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Q7RTV5 (AAED1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin-like protein AAED1
Alternative name(s):
AhpC/TSA antioxidant enzyme domain-containing protein 1
Gene names
Name:AAED1
Synonyms:C9orf21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AAED1 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Thioredoxin-like protein AAED1
PRO_0000221624

Natural variations

Natural variant831R → K.
Corresponds to variant rs9886834 [ dbSNP | Ensembl ].
VAR_052598

Sequences

Sequence LengthMass (Da)Tools
Q7RTV5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 2C6D01B15C8F8738

FASTA22624,857
        10         20         30         40         50         60 
MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG ALFRERRAVV 

        70         80         90        100        110        120 
VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS YHHIEPFCKL TGYSHEIYVD 

       130        140        150        160        170        180 
PEREIYKRLG MKRGEEIASS GQSPHIKSNL LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL 

       190        200        210        220 
ILGPGNNIHF IHRDRNRLDH KPINSVLQLV GVQHVNFTNR PSVIHV 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
Gilligan P., Brenner S., Venkatesh B.
Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL353578 Genomic DNA. Translation: CAI40534.1.
CH471174 Genomic DNA. Translation: EAW92662.1.
BC136503 mRNA. Translation: AAI36504.1.
BK000255 mRNA. Translation: DAA00065.1.
CCDSCCDS35073.1.
RefSeqNP_714542.1. NM_153698.1.
UniGeneHs.44640.

3D structure databases

ProteinModelPortalQ7RTV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128185. 1 interaction.
STRING9606.ENSP00000364382.

Proteomic databases

MaxQBQ7RTV5.
PaxDbQ7RTV5.
PRIDEQ7RTV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375234; ENSP00000364382; ENSG00000158122.
GeneID195827.
KEGGhsa:195827.
UCSCuc004awm.3. human.

Organism-specific databases

CTD195827.
GeneCardsGC09M099404.
H-InvDBHIX0035200.
HGNCHGNC:16881. AAED1.
HPAHPA021294.
neXtProtNX_Q7RTV5.
PharmGKBPA38190.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281582.
HOGENOMHOG000060076.
HOVERGENHBG050959.
InParanoidQ7RTV5.
OMADKNRLDH.
PhylomeDBQ7RTV5.
TreeFamTF329293.

Gene expression databases

ArrayExpressQ7RTV5.
BgeeQ7RTV5.
CleanExHS_C9orf21.
GenevestigatorQ7RTV5.

Family and domain databases

Gene3D3.40.30.10. 2 hits.
InterProIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi195827.
NextBio89392.

Entry information

Entry nameAAED1_HUMAN
AccessionPrimary (citable) accession number: Q7RTV5
Secondary accession number(s): B2RMW4, Q5JU02
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM