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Protein

Monocarboxylate transporter 14

Gene

SLC16A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.12. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 14
Short name:
MCT 14
Alternative name(s):
Solute carrier family 16 member 14
Gene namesi
Name:SLC16A14
Synonyms:MCT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26417. SLC16A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 7325CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Topological domaini95 – 1028ExtracellularSequence Analysis
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 1263CytoplasmicSequence Analysis
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Topological domaini148 – 15811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 19011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 20919HelicalSequence AnalysisAdd
BLAST
Topological domaini210 – 314105ExtracellularSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Topological domaini336 – 35217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence AnalysisAdd
BLAST
Topological domaini374 – 3785ExtracellularSequence Analysis
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Topological domaini400 – 4078CytoplasmicSequence Analysis
Transmembranei408 – 42821HelicalSequence AnalysisAdd
BLAST
Topological domaini429 – 44214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence AnalysisAdd
BLAST
Topological domaini464 – 47310CytoplasmicSequence Analysis
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST
Topological domaini495 – 51016ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983567.

Polymorphism and mutation databases

BioMutaiSLC16A14.
DMDMi74738645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Monocarboxylate transporter 14PRO_0000288923Add
BLAST

Proteomic databases

PaxDbiQ7RTX9.
PRIDEiQ7RTX9.

PTM databases

PhosphoSiteiQ7RTX9.

Expressioni

Gene expression databases

BgeeiQ7RTX9.
CleanExiHS_SLC16A14.
ExpressionAtlasiQ7RTX9. baseline and differential.
GenevisibleiQ7RTX9. HS.

Organism-specific databases

HPAiHPA040518.

Interactioni

Protein-protein interaction databases

BioGridi127380. 1 interaction.
STRINGi9606.ENSP00000295190.

Structurei

3D structure databases

ProteinModelPortaliQ7RTX9.
SMRiQ7RTX9. Positions 443-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000013205.
HOVERGENiHBG094888.
InParanoidiQ7RTX9.
KOiK08190.
OMAiYNLSEQN.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7RTX9.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7RTX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS
60 70 80 90 100
QMALGVLNVE WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR
110 120 130 140 150
QTAIIGGLVN SLGWVLSAYA ANVHYLFITF GVAAGLGSGM AYLPAVVMVG
160 170 180 190 200
RYFQKRRALA QGLSTTGTGF GTFLMTVLLK YLCAEYGWRN AMLIQGAVSL
210 220 230 240 250
NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST GQQGRTEEKD
260 270 280 290 300
GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW
310 320 330 340 350
YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN
360 370 380 390 400
DVFPLTSIIA IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP
410 420 430 440 450
LMHTYAGLAV ICALIGFSSG YFSLMPVVTE DLVGIEHLAN AYGIIICANG
460 470 480 490 500
ISALLGPPFA GWIYDITQKY DFSFYICGLL YMIGILFLLI QPCIRIIEQS
510
RRKYMDGAHV
Length:510
Mass (Da):56,254
Last modified:December 15, 2003 - v1
Checksum:i5510E3E9ED63C280
GO
Isoform 2 (identifier: Q7RTX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,367
Checksum:i09DCD3205470CD02
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091M → T in BAB70909 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 174174Missing in isoform 2. 1 PublicationVSP_025826Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055356 mRNA. Translation: BAB70909.1.
AK292873 mRNA. Translation: BAF85562.1.
AC093171 Genomic DNA. Translation: AAY24109.1.
CH471063 Genomic DNA. Translation: EAW70913.1.
BC065524 mRNA. Translation: AAH65524.1.
BN000146 mRNA. Translation: CAD80157.1.
CCDSiCCDS2473.1. [Q7RTX9-1]
RefSeqiNP_689740.2. NM_152527.4. [Q7RTX9-1]
XP_011509053.1. XM_011510751.1. [Q7RTX9-1]
UniGeneiHs.504317.

Genome annotation databases

EnsembliENST00000295190; ENSP00000295190; ENSG00000163053.
GeneIDi151473.
KEGGihsa:151473.
UCSCiuc002vqd.2. human. [Q7RTX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055356 mRNA. Translation: BAB70909.1.
AK292873 mRNA. Translation: BAF85562.1.
AC093171 Genomic DNA. Translation: AAY24109.1.
CH471063 Genomic DNA. Translation: EAW70913.1.
BC065524 mRNA. Translation: AAH65524.1.
BN000146 mRNA. Translation: CAD80157.1.
CCDSiCCDS2473.1. [Q7RTX9-1]
RefSeqiNP_689740.2. NM_152527.4. [Q7RTX9-1]
XP_011509053.1. XM_011510751.1. [Q7RTX9-1]
UniGeneiHs.504317.

3D structure databases

ProteinModelPortaliQ7RTX9.
SMRiQ7RTX9. Positions 443-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127380. 1 interaction.
STRINGi9606.ENSP00000295190.

Protein family/group databases

TCDBi2.A.1.13.12. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ7RTX9.

Polymorphism and mutation databases

BioMutaiSLC16A14.
DMDMi74738645.

Proteomic databases

PaxDbiQ7RTX9.
PRIDEiQ7RTX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295190; ENSP00000295190; ENSG00000163053.
GeneIDi151473.
KEGGihsa:151473.
UCSCiuc002vqd.2. human. [Q7RTX9-1]

Organism-specific databases

CTDi151473.
GeneCardsiGC02M230899.
HGNCiHGNC:26417. SLC16A14.
HPAiHPA040518.
neXtProtiNX_Q7RTX9.
PharmGKBiPA134983567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000013205.
HOVERGENiHBG094888.
InParanoidiQ7RTX9.
KOiK08190.
OMAiYNLSEQN.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7RTX9.
TreeFamiTF313792.

Miscellaneous databases

GenomeRNAii151473.
NextBioi86699.
PROiQ7RTX9.

Gene expression databases

BgeeiQ7RTX9.
CleanExiHS_SLC16A14.
ExpressionAtlasiQ7RTX9. baseline and differential.
GenevisibleiQ7RTX9. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Brain cortex and Trachea.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lung.
  5. "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
    Halestrap A.P., Meredith D.
    Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1).

Entry informationi

Entry nameiMOT14_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX9
Secondary accession number(s): A8KA08, Q53R92, Q96NI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.