Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase A5

Gene

GSTA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A5 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 5
Glutathione S-transferase A5-5
Gene namesi
Name:GSTA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19662. GSTA5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • extracellular exosome Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi221357.
OpenTargetsiENSG00000182793.
PharmGKBiPA134962856.

Chemistry databases

DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiGSTA5.
DMDMi50400409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001857872 – 222Glutathione S-transferase A5Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7RTV2.
PaxDbiQ7RTV2.
PeptideAtlasiQ7RTV2.
PRIDEiQ7RTV2.

PTM databases

iPTMnetiQ7RTV2.
PhosphoSitePlusiQ7RTV2.

Expressioni

Tissue specificityi

Expression not detected.

Gene expression databases

BgeeiENSG00000182793.
CleanExiHS_GSTA5.

Organism-specific databases

HPAiHPA004342.
HPA048934.
HPA053817.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi128713. 1 interactor.
IntActiQ7RTV2. 1 interactor.
STRINGi9606.ENSP00000284562.

Structurei

3D structure databases

ProteinModelPortaliQ7RTV2.
SMRiQ7RTV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ7RTV2.
KOiK00799.
OMAiHRNERAV.
PhylomeDBiQ7RTV2.
TreeFamiTF105321.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPKLHYS NARGSMESIR WLLAAAGVEL EEKFLESAED LDKLRNDGSL
60 70 80 90 100
LFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDMKERA LIDMYTEGIV
110 120 130 140 150
DLTEMILLLL ICQPEERDAK TALVKEKIKN RYFPAFEKVL KSHRQDYLVG
160 170 180 190 200
NKLSWADIHL VELFYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP
210 220
GSQRKPPMDE KSLEEARKIF RF
Length:222
Mass (Da):25,722
Last modified:December 15, 2003 - v1
Checksum:i6DFCECF202F2D898
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02448355V → I. Corresponds to variant dbSNP:rs2397118Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590363 Genomic DNA. No translation available.
BK000212 Genomic DNA. Translation: DAA00071.1.
CCDSiCCDS4946.1.
RefSeqiNP_714543.1. NM_153699.1.
UniGeneiHs.646984.

Genome annotation databases

EnsembliENST00000284562; ENSP00000284562; ENSG00000182793.
ENST00000370989; ENSP00000360028; ENSG00000182793.
GeneIDi221357.
KEGGihsa:221357.
UCSCiuc003pba.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGSTA5_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV2
Secondary accession number(s): Q5SZC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 15, 2003
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families