Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin-like protein AAED1

Gene

AAED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein AAED1
Alternative name(s):
AhpC/TSA antioxidant enzyme domain-containing protein 1
Gene namesi
Name:AAED1
Synonyms:C9orf21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16881. AAED1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Thioredoxin-like protein AAED1PRO_0000221624Add
BLAST

Proteomic databases

MaxQBiQ7RTV5.
PaxDbiQ7RTV5.
PRIDEiQ7RTV5.

Expressioni

Gene expression databases

BgeeiQ7RTV5.
CleanExiHS_C9orf21.
ExpressionAtlasiQ7RTV5. baseline and differential.
GenevestigatoriQ7RTV5.

Organism-specific databases

HPAiHPA021294.

Interactioni

Protein-protein interaction databases

BioGridi128185. 2 interactions.
STRINGi9606.ENSP00000364382.

Structurei

3D structure databases

ProteinModelPortaliQ7RTV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAED1 family.Curated

Phylogenomic databases

eggNOGiNOG281582.
GeneTreeiENSGT00510000048363.
HOGENOMiHOG000060076.
HOVERGENiHBG050959.
InParanoidiQ7RTV5.
OMAiQDWKLSF.
PhylomeDBiQ7RTV5.
TreeFamiTF329293.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7RTV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG
60 70 80 90 100
ALFRERRAVV VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS
110 120 130 140 150
YHHIEPFCKL TGYSHEIYVD PEREIYKRLG MKRGEEIASS GQSPHIKSNL
160 170 180 190 200
LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL ILGPGNNIHF IHRDRNRLDH
210 220
KPINSVLQLV GVQHVNFTNR PSVIHV
Length:226
Mass (Da):24,857
Last modified:December 15, 2003 - v1
Checksum:i2C6D01B15C8F8738
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831R → K.
Corresponds to variant rs9886834 [ dbSNP | Ensembl ].
VAR_052598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353578 Genomic DNA. Translation: CAI40534.1.
CH471174 Genomic DNA. Translation: EAW92662.1.
BC136503 mRNA. Translation: AAI36504.1.
BK000255 mRNA. Translation: DAA00065.1.
CCDSiCCDS35073.1.
RefSeqiNP_714542.1. NM_153698.1.
UniGeneiHs.44640.

Genome annotation databases

EnsembliENST00000375234; ENSP00000364382; ENSG00000158122.
GeneIDi195827.
KEGGihsa:195827.
UCSCiuc004awm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353578 Genomic DNA. Translation: CAI40534.1.
CH471174 Genomic DNA. Translation: EAW92662.1.
BC136503 mRNA. Translation: AAI36504.1.
BK000255 mRNA. Translation: DAA00065.1.
CCDSiCCDS35073.1.
RefSeqiNP_714542.1. NM_153698.1.
UniGeneiHs.44640.

3D structure databases

ProteinModelPortaliQ7RTV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128185. 2 interactions.
STRINGi9606.ENSP00000364382.

Proteomic databases

MaxQBiQ7RTV5.
PaxDbiQ7RTV5.
PRIDEiQ7RTV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375234; ENSP00000364382; ENSG00000158122.
GeneIDi195827.
KEGGihsa:195827.
UCSCiuc004awm.3. human.

Organism-specific databases

CTDi195827.
GeneCardsiGC09M099404.
H-InvDBHIX0035200.
HGNCiHGNC:16881. AAED1.
HPAiHPA021294.
neXtProtiNX_Q7RTV5.
PharmGKBiPA38190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281582.
GeneTreeiENSGT00510000048363.
HOGENOMiHOG000060076.
HOVERGENiHBG050959.
InParanoidiQ7RTV5.
OMAiQDWKLSF.
PhylomeDBiQ7RTV5.
TreeFamiTF329293.

Miscellaneous databases

GenomeRNAii195827.
NextBioi89392.

Gene expression databases

BgeeiQ7RTV5.
CleanExiHS_C9orf21.
ExpressionAtlasiQ7RTV5. baseline and differential.
GenevestigatoriQ7RTV5.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
    Gilligan P., Brenner S., Venkatesh B.
    Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiAAED1_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV5
Secondary accession number(s): B2RMW4, Q5JU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.