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Q7RTX9 (MOT14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 14

Short name=MCT 14
Alternative name(s):
Solute carrier family 16 member 14
Gene names
Name:SLC16A14
Synonyms:MCT14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7RTX9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7RTX9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Monocarboxylate transporter 14
PRO_0000288923

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Potential
Topological domain49 – 7325Cytoplasmic Potential
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 1028Extracellular Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 1263Cytoplasmic Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 15811Extracellular Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 19011Cytoplasmic Potential
Transmembrane191 – 20919Helical; Potential
Topological domain210 – 314105Extracellular Potential
Transmembrane315 – 33521Helical; Potential
Topological domain336 – 35217Cytoplasmic Potential
Transmembrane353 – 37321Helical; Potential
Topological domain374 – 3785Extracellular Potential
Transmembrane379 – 39921Helical; Potential
Topological domain400 – 4078Cytoplasmic Potential
Transmembrane408 – 42821Helical; Potential
Topological domain429 – 44214Extracellular Potential
Transmembrane443 – 46321Helical; Potential
Topological domain464 – 47310Cytoplasmic Potential
Transmembrane474 – 49421Helical; Potential
Topological domain495 – 51016Extracellular Potential

Natural variations

Alternative sequence1 – 174174Missing in isoform 2.
VSP_025826

Experimental info

Sequence conflict2091M → T in BAB70909. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 5510E3E9ED63C280

FASTA51056,254
        10         20         30         40         50         60 
MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS QMALGVLNVE 

        70         80         90        100        110        120 
WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR QTAIIGGLVN SLGWVLSAYA 

       130        140        150        160        170        180 
ANVHYLFITF GVAAGLGSGM AYLPAVVMVG RYFQKRRALA QGLSTTGTGF GTFLMTVLLK 

       190        200        210        220        230        240 
YLCAEYGWRN AMLIQGAVSL NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST 

       250        260        270        280        290        300 
GQQGRTEEKD GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW 

       310        320        330        340        350        360 
YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN DVFPLTSIIA 

       370        380        390        400        410        420 
IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP LMHTYAGLAV ICALIGFSSG 

       430        440        450        460        470        480 
YFSLMPVVTE DLVGIEHLAN AYGIIICANG ISALLGPPFA GWIYDITQKY DFSFYICGLL 

       490        500        510 
YMIGILFLLI QPCIRIIEQS RRKYMDGAHV 

« Hide

Isoform 2 [UniParc].

Checksum: 09DCD3205470CD02
Show »

FASTA33637,367

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Brain cortex and Trachea.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Lung.
[5]"The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
Halestrap A.P., Meredith D.
Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK055356 mRNA. Translation: BAB70909.1.
AK292873 mRNA. Translation: BAF85562.1.
AC093171 Genomic DNA. Translation: AAY24109.1.
CH471063 Genomic DNA. Translation: EAW70913.1.
BC065524 mRNA. Translation: AAH65524.1.
BN000146 mRNA. Translation: CAD80157.1.
CCDSCCDS2473.1. [Q7RTX9-1]
RefSeqNP_689740.2. NM_152527.4. [Q7RTX9-1]
UniGeneHs.504317.

3D structure databases

ProteinModelPortalQ7RTX9.
SMRQ7RTX9. Positions 430-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000295190.

Protein family/group databases

TCDB2.A.1.13.12. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ7RTX9.

Polymorphism databases

DMDM74738645.

Proteomic databases

PaxDbQ7RTX9.
PRIDEQ7RTX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295190; ENSP00000295190; ENSG00000163053. [Q7RTX9-1]
GeneID151473.
KEGGhsa:151473.
UCSCuc002vqd.2. human. [Q7RTX9-1]

Organism-specific databases

CTD151473.
GeneCardsGC02M230899.
HGNCHGNC:26417. SLC16A14.
HPAHPA040518.
neXtProtNX_Q7RTX9.
PharmGKBPA134983567.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000013205.
HOVERGENHBG094888.
InParanoidQ7RTX9.
KOK08190.
OMALTMRVRK.
OrthoDBEOG7TMZRG.
PhylomeDBQ7RTX9.
TreeFamTF313792.

Gene expression databases

ArrayExpressQ7RTX9.
BgeeQ7RTX9.
CleanExHS_SLC16A14.
GenevestigatorQ7RTX9.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi151473.
NextBio86699.
PROQ7RTX9.

Entry information

Entry nameMOT14_HUMAN
AccessionPrimary (citable) accession number: Q7RTX9
Secondary accession number(s): A8KA08, Q53R92, Q96NI7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM