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Q7RTU5

- ASCL5_HUMAN

UniProt

Q7RTU5 - ASCL5_HUMAN

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Protein

Achaete-scute homolog 5

Gene

ASCL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 5
Short name:
ASH-5
Short name:
hASH5
Alternative name(s):
Class A basic helix-loop-helix protein 47
Short name:
bHLHa47
Gene namesi
Name:ASCL5
Synonyms:BHLHA47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:33169. ASCL5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Achaete-scute homolog 5PRO_0000317298Add
BLAST

Proteomic databases

PRIDEiQ7RTU5.

Expressioni

Gene expression databases

ExpressionAtlasiQ7RTU5. baseline.
GenevestigatoriQ7RTU5.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 20753bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ7RTU5.
OMAiVPFPGAF.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. ASH.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMGAAERGA GPQSSAAPWA GSEKAAKRGP SKSWYPRAAA SDVTCPTGGD
60 70 80 90 100
GADPKPGPFG GGLALGPAPR GTMNNNFCRA LVDRRPLGPP SCMQLGVMPP
110 120 130 140 150
PRQAPLPPAE PLGNVPFLLY PGPAEPPYYD AYAGVFPYVP FPGAFGVYEY
160 170 180 190 200
PFEPAFIQKR NERERQRVKC VNEGYARLRG HLPGALAEKR LSKVETLRAA
210 220 230 240 250
IRYIKYLQEL LSSAPDGSTP PASRGLPGTG PCPAPPATPR PDRPGDGEAR
260 270
APSSLVPESS ESSCFSPSPF LESEESWH
Length:278
Mass (Da):29,462
Last modified:February 5, 2008 - v2
Checksum:i96DC775BDA61C176
GO

Sequence cautioni

The sequence DAA00301.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139159 Genomic DNA. No translation available.
BK000139 Genomic DNA. Translation: DAA00301.1. Different initiation.
UniGeneiHs.143949.
Hs.721460.

Genome annotation databases

EnsembliENST00000458416; ENSP00000469019; ENSG00000232237.
UCSCiuc031prl.1. human.

Polymorphism databases

DMDMi166988402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139159 Genomic DNA. No translation available.
BK000139 Genomic DNA. Translation: DAA00301.1 . Different initiation.
UniGenei Hs.143949.
Hs.721460.

3D structure databases

ProteinModelPortali Q7RTU5.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 166988402.

Proteomic databases

PRIDEi Q7RTU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000458416 ; ENSP00000469019 ; ENSG00000232237 .
UCSCi uc031prl.1. human.

Organism-specific databases

GeneCardsi GC01M201094.
HGNCi HGNC:33169. ASCL5.
neXtProti NX_Q7RTU5.
GenAtlasi Search...

Phylogenomic databases

InParanoidi Q7RTU5.
OMAi VPFPGAF.

Miscellaneous databases

PROi Q7RTU5.

Gene expression databases

ExpressionAtlasi Q7RTU5. baseline.
Genevestigatori Q7RTU5.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR015660. ASH.
IPR011598. bHLH_dom.
[Graphical view ]
PANTHERi PTHR13935. PTHR13935. 1 hit.
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
    McLellan A.S., Langlands K., Kealey T.
    Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiASCL5_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3