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Q7RTX0

- TS1R3_HUMAN

UniProt

Q7RTX0 - TS1R3_HUMAN

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Protein

Taste receptor type 1 member 3

Gene
TAS1R3, T1R3, TR3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose By similarity. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.3 Publications

GO - Molecular functioni

  1. protein heterodimerization activity Source: UniProtKB
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
  2. G-protein coupled receptor signaling pathway Source: HGNC
  3. sensory perception of sweet taste Source: UniProtKB
  4. sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene namesi
Name:TAS1R3
Synonyms:T1R3, TR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15661. TAS1R3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 570550Extracellular Reviewed predictionAdd
BLAST
Transmembranei571 – 59121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini592 – 60312Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei604 – 62421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini625 – 63915Extracellular Reviewed predictionAdd
BLAST
Transmembranei640 – 66021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini661 – 68222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei683 – 70321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini704 – 72926Extracellular Reviewed predictionAdd
BLAST
Transmembranei730 – 75021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini751 – 76212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei763 – 78321Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini784 – 7896Extracellular Reviewed prediction
Transmembranei790 – 81021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini811 – 85242Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi537 – 5371A → G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed. 1 Publication
Mutagenesisi537 – 5371A → P: Receptor unresponsive to all sweeteners tested. 1 Publication
Mutagenesisi537 – 5371A → T, S, E or V: Abolished the response to brazzein. 1 Publication
Mutagenesisi540 – 5401F → A or H: Reduces the response to brazzein and monellin. 1 Publication
Mutagenesisi540 – 5401F → L: Reduces the response to monellin. 1 Publication
Mutagenesisi540 – 5401F → Y or P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners. 1 Publication

Organism-specific databases

PharmGKBiPA38012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 852832Taste receptor type 1 member 3PRO_0000012961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi380 – 3801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7RTX0.
PRIDEiQ7RTX0.

Expressioni

Gene expression databases

BgeeiQ7RTX0.
CleanExiHS_TAS1R3.
GenevestigatoriQ7RTX0.

Organism-specific databases

HPAiHPA053439.

Interactioni

Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2.

Protein-protein interaction databases

BioGridi123757. 2 interactions.
STRINGi9606.ENSP00000344411.

Structurei

3D structure databases

ProteinModelPortaliQ7RTX0.
SMRiQ7RTX0. Positions 25-555, 560-824.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni536 – 54510Required for brazzein responsiveness

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303330.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ7RTX0.
KOiK04626.
OMAiQLLENMY.
OrthoDBiEOG7K0ZBJ.
PhylomeDBiQ7RTX0.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTX0-1 [UniParc]FASTAAdd to Basket

« Hide

MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG    50
LRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF 100
DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA 150
MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL 200
LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD 250
SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS 300
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF 350
CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV 400
AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHVGGL PLRFDSSGNV 450
DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS 500
RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF CGQDEWSPER 550
STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ 600
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST 650
LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL 700
VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL 750
VRSQPGCYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL 800
CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ NDGNTGNQGK 850
HE 852
Length:852
Mass (Da):93,386
Last modified:March 29, 2005 - v2
Checksum:i9690DEC23E75EB3E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti757 – 7571C → R.
Corresponds to variant rs307377 [ dbSNP | Ensembl ].
VAR_020788

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti852 – 8521E → EAPILHPARHHSSGRPGGGT QAYAQGRARRGRGGTQLPTL PFAQWVDSIMTVTSTRDRAQ DLTPARRQAHTGSPVRVPGS APSRA in BAC05873. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065647 Genomic DNA. Translation: BAC05873.1.
AL139287 Genomic DNA. Translation: CAI23184.1.
BK000152 mRNA. Translation: DAA00013.1.
CCDSiCCDS30556.1.
RefSeqiNP_689414.1. NM_152228.1.
UniGeneiHs.74375.

Genome annotation databases

EnsembliENST00000339381; ENSP00000344411; ENSG00000169962.
GeneIDi83756.
KEGGihsa:83756.
UCSCiuc010nyk.2. human.

Polymorphism databases

DMDMi62299063.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The taste experience - Issue 55 of February 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065647 Genomic DNA. Translation: BAC05873.1 .
AL139287 Genomic DNA. Translation: CAI23184.1 .
BK000152 mRNA. Translation: DAA00013.1 .
CCDSi CCDS30556.1.
RefSeqi NP_689414.1. NM_152228.1.
UniGenei Hs.74375.

3D structure databases

ProteinModelPortali Q7RTX0.
SMRi Q7RTX0. Positions 25-555, 560-824.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123757. 2 interactions.
STRINGi 9606.ENSP00000344411.

Chemistry

DrugBanki DB00168. Aspartame.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 62299063.

Proteomic databases

PaxDbi Q7RTX0.
PRIDEi Q7RTX0.

Protocols and materials databases

DNASUi 83756.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339381 ; ENSP00000344411 ; ENSG00000169962 .
GeneIDi 83756.
KEGGi hsa:83756.
UCSCi uc010nyk.2. human.

Organism-specific databases

CTDi 83756.
GeneCardsi GC01P001266.
HGNCi HGNC:15661. TAS1R3.
HPAi HPA053439.
MIMi 605865. gene.
neXtProti NX_Q7RTX0.
PharmGKBi PA38012.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303330.
HOGENOMi HOG000231293.
HOVERGENi HBG098572.
InParanoidi Q7RTX0.
KOi K04626.
OMAi QLLENMY.
OrthoDBi EOG7K0ZBJ.
PhylomeDBi Q7RTX0.
TreeFami TF331269.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikii TAS1R3.
GenomeRNAii 83756.
NextBioi 72785.
PROi Q7RTX0.
SOURCEi Search...

Gene expression databases

Bgeei Q7RTX0.
CleanExi HS_TAS1R3.
Genevestigatori Q7RTX0.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION, FUNCTION.
  4. "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose."
    Ariyasu T., Matsumoto S., Kyono F., Hanaya T., Arai S., Ikeda M., Kurimoto M.
    In Vitro Cell. Dev. Biol. Anim. 39:80-88(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins."
    Jiang P., Ji Q., Liu Z., Snyder L.A., Benard L.M.J., Margolskee R.F., Max M.
    J. Biol. Chem. 279:45068-45075(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION IMPLICATED IN SWEET RECEPTOR FUNCTION, MUTAGENESIS OF ALA-537 AND PHE-540.

Entry informationi

Entry nameiTS1R3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX0
Secondary accession number(s): Q5TA49, Q8NGW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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