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Protein

Monocarboxylate transporter 14

Gene

SLC16A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Protein family/group databases

TCDBi2.A.1.13.12. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 14
Short name:
MCT 14
Alternative name(s):
Solute carrier family 16 member 14
Gene namesi
Name:SLC16A14
Synonyms:MCT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163053.10.
HGNCiHGNC:26417. SLC16A14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei191 – 209HelicalSequence analysisAdd BLAST19
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 510CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163053.
PharmGKBiPA134983567.

Polymorphism and mutation databases

BioMutaiSLC16A14.
DMDMi74738645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889231 – 510Monocarboxylate transporter 14Add BLAST510

Proteomic databases

PaxDbiQ7RTX9.
PeptideAtlasiQ7RTX9.
PRIDEiQ7RTX9.

PTM databases

iPTMnetiQ7RTX9.
PhosphoSitePlusiQ7RTX9.

Expressioni

Gene expression databases

BgeeiENSG00000163053.
CleanExiHS_SLC16A14.
ExpressionAtlasiQ7RTX9. baseline and differential.
GenevisibleiQ7RTX9. HS.

Organism-specific databases

HPAiHPA040518.

Interactioni

Protein-protein interaction databases

BioGridi127380. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ7RTX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
ENOG411000Y. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000013205.
HOVERGENiHBG094888.
InParanoidiQ7RTX9.
KOiK08190.
OMAiCGLLYMI.
OrthoDBiEOG091G04XL.
PhylomeDBiQ7RTX9.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR030767. MCT9.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR036259. MFS_trans_sf.
PANTHERiPTHR11360:SF158. PTHR11360:SF158. 1 hit.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7RTX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS
60 70 80 90 100
QMALGVLNVE WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR
110 120 130 140 150
QTAIIGGLVN SLGWVLSAYA ANVHYLFITF GVAAGLGSGM AYLPAVVMVG
160 170 180 190 200
RYFQKRRALA QGLSTTGTGF GTFLMTVLLK YLCAEYGWRN AMLIQGAVSL
210 220 230 240 250
NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST GQQGRTEEKD
260 270 280 290 300
GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW
310 320 330 340 350
YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN
360 370 380 390 400
DVFPLTSIIA IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP
410 420 430 440 450
LMHTYAGLAV ICALIGFSSG YFSLMPVVTE DLVGIEHLAN AYGIIICANG
460 470 480 490 500
ISALLGPPFA GWIYDITQKY DFSFYICGLL YMIGILFLLI QPCIRIIEQS
510
RRKYMDGAHV
Length:510
Mass (Da):56,254
Last modified:December 15, 2003 - v1
Checksum:i5510E3E9ED63C280
GO
Isoform 2 (identifier: Q7RTX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,367
Checksum:i09DCD3205470CD02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209M → T in BAB70909 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258261 – 174Missing in isoform 2. 1 PublicationAdd BLAST174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055356 mRNA. Translation: BAB70909.1.
AK292873 mRNA. Translation: BAF85562.1.
AC093171 Genomic DNA. Translation: AAY24109.1.
CH471063 Genomic DNA. Translation: EAW70913.1.
BC065524 mRNA. Translation: AAH65524.1.
BN000146 mRNA. Translation: CAD80157.1.
CCDSiCCDS2473.1. [Q7RTX9-1]
RefSeqiNP_689740.2. NM_152527.4. [Q7RTX9-1]
XP_011509053.1. XM_011510751.2. [Q7RTX9-1]
XP_016858969.1. XM_017003480.1. [Q7RTX9-1]
UniGeneiHs.504317.

Genome annotation databases

EnsembliENST00000295190; ENSP00000295190; ENSG00000163053. [Q7RTX9-1]
GeneIDi151473.
KEGGihsa:151473.
UCSCiuc002vqd.2. human. [Q7RTX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOT14_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX9
Secondary accession number(s): A8KA08, Q53R92, Q96NI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families