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Q7RTX7

- CTSR4_HUMAN

UniProt

Q7RTX7 - CTSR4_HUMAN

Protein

Cation channel sperm-associated protein 4

Gene

CATSPER4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.2 Publications

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: Ensembl
    2. voltage-gated calcium channel activity Source: RefGenome

    GO - Biological processi

    1. calcium ion import Source: RefGenome
    2. cell differentiation Source: UniProtKB-KW
    3. cilium or flagellum-dependent cell motility Source: Ensembl
    4. membrane depolarization during action potential Source: RefGenome
    5. multicellular organismal development Source: UniProtKB-KW
    6. multicellular organism reproduction Source: Reactome
    7. single fertilization Source: Reactome
    8. sodium ion transport Source: Ensembl
    9. spermatogenesis Source: UniProtKB-KW
    10. sperm-egg recognition Source: Reactome
    11. sperm motility Source: RefGenome

    Keywords - Molecular functioni

    Calcium channel, Developmental protein, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Differentiation, Ion transport, Spermatogenesis, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation channel sperm-associated protein 4
    Short name:
    CatSper4
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23220. CATSPER4.

    Subcellular locationi

    Cell projectionciliumflagellum membrane; Multi-pass membrane protein
    Note: Specifically located in the principal piece of sperm tail.

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. CatSper complex Source: UniProtKB
    3. motile cilium Source: Ensembl
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Flagellum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941696.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Cation channel sperm-associated protein 4PRO_0000295681Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTX7.
    PRIDEiQ7RTX7.

    PTM databases

    PhosphoSiteiQ7RTX7.

    Expressioni

    Tissue specificityi

    Testis-specific.2 Publications

    Gene expression databases

    BgeeiQ7RTX7.
    CleanExiHS_CATSPER4.
    GenevestigatoriQ7RTX7.

    Organism-specific databases

    HPAiHPA045257.

    Interactioni

    Subunit structurei

    Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 Potential. Component of the CatSper complex. Interacts with CATSPER1 By similarity.By similarityCurated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTX7.
    SMRiQ7RTX7. Positions 94-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini152 – 1576CytoplasmicSequence Analysis
    Topological domaini179 – 1791ExtracellularSequence Analysis
    Topological domaini198 – 21619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 2469ExtracellularSequence Analysis
    Topological domaini268 – 28417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 472167CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei247 – 26721Helical; Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 19718Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000112053.
    HOVERGENiHBG102124.
    InParanoidiQ7RTX7.
    KOiK16892.
    PhylomeDBiQ7RTX7.
    TreeFamiTF343841.

    Family and domain databases

    InterProiIPR028744. CatSper4.
    IPR005821. Ion_trans_dom.
    [Graphical view]
    PANTHERiPTHR10037:SF199. PTHR10037:SF199. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7RTX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRDNEKAWWQ QWTSHTGLEG WGGTQEDRMG FGGAVAALRG RPSPLQSTIH    50
    ESYGRPEEQV LINRQEITNK ADAWDMQEFI THMYIKQLLR HPAFQLLLAL 100
    LLVINAITIA LRTNSYLDQK HYELFSTIDD IVLTILLCEV LLGWLNGFWI 150
    FWKDGWNILN FIIVFILLLR FFINEINIPS INYTLRALRL VHVCMAVEPL 200
    ARIIRVILQS VPDMANIMVL ILFFMLVFSV FGVTLFGAFV PKHFQNIQVA 250
    LYTLFICITQ DGWVDIYSDF QTEKREYAME IGGAIYFTIF ITIGAFIGIN 300
    LFVIVVTTNL EQMMKAGEQG QQQRITFSET GAEEEEENDQ LPLVHCVVAR 350
    SEKSGLLQEP LAGGPLSNLS ENTCDNFCLV LEAIQENLRQ YKEIRDELNM 400
    IVEEVRAIRF NQEQESEVLN RRSSTSGSLE TTSSKDIRQM SQQQDLLSAL 450
    VSMEKVHDSS SQILLKKHKS SH 472
    Length:472
    Mass (Da):54,092
    Last modified:December 15, 2003 - v1
    Checksum:i5AC94CD0971A25FE
    GO
    Isoform 2 (identifier: Q7RTX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-242: Missing.
         401-472: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:384
    Mass (Da):44,229
    Checksum:i00D375891B88F6F3
    GO

    Sequence cautioni

    The sequence AAI28139.1 differs from that shown. Reason: Frameshift at position 21.
    The sequence CAH71538.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771Q → R.
    Corresponds to variant rs11247866 [ dbSNP | Ensembl ].
    VAR_033310
    Natural varianti124 – 1241L → F.
    Corresponds to variant rs12138368 [ dbSNP | Ensembl ].
    VAR_033311
    Natural varianti293 – 2931I → V.
    Corresponds to variant rs17257155 [ dbSNP | Ensembl ].
    VAR_033312
    Natural varianti436 – 4361D → N.
    Corresponds to variant rs6657616 [ dbSNP | Ensembl ].
    VAR_033313

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei227 – 24216Missing in isoform 2. 1 PublicationVSP_026979Add
    BLAST
    Alternative sequencei401 – 47272Missing in isoform 2. 1 PublicationVSP_026980Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355877 Genomic DNA. Translation: CAH71538.1. Different initiation.
    BC128138 mRNA. Translation: AAI28139.1. Frameshift.
    BC128139 mRNA. Translation: AAI28140.1.
    BN000273 mRNA. Translation: CAE30475.1.
    CCDSiCCDS30645.1. [Q7RTX7-1]
    RefSeqiNP_937770.1. NM_198137.1. [Q7RTX7-1]
    UniGeneiHs.123532.

    Genome annotation databases

    EnsembliENST00000456354; ENSP00000390423; ENSG00000188782. [Q7RTX7-1]
    ENST00000518899; ENSP00000429464; ENSG00000188782. [Q7RTX7-2]
    GeneIDi378807.
    KEGGihsa:378807.
    UCSCiuc010oez.2. human. [Q7RTX7-1]

    Polymorphism databases

    DMDMi74713153.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355877 Genomic DNA. Translation: CAH71538.1 . Different initiation.
    BC128138 mRNA. Translation: AAI28139.1 . Frameshift.
    BC128139 mRNA. Translation: AAI28140.1 .
    BN000273 mRNA. Translation: CAE30475.1 .
    CCDSi CCDS30645.1. [Q7RTX7-1 ]
    RefSeqi NP_937770.1. NM_198137.1. [Q7RTX7-1 ]
    UniGenei Hs.123532.

    3D structure databases

    ProteinModelPortali Q7RTX7.
    SMRi Q7RTX7. Positions 94-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341006.

    Chemistry

    GuidetoPHARMACOLOGYi 391.

    Protein family/group databases

    TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q7RTX7.

    Polymorphism databases

    DMDMi 74713153.

    Proteomic databases

    PaxDbi Q7RTX7.
    PRIDEi Q7RTX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000456354 ; ENSP00000390423 ; ENSG00000188782 . [Q7RTX7-1 ]
    ENST00000518899 ; ENSP00000429464 ; ENSG00000188782 . [Q7RTX7-2 ]
    GeneIDi 378807.
    KEGGi hsa:378807.
    UCSCi uc010oez.2. human. [Q7RTX7-1 ]

    Organism-specific databases

    CTDi 378807.
    GeneCardsi GC01P026517.
    HGNCi HGNC:23220. CATSPER4.
    HPAi HPA045257.
    MIMi 609121. gene.
    neXtProti NX_Q7RTX7.
    PharmGKBi PA134941696.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000112053.
    HOVERGENi HBG102124.
    InParanoidi Q7RTX7.
    KOi K16892.
    PhylomeDBi Q7RTX7.
    TreeFami TF343841.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    GeneWikii CatSper4.
    GenomeRNAii 378807.
    NextBioi 100804.
    PROi Q7RTX7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7RTX7.
    CleanExi HS_CATSPER4.
    Genevestigatori Q7RTX7.

    Family and domain databases

    InterProi IPR028744. CatSper4.
    IPR005821. Ion_trans_dom.
    [Graphical view ]
    PANTHERi PTHR10037:SF199. PTHR10037:SF199. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis."
      Lobley A., Pierron V., Reynolds L., Allen L., Michalovich D.
      Reprod. Biol. Endocrinol. 1:53-53(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    4. "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."
      Li H.-G., Ding X.-F., Liao A.-H., Kong X.-B., Xiong C.-L.
      Mol. Hum. Reprod. 13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."
      Strunker T., Goodwin N., Brenker C., Kashikar N.D., Weyand I., Seifert R., Kaupp U.B.
      Nature 471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.
    6. "Progesterone activates the principal Ca2+ channel of human sperm."
      Lishko P.V., Botchkina I.L., Kirichok Y.
      Nature 471:387-391(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ACTIVATION BY PROGESTERONE.

    Entry informationi

    Entry nameiCTSR4_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTX7
    Secondary accession number(s): A1A4W6, Q5VY71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3