SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7RTV5

- AAED1_HUMAN

UniProt

Q7RTV5 - AAED1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Thioredoxin-like protein AAED1
Gene
AAED1, C9orf21
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein AAED1
Alternative name(s):
AhpC/TSA antioxidant enzyme domain-containing protein 1
Gene namesi
Name:AAED1
Synonyms:C9orf21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16881. AAED1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Thioredoxin-like protein AAED1
PRO_0000221624Add
BLAST

Proteomic databases

MaxQBiQ7RTV5.
PaxDbiQ7RTV5.
PRIDEiQ7RTV5.

Expressioni

Gene expression databases

ArrayExpressiQ7RTV5.
BgeeiQ7RTV5.
CleanExiHS_C9orf21.
GenevestigatoriQ7RTV5.

Organism-specific databases

HPAiHPA021294.

Interactioni

Protein-protein interaction databases

BioGridi128185. 1 interaction.
STRINGi9606.ENSP00000364382.

Structurei

3D structure databases

ProteinModelPortaliQ7RTV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAED1 family.

Phylogenomic databases

eggNOGiNOG281582.
HOGENOMiHOG000060076.
HOVERGENiHBG050959.
InParanoidiQ7RTV5.
OMAiDKNRLDH.
PhylomeDBiQ7RTV5.
TreeFamiTF329293.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7RTV5-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG    50
ALFRERRAVV VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS 100
YHHIEPFCKL TGYSHEIYVD PEREIYKRLG MKRGEEIASS GQSPHIKSNL 150
LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL ILGPGNNIHF IHRDRNRLDH 200
KPINSVLQLV GVQHVNFTNR PSVIHV 226
Length:226
Mass (Da):24,857
Last modified:December 15, 2003 - v1
Checksum:i2C6D01B15C8F8738
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831R → K.
Corresponds to variant rs9886834 [ dbSNP | Ensembl ].
VAR_052598

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353578 Genomic DNA. Translation: CAI40534.1.
CH471174 Genomic DNA. Translation: EAW92662.1.
BC136503 mRNA. Translation: AAI36504.1.
BK000255 mRNA. Translation: DAA00065.1.
CCDSiCCDS35073.1.
RefSeqiNP_714542.1. NM_153698.1.
UniGeneiHs.44640.

Genome annotation databases

EnsembliENST00000375234; ENSP00000364382; ENSG00000158122.
GeneIDi195827.
KEGGihsa:195827.
UCSCiuc004awm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353578 Genomic DNA. Translation: CAI40534.1 .
CH471174 Genomic DNA. Translation: EAW92662.1 .
BC136503 mRNA. Translation: AAI36504.1 .
BK000255 mRNA. Translation: DAA00065.1 .
CCDSi CCDS35073.1.
RefSeqi NP_714542.1. NM_153698.1.
UniGenei Hs.44640.

3D structure databases

ProteinModelPortali Q7RTV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128185. 1 interaction.
STRINGi 9606.ENSP00000364382.

Proteomic databases

MaxQBi Q7RTV5.
PaxDbi Q7RTV5.
PRIDEi Q7RTV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375234 ; ENSP00000364382 ; ENSG00000158122 .
GeneIDi 195827.
KEGGi hsa:195827.
UCSCi uc004awm.3. human.

Organism-specific databases

CTDi 195827.
GeneCardsi GC09M099404.
H-InvDB HIX0035200.
HGNCi HGNC:16881. AAED1.
HPAi HPA021294.
neXtProti NX_Q7RTV5.
PharmGKBi PA38190.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281582.
HOGENOMi HOG000060076.
HOVERGENi HBG050959.
InParanoidi Q7RTV5.
OMAi DKNRLDH.
PhylomeDBi Q7RTV5.
TreeFami TF329293.

Miscellaneous databases

GenomeRNAii 195827.
NextBioi 89392.

Gene expression databases

ArrayExpressi Q7RTV5.
Bgeei Q7RTV5.
CleanExi HS_C9orf21.
Genevestigatori Q7RTV5.

Family and domain databases

Gene3Di 3.40.30.10. 2 hits.
InterProi IPR012336. Thioredoxin-like_fold.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
    Gilligan P., Brenner S., Venkatesh B.
    Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiAAED1_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV5
Secondary accession number(s): B2RMW4, Q5JU02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi