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Q7RTX9

- MOT14_HUMAN

UniProt

Q7RTX9 - MOT14_HUMAN

Protein

Monocarboxylate transporter 14

Gene

SLC16A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.13.12. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 14
    Short name:
    MCT 14
    Alternative name(s):
    Solute carrier family 16 member 14
    Gene namesi
    Name:SLC16A14
    Synonyms:MCT14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26417. SLC16A14.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Monocarboxylate transporter 14PRO_0000288923Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTX9.
    PRIDEiQ7RTX9.

    PTM databases

    PhosphoSiteiQ7RTX9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7RTX9.
    BgeeiQ7RTX9.
    CleanExiHS_SLC16A14.
    GenevestigatoriQ7RTX9.

    Organism-specific databases

    HPAiHPA040518.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTX9.
    SMRiQ7RTX9. Positions 430-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 7325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 1028ExtracellularSequence Analysis
    Topological domaini124 – 1263CytoplasmicSequence Analysis
    Topological domaini148 – 15811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini210 – 314105ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini336 – 35217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini374 – 3785ExtracellularSequence Analysis
    Topological domaini400 – 4078CytoplasmicSequence Analysis
    Topological domaini429 – 44214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini464 – 47310CytoplasmicSequence Analysis
    Topological domaini495 – 51016ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 20919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000013205.
    HOVERGENiHBG094888.
    InParanoidiQ7RTX9.
    KOiK08190.
    OMAiLTMRVRK.
    OrthoDBiEOG7TMZRG.
    PhylomeDBiQ7RTX9.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7RTX9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS    50
    QMALGVLNVE WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR 100
    QTAIIGGLVN SLGWVLSAYA ANVHYLFITF GVAAGLGSGM AYLPAVVMVG 150
    RYFQKRRALA QGLSTTGTGF GTFLMTVLLK YLCAEYGWRN AMLIQGAVSL 200
    NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST GQQGRTEEKD 250
    GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW 300
    YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN 350
    DVFPLTSIIA IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP 400
    LMHTYAGLAV ICALIGFSSG YFSLMPVVTE DLVGIEHLAN AYGIIICANG 450
    ISALLGPPFA GWIYDITQKY DFSFYICGLL YMIGILFLLI QPCIRIIEQS 500
    RRKYMDGAHV 510
    Length:510
    Mass (Da):56,254
    Last modified:December 15, 2003 - v1
    Checksum:i5510E3E9ED63C280
    GO
    Isoform 2 (identifier: Q7RTX9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-174: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:336
    Mass (Da):37,367
    Checksum:i09DCD3205470CD02
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091M → T in BAB70909. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 174174Missing in isoform 2. 1 PublicationVSP_025826Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055356 mRNA. Translation: BAB70909.1.
    AK292873 mRNA. Translation: BAF85562.1.
    AC093171 Genomic DNA. Translation: AAY24109.1.
    CH471063 Genomic DNA. Translation: EAW70913.1.
    BC065524 mRNA. Translation: AAH65524.1.
    BN000146 mRNA. Translation: CAD80157.1.
    CCDSiCCDS2473.1. [Q7RTX9-1]
    RefSeqiNP_689740.2. NM_152527.4. [Q7RTX9-1]
    UniGeneiHs.504317.

    Genome annotation databases

    EnsembliENST00000295190; ENSP00000295190; ENSG00000163053. [Q7RTX9-1]
    GeneIDi151473.
    KEGGihsa:151473.
    UCSCiuc002vqd.2. human. [Q7RTX9-1]

    Polymorphism databases

    DMDMi74738645.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055356 mRNA. Translation: BAB70909.1 .
    AK292873 mRNA. Translation: BAF85562.1 .
    AC093171 Genomic DNA. Translation: AAY24109.1 .
    CH471063 Genomic DNA. Translation: EAW70913.1 .
    BC065524 mRNA. Translation: AAH65524.1 .
    BN000146 mRNA. Translation: CAD80157.1 .
    CCDSi CCDS2473.1. [Q7RTX9-1 ]
    RefSeqi NP_689740.2. NM_152527.4. [Q7RTX9-1 ]
    UniGenei Hs.504317.

    3D structure databases

    ProteinModelPortali Q7RTX9.
    SMRi Q7RTX9. Positions 430-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295190.

    Protein family/group databases

    TCDBi 2.A.1.13.12. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q7RTX9.

    Polymorphism databases

    DMDMi 74738645.

    Proteomic databases

    PaxDbi Q7RTX9.
    PRIDEi Q7RTX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295190 ; ENSP00000295190 ; ENSG00000163053 . [Q7RTX9-1 ]
    GeneIDi 151473.
    KEGGi hsa:151473.
    UCSCi uc002vqd.2. human. [Q7RTX9-1 ]

    Organism-specific databases

    CTDi 151473.
    GeneCardsi GC02M230899.
    HGNCi HGNC:26417. SLC16A14.
    HPAi HPA040518.
    neXtProti NX_Q7RTX9.
    PharmGKBi PA134983567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000013205.
    HOVERGENi HBG094888.
    InParanoidi Q7RTX9.
    KOi K08190.
    OMAi LTMRVRK.
    OrthoDBi EOG7TMZRG.
    PhylomeDBi Q7RTX9.
    TreeFami TF313792.

    Miscellaneous databases

    GenomeRNAii 151473.
    NextBioi 86699.
    PROi Q7RTX9.

    Gene expression databases

    ArrayExpressi Q7RTX9.
    Bgeei Q7RTX9.
    CleanExi HS_SLC16A14.
    Genevestigatori Q7RTX9.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Brain cortex and Trachea.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lung.
    5. "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond."
      Halestrap A.P., Meredith D.
      Pflugers Arch. 447:619-628(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 1).

    Entry informationi

    Entry nameiMOT14_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTX9
    Secondary accession number(s): A8KA08, Q53R92, Q96NI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3