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Protein

Zinc finger protein 367

Gene

ZNF367

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 367
Alternative name(s):
C2H2 zinc finger protein ZFF29
Gene namesi
Name:ZNF367
Synonyms:ZFF29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18320. ZNF367.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38316.

Polymorphism and mutation databases

BioMutaiZNF367.
DMDMi74762420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Zinc finger protein 367PRO_0000285297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei310 – 3101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7RTV3.
PaxDbiQ7RTV3.
PRIDEiQ7RTV3.

PTM databases

iPTMnetiQ7RTV3.
PhosphoSiteiQ7RTV3.

Expressioni

Gene expression databases

BgeeiQ7RTV3.
CleanExiHS_ZNF367.
GenevisibleiQ7RTV3. HS.

Organism-specific databases

HPAiHPA015319.
HPA015785.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364405.

Structurei

3D structure databases

ProteinModelPortaliQ7RTV3.
SMRiQ7RTV3. Positions 169-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili308 – 34235Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 6154Pro-richAdd
BLAST
Compositional biasi86 – 12237Ala-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 18923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098074.
HOGENOMiHOG000049286.
HOVERGENiHBG061619.
InParanoidiQ7RTV3.
OMAiKYWQTRE.
OrthoDBiEOG7M6D7P.
PhylomeDBiQ7RTV3.
TreeFamiTF321334.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7RTV3-1) [UniParc]FASTAAdd to basket

Also known as: ZFF29B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRGFEAPMA ENPPPPPPPV IFCHDSPKRV LVSVIRTTPI KPTCGGGGEP
60 70 80 90 100
EPPPPLIPTS PGFSDFMVYP WRWGENAHNV TLSPGAAGAA ASAALPAAAA
110 120 130 140 150
AEHSGLRGRG APPPAASASA AASGGEDEEE ASSPDSGHLK DGIRRGRPRA
160 170 180 190 200
DTVRDLINEG EHSSSRIRCN ICNRVFPREK SLQAHKRTHT GERPYLCDYP
210 220 230 240 250
DCGKAFVQSG QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN RHCPKHPYAR
260 270 280 290 300
LKREEPTDTL SKHQAADNKA AAEWLARYWE MREQRTPTLK GKLVQKADQE
310 320 330 340 350
QQDPLEYLQS DEEDDEKRGA QRRLQEQRER LHGALALIEL ANLTGAPLRQ
Length:350
Mass (Da):38,411
Last modified:December 15, 2003 - v1
Checksum:i01C3A79E0E408454
GO
Isoform 2 (identifier: Q7RTV3-2) [UniParc]FASTAAdd to basket

Also known as: ZFF29A

The sequence of this isoform differs from the canonical sequence as follows:
     278-350: YWEMREQRTP...ANLTGAPLRQ → SGMLPLVHREDAQRGLGLCQGPGHASHFK

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):32,894
Checksum:i758425EAA468D9A3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 35073YWEMR…APLRQ → SGMLPLVHREDAQRGLGLCQ GPGHASHFK in isoform 2. 1 PublicationVSP_024865Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY554164 mRNA. Translation: AAS66302.1.
AY554165 mRNA. Translation: AAS66303.1.
AL133477 Genomic DNA. Translation: CAI39622.1.
BC126141 mRNA. Translation: AAI26142.1.
BK000211 mRNA. Translation: DAA00067.1.
CCDSiCCDS6718.1. [Q7RTV3-1]
RefSeqiNP_710162.1. NM_153695.3. [Q7RTV3-1]
UniGeneiHs.494557.

Genome annotation databases

EnsembliENST00000375256; ENSP00000364405; ENSG00000165244. [Q7RTV3-1]
GeneIDi195828.
KEGGihsa:195828.
UCSCiuc004awf.4. human. [Q7RTV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY554164 mRNA. Translation: AAS66302.1.
AY554165 mRNA. Translation: AAS66303.1.
AL133477 Genomic DNA. Translation: CAI39622.1.
BC126141 mRNA. Translation: AAI26142.1.
BK000211 mRNA. Translation: DAA00067.1.
CCDSiCCDS6718.1. [Q7RTV3-1]
RefSeqiNP_710162.1. NM_153695.3. [Q7RTV3-1]
UniGeneiHs.494557.

3D structure databases

ProteinModelPortaliQ7RTV3.
SMRiQ7RTV3. Positions 169-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364405.

PTM databases

iPTMnetiQ7RTV3.
PhosphoSiteiQ7RTV3.

Polymorphism and mutation databases

BioMutaiZNF367.
DMDMi74762420.

Proteomic databases

MaxQBiQ7RTV3.
PaxDbiQ7RTV3.
PRIDEiQ7RTV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375256; ENSP00000364405; ENSG00000165244. [Q7RTV3-1]
GeneIDi195828.
KEGGihsa:195828.
UCSCiuc004awf.4. human. [Q7RTV3-1]

Organism-specific databases

CTDi195828.
GeneCardsiZNF367.
HGNCiHGNC:18320. ZNF367.
HPAiHPA015319.
HPA015785.
MIMi610160. gene.
neXtProtiNX_Q7RTV3.
PharmGKBiPA38316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098074.
HOGENOMiHOG000049286.
HOVERGENiHBG061619.
InParanoidiQ7RTV3.
OMAiKYWQTRE.
OrthoDBiEOG7M6D7P.
PhylomeDBiQ7RTV3.
TreeFamiTF321334.

Miscellaneous databases

GenomeRNAii195828.
NextBioi89396.
PROiQ7RTV3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7RTV3.
CleanExiHS_ZNF367.
GenevisibleiQ7RTV3. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif."
    Asano H., Murate T., Naoe T., Saito H., Stamatoyannopoulos G.
    Biochem. J. 384:647-653(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Fetal liver.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
    Gilligan P., Brenner S., Venkatesh B.
    Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1).
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZN367_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV3
Secondary accession number(s): Q6Q7C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 15, 2003
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.