPGPV TRLLMLWTTL TGVSLALFPV
310 320 330 340 350
AQAPTALVAL AVAYGFTSGA LAPLAFSVLP ELIGTRRIYC GLGLLQMIES
360 370 380 390 400
IGGLLGPPLS GYLRDVTGNY TASFVVAGAF LLSGSGILLT LPHFFCFSTT
410 420
TSGPQDLVTE ALDTKVPLPK EGLEED
Length:426
Mass (Da):44,992
Last modified:December 15, 2003 - v1
Checksum:i6A6849507C933624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471108 Genomic DNA. Translation: EAW90272.1.
BC109286 mRNA. Translation: AAI09287.1.
BC131739 mRNA. Translation: AAI31740.1.
BC142618 mRNA. Translation: AAI42619.1.
BN000145 mRNA. Translation: CAD80156.1.
CCDSiCCDS11085.1.
RefSeqiNP_963860.1. NM_201566.2.
UniGeneiHs.448010.

Genome annotation databases

EnsembliENST00000308027; ENSP00000309751; ENSG00000174327.
GeneIDi201232.
KEGGihsa:201232.
UCSCiuc002geh.3. human.

Similar proteinsi

Entry informationi

Entry nameiMOT13_HUMAN
AccessioniPrimary (citable) accession number: Q7RTY0
Secondary accession number(s): A3KMG3, A5PKU5, Q2VP92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families