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Protein

Zinc finger protein 367

Gene

ZNF367

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 367
Alternative name(s):
C2H2 zinc finger protein ZFF29
Gene namesi
Name:ZNF367
Synonyms:ZFF29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165244.6
HGNCiHGNC:18320 ZNF367
MIMi610160 gene
neXtProtiNX_Q7RTV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi195828
OpenTargetsiENSG00000165244
PharmGKBiPA38316

Polymorphism and mutation databases

BioMutaiZNF367
DMDMi74762420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852971 – 350Zinc finger protein 367Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7RTV3
PaxDbiQ7RTV3
PeptideAtlasiQ7RTV3
PRIDEiQ7RTV3
ProteomicsDBi68913
68914 [Q7RTV3-2]

PTM databases

iPTMnetiQ7RTV3
PhosphoSitePlusiQ7RTV3

Expressioni

Gene expression databases

BgeeiENSG00000165244
CleanExiHS_ZNF367
GenevisibleiQ7RTV3 HS

Organism-specific databases

HPAiHPA015319
HPA015785

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364405

Structurei

3D structure databases

ProteinModelPortaliQ7RTV3
SMRiQ7RTV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili308 – 342Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 61Pro-richAdd BLAST54
Compositional biasi86 – 122Ala-richAdd BLAST37

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00670000098074
HOGENOMiHOG000049286
HOVERGENiHBG061619
InParanoidiQ7RTV3
OMAiLAKYWEM
OrthoDBiEOG091G0H1R
PhylomeDBiQ7RTV3
TreeFamiTF321334

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7RTV3-1) [UniParc]FASTAAdd to basket
Also known as: ZFF29B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRGFEAPMA ENPPPPPPPV IFCHDSPKRV LVSVIRTTPI KPTCGGGGEP
60 70 80 90 100
EPPPPLIPTS PGFSDFMVYP WRWGENAHNV TLSPGAAGAA ASAALPAAAA
110 120 130 140 150
AEHSGLRGRG APPPAASASA AASGGEDEEE ASSPDSGHLK DGIRRGRPRA
160 170 180 190 200
DTVRDLINEG EHSSSRIRCN ICNRVFPREK SLQAHKRTHT GERPYLCDYP
210 220 230 240 250
DCGKAFVQSG QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN RHCPKHPYAR
260 270 280 290 300
LKREEPTDTL SKHQAADNKA AAEWLARYWE MREQRTPTLK GKLVQKADQE
310 320 330 340 350
QQDPLEYLQS DEEDDEKRGA QRRLQEQRER LHGALALIEL ANLTGAPLRQ
Length:350
Mass (Da):38,411
Last modified:December 15, 2003 - v1
Checksum:i01C3A79E0E408454
GO
Isoform 2 (identifier: Q7RTV3-2) [UniParc]FASTAAdd to basket
Also known as: ZFF29A

The sequence of this isoform differs from the canonical sequence as follows:
     278-350: YWEMREQRTP...ANLTGAPLRQ → SGMLPLVHREDAQRGLGLCQGPGHASHFK

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):32,894
Checksum:i758425EAA468D9A3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024865278 – 350YWEMR…APLRQ → SGMLPLVHREDAQRGLGLCQ GPGHASHFK in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY554164 mRNA Translation: AAS66302.1
AY554165 mRNA Translation: AAS66303.1
AL133477 Genomic DNA No translation available.
BC126141 mRNA Translation: AAI26142.1
BK000211 mRNA Translation: DAA00067.1
CCDSiCCDS6718.1 [Q7RTV3-1]
RefSeqiNP_710162.1, NM_153695.3 [Q7RTV3-1]
UniGeneiHs.494557

Genome annotation databases

EnsembliENST00000375256; ENSP00000364405; ENSG00000165244 [Q7RTV3-1]
GeneIDi195828
KEGGihsa:195828
UCSCiuc004awf.4 human [Q7RTV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN367_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV3
Secondary accession number(s): Q6Q7C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 15, 2003
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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