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Q7RTX0

- TS1R3_HUMAN

UniProt

Q7RTX0 - TS1R3_HUMAN

Protein

Taste receptor type 1 member 3

Gene

TAS1R3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose By similarity. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.By similarity2 Publications

    GO - Molecular functioni

    1. protein heterodimerization activity Source: UniProtKB
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
    2. G-protein coupled receptor signaling pathway Source: HGNC
    3. sensory perception of sweet taste Source: UniProtKB
    4. sensory perception of umami taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 1 member 3
    Alternative name(s):
    Sweet taste receptor T1R3
    Gene namesi
    Name:TAS1R3
    Synonyms:T1R3, TR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15661. TAS1R3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi537 – 5371A → G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed. 1 Publication
    Mutagenesisi537 – 5371A → P: Receptor unresponsive to all sweeteners tested. 1 Publication
    Mutagenesisi537 – 5371A → T, S, E or V: Abolished the response to brazzein. 1 Publication
    Mutagenesisi540 – 5401F → A or H: Reduces the response to brazzein and monellin. 1 Publication
    Mutagenesisi540 – 5401F → L: Reduces the response to monellin. 1 Publication
    Mutagenesisi540 – 5401F → Y or P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners. 1 Publication

    Organism-specific databases

    PharmGKBiPA38012.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 852832Taste receptor type 1 member 3PRO_0000012961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi411 – 4111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7RTX0.
    PRIDEiQ7RTX0.

    Expressioni

    Gene expression databases

    BgeeiQ7RTX0.
    CleanExiHS_TAS1R3.
    GenevestigatoriQ7RTX0.

    Organism-specific databases

    HPAiHPA053439.

    Interactioni

    Subunit structurei

    Forms homodimers or heterodimers with TAS1R1 and TAS1R2.

    Protein-protein interaction databases

    BioGridi123757. 2 interactions.
    STRINGi9606.ENSP00000344411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTX0.
    SMRiQ7RTX0. Positions 25-555, 560-824.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 570550ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini592 – 60312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini625 – 63915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini661 – 68222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini704 – 72926ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini751 – 76212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini784 – 7896ExtracellularSequence Analysis
    Topological domaini811 – 85242CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei571 – 59121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei604 – 62421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei640 – 66021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei683 – 70321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei730 – 75021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei763 – 78321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei790 – 81021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni536 – 54510Required for brazzein responsiveness

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303330.
    HOGENOMiHOG000231293.
    HOVERGENiHBG098572.
    InParanoidiQ7RTX0.
    KOiK04626.
    OMAiQLLENMY.
    OrthoDBiEOG7K0ZBJ.
    PhylomeDBiQ7RTX0.
    TreeFamiTF331269.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7RTX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG    50
    LRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF 100
    DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA 150
    MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL 200
    LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD 250
    SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS 300
    EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF 350
    CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV 400
    AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHVGGL PLRFDSSGNV 450
    DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS 500
    RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF CGQDEWSPER 550
    STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ 600
    ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST 650
    LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL 700
    VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL 750
    VRSQPGCYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL 800
    CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ NDGNTGNQGK 850
    HE 852
    Length:852
    Mass (Da):93,386
    Last modified:March 29, 2005 - v2
    Checksum:i9690DEC23E75EB3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti852 – 8521E → EAPILHPARHHSSGRPGGGT QAYAQGRARRGRGGTQLPTL PFAQWVDSIMTVTSTRDRAQ DLTPARRQAHTGSPVRVPGS APSRA in BAC05873. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti757 – 7571C → R.
    Corresponds to variant rs307377 [ dbSNP | Ensembl ].
    VAR_020788

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065647 Genomic DNA. Translation: BAC05873.1.
    AL139287 Genomic DNA. Translation: CAI23184.1.
    BK000152 mRNA. Translation: DAA00013.1.
    CCDSiCCDS30556.1.
    RefSeqiNP_689414.1. NM_152228.1.
    UniGeneiHs.74375.

    Genome annotation databases

    EnsembliENST00000339381; ENSP00000344411; ENSG00000169962.
    GeneIDi83756.
    KEGGihsa:83756.
    UCSCiuc010nyk.2. human.

    Polymorphism databases

    DMDMi62299063.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The taste experience - Issue 55 of February 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065647 Genomic DNA. Translation: BAC05873.1 .
    AL139287 Genomic DNA. Translation: CAI23184.1 .
    BK000152 mRNA. Translation: DAA00013.1 .
    CCDSi CCDS30556.1.
    RefSeqi NP_689414.1. NM_152228.1.
    UniGenei Hs.74375.

    3D structure databases

    ProteinModelPortali Q7RTX0.
    SMRi Q7RTX0. Positions 25-555, 560-824.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123757. 2 interactions.
    STRINGi 9606.ENSP00000344411.

    Chemistry

    DrugBanki DB00168. Aspartame.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 62299063.

    Proteomic databases

    PaxDbi Q7RTX0.
    PRIDEi Q7RTX0.

    Protocols and materials databases

    DNASUi 83756.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339381 ; ENSP00000344411 ; ENSG00000169962 .
    GeneIDi 83756.
    KEGGi hsa:83756.
    UCSCi uc010nyk.2. human.

    Organism-specific databases

    CTDi 83756.
    GeneCardsi GC01P001266.
    HGNCi HGNC:15661. TAS1R3.
    HPAi HPA053439.
    MIMi 605865. gene.
    neXtProti NX_Q7RTX0.
    PharmGKBi PA38012.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303330.
    HOGENOMi HOG000231293.
    HOVERGENi HBG098572.
    InParanoidi Q7RTX0.
    KOi K04626.
    OMAi QLLENMY.
    OrthoDBi EOG7K0ZBJ.
    PhylomeDBi Q7RTX0.
    TreeFami TF331269.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

    Miscellaneous databases

    GeneWikii TAS1R3.
    GenomeRNAii 83756.
    NextBioi 72785.
    PROi Q7RTX0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7RTX0.
    CleanExi HS_TAS1R3.
    Genevestigatori Q7RTX0.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION, FUNCTION.
    4. "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose."
      Ariyasu T., Matsumoto S., Kyono F., Hanaya T., Arai S., Ikeda M., Kurimoto M.
      In Vitro Cell. Dev. Biol. Anim. 39:80-88(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins."
      Jiang P., Ji Q., Liu Z., Snyder L.A., Benard L.M.J., Margolskee R.F., Max M.
      J. Biol. Chem. 279:45068-45075(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGION IMPLICATED IN SWEET RECEPTOR FUNCTION, MUTAGENESIS OF ALA-537 AND PHE-540.

    Entry informationi

    Entry nameiTS1R3_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTX0
    Secondary accession number(s): Q5TA49, Q8NGW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3