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Protein

Basic helix-loop-helix transcription factor scleraxis

Gene

SCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic helix-loop-helix transcription factor scleraxis
Alternative name(s):
Class A basic helix-loop-helix protein 41
Short name:
bHLHa41
Class A basic helix-loop-helix protein 48
Short name:
bHLHa48
Gene namesi
Name:SCX
Synonyms:BHLHA41, BHLHA48, SCXA, SCXB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000260428.2.
HGNCiHGNC:32322. SCX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000260428.
PharmGKBiPA142670943.

Polymorphism and mutation databases

DMDMi74749943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733171 – 201Basic helix-loop-helix transcription factor scleraxisAdd BLAST201

Proteomic databases

PaxDbiQ7RTU7.
PeptideAtlasiQ7RTU7.
PRIDEiQ7RTU7.

PTM databases

iPTMnetiQ7RTU7.
PhosphoSitePlusiQ7RTU7.

Expressioni

Gene expression databases

BgeeiENSG00000260428.
CleanExiHS_SCXA.

Organism-specific databases

HPAiHPA043183.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi568157. 3 interactors.
STRINGi9606.ENSP00000345599.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU7.
SMRiQ7RTU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 127bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 166Poly-Pro9

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000231706.
HOVERGENiHBG036149.
InParanoidiQ7RTU7.
OMAiGQPCHTT.
OrthoDBiEOG091G0RR2.
PhylomeDBiQ7RTU7.
TreeFamiTF315153.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7RTU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFATLRPAP PGRYLYPEVS PLSEDEDRGS DSSGSDEKPC RVHAARCGLQ
60 70 80 90 100
GARRRAGGRR AGGGGPGGRP GREPRQRHTA NARERDRTNS VNTAFTALRT
110 120 130 140 150
LIPTEPADRK LSKIETLRLA SSYISHLGNV LLAGEACGDG QPCHSGPAFF
160 170 180 190 200
HAARAGSPPP PPPPPPARDG ENTQPKQICT FCLSNQRKLS KDRDRKTAIR

S
Length:201
Mass (Da):21,596
Last modified:December 15, 2003 - v1
Checksum:i4FDF2D23F977032A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145291 Genomic DNA. No translation available.
BK000280 Genomic DNA. Translation: DAA00239.1.
CCDSiCCDS43779.1.
RefSeqiNP_001073983.1. NM_001080514.2.
XP_006716679.1. XM_006716616.2.
UniGeneiHs.553250.
Hs.723088.

Genome annotation databases

EnsembliENST00000567180; ENSP00000476384; ENSG00000260428.
GeneIDi642658.
KEGGihsa:642658.
UCSCiuc003zbn.4. human.

Similar proteinsi

Entry informationi

Entry nameiSCX_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot