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Q7RTU3

- OLIG3_HUMAN

UniProt

Q7RTU3 - OLIG3_HUMAN

Protein

Oligodendrocyte transcription factor 3

Gene

OLIG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA polymerase II transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. spinal cord motor neuron cell fate specification Source: Ensembl
    2. spinal cord motor neuron migration Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligodendrocyte transcription factor 3
    Short name:
    Oligo3
    Alternative name(s):
    Class B basic helix-loop-helix protein 7
    Short name:
    bHLHb7
    Class E basic helix-loop-helix protein 20
    Short name:
    bHLHe20
    Gene namesi
    Name:OLIG3
    Synonyms:BHLHB7, BHLHE20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18003. OLIG3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945348.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Oligodendrocyte transcription factor 3PRO_0000127417Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTU3.
    PRIDEiQ7RTU3.

    PTM databases

    PhosphoSiteiQ7RTU3.

    Expressioni

    Gene expression databases

    BgeeiQ7RTU3.
    CleanExiHS_OLIG3.
    GenevestigatoriQ7RTU3.

    Organism-specific databases

    HPAiCAB024865.
    HPA018303.

    Interactioni

    Protein-protein interaction databases

    BioGridi127951. 2 interactions.
    STRINGi9606.ENSP00000356708.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTU3.
    SMRiQ7RTU3. Positions 85-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 13755bHLHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili68 – 8922Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 328Poly-His
    Compositional biasi247 – 2504Poly-Pro

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG313428.
    HOGENOMiHOG000015765.
    HOVERGENiHBG053370.
    InParanoidiQ7RTU3.
    KOiK09085.
    OMAiVQKMPGE.
    OrthoDBiEOG7GQXWR.
    PhylomeDBiQ7RTU3.
    TreeFamiTF322733.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RTU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK    50
    MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN 100
    LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE 150
    IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA 200
    ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP 250
    HLSALSTANM ARLSAESKDL LK 272
    Length:272
    Mass (Da):29,358
    Last modified:August 31, 2004 - v2
    Checksum:i9ED98EF52F34D9A5
    GO

    Sequence cautioni

    The sequence DAA00303.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096362 mRNA. Translation: BAC04768.1.
    AL023580 Genomic DNA. Translation: CAI20348.1.
    BC051352 mRNA. Translation: AAH51352.1.
    BK000141 Genomic DNA. Translation: DAA00303.1. Different initiation.
    CCDSiCCDS5186.1.
    RefSeqiNP_786923.1. NM_175747.2.
    UniGeneiHs.195398.

    Genome annotation databases

    EnsembliENST00000367734; ENSP00000356708; ENSG00000177468.
    GeneIDi167826.
    KEGGihsa:167826.
    UCSCiuc003qhp.1. human.

    Polymorphism databases

    DMDMi51701664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096362 mRNA. Translation: BAC04768.1 .
    AL023580 Genomic DNA. Translation: CAI20348.1 .
    BC051352 mRNA. Translation: AAH51352.1 .
    BK000141 Genomic DNA. Translation: DAA00303.1 . Different initiation.
    CCDSi CCDS5186.1.
    RefSeqi NP_786923.1. NM_175747.2.
    UniGenei Hs.195398.

    3D structure databases

    ProteinModelPortali Q7RTU3.
    SMRi Q7RTU3. Positions 85-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127951. 2 interactions.
    STRINGi 9606.ENSP00000356708.

    PTM databases

    PhosphoSitei Q7RTU3.

    Polymorphism databases

    DMDMi 51701664.

    Proteomic databases

    PaxDbi Q7RTU3.
    PRIDEi Q7RTU3.

    Protocols and materials databases

    DNASUi 167826.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367734 ; ENSP00000356708 ; ENSG00000177468 .
    GeneIDi 167826.
    KEGGi hsa:167826.
    UCSCi uc003qhp.1. human.

    Organism-specific databases

    CTDi 167826.
    GeneCardsi GC06M137855.
    HGNCi HGNC:18003. OLIG3.
    HPAi CAB024865.
    HPA018303.
    MIMi 609323. gene.
    neXtProti NX_Q7RTU3.
    PharmGKBi PA134945348.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313428.
    HOGENOMi HOG000015765.
    HOVERGENi HBG053370.
    InParanoidi Q7RTU3.
    KOi K09085.
    OMAi VQKMPGE.
    OrthoDBi EOG7GQXWR.
    PhylomeDBi Q7RTU3.
    TreeFami TF322733.

    Miscellaneous databases

    GenomeRNAii 167826.
    NextBioi 88689.
    PROi Q7RTU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7RTU3.
    CleanExi HS_OLIG3.
    Genevestigatori Q7RTU3.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    4. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
      McLellan A.S., Langlands K., Kealey T.
      Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOLIG3_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTU3
    Secondary accession number(s): Q8N8Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3