Q7RTV5 (AAED1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin-like protein AAED1

Alternative name(s):
AhpC/TSA antioxidant enzyme domain-containing protein 1

Gene names

Name:	AAED1
Synonyms:	C9orf21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AAED1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Thioredoxin-like protein AAED1		PRO_0000221624
Natural variations
	Natural variant	83	1	R → K. Corresponds to variant rs9886834 [ dbSNP | Ensembl ].		VAR_052598

Sequences

	Sequence		Length	Mass (Da)
	Q7RTV5 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 2C6D01B15C8F8738	FASTA	226	24,857
	10 20 30 40 50 60 MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG ALFRERRAVV 70 80 90 100 110 120 VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS YHHIEPFCKL TGYSHEIYVD 130 140 150 160 170 180 PEREIYKRLG MKRGEEIASS GQSPHIKSNL LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL 190 200 210 220 ILGPGNNIHF IHRDRNRLDH KPINSVLQLV GVQHVNFTNR PSVIHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences." Gilligan P., Brenner S., Venkatesh B. Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353578 Genomic DNA. Translation: CAI40534.1. CH471174 Genomic DNA. Translation: EAW92662.1. BC136503 mRNA. Translation: AAI36504.1. BK000255 mRNA. Translation: DAA00065.1.
IPI	IPI00146380.
RefSeq	NP_714542.1. NM_153698.1.
UniGene	Hs.44640.
3D structure databases
ProteinModelPortal	Q7RTV5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000364382.
Polymorphism databases
DMDM	46395720.
Proteomic databases
PaxDb	Q7RTV5.
PRIDE	Q7RTV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375234; ENSP00000364382; ENSG00000158122.
GeneID	195827.
KEGG	hsa:195827.
UCSC	uc004awm.3. human.
Organism-specific databases
CTD	195827.
GeneCards	GC09M099404.
H-InvDB	HIX0035200.
HGNC	HGNC:16881. AAED1.
HPA	HPA021294.
neXtProt	NX_Q7RTV5.
PharmGKB	PA38190.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281582.
HOGENOM	HOG000060076.
HOVERGEN	HBG050959.
InParanoid	Q7RTV5.
OMA	IVVFVRH.
PhylomeDB	Q7RTV5.
Gene expression databases
ArrayExpress	Q7RTV5.
Bgee	Q7RTV5.
CleanEx	HS_C9orf21.
Genevestigator	Q7RTV5.
GermOnline	ENSG00000158122. Homo sapiens.
Family and domain databases
Gene3D	3.40.30.10. 2 hits.
InterPro	IPR012336. Thioredoxin-like_fold. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	195827.
NextBio	89392.

Entry information

Entry name

AAED1_HUMAN

Accession

Primary (citable) accession number: Q7RTV5
Secondary accession number(s): B2RMW4, Q5JU02

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.