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Q7RTU3

- OLIG3_HUMAN

UniProt

Q7RTU3 - OLIG3_HUMAN

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Protein

Oligodendrocyte transcription factor 3

Gene

OLIG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. spinal cord motor neuron cell fate specification Source: Ensembl
  2. spinal cord motor neuron migration Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 3
Short name:
Oligo3
Alternative name(s):
Class B basic helix-loop-helix protein 7
Short name:
bHLHb7
Class E basic helix-loop-helix protein 20
Short name:
bHLHe20
Gene namesi
Name:OLIG3
Synonyms:BHLHB7, BHLHE20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18003. OLIG3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Oligodendrocyte transcription factor 3PRO_0000127417Add
BLAST

Proteomic databases

PaxDbiQ7RTU3.
PRIDEiQ7RTU3.

PTM databases

PhosphoSiteiQ7RTU3.

Expressioni

Gene expression databases

BgeeiQ7RTU3.
CleanExiHS_OLIG3.
GenevestigatoriQ7RTU3.

Organism-specific databases

HPAiCAB024865.
HPA018303.

Interactioni

Protein-protein interaction databases

BioGridi127951. 2 interactions.
STRINGi9606.ENSP00000356708.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU3.
SMRiQ7RTU3. Positions 85-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13755bHLHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 8922Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 328Poly-His
Compositional biasi247 – 2504Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG313428.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ7RTU3.
KOiK09085.
OMAiVQKMPGE.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ7RTU3.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK
60 70 80 90 100
MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN
110 120 130 140 150
LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE
160 170 180 190 200
IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA
210 220 230 240 250
ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP
260 270
HLSALSTANM ARLSAESKDL LK
Length:272
Mass (Da):29,358
Last modified:August 31, 2004 - v2
Checksum:i9ED98EF52F34D9A5
GO

Sequence cautioni

The sequence DAA00303.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096362 mRNA. Translation: BAC04768.1.
AL023580 Genomic DNA. Translation: CAI20348.1.
BC051352 mRNA. Translation: AAH51352.1.
BK000141 Genomic DNA. Translation: DAA00303.1. Different initiation.
CCDSiCCDS5186.1.
RefSeqiNP_786923.1. NM_175747.2.
UniGeneiHs.195398.

Genome annotation databases

EnsembliENST00000367734; ENSP00000356708; ENSG00000177468.
GeneIDi167826.
KEGGihsa:167826.
UCSCiuc003qhp.1. human.

Polymorphism databases

DMDMi51701664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096362 mRNA. Translation: BAC04768.1 .
AL023580 Genomic DNA. Translation: CAI20348.1 .
BC051352 mRNA. Translation: AAH51352.1 .
BK000141 Genomic DNA. Translation: DAA00303.1 . Different initiation.
CCDSi CCDS5186.1.
RefSeqi NP_786923.1. NM_175747.2.
UniGenei Hs.195398.

3D structure databases

ProteinModelPortali Q7RTU3.
SMRi Q7RTU3. Positions 85-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127951. 2 interactions.
STRINGi 9606.ENSP00000356708.

PTM databases

PhosphoSitei Q7RTU3.

Polymorphism databases

DMDMi 51701664.

Proteomic databases

PaxDbi Q7RTU3.
PRIDEi Q7RTU3.

Protocols and materials databases

DNASUi 167826.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367734 ; ENSP00000356708 ; ENSG00000177468 .
GeneIDi 167826.
KEGGi hsa:167826.
UCSCi uc003qhp.1. human.

Organism-specific databases

CTDi 167826.
GeneCardsi GC06M137855.
HGNCi HGNC:18003. OLIG3.
HPAi CAB024865.
HPA018303.
MIMi 609323. gene.
neXtProti NX_Q7RTU3.
PharmGKBi PA134945348.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313428.
GeneTreei ENSGT00530000063239.
HOGENOMi HOG000015765.
HOVERGENi HBG053370.
InParanoidi Q7RTU3.
KOi K09085.
OMAi VQKMPGE.
OrthoDBi EOG7GQXWR.
PhylomeDBi Q7RTU3.
TreeFami TF322733.

Miscellaneous databases

GenomeRNAii 167826.
NextBioi 88689.
PROi Q7RTU3.
SOURCEi Search...

Gene expression databases

Bgeei Q7RTU3.
CleanExi HS_OLIG3.
Genevestigatori Q7RTU3.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
    McLellan A.S., Langlands K., Kealey T.
    Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOLIG3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU3
Secondary accession number(s): Q8N8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3