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Protein

Basic helix-loop-helix transcription factor scleraxis

Gene

SCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32834-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Basic helix-loop-helix transcription factor scleraxis
Alternative name(s):
Class A basic helix-loop-helix protein 41
Short name:
bHLHa41
Class A basic helix-loop-helix protein 48
Short name:
bHLHa48
Gene namesi
Name:SCX
Synonyms:BHLHA41, BHLHA48, SCXA, SCXB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32322. SCX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000260428.
PharmGKBiPA142670943.

Polymorphism and mutation databases

DMDMi74749943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733171 – 201Basic helix-loop-helix transcription factor scleraxisAdd BLAST201

Proteomic databases

PaxDbiQ7RTU7.
PeptideAtlasiQ7RTU7.
PRIDEiQ7RTU7.

PTM databases

iPTMnetiQ7RTU7.
PhosphoSitePlusiQ7RTU7.

Expressioni

Gene expression databases

BgeeiENSG00000187786.
CleanExiHS_SCXA.

Organism-specific databases

HPAiHPA043183.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12 (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi568157. 3 interactors.
STRINGi9606.ENSP00000345599.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU7.
SMRiQ7RTU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 127bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 166Poly-Pro9

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000231706.
HOVERGENiHBG036149.
InParanoidiQ7RTU7.
OMAiGQPCHTT.
OrthoDBiEOG091G0RR2.
PhylomeDBiQ7RTU7.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFATLRPAP PGRYLYPEVS PLSEDEDRGS DSSGSDEKPC RVHAARCGLQ
60 70 80 90 100
GARRRAGGRR AGGGGPGGRP GREPRQRHTA NARERDRTNS VNTAFTALRT
110 120 130 140 150
LIPTEPADRK LSKIETLRLA SSYISHLGNV LLAGEACGDG QPCHSGPAFF
160 170 180 190 200
HAARAGSPPP PPPPPPARDG ENTQPKQICT FCLSNQRKLS KDRDRKTAIR

S
Length:201
Mass (Da):21,596
Last modified:December 15, 2003 - v1
Checksum:i4FDF2D23F977032A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145291 Genomic DNA. No translation available.
BK000280 Genomic DNA. Translation: DAA00239.1.
CCDSiCCDS43779.1.
RefSeqiNP_001073983.1. NM_001080514.2.
XP_006716679.1. XM_006716616.2.
UniGeneiHs.553250.
Hs.723088.

Genome annotation databases

EnsembliENST00000567180; ENSP00000476384; ENSG00000260428.
GeneIDi642658.
KEGGihsa:642658.
UCSCiuc003zbn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145291 Genomic DNA. No translation available.
BK000280 Genomic DNA. Translation: DAA00239.1.
CCDSiCCDS43779.1.
RefSeqiNP_001073983.1. NM_001080514.2.
XP_006716679.1. XM_006716616.2.
UniGeneiHs.553250.
Hs.723088.

3D structure databases

ProteinModelPortaliQ7RTU7.
SMRiQ7RTU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi568157. 3 interactors.
STRINGi9606.ENSP00000345599.

PTM databases

iPTMnetiQ7RTU7.
PhosphoSitePlusiQ7RTU7.

Polymorphism and mutation databases

DMDMi74749943.

Proteomic databases

PaxDbiQ7RTU7.
PeptideAtlasiQ7RTU7.
PRIDEiQ7RTU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000567180; ENSP00000476384; ENSG00000260428.
GeneIDi642658.
KEGGihsa:642658.
UCSCiuc003zbn.4. human.

Organism-specific databases

CTDi642658.
GeneCardsiSCX.
HGNCiHGNC:32322. SCX.
HPAiHPA043183.
MIMi609067. gene.
neXtProtiNX_Q7RTU7.
OpenTargetsiENSG00000260428.
PharmGKBiPA142670943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000231706.
HOVERGENiHBG036149.
InParanoidiQ7RTU7.
OMAiGQPCHTT.
OrthoDBiEOG091G0RR2.
PhylomeDBiQ7RTU7.
TreeFamiTF315153.

Enzyme and pathway databases

BioCyciZFISH:G66-32834-MONOMER.

Miscellaneous databases

GeneWikiiLOC642658.
GenomeRNAii642658.
PROiQ7RTU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187786.
CleanExiHS_SCXA.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCX_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.