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Protein

PHD finger-like domain-containing protein 5A

Gene

PHF5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha. Also involved in pre-mRNA splicing.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger-like domain-containing protein 5A
Short name:
PHD finger-like domain protein 5A
Alternative name(s):
Splicing factor 3B-associated 14 kDa protein
Short name:
SF3b14b
Gene namesi
Name:PHF5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18000. PHF5A.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • nuclear matrix Source: Ensembl
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: HPA
  • precatalytic spliceosome Source: GO_Central
  • U12-type spliceosomal complex Source: UniProtKB
  • U2 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876104.

Polymorphism and mutation databases

BioMutaiPHF5A.
DMDMi46577625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 110109PHD finger-like domain-containing protein 5APRO_0000218716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31N6-acetyllysineCombined sources
Modified residuei94 – 941PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7RTV0.
MaxQBiQ7RTV0.
PaxDbiQ7RTV0.
PeptideAtlasiQ7RTV0.
PRIDEiQ7RTV0.
TopDownProteomicsiQ7RTV0.

PTM databases

iPTMnetiQ7RTV0.
PhosphoSiteiQ7RTV0.

Expressioni

Gene expression databases

BgeeiENSG00000100410.
CleanExiHS_PHF5A.
ExpressionAtlasiQ7RTV0. baseline and differential.
GenevisibleiQ7RTV0. HS.

Organism-specific databases

HPAiHPA028885.

Interactioni

Subunit structurei

Interacts (via N-terminus) with U2AF1 and SRSF5; acts to bridge the two. Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two (By similarity). Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.By similarity3 Publications

Protein-protein interaction databases

BioGridi124296. 35 interactions.
IntActiQ7RTV0. 14 interactions.
MINTiMINT-3033866.
STRINGi9606.ENSP00000216252.

Structurei

3D structure databases

ProteinModelPortaliQ7RTV0.
SMRiQ7RTV0. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHF5 family.Curated

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiQ7RTV0.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiQ7RTV0.
TreeFamiTF105627.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RTV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHHPDLIF CRKQAGVAIG RLCEKCDGKC VICDSYVRPC TLVRICDECN
60 70 80 90 100
YGSYQGRCVI CGGPGVSDAY YCKECTIQEK DRDGCPKIVN LGSSKTDLFY
110
ERKKYGFKKR
Length:110
Mass (Da):12,405
Last modified:December 15, 2003 - v1
Checksum:i90F7469DE7292BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456398 mRNA. Translation: CAG30284.1.
AL008582 Genomic DNA. Translation: CAB62939.1.
BC007321 mRNA. Translation: AAH07321.1.
BC075808 mRNA. Translation: AAH75808.1.
BK000563 mRNA. Translation: DAA00074.1.
CCDSiCCDS14016.1.
RefSeqiNP_116147.1. NM_032758.3.
UniGeneiHs.474980.
Hs.707800.

Genome annotation databases

EnsembliENST00000216252; ENSP00000216252; ENSG00000100410.
GeneIDi84844.
KEGGihsa:84844.
UCSCiuc003bab.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456398 mRNA. Translation: CAG30284.1.
AL008582 Genomic DNA. Translation: CAB62939.1.
BC007321 mRNA. Translation: AAH07321.1.
BC075808 mRNA. Translation: AAH75808.1.
BK000563 mRNA. Translation: DAA00074.1.
CCDSiCCDS14016.1.
RefSeqiNP_116147.1. NM_032758.3.
UniGeneiHs.474980.
Hs.707800.

3D structure databases

ProteinModelPortaliQ7RTV0.
SMRiQ7RTV0. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124296. 35 interactions.
IntActiQ7RTV0. 14 interactions.
MINTiMINT-3033866.
STRINGi9606.ENSP00000216252.

PTM databases

iPTMnetiQ7RTV0.
PhosphoSiteiQ7RTV0.

Polymorphism and mutation databases

BioMutaiPHF5A.
DMDMi46577625.

Proteomic databases

EPDiQ7RTV0.
MaxQBiQ7RTV0.
PaxDbiQ7RTV0.
PeptideAtlasiQ7RTV0.
PRIDEiQ7RTV0.
TopDownProteomicsiQ7RTV0.

Protocols and materials databases

DNASUi84844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216252; ENSP00000216252; ENSG00000100410.
GeneIDi84844.
KEGGihsa:84844.
UCSCiuc003bab.4. human.

Organism-specific databases

CTDi84844.
GeneCardsiPHF5A.
HGNCiHGNC:18000. PHF5A.
HPAiHPA028885.
neXtProtiNX_Q7RTV0.
PharmGKBiPA134876104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiQ7RTV0.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiQ7RTV0.
TreeFamiTF105627.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiPHF5A. human.
GenomeRNAii84844.
PROiQ7RTV0.

Gene expression databases

BgeeiENSG00000100410.
CleanExiHS_PHF5A.
ExpressionAtlasiQ7RTV0. baseline and differential.
GenevisibleiQ7RTV0. HS.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHF5A_HUMAN
AccessioniPrimary (citable) accession number: Q7RTV0
Secondary accession number(s): Q9UH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 15, 2003
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.