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Protein

Taste receptor type 1 member 3

Gene

TAS1R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.By similarity2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • taste receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of sweet taste Source: HGNC
  • G-protein coupled receptor signaling pathway Source: HGNC
  • sensory perception of sweet taste Source: UniProtKB
  • sensory perception of umami taste Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene namesi
Name:TAS1R3
Synonyms:T1R3, TR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169962.4.
HGNCiHGNC:15661. TAS1R3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 570ExtracellularSequence analysisAdd BLAST550
Transmembranei571 – 591Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini592 – 603CytoplasmicSequence analysisAdd BLAST12
Transmembranei604 – 624Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini625 – 639ExtracellularSequence analysisAdd BLAST15
Transmembranei640 – 660Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini661 – 682CytoplasmicSequence analysisAdd BLAST22
Transmembranei683 – 703Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini704 – 729ExtracellularSequence analysisAdd BLAST26
Transmembranei730 – 750Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini751 – 762CytoplasmicSequence analysisAdd BLAST12
Transmembranei763 – 783Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini784 – 789ExtracellularSequence analysis6
Transmembranei790 – 810Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini811 – 852CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi537A → G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed. 1 Publication1
Mutagenesisi537A → P: Receptor unresponsive to all sweeteners tested. 1 Publication1
Mutagenesisi537A → T, S, E or V: Abolished the response to brazzein. 1 Publication1
Mutagenesisi540F → A or H: Reduces the response to brazzein and monellin. 1 Publication1
Mutagenesisi540F → L: Reduces the response to monellin. 1 Publication1
Mutagenesisi540F → Y or P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners. 1 Publication1

Organism-specific databases

DisGeNETi83756.
OpenTargetsiENSG00000169962.
PharmGKBiPA38012.

Chemistry databases

ChEMBLiCHEMBL1613742.

Polymorphism and mutation databases

BioMutaiTAS1R3.
DMDMi62299063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001296121 – 852Taste receptor type 1 member 3Add BLAST832

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ7RTX0.
PaxDbiQ7RTX0.
PeptideAtlasiQ7RTX0.
PRIDEiQ7RTX0.

Expressioni

Gene expression databases

BgeeiENSG00000169962.
CleanExiHS_TAS1R3.

Organism-specific databases

HPAiHPA053439.

Interactioni

Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi123757. 2 interactors.
STRINGi9606.ENSP00000344411.

Structurei

3D structure databases

ProteinModelPortaliQ7RTX0.
SMRiQ7RTX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni536 – 545Required for brazzein responsiveness10

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ7RTX0.
KOiK04626.
OMAiCFGLACL.
OrthoDBiEOG091G01UW.
PhylomeDBiQ7RTX0.
TreeFamiTF331269.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGPAVLGLS LWALLHPGTG APLCLSQQLR MKGDYVLGGL FPLGEAEEAG
60 70 80 90 100
LRSRTRPSSP VCTRFSSNGL LWALAMKMAV EEINNKSDLL PGLRLGYDLF
110 120 130 140 150
DTCSEPVVAM KPSLMFLAKA GSRDIAAYCN YTQYQPRVLA VIGPHSSELA
160 170 180 190 200
MVTGKFFSFF LMPQVSYGAS MELLSARETF PSFFRTVPSD RVQLTAAAEL
210 220 230 240 250
LQEFGWNWVA ALGSDDEYGR QGLSIFSALA AARGICIAHE GLVPLPRADD
260 270 280 290 300
SRLGKVQDVL HQVNQSSVQV VLLFASVHAA HALFNYSISS RLSPKVWVAS
310 320 330 340 350
EAWLTSDLVM GLPGMAQMGT VLGFLQRGAQ LHEFPQYVKT HLALATDPAF
360 370 380 390 400
CSALGEREQG LEEDVVGQRC PQCDCITLQN VSAGLNHHQT FSVYAAVYSV
410 420 430 440 450
AQALHNTLQC NASGCPAQDP VKPWQLLENM YNLTFHVGGL PLRFDSSGNV
460 470 480 490 500
DMEYDLKLWV WQGSVPRLHD VGRFNGSLRT ERLKIRWHTS DNQKPVSRCS
510 520 530 540 550
RQCQEGQVRR VKGFHSCCYD CVDCEAGSYR QNPDDIACTF CGQDEWSPER
560 570 580 590 600
STRCFRRRSR FLAWGEPAVL LLLLLLSLAL GLVLAALGLF VHHRDSPLVQ
610 620 630 640 650
ASGGPLACFG LVCLGLVCLS VLLFPGQPSP ARCLAQQPLS HLPLTGCLST
660 670 680 690 700
LFLQAAEIFV ESELPLSWAD RLSGCLRGPW AWLVVLLAML VEVALCTWYL
710 720 730 740 750
VAFPPEVVTD WHMLPTEALV HCRTRSWVSF GLAHATNATL AFLCFLGTFL
760 770 780 790 800
VRSQPGCYNR ARGLTFAMLA YFITWVSFVP LLANVQVVLR PAVQMGALLL
810 820 830 840 850
CVLGILAAFH LPRCYLLMRQ PGLNTPEFFL GGGPGDAQGQ NDGNTGNQGK

HE
Length:852
Mass (Da):93,386
Last modified:March 29, 2005 - v2
Checksum:i9690DEC23E75EB3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti852E → EAPILHPARHHSSGRPGGGT QAYAQGRARRGRGGTQLPTL PFAQWVDSIMTVTSTRDRAQ DLTPARRQAHTGSPVRVPGS APSRA in BAC05873 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020788757C → R. Corresponds to variant dbSNP:rs307377Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065647 Genomic DNA. Translation: BAC05873.1.
AL139287 Genomic DNA. No translation available.
BK000152 mRNA. Translation: DAA00013.1.
CCDSiCCDS30556.1.
RefSeqiNP_689414.1. NM_152228.2.
UniGeneiHs.74375.

Genome annotation databases

EnsembliENST00000339381; ENSP00000344411; ENSG00000169962.
GeneIDi83756.
KEGGihsa:83756.
UCSCiuc010nyk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTS1R3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTX0
Secondary accession number(s): Q5TA49, Q8NGW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 29, 2005
Last modified: September 27, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families