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Protein

Oligodendrocyte transcription factor 3

Gene

OLIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 3
Short name:
Oligo3
Alternative name(s):
Class B basic helix-loop-helix protein 7
Short name:
bHLHb7
Class E basic helix-loop-helix protein 20
Short name:
bHLHe20
Gene namesi
Name:OLIG3
Synonyms:BHLHB7, BHLHE20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000177468.6
HGNCiHGNC:18003 OLIG3
MIMi609323 gene
neXtProtiNX_Q7RTU3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi167826
OpenTargetsiENSG00000177468
PharmGKBiPA134945348

Polymorphism and mutation databases

BioMutaiOLIG3
DMDMi51701664

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274171 – 272Oligodendrocyte transcription factor 3Add BLAST272

Proteomic databases

PaxDbiQ7RTU3
PeptideAtlasiQ7RTU3
PRIDEiQ7RTU3
ProteomicsDBi68906

PTM databases

iPTMnetiQ7RTU3
PhosphoSitePlusiQ7RTU3

Expressioni

Gene expression databases

BgeeiENSG00000177468
CleanExiHS_OLIG3
GenevisibleiQ7RTU3 HS

Organism-specific databases

HPAiCAB024865
HPA018303

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127951, 6 interactors
IntActiQ7RTU3, 25 interactors
STRINGi9606.ENSP00000356708

Structurei

3D structure databases

ProteinModelPortaliQ7RTU3
SMRiQ7RTU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 137bHLHPROSITE-ProRule annotationAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 89Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 32Poly-His8
Compositional biasi247 – 250Poly-Pro4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQ4F Eukaryota
ENOG410XTTW LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015765
HOVERGENiHBG053370
InParanoidiQ7RTU3
KOiK09085
OMAiVQKMPGE
OrthoDBiEOG091G129L
PhylomeDBiQ7RTU3
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032659 Olig3
PANTHERiPTHR19290:SF96 PTHR19290:SF96, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7RTU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK
60 70 80 90 100
MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN
110 120 130 140 150
LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE
160 170 180 190 200
IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA
210 220 230 240 250
ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP
260 270
HLSALSTANM ARLSAESKDL LK
Length:272
Mass (Da):29,358
Last modified:August 31, 2004 - v2
Checksum:i9ED98EF52F34D9A5
GO

Sequence cautioni

The sequence DAA00303 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096362 mRNA Translation: BAC04768.1
AL023580 Genomic DNA No translation available.
BC051352 mRNA Translation: AAH51352.1
BK000141 Genomic DNA Translation: DAA00303.1 Different initiation.
CCDSiCCDS5186.1
RefSeqiNP_786923.1, NM_175747.2
UniGeneiHs.195398

Genome annotation databases

EnsembliENST00000367734; ENSP00000356708; ENSG00000177468
GeneIDi167826
KEGGihsa:167826
UCSCiuc003qhp.2 human

Similar proteinsi

Entry informationi

Entry nameiOLIG3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU3
Secondary accession number(s): Q8N8Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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