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Protein
Submitted name:

Neuregulin 1 isoform HRG-beta2

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1 isoform HRG-beta2Imported
Submitted name:
Neuregulin 1, isoform CRA_jImported
Submitted name:
cDNA FLJ77413, highly similar to Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta2, mRNAImported
Gene namesi
Name:NRG1Imported
ORF Names:hCG_14780Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei240 – 26122HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31776.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12892Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini178 – 22245EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG
60 70 80 90 100
SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN
110 120 130 140 150
KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS
160 170 180 190 200
ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK
210 220 230 240 250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KAEELYQKRV LTITGICIAL
260 270 280 290 300
LVVGIMCVVA YCKTKKQRKK LHDRLRQSLR SERNNTMNIA NGPHHPNPPP
310 320 330 340 350
ENVQLVNQYV SKNVISSEHI VEREAETSFS TSHYTSTAHH STTVTQTPSH
360 370 380 390 400
SWSNGHTESI LSESHSVIVM SSVENSRHSS PTGGPRGRLN GTGGPRECNS
410 420 430 440 450
FLRHARETPD SYRDSPHSER YVSAMTTPAR MSPVDFHTPS SPKSPPSEMS
460 470 480 490 500
PPVSSMTVSM PSMAVSPFME EERPLLLVTP PRLREKKFDH HPQQFSSFHH
510 520 530 540 550
NPAHDSNSLP ASPLRIVEDE EYETTQEYEP AQEPVKKLAN SRRAKRTKPN
560 570 580 590 600
GHIANRLEVD SNTSSQSSNS ESETEDERVG EDTPFLGIQN PLAASLEATP
610 620 630
AFRLADSRTN PAGRFSTQEE IQARLSSVIA NQDPIAV
Length:637
Mass (Da):70,169
Last modified:December 15, 2003 - v1
Checksum:i0B89DF6E2ED70333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290730 mRNA. Translation: BAF83419.1.
BK000383 Genomic DNA. Translation: DAA00042.1.
CH471080 Genomic DNA. Translation: EAW63416.1.
RefSeqiNP_039251.2. NM_013957.4.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290730 mRNA. Translation: BAF83419.1.
BK000383 Genomic DNA. Translation: DAA00042.1.
CH471080 Genomic DNA. Translation: EAW63416.1.
RefSeqiNP_039251.2. NM_013957.4.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349275.

Protocols and materials databases

DNASUi3084.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Organism-specific databases

CTDi3084.
PharmGKBiPA31776.

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Miscellaneous databases

ChiTaRSiNRG1. human.
GenomeRNAii3084.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7RTW3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTW3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.