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Reviewed, UniProtKB/Swiss-Prot Q7RTX1 (TS1R1_HUMAN)

Last modified November 4, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Taste receptor type 1 member 1
Alternative name(s):
    G-protein coupled receptor 70
Gene names
Name: TAS1R1
Synonyms: GPR70, T1R1, TR1
ORF Names: GM148
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length841 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Subunit structure

Forms heterodimers with TAS1R3.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Sequence caution

The sequence BAC05845.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords

   Biological processSensory transduction
Taste
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processsensory perception of umami taste Ref.4

Inferred from direct assay. Source: UniProtKB

   Cellular componentintegral to membrane Ref.4

Inferred by curator. Source: UniProtKB

   Molecular functionprotein heterodimerization activity Ref.4

Non-traceable author statement. Source: UniProtKB

taste receptor activity Ref.4

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7RTX1-1)

Also known as: Gm148 form B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7RTX1-2)

Also known as: Gm148 form C;

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
Notes: No experimental confirmation available.
Isoform 3 (identifier: Q7RTX1-3)

Also known as: Gm148 form A;

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     421-841: LLEQIHKVHF...QDYTRRCGST → LSYAASSETL...LGLLACLPGT
Notes: No experimental confirmation available. Ref.4 (AAL91358) sequence differs from that shown due to frameshifts in positions 340 and 548.
Isoform 4 (identifier: Q7RTX1-4)

Also known as: Gm148 form D;

The sequence of this isoform differs from the canonical sequence as follows:
     167-420: Missing.
     532-574: DLYRCQPCGK...HTSWVLLAAN → ATWVRTCQRT...RPASTTAXTC
     575-841: Missing.
Notes: Incomplete sequence.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 841821Taste receptor type 1 member 1
PRO_0000012954

Regions

Topological domain21 – 567547Extracellular Potential
Transmembrane568 – 588211 Potential
Topological domain589 – 60315Cytoplasmic Potential
Transmembrane604 – 624212 Potential
Topological domain625 – 63915Extracellular Potential
Transmembrane640 – 660213 Potential
Topological domain661 – 68020Cytoplasmic Potential
Transmembrane681 – 701214 Potential
Topological domain702 – 72524Extracellular Potential
Transmembrane726 – 746215 Potential
Topological domain747 – 76115Cytoplasmic Potential
Transmembrane762 – 782216 Potential
Topological domain783 – 79513Extracellular Potential
Transmembrane796 – 816217 Potential
Topological domain817 – 84125Cytoplasmic Potential

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation4791N-linked (GlcNAc...) Potential
Glycosylation5291N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence167 – 420254Missing in isoform 2, isoform 3 and isoform 4.
VSP_012418
Alternative sequence421 – 841421LLEQI…RCGST → LSYAASSETLSVKRQYPSFL RTIPNDKYQVETMVLLLQKF GWTWISLVGSSDDYGQLGVQ ALENQATGQGICIAFKDIMP FSAQVGDERMQCLMRHLAQA GATVVVVFSSRQLARVFFES VVLTNLTGKVWVASEAWALS RHITGVPGIQRIGMVLGVAI QKRAVPGLKAFEEAYARADK KAPRPCHKGSWCSSNQLCRE CQAFMAHTMPKLKAFSMSSA YNAYRAVYAVAHGLHQLLGC ASGACSRGRVYPWQTSTDAS LVGKKSGHLREARPASRALW CFWLCVSTPLGCCWQLTRCC CCCCLGLLACLPGT in isoform 3.
VSP_012420
Alternative sequence532 – 57443DLYRC…LLAAN → ATWVRTCQRTTTRTNVSPSA CSSTSCPGSPSSPRPASTTA XTC in isoform 4.
VSP_012421
Alternative sequence575 – 841267Missing in isoform 4.
VSP_012422
Natural variant3471K → E: dbSNP rs10864628.
VAR_036707
Natural variant3721A → T: dbSNP rs34160967.
VAR_036708
Natural variant5071R → Q: dbSNP rs35118458.
VAR_036709

Experimental info

Sequence conflict1671I → L in AAL91358. Ref.3
Sequence conflict5501Q → R in CAI16076. Ref.3
Sequence conflict6481C → W in AAL91360. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Gm148 form B) [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: E800772B267D0216

FASTA84193,074
        10         20         30         40         50         60 
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC LQVRHRPEVT 

        70         80         90        100        110        120 
LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY QLYDVCSDSA NVYATLRVLS 

       130        140        150        160        170        180 
LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN RAATTAALLS PFLVPMISYA ASSETLSVKR 

       190        200        210        220        230        240 
QYPSFLRTIP NDKYQVETMV LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA 

       250        260        270        280        290        300 
FKDIMPFSAQ VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS 

       310        320        330        340        350        360 
EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR PCHKGSWCSS 

       370        380        390        400        410        420 
NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL HQLLGCASGA CSRGRVYPWQ 

       430        440        450        460        470        480 
LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN IIAWDWNGPK WTFTVLGSST WSPVQLNINE 

       490        500        510        520        530        540 
TKIQWHGKDN QVPKSVCSSD CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG 

       550        560        570        580        590        600 
KEEWAPEGSQ TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA 

       610        620        630        640        650        660 
GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT VRSFQLIIIF 

       670        680        690        700        710        720 
KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV WTPLPAREYQ RFPHLVMLEC 

       730        740        750        760        770        780 
TETNSLGFIL AFLYNGLLSI SAFACSYLGK DLPENYNEAK CVTFSLLFNF VSWIAFFTTA 

       790        800        810        820        830        840 
SVYDGKYLPA ANMMAGLSSL SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS 


T

« Hide

Isoform 2 (Gm148 form C) [UniParc].

Checksum: 236CCE778949C68F
Show »

58765,130
Isoform 3 (Gm148 form A) [UniParc].

Checksum: 451E536935DD36D9
Show »

48052,522
Isoform 4 (Gm148 form D) [UniParc].

Checksum: 9A44A1B5A61BA88C
Show »

32035,134

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References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Identification of six novel genes by experimental validation of GeneMachine predicted genes."
Makalowska I., Sood R., Faruque M.U., Hu P., Robbins C.M., Eddings E.M., Mestre J.D., Baxevanis A.D., Carpten J.D.
Gene 284:203-213(2002) [PubMed: 11891061] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-841 (ISOFORMS 1; 2; 3 AND 4), VARIANT GLU-347.
[4]"Human receptors for sweet and umami taste."
Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.
Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002) [PubMed: 11917125] [Abstract]
Cited for: IDENTIFICATION OF ISOFORM 1, FUNCTION.
+Additional computationally mapped references.

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Web resources

Protein Spotlight

The taste experience - Issue 55 of February 2005

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Cross-references

Sequence databases

AB065618 Genomic DNA. Translation: BAC05845.1. Sequence problems.
AL591866 Genomic DNA. Translation: CAI16073.1.
AL591866 Genomic DNA. Translation: CAI16074.1.
AL591866 Genomic DNA. Translation: CAI16076.1.
AF387617 mRNA. Translation: AAL91358.1. Sequence problems.
AF387618 mRNA. Translation: AAL91359.1. Different initiation.
AF387619 mRNA. Translation: AAL91360.1. Different initiation.
AF387620 mRNA. Translation: AAL91361.1. Different initiation.
BK000153 mRNA. Translation: DAA00012.1.
RefSeqNP_619642.2.
NP_803883.1.
NP_803884.1.
NP_803885.1.
UniGeneHs.124574

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSG00000173662. Homo sapiens. [Contig view]
GeneID80835.
KEGGhsa:80835.

Organism-specific databases

H-InvDBHIX0000082.
HGNCHGNC:14448. TAS1R1.
MIM606225. gene.
PharmGKBPA37882.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ7RTX1.
HOVERGENQ7RTX1.

Gene expression databases

ArrayExpressQ7RTX1.
CleanExHS_TAS1R1.
GermOnlineENSG00000173662. Homo sapiens.

Family and domain databases

InterProIPR001828. ANF_lig_bd_rcpt.
IPR000337. GPCR_3.
IPR000068. GPCR_3_Ca_sens_rcpt-rel.
IPR011500. GPCR_3_NCR.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00592. CASENSINGR.
PR00248. GPCRMGR.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio71274.
SOURCESearch...

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Entry information

Entry nameTS1R1_HUMAN
AccessionPrimary (citable) accession number: Q7RTX1
Secondary accession number(s): Q5SY22 expand/collapse secondary AC list , Q5SY24, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 15, 2003
Last modified: November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents