Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7RTU7 (SCX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basic helix-loop-helix transcription factor scleraxis
Alternative name(s):
Class A basic helix-loop-helix protein 41
Short name=bHLHa41
Class A basic helix-loop-helix protein 48
Short name=bHLHa48
Gene names
Name:SCXA
Synonyms:BHLHA41, SCX
AND
Name:SCXB
Synonyms:BHLHA48, SCX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages By similarity.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

Sertoli cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

chondrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

collagen fibril organization

Inferred from sequence or structural similarity. Source: UniProtKB

deltoid tuberosity development

Inferred from sequence or structural similarity. Source: UniProtKB

endochondral ossification

Inferred from sequence or structural similarity. Source: UniProtKB

heart valve formation

Inferred from sequence or structural similarity. Source: UniProtKB

heart valve morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

mesoderm formation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cartilage development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of collagen biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gastrulation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cartilage development

Inferred from sequence or structural similarity. Source: UniProtKB

tendon cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

tendon development

Inferred from sequence or structural similarity. Source: UniProtKB

tendon formation

Inferred from sequence or structural similarity. Source: UniProtKB

tissue homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from direct assay PubMed 10775504. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay PubMed 10775504PubMed 19828133. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 10775504. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

bHLH transcription factor binding

Inferred from physical interaction PubMed 10775504. Source: UniProtKB

protein heterodimerization activity

Inferred from direct assay PubMed 10775504. Source: UniProtKB

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Basic helix-loop-helix transcription factor scleraxis
PRO_0000273317

Regions

Domain75 – 12753bHLH
Compositional bias158 – 1669Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
Q7RTU7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 4FDF2D23F977032A

FASTA20121,596
        10         20         30         40         50         60 
MSFATLRPAP PGRYLYPEVS PLSEDEDRGS DSSGSDEKPC RVHAARCGLQ GARRRAGGRR 

        70         80         90        100        110        120 
AGGGGPGGRP GREPRQRHTA NARERDRTNS VNTAFTALRT LIPTEPADRK LSKIETLRLA 

       130        140        150        160        170        180 
SSYISHLGNV LLAGEACGDG QPCHSGPAFF HAARAGSPPP PPPPPPARDG ENTQPKQICT 

       190        200 
FCLSNQRKLS KDRDRKTAIR S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC110280 Genomic DNA. No translation available.
AC145291 Genomic DNA. No translation available.
BK000280 Genomic DNA. Translation: DAA00239.1.
CCDSCCDS43779.1.
RefSeqNP_001073983.1. NM_001080514.2.
XP_006716679.1. XM_006716616.1.
UniGeneHs.553250.
Hs.723088.

3D structure databases

ProteinModelPortalQ7RTU7.
SMRQ7RTU7. Positions 70-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130613. 3 interactions.
STRING9606.ENSP00000342868.

PTM databases

PhosphoSiteQ7RTU7.

Polymorphism databases

DMDM74749943.

Proteomic databases

PaxDbQ7RTU7.
PRIDEQ7RTU7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340210; ENSP00000342868; ENSG00000187786.
ENST00000340695; ENSP00000345599; ENSG00000188686.
GeneID642658.
KEGGhsa:100129885.
hsa:642658.
UCSCuc003zbn.2. human.

Organism-specific databases

CTD642658.
GeneCardsGC08P145397.
GC08P145490.
HGNCHGNC:24312. SCXA.
HGNC:32322. SCXB.
HPAHPA043183.
MIM609067. gene.
neXtProtNX_Q7RTU7.
PharmGKBPA142670943.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288076.
HOGENOMHOG000231706.
HOVERGENHBG036149.
InParanoidQ7RTU7.
OMAGRYLYPE.
OrthoDBEOG7G1V82.
PhylomeDBQ7RTU7.
TreeFamTF315153.

Gene expression databases

BgeeQ7RTU7.
CleanExHS_SCXA.
GenevestigatorQ7RTU7.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLOC642658.
NextBio114037.
PROQ7RTU7.
SOURCESearch...

Entry information

Entry nameSCX_HUMAN
AccessionPrimary (citable) accession number: Q7RTU7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM