Q7RTX9 (MOT14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monocarboxylate transporter 14
Short name=MCT 14

Alternative name(s):
Solute carrier family 16 member 14

Gene names

Name:	SLC16A14
Synonyms:	MCT14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Ontologies

Keywords
Biological process	Symport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7RTX9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7RTX9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	Monocarboxylate transporter 14		PRO_0000288923
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Potential
	Topological domain	49 – 73	25	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Potential
	Topological domain	95 – 102	8	Extracellular Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Topological domain	124 – 126	3	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Topological domain	148 – 158	11	Extracellular Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Topological domain	180 – 190	11	Cytoplasmic Potential
	Transmembrane	191 – 209	19	Helical; Potential
	Topological domain	210 – 314	105	Extracellular Potential
	Transmembrane	315 – 335	21	Helical; Potential
	Topological domain	336 – 352	17	Cytoplasmic Potential
	Transmembrane	353 – 373	21	Helical; Potential
	Topological domain	374 – 378	5	Extracellular Potential
	Transmembrane	379 – 399	21	Helical; Potential
	Topological domain	400 – 407	8	Cytoplasmic Potential
	Transmembrane	408 – 428	21	Helical; Potential
	Topological domain	429 – 442	14	Extracellular Potential
	Transmembrane	443 – 463	21	Helical; Potential
	Topological domain	464 – 473	10	Cytoplasmic Potential
	Transmembrane	474 – 494	21	Helical; Potential
	Topological domain	495 – 510	16	Extracellular Potential
Natural variations
	Alternative sequence	1 – 174	174	Missing in isoform 2.		VSP_025826
Experimental info
	Sequence conflict	209	1	M → T in BAB70909. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 5510E3E9ED63C280	FASTA	510	56,254
	10 20 30 40 50 60 MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS QMALGVLNVE 70 80 90 100 110 120 WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR QTAIIGGLVN SLGWVLSAYA 130 140 150 160 170 180 ANVHYLFITF GVAAGLGSGM AYLPAVVMVG RYFQKRRALA QGLSTTGTGF GTFLMTVLLK 190 200 210 220 230 240 YLCAEYGWRN AMLIQGAVSL NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST 250 260 270 280 290 300 GQQGRTEEKD GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW 310 320 330 340 350 360 YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN DVFPLTSIIA 370 380 390 400 410 420 IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP LMHTYAGLAV ICALIGFSSG 430 440 450 460 470 480 YFSLMPVVTE DLVGIEHLAN AYGIIICANG ISALLGPPFA GWIYDITQKY DFSFYICGLL 490 500 510 YMIGILFLLI QPCIRIIEQS RRKYMDGAHV
	Isoform 2 [UniParc]. Checksum: 09DCD3205470CD02	FASTA	336	37,367
	10 20 30 40 50 60 MTVLLKYLCA EYGWRNAMLI QGAVSLNLCV CGALMRPLSP GKNPNDPGEK DVRGLPAHST 70 80 90 100 110 120 ESVKSTGQQG RTEEKDGGLG NEETLCDLQA QECPDQAGHR KNMCALRILK TVSWLTMRVR 130 140 150 160 170 180 KGFEDWYSGY FGTASLFTNR MFVAFIFWAL FAYSSFVIPF IHLPEIVNLY NLSEQNDVFP 190 200 210 220 230 240 LTSIIAIVHI FGKVILGVIA DLPCISVWNV FLLANFTLVL SIFILPLMHT YAGLAVICAL 250 260 270 280 290 300 IGFSSGYFSL MPVVTEDLVG IEHLANAYGI IICANGISAL LGPPFAGWIY DITQKYDFSF 310 320 330 YICGLLYMIG ILFLLIQPCI RIIEQSRRKY MDGAHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain, Brain cortex and Trachea.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Lung.
[5]	"The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond." Halestrap A.P., Meredith D. Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055356 mRNA. Translation: BAB70909.1. AK292873 mRNA. Translation: BAF85562.1. AC093171 Genomic DNA. Translation: AAY24109.1. CH471063 Genomic DNA. Translation: EAW70913.1. BC065524 mRNA. Translation: AAH65524.1. BN000146 mRNA. Translation: CAD80157.1.
IPI	IPI00043689. IPI00847918.
RefSeq	NP_689740.2. NM_152527.4.
UniGene	Hs.504317.
3D structure databases
ProteinModelPortal	Q7RTX9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000295190.
PTM databases
PhosphoSite	Q7RTX9.
Polymorphism databases
DMDM	74738645.
Proteomic databases
PaxDb	Q7RTX9.
PRIDE	Q7RTX9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295190; ENSP00000295190; ENSG00000163053.
GeneID	151473.
KEGG	hsa:151473.
UCSC	uc002vqd.2. human.
Organism-specific databases
CTD	151473.
GeneCards	GC02M230899.
HGNC	HGNC:26417. SLC16A14.
HPA	HPA040518.
neXtProt	NX_Q7RTX9.
PharmGKB	PA134983567.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000013205.
HOVERGEN	HBG094888.
InParanoid	Q7RTX9.
KO	K08190.
OMA	CRQTAII.
OrthoDB	EOG4C87S4.
PhylomeDB	Q7RTX9.
Gene expression databases
ArrayExpress	Q7RTX9.
Bgee	Q7RTX9.
CleanEx	HS_SLC16A14.
Genevestigator	Q7RTX9.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	151473.
NextBio	86699.

Entry information

Entry name

MOT14_HUMAN

Accession

Primary (citable) accession number: Q7RTX9
Secondary accession number(s): A8KA08, Q53R92, Q96NI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.