Q7RTW8 (OTOAN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Otoancorin

Gene names

Name:

OTOA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as an adhesion molecule.
Subcellular location	Apical cell membrane; Lipid-anchor › GPI-anchor; Extracellular side Probable. Secreted › extracellular space › extracellular matrix Probable. Note: At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes By similarity.
Involvement in disease	Deafness, autosomal recessive, 22 (DFNB22) [MIM:607039]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4
Sequence similarities	Belongs to the stereocilin family.
Sequence caution	The sequence AK057335 differs from that shown. Reason: Frameshift at position 1139.

Ontologies

Keywords
Biological process	Hearing
Cellular component	Cell membrane Extracellular matrix Membrane Secreted
Coding sequence diversity	Alternative splicing
Disease	Deafness Non-syndromic deafness
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of sound Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7RTW8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7RTW8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-338: Missing.
     339-341: PKM → MFR

Isoform 3 (identifier: Q7RTW8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-728: Missing.
     729-750: DCPDLNPEQKAAVRLKLLGQYG → MNVCKDSPRNKVNQKSKVMEKK

Isoform 4 (identifier: Q7RTW8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MSQEPTTYS → MGNSITYRD
     10-88: Missing.
     328-341: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q7RTW8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     328-341: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 1130	1108	Otoancorin		PRO_0000021971
	Propeptide	1131 – 1153	23	Removed in mature form Potential		PRO_0000021972
Amino acid modifications
	Lipidation	1130	1	GPI-anchor amidated alanine Potential
	Glycosylation	156	1	N-linked (GlcNAc...) Potential
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	244	1	N-linked (GlcNAc...) Potential
	Glycosylation	289	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
	Glycosylation	394	1	N-linked (GlcNAc...) Potential
	Glycosylation	398	1	N-linked (GlcNAc...) Potential
	Glycosylation	460	1	N-linked (GlcNAc...) Potential
	Glycosylation	544	1	N-linked (GlcNAc...) Potential
	Glycosylation	812	1	N-linked (GlcNAc...) Potential
	Glycosylation	911	1	N-linked (GlcNAc...) Potential
	Glycosylation	974	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 728	728	Missing in isoform 3.		VSP_012211
	Alternative sequence	1 – 338	338	Missing in isoform 2.		VSP_012212
	Alternative sequence	1 – 9	9	MSQEPTTYS → MGNSITYRD in isoform 4.		VSP_043345
	Alternative sequence	10 – 88	79	Missing in isoform 4.		VSP_043346
	Alternative sequence	328 – 341	14	Missing in isoform 4 and isoform 5.		VSP_043347
	Alternative sequence	339 – 341	3	PKM → MFR in isoform 2.		VSP_012213
	Alternative sequence	729 – 750	22	DCPDL…LGQYG → MNVCKDSPRNKVNQKSKVME KK in isoform 3.		VSP_012214
Experimental info
	Sequence conflict	1039	1	E → A in AAI29994. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: D23E5767718021D7	FASTA	1,153	128,533
	10 20 30 40 50 60 MSQEPTTYSL FLFLFLSHGV SSYTVPNSRQ DLHPLLQNMA EEIIDGSYLN ALLDLIQFQS 70 80 90 100 110 120 SHVWTDDLSH RVLAYLNSRN VAFTIPSLQA AVENHLEQRL HQPQKLLEDL RKTDAQQFRT 130 140 150 160 170 180 AMKCLLEDKK DGLDLKDIII DLGEIRERAL QSPGVNRSLF LITLERCFQM LNSLECVEIL 190 200 210 220 230 240 GKVLRGSSGS FLQPDITERL PRDLREDAFK NLSAVFKDLY DKTSAHSQRA LYSWMTGILQ 250 260 270 280 290 300 TSSNATDDSA SWVSAEHLWV LGRYMVHLSF EEITKISPIE IGLFISYDNA TKQLDMVYDI 310 320 330 340 350 360 TPELAQAFLE RISSSNFNMR NTSTIHRQAH ELWALEPFPK MLGLLVCFYN DLELLDATVA 370 380 390 400 410 420 QVLLYQMIKC SHLRGFQAGV QKLKAELLDI AMENQTLNET LGSLSDAVVG LTYSQLESLS 430 440 450 460 470 480 PEAVHGAIST LNQVSGWAKS QVIILSAKYL AHEKVLSFYN VSQMGALLAG VSTQAFCSMK 490 500 510 520 530 540 RKDISQVLRS AVSQYVSDLS PAQQQGILSK MVQAEDTAPG IVEIQGAFFK EVSLFDLRRQ 550 560 570 580 590 600 PGFNSTVLKD KELGRSQALF LYELLLKTTR RPEELLSAGQ LVKGVTCSHI DAMSTDFFLA 610 620 630 640 650 660 HFQDFQNNFA LLSPYQVNCL AWKYWEVSRL SMPPFLLAAL PARYLASVPA SQCVPFLISL 670 680 690 700 710 720 GKSWLDSLVL DSHKKTSVLR KVQQCLDDSI ADEYTVDIMG NLLCHLPAAI IDRGISPRAW 730 740 750 760 770 780 ATALHGLRDC PDLNPEQKAA VRLKLLGQYG LPQHWTAETT KDLGPFLVLF SGDELSSIAT 790 800 810 820 830 840 KFPEILLQAA SKMARTLPTK EFLWAVFQSV RNSSDKIPSY DPMPGCHGVV APSSDDIFKL 850 860 870 880 890 900 AEANACWALE DLRCMEEDTF IRTVELLGAV QGFSRPQLMT LKEKAIQVWD MPSYWREHHI 910 920 930 940 950 960 VSLGRIALAL NESELEQLDL SSIDTVASLS WQTEWTPGQA ESILQGYLDD SGYSIQDLKS 970 980 990 1000 1010 1020 FHLVGLGATL CAINITEIPL IKISEFRVVV ARIGTLLCST HVLAEFKRKA EVVFGDPTEW 1030 1040 1050 1060 1070 1080 TSSVLQELGT IAAGLTKAEL RMLDKDLMPY FQPSAIKCLP DEIFKELSAE QIASLGPENA 1090 1100 1110 1120 1130 1140 AAVTHAQRRR LSPLQLQSLQ QALDGAKTHS WQDAPASAGP TRTSSSRSPA GALQSWGLWL 1150 GCPLLVLMAK LLW
	Isoform 2 [UniParc]. Checksum: A8EFF6FA5850C894	FASTA	815	89,914
	10 20 30 40 50 60 MFRLGLLVCF YNDLELLDAT VAQVLLYQMI KCSHLRGFQA GVQKLKAELL DIAMENQTLN 70 80 90 100 110 120 ETLGSLSDAV VGLTYSQLES LSPEAVHGAI STLNQVSGWA KSQVIILSAK YLAHEKVLSF 130 140 150 160 170 180 YNVSQMGALL AGVSTQAFCS MKRKDISQVL RSAVSQYVSD LSPAQQQGIL SKMVQAEDTA 190 200 210 220 230 240 PGIVEIQGAF FKEVSLFDLR RQPGFNSTVL KDKELGRSQA LFLYELLLKT TRRPEELLSA 250 260 270 280 290 300 GQLVKGVTCS HIDAMSTDFF LAHFQDFQNN FALLSPYQVN CLAWKYWEVS RLSMPPFLLA 310 320 330 340 350 360 ALPARYLASV PASQCVPFLI SLGKSWLDSL VLDSHKKTSV LRKVQQCLDD SIADEYTVDI 370 380 390 400 410 420 MGNLLCHLPA AIIDRGISPR AWATALHGLR DCPDLNPEQK AAVRLKLLGQ YGLPQHWTAE 430 440 450 460 470 480 TTKDLGPFLV LFSGDELSSI ATKFPEILLQ AASKMARTLP TKEFLWAVFQ SVRNSSDKIP 490 500 510 520 530 540 SYDPMPGCHG VVAPSSDDIF KLAEANACWA LEDLRCMEED TFIRTVELLG AVQGFSRPQL 550 560 570 580 590 600 MTLKEKAIQV WDMPSYWREH HIVSLGRIAL ALNESELEQL DLSSIDTVAS LSWQTEWTPG 610 620 630 640 650 660 QAESILQGYL DDSGYSIQDL KSFHLVGLGA TLCAINITEI PLIKISEFRV VVARIGTLLC 670 680 690 700 710 720 STHVLAEFKR KAEVVFGDPT EWTSSVLQEL GTIAAGLTKA ELRMLDKDLM PYFQPSAIKC 730 740 750 760 770 780 LPDEIFKELS AEQIASLGPE NAAAVTHAQR RRLSPLQLQS LQQALDGAKT HSWQDAPASA 790 800 810 GPTRTSSSRS PAGALQSWGL WLGCPLLVLM AKLLW
	Isoform 3 [UniParc]. Checksum: A17635E55BA47451	FASTA	425	46,980
	10 20 30 40 50 60 MNVCKDSPRN KVNQKSKVME KKLPQHWTAE TTKDLGPFLV LFSGDELSSI ATKFPEILLQ 70 80 90 100 110 120 AASKMARTLP TKEFLWAVFQ SVRNSSDKIP SYDPMPGCHG VVAPSSDDIF KLAEANACWA 130 140 150 160 170 180 LEDLRCMEED TFIRTVELLG AVQGFSRPQL MTLKEKAIQV WDMPSYWREH HIVSLGRIAL 190 200 210 220 230 240 ALNESELEQL DLSSIDTVAS LSWQTEWTPG QAESILQGYL DDSGYSIQDL KSFHLVGLGA 250 260 270 280 290 300 TLCAINITEI PLIKISEFRV VVARIGTLLC STHVLAEFKR KAEVVFGDPT EWTSSVLQEL 310 320 330 340 350 360 GTIAAGLTKA ELRMLDKDLM PYFQPSAIKC LPDEIFKELS AEQIASLGPE NAAAVTHAQR 370 380 390 400 410 420 RRLSPLQLQS LQQALDGAKT HSWQDAPASA GPTRTSSSRS PAGALQSWGL WLGCPLLVLM AKLLW
	Isoform 4 [UniParc]. Checksum: 816E440E9023D5D9	FASTA	1,060	117,880
	10 20 30 40 50 60 MGNSITYRDQ AAVENHLEQR LHQPQKLLED LRKTDAQQFR TAMKCLLEDK KDGLDLKDII 70 80 90 100 110 120 IDLGEIRERA LQSPGVNRSL FLITLERCFQ MLNSLECVEI LGKVLRGSSG SFLQPDITER 130 140 150 160 170 180 LPRDLREDAF KNLSAVFKDL YDKTSAHSQR ALYSWMTGIL QTSSNATDDS ASWVSAEHLW 190 200 210 220 230 240 VLGRYMVHLS FEEITKISPI EIGLFISYDN ATKQLDMVYD ITPELAQAFL ERISSSNFNM 250 260 270 280 290 300 RNTSTIHRLG LLVCFYNDLE LLDATVAQVL LYQMIKCSHL RGFQAGVQKL KAELLDIAME 310 320 330 340 350 360 NQTLNETLGS LSDAVVGLTY SQLESLSPEA VHGAISTLNQ VSGWAKSQVI ILSAKYLAHE 370 380 390 400 410 420 KVLSFYNVSQ MGALLAGVST QAFCSMKRKD ISQVLRSAVS QYVSDLSPAQ QQGILSKMVQ 430 440 450 460 470 480 AEDTAPGIVE IQGAFFKEVS LFDLRRQPGF NSTVLKDKEL GRSQALFLYE LLLKTTRRPE 490 500 510 520 530 540 ELLSAGQLVK GVTCSHIDAM STDFFLAHFQ DFQNNFALLS PYQVNCLAWK YWEVSRLSMP 550 560 570 580 590 600 PFLLAALPAR YLASVPASQC VPFLISLGKS WLDSLVLDSH KKTSVLRKVQ QCLDDSIADE 610 620 630 640 650 660 YTVDIMGNLL CHLPAAIIDR GISPRAWATA LHGLRDCPDL NPEQKAAVRL KLLGQYGLPQ 670 680 690 700 710 720 HWTAETTKDL GPFLVLFSGD ELSSIATKFP EILLQAASKM ARTLPTKEFL WAVFQSVRNS 730 740 750 760 770 780 SDKIPSYDPM PGCHGVVAPS SDDIFKLAEA NACWALEDLR CMEEDTFIRT VELLGAVQGF 790 800 810 820 830 840 SRPQLMTLKE KAIQVWDMPS YWREHHIVSL GRIALALNES ELEQLDLSSI DTVASLSWQT 850 860 870 880 890 900 EWTPGQAESI LQGYLDDSGY SIQDLKSFHL VGLGATLCAI NITEIPLIKI SEFRVVVARI 910 920 930 940 950 960 GTLLCSTHVL AEFKRKAEVV FGDPTEWTSS VLQELGTIAA GLTKAELRML DKDLMPYFQP 970 980 990 1000 1010 1020 SAIKCLPDEI FKELSAEQIA SLGPENAAAV THAQRRRLSP LQLQSLQQAL DGAKTHSWQD 1030 1040 1050 1060 APASAGPTRT SSSRSPAGAL QSWGLWLGCP LLVLMAKLLW
	Isoform 5 [UniParc]. Checksum: 3B8E705089670E8C	FASTA	1,139	126,854
	10 20 30 40 50 60 MSQEPTTYSL FLFLFLSHGV SSYTVPNSRQ DLHPLLQNMA EEIIDGSYLN ALLDLIQFQS 70 80 90 100 110 120 SHVWTDDLSH RVLAYLNSRN VAFTIPSLQA AVENHLEQRL HQPQKLLEDL RKTDAQQFRT 130 140 150 160 170 180 AMKCLLEDKK DGLDLKDIII DLGEIRERAL QSPGVNRSLF LITLERCFQM LNSLECVEIL 190 200 210 220 230 240 GKVLRGSSGS FLQPDITERL PRDLREDAFK NLSAVFKDLY DKTSAHSQRA LYSWMTGILQ 250 260 270 280 290 300 TSSNATDDSA SWVSAEHLWV LGRYMVHLSF EEITKISPIE IGLFISYDNA TKQLDMVYDI 310 320 330 340 350 360 TPELAQAFLE RISSSNFNMR NTSTIHRLGL LVCFYNDLEL LDATVAQVLL YQMIKCSHLR 370 380 390 400 410 420 GFQAGVQKLK AELLDIAMEN QTLNETLGSL SDAVVGLTYS QLESLSPEAV HGAISTLNQV 430 440 450 460 470 480 SGWAKSQVII LSAKYLAHEK VLSFYNVSQM GALLAGVSTQ AFCSMKRKDI SQVLRSAVSQ 490 500 510 520 530 540 YVSDLSPAQQ QGILSKMVQA EDTAPGIVEI QGAFFKEVSL FDLRRQPGFN STVLKDKELG 550 560 570 580 590 600 RSQALFLYEL LLKTTRRPEE LLSAGQLVKG VTCSHIDAMS TDFFLAHFQD FQNNFALLSP 610 620 630 640 650 660 YQVNCLAWKY WEVSRLSMPP FLLAALPARY LASVPASQCV PFLISLGKSW LDSLVLDSHK 670 680 690 700 710 720 KTSVLRKVQQ CLDDSIADEY TVDIMGNLLC HLPAAIIDRG ISPRAWATAL HGLRDCPDLN 730 740 750 760 770 780 PEQKAAVRLK LLGQYGLPQH WTAETTKDLG PFLVLFSGDE LSSIATKFPE ILLQAASKMA 790 800 810 820 830 840 RTLPTKEFLW AVFQSVRNSS DKIPSYDPMP GCHGVVAPSS DDIFKLAEAN ACWALEDLRC 850 860 870 880 890 900 MEEDTFIRTV ELLGAVQGFS RPQLMTLKEK AIQVWDMPSY WREHHIVSLG RIALALNESE 910 920 930 940 950 960 LEQLDLSSID TVASLSWQTE WTPGQAESIL QGYLDDSGYS IQDLKSFHLV GLGATLCAIN 970 980 990 1000 1010 1020 ITEIPLIKIS EFRVVVARIG TLLCSTHVLA EFKRKAEVVF GDPTEWTSSV LQELGTIAAG 1030 1040 1050 1060 1070 1080 LTKAELRMLD KDLMPYFQPS AIKCLPDEIF KELSAEQIAS LGPENAAAVT HAQRRRLSPL 1090 1100 1110 1120 1130 QLQSLQQALD GAKTHSWQDA PASAGPTRTS SSRSPAGALQ SWGLWLGCPL LVLMAKLLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Testis.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22." Zwaenepoel I., Mustapha M., Leibovici M., Verpy E., Goodyear R., Liu X.Z., Nouaille S., Nance W.E., Kanaan M., Avraham K.B., Tekaia F., Loiselet J., Lathrop M., Richardson G., Petit C. Proc. Natl. Acad. Sci. U.S.A. 99:6240-6245(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 1), INVOLVEMENT IN DFNB22.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057335 mRNA. No translation available. AK093062 mRNA. Translation: BAC04040.1. AK125840 mRNA. Translation: BAG54255.1. AC092719 Genomic DNA. No translation available. BC129992 mRNA. Translation: AAI29993.1. BC129993 mRNA. Translation: AAI29994.1. BK000099 Genomic DNA. Translation: DAA00022.1.
IPI	IPI00065386. IPI00170800. IPI00186424. IPI00657771. IPI00658074.
RefSeq	NP_001155155.1. NM_001161683.1. NP_733764.1. NM_170664.2.
UniGene	Hs.408336.
3D structure databases
ProteinModelPortal	Q7RTW8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000373610.
PTM databases
PhosphoSite	Q7RTW8.
Polymorphism databases
DMDM	56404568.
Proteomic databases
PaxDb	Q7RTW8.
PRIDE	Q7RTW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286149; ENSP00000286149; ENSG00000155719. ENST00000388956; ENSP00000373608; ENSG00000155719. ENST00000388957; ENSP00000373609; ENSG00000155719. ENST00000388958; ENSP00000373610; ENSG00000155719.
GeneID	146183.
KEGG	hsa:146183.
UCSC	uc002dji.3. human. uc002dlh.3. human. uc010vbk.2. human.
Organism-specific databases
CTD	146183.
GeneCards	GC16P021689.
HGNC	HGNC:16378. OTOA.
HPA	HPA041405.
MIM	607038. gene. 607039. phenotype.
neXtProt	NX_Q7RTW8.
Orphanet	90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKB	PA38403.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG27847.
HOGENOM	HOG000065777.
HOVERGEN	HBG053381.
InParanoid	Q7RTW8.
OMA	NLWILGR.
PhylomeDB	Q7RTW8.
Gene expression databases
ArrayExpress	Q7RTW8.
Bgee	Q7RTW8.
CleanEx	HS_OTOA.
Genevestigator	Q7RTW8.
GermOnline	ENSG00000155719. Homo sapiens.
Family and domain databases
InterPro	IPR026663. Otoancorin. IPR026664. Stereocilin_related. [Graphical view]
PANTHER	PTHR23412. PTHR23412. 1 hit. PTHR23412:SF2. PTHR23412:SF2. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	146183.
NextBio	35460528.
SOURCE	Search...

Entry information

Entry name

OTOAN_HUMAN

Accession

Primary (citable) accession number: Q7RTW8
Secondary accession number(s): A1L3A8 , A2VDI0, B3KWU3, E9PF51, Q8NA86, Q96M76

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.