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Q7RTV5

- AAED1_HUMAN

UniProt

Q7RTV5 - AAED1_HUMAN

Protein

Thioredoxin-like protein AAED1

Gene

AAED1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin-like protein AAED1
    Alternative name(s):
    AhpC/TSA antioxidant enzyme domain-containing protein 1
    Gene namesi
    Name:AAED1
    Synonyms:C9orf21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16881. AAED1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38190.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226Thioredoxin-like protein AAED1PRO_0000221624Add
    BLAST

    Proteomic databases

    MaxQBiQ7RTV5.
    PaxDbiQ7RTV5.
    PRIDEiQ7RTV5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7RTV5.
    BgeeiQ7RTV5.
    CleanExiHS_C9orf21.
    GenevestigatoriQ7RTV5.

    Organism-specific databases

    HPAiHPA021294.

    Interactioni

    Protein-protein interaction databases

    BioGridi128185. 1 interaction.
    STRINGi9606.ENSP00000364382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAED1 family.Curated

    Phylogenomic databases

    eggNOGiNOG281582.
    HOGENOMiHOG000060076.
    HOVERGENiHBG050959.
    InParanoidiQ7RTV5.
    OMAiDKNRLDH.
    PhylomeDBiQ7RTV5.
    TreeFamiTF329293.

    Family and domain databases

    Gene3Di3.40.30.10. 2 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7RTV5-1 [UniParc]FASTAAdd to Basket

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    MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG    50
    ALFRERRAVV VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS 100
    YHHIEPFCKL TGYSHEIYVD PEREIYKRLG MKRGEEIASS GQSPHIKSNL 150
    LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL ILGPGNNIHF IHRDRNRLDH 200
    KPINSVLQLV GVQHVNFTNR PSVIHV 226
    Length:226
    Mass (Da):24,857
    Last modified:December 15, 2003 - v1
    Checksum:i2C6D01B15C8F8738
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831R → K.
    Corresponds to variant rs9886834 [ dbSNP | Ensembl ].
    VAR_052598

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353578 Genomic DNA. Translation: CAI40534.1.
    CH471174 Genomic DNA. Translation: EAW92662.1.
    BC136503 mRNA. Translation: AAI36504.1.
    BK000255 mRNA. Translation: DAA00065.1.
    CCDSiCCDS35073.1.
    RefSeqiNP_714542.1. NM_153698.1.
    UniGeneiHs.44640.

    Genome annotation databases

    EnsembliENST00000375234; ENSP00000364382; ENSG00000158122.
    GeneIDi195827.
    KEGGihsa:195827.
    UCSCiuc004awm.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353578 Genomic DNA. Translation: CAI40534.1 .
    CH471174 Genomic DNA. Translation: EAW92662.1 .
    BC136503 mRNA. Translation: AAI36504.1 .
    BK000255 mRNA. Translation: DAA00065.1 .
    CCDSi CCDS35073.1.
    RefSeqi NP_714542.1. NM_153698.1.
    UniGenei Hs.44640.

    3D structure databases

    ProteinModelPortali Q7RTV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128185. 1 interaction.
    STRINGi 9606.ENSP00000364382.

    Proteomic databases

    MaxQBi Q7RTV5.
    PaxDbi Q7RTV5.
    PRIDEi Q7RTV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375234 ; ENSP00000364382 ; ENSG00000158122 .
    GeneIDi 195827.
    KEGGi hsa:195827.
    UCSCi uc004awm.3. human.

    Organism-specific databases

    CTDi 195827.
    GeneCardsi GC09M099404.
    H-InvDB HIX0035200.
    HGNCi HGNC:16881. AAED1.
    HPAi HPA021294.
    neXtProti NX_Q7RTV5.
    PharmGKBi PA38190.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281582.
    HOGENOMi HOG000060076.
    HOVERGENi HBG050959.
    InParanoidi Q7RTV5.
    OMAi DKNRLDH.
    PhylomeDBi Q7RTV5.
    TreeFami TF329293.

    Miscellaneous databases

    GenomeRNAii 195827.
    NextBioi 89392.

    Gene expression databases

    ArrayExpressi Q7RTV5.
    Bgeei Q7RTV5.
    CleanExi HS_C9orf21.
    Genevestigatori Q7RTV5.

    Family and domain databases

    Gene3Di 3.40.30.10. 2 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
      Gilligan P., Brenner S., Venkatesh B.
      Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiAAED1_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTV5
    Secondary accession number(s): B2RMW4, Q5JU02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3