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Protein

Oligodendrocyte transcription factor 3

Gene

OLIG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 3
Short name:
Oligo3
Alternative name(s):
Class B basic helix-loop-helix protein 7
Short name:
bHLHb7
Class E basic helix-loop-helix protein 20
Short name:
bHLHe20
Gene namesi
Name:OLIG3
Synonyms:BHLHB7, BHLHE20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18003. OLIG3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945348.

Polymorphism and mutation databases

BioMutaiOLIG3.
DMDMi51701664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Oligodendrocyte transcription factor 3PRO_0000127417Add
BLAST

Proteomic databases

PaxDbiQ7RTU3.
PRIDEiQ7RTU3.

PTM databases

PhosphoSiteiQ7RTU3.

Expressioni

Gene expression databases

BgeeiQ7RTU3.
CleanExiHS_OLIG3.
GenevisibleiQ7RTU3. HS.

Organism-specific databases

HPAiCAB024865.
HPA018303.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-10225049,EBI-717810
BYSLQ138955EBI-10225049,EBI-358049
MDFIQ997503EBI-10225049,EBI-724076
TRAF1Q130773EBI-10225049,EBI-359224

Protein-protein interaction databases

BioGridi127951. 6 interactions.
IntActiQ7RTU3. 4 interactions.
STRINGi9606.ENSP00000356708.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU3.
SMRiQ7RTU3. Positions 85-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13755bHLHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 8922Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 328Poly-His
Compositional biasi247 – 2504Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG313428.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ7RTU3.
KOiK09085.
OMAiVQKMPGE.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ7RTU3.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK
60 70 80 90 100
MPGESLSRAG AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN
110 120 130 140 150
LAMDGLREVM PYAHGPSVRK LSKIATLLLA RNYILMLTSS LEEMKRLVGE
160 170 180 190 200
IYGGHHSAFH CGTVGHSAGH PAHAANSVHP VHPILGGALS SGNASSPLSA
210 220 230 240 250
ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP CTICQMPPPP
260 270
HLSALSTANM ARLSAESKDL LK
Length:272
Mass (Da):29,358
Last modified:August 31, 2004 - v2
Checksum:i9ED98EF52F34D9A5
GO

Sequence cautioni

The sequence DAA00303.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096362 mRNA. Translation: BAC04768.1.
AL023580 Genomic DNA. Translation: CAI20348.1.
BC051352 mRNA. Translation: AAH51352.1.
BK000141 Genomic DNA. Translation: DAA00303.1. Different initiation.
CCDSiCCDS5186.1.
RefSeqiNP_786923.1. NM_175747.2.
UniGeneiHs.195398.

Genome annotation databases

EnsembliENST00000367734; ENSP00000356708; ENSG00000177468.
GeneIDi167826.
KEGGihsa:167826.
UCSCiuc003qhp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096362 mRNA. Translation: BAC04768.1.
AL023580 Genomic DNA. Translation: CAI20348.1.
BC051352 mRNA. Translation: AAH51352.1.
BK000141 Genomic DNA. Translation: DAA00303.1. Different initiation.
CCDSiCCDS5186.1.
RefSeqiNP_786923.1. NM_175747.2.
UniGeneiHs.195398.

3D structure databases

ProteinModelPortaliQ7RTU3.
SMRiQ7RTU3. Positions 85-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127951. 6 interactions.
IntActiQ7RTU3. 4 interactions.
STRINGi9606.ENSP00000356708.

PTM databases

PhosphoSiteiQ7RTU3.

Polymorphism and mutation databases

BioMutaiOLIG3.
DMDMi51701664.

Proteomic databases

PaxDbiQ7RTU3.
PRIDEiQ7RTU3.

Protocols and materials databases

DNASUi167826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367734; ENSP00000356708; ENSG00000177468.
GeneIDi167826.
KEGGihsa:167826.
UCSCiuc003qhp.1. human.

Organism-specific databases

CTDi167826.
GeneCardsiGC06M137855.
HGNCiHGNC:18003. OLIG3.
HPAiCAB024865.
HPA018303.
MIMi609323. gene.
neXtProtiNX_Q7RTU3.
PharmGKBiPA134945348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313428.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ7RTU3.
KOiK09085.
OMAiVQKMPGE.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ7RTU3.
TreeFamiTF322733.

Miscellaneous databases

GenomeRNAii167826.
NextBioi88689.
PROiQ7RTU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7RTU3.
CleanExiHS_OLIG3.
GenevisibleiQ7RTU3. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
    McLellan A.S., Langlands K., Kealey T.
    Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOLIG3_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU3
Secondary accession number(s): Q8N8Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 24, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.