Reviewed,
UniProtKB/Swiss-Prot Q7RTX1 (TS1R1_HUMAN)
Last modified
June 16, 2009.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Taste receptor type 1 member 1 Alternative name(s): G-protein coupled receptor 70 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 841 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Ref.5 |
| Subunit structure | Forms heterodimers with TAS1R3. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. |
| Sequence caution | The sequence BAC05845.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Taste |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulusInferred from electronic annotation. Source: UniProtKB-KW sensory perception of umami taste Ref.5Inferred from direct assay. Source: UniProtKB |
| Cellular component | integral to membrane Ref.5 Inferred by curator. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein heterodimerization activity Ref.5 Non-traceable author statement. Source: UniProtKB taste receptor activity Ref.5Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q7RTX1-1) Also known as: Gm148 form B; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q7RTX1-2) Also known as: Gm148 form C; The sequence of this isoform differs from the canonical sequence as follows: 167-420: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q7RTX1-3) Also known as: Gm148 form A; The sequence of this isoform differs from the canonical sequence as follows: 167-420: Missing. 421-841: LLEQIHKVHF...QDYTRRCGST → LSYAASSETL...LGLLACLPGT | ||||||
| Note: No experimental confirmation available. Ref.5 (AAL91358) sequence differs from that shown due to frameshifts in positions 340 and 548. | ||||||
| Isoform 4 (identifier: Q7RTX1-4) Also known as: Gm148 form D; The sequence of this isoform differs from the canonical sequence as follows: 167-420: Missing. 532-574: DLYRCQPCGK...HTSWVLLAAN → ATWVRTCQRT...RPASTTAXTC 575-841: Missing. | ||||||
| Note: Incomplete sequence. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||
| Chain | 21 – 841 | 821 | Taste receptor type 1 member 1 | PRO_0000012954 | |||||
Regions | |||||||||
| Topological domain | 21 – 567 | 547 | Extracellular Potential | ||||||
| Transmembrane | 568 – 588 | 21 | 1 Potential | ||||||
| Topological domain | 589 – 603 | 15 | Cytoplasmic Potential | ||||||
| Transmembrane | 604 – 624 | 21 | 2 Potential | ||||||
| Topological domain | 625 – 639 | 15 | Extracellular Potential | ||||||
| Transmembrane | 640 – 660 | 21 | 3 Potential | ||||||
| Topological domain | 661 – 680 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 681 – 701 | 21 | 4 Potential | ||||||
| Topological domain | 702 – 725 | 24 | Extracellular Potential | ||||||
| Transmembrane | 726 – 746 | 21 | 5 Potential | ||||||
| Topological domain | 747 – 761 | 15 | Cytoplasmic Potential | ||||||
| Transmembrane | 762 – 782 | 21 | 6 Potential | ||||||
| Topological domain | 783 – 795 | 13 | Extracellular Potential | ||||||
| Transmembrane | 796 – 816 | 21 | 7 Potential | ||||||
| Topological domain | 817 – 841 | 25 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 87 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 88 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 95 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 291 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 479 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 529 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 167 – 420 | 254 | Missing in isoform 2, isoform 3 and isoform 4. | VSP_012418 | |||||
| Alternative sequence | 421 – 841 | 421 | LLEQI…RCGST → LSYAASSETLSVKRQYPSFL RTIPNDKYQVETMVLLLQKF GWTWISLVGSSDDYGQLGVQ ALENQATGQGICIAFKDIMP FSAQVGDERMQCLMRHLAQA GATVVVVFSSRQLARVFFES VVLTNLTGKVWVASEAWALS RHITGVPGIQRIGMVLGVAI QKRAVPGLKAFEEAYARADK KAPRPCHKGSWCSSNQLCRE CQAFMAHTMPKLKAFSMSSA YNAYRAVYAVAHGLHQLLGC ASGACSRGRVYPWQTSTDAS LVGKKSGHLREARPASRALW CFWLCVSTPLGCCWQLTRCC CCCCLGLLACLPGT in isoform 3. | VSP_012420 | |||||
| Alternative sequence | 532 – 574 | 43 | DLYRC…LLAAN → ATWVRTCQRTTTRTNVSPSA CSSTSCPGSPSSPRPASTTA XTC in isoform 4. | VSP_012421 | |||||
| Alternative sequence | 575 – 841 | 267 | Missing in isoform 4. | VSP_012422 | |||||
| Natural variant | 347 | 1 | K → E: dbSNP rs10864628. Ref.3 Ref.4 | VAR_036707 | |||||
| Natural variant | 372 | 1 | A → T: dbSNP rs34160967. | VAR_036708 | |||||
| Natural variant | 507 | 1 | R → Q: dbSNP rs35118458. | VAR_036709 | |||||
Experimental info | |||||||||
| Sequence conflict | 167 | 1 | I → L in AAL91358. Ref.4 | ||||||
| Sequence conflict | 550 | 1 | Q → R in CAI16076. Ref.2 | ||||||
| Sequence conflict | 648 | 1 | C → W in AAL91360. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-347. |
| [4] | "Identification of six novel genes by experimental validation of GeneMachine predicted genes." Makalowska I., Sood R., Faruque M.U., Hu P., Robbins C.M., Eddings E.M., Mestre J.D., Baxevanis A.D., Carpten J.D. Gene 284:203-213(2002) [PubMed: 11891061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-841 (ISOFORMS 1; 2; 3 AND 4), VARIANT GLU-347. |
| [5] | "Human receptors for sweet and umami taste." Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E. Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002) [PubMed: 11917125] [Abstract] Cited for: IDENTIFICATION OF ISOFORM 1, FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB065618 Genomic DNA. Translation: BAC05845.1. Sequence problems. AL591866 Genomic DNA. Translation: CAI16073.1. AL591866 Genomic DNA. Translation: CAI16074.1. AL591866 Genomic DNA. Translation: CAI16076.1. BC136515 mRNA. Translation: AAI36516.1. BC136516 mRNA. Translation: AAI36517.1. AF387617 mRNA. Translation: AAL91358.1. Sequence problems. AF387618 mRNA. Translation: AAL91359.1. Different initiation. AF387619 mRNA. Translation: AAL91360.1. Different initiation. AF387620 mRNA. Translation: AAL91361.1. Different initiation. BK000153 mRNA. Translation: DAA00012.1. | |
| IPI | IPI00220275. IPI00291392. IPI00332575. IPI00514989. |
| RefSeq | NP_619642.2. NP_803883.1. NP_803884.1. NP_803885.1. |
| UniGene | Hs.124574 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | Q7RTX1. |
Genome annotation databases | |
| Ensembl | ENSG00000173662. Homo sapiens. [Contig view] |
| GeneID | 80835. |
| KEGG | hsa:80835. |
Organism-specific databases | |
| GeneCards | GC01P006550. |
| H-InvDB | HIX0000082. |
| HGNC | HGNC:14448. TAS1R1. |
| MIM | 606225. gene. |
| PharmGKB | PA37882. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q7RTX1. |
| HOVERGEN | Q7RTX1. |
| OMA | Q7RTX1. KCVTFSL. |
Gene expression databases | |
| ArrayExpress | Q7RTX1. |
| Bgee | Q7RTX1. |
| GermOnline | ENSG00000173662. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001828. ANF_lig_bd_rcpt. IPR000337. GPCR_3. IPR017978. GPCR_3_C. IPR000068. GPCR_3_Ca_sens_rcpt-rel. IPR017979. GPCR_3_CS. IPR011500. GPCR_3_NCR. [Graphical view] |
| Pfam | PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view] |
| PRINTS | PR00592. CASENSINGR. PR00248. GPCRMGR. |
| PROSITE | PS00979. G_PROTEIN_RECEP_F3_1. False negative. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 71274. |
| SOURCE | Search... |
Entry information
| Entry name | TS1R1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q7RTX1 Secondary accession number(s): B2RMX0 Q8TDK0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

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