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Protein

Glutathione S-transferase A5

Gene

GSTA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A5 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 5
Glutathione S-transferase A5-5
Gene namesi
Name:GSTA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000182793.10
HGNCiHGNC:19662 GSTA5
MIMi607605 gene
neXtProtiNX_Q7RTV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi221357
OpenTargetsiENSG00000182793
PharmGKBiPA134962856

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGSTA5
DMDMi50400409

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001857872 – 222Glutathione S-transferase A5Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7RTV2
PaxDbiQ7RTV2
PeptideAtlasiQ7RTV2
PRIDEiQ7RTV2

PTM databases

iPTMnetiQ7RTV2
PhosphoSitePlusiQ7RTV2

Expressioni

Tissue specificityi

Expression not detected.

Gene expression databases

BgeeiENSG00000182793
CleanExiHS_GSTA5

Organism-specific databases

HPAiHPA004342
HPA048934
HPA053817

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi128713, 1 interactor
IntActiQ7RTV2, 1 interactor
STRINGi9606.ENSP00000284562

Structurei

3D structure databases

ProteinModelPortaliQ7RTV2
SMRiQ7RTV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiQ7RTV2
KOiK00799
OMAiPFDDEKC
PhylomeDBiQ7RTV2
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKPKLHYS NARGSMESIR WLLAAAGVEL EEKFLESAED LDKLRNDGSL
60 70 80 90 100
LFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDMKERA LIDMYTEGIV
110 120 130 140 150
DLTEMILLLL ICQPEERDAK TALVKEKIKN RYFPAFEKVL KSHRQDYLVG
160 170 180 190 200
NKLSWADIHL VELFYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP
210 220
GSQRKPPMDE KSLEEARKIF RF
Length:222
Mass (Da):25,722
Last modified:December 15, 2003 - v1
Checksum:i6DFCECF202F2D898
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02448355V → I. Corresponds to variant dbSNP:rs2397118Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590363 Genomic DNA No translation available.
BK000212 Genomic DNA Translation: DAA00071.1
CCDSiCCDS4946.1
RefSeqiNP_714543.1, NM_153699.1
UniGeneiHs.646984

Genome annotation databases

EnsembliENST00000284562; ENSP00000284562; ENSG00000182793
ENST00000370989; ENSP00000360028; ENSG00000182793
GeneIDi221357
KEGGihsa:221357
UCSCiuc003pba.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGSTA5_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV2
Secondary accession number(s): Q5SZC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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