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Protein

Transcription factor 23

Gene

TCF23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 23
Short name:
TCF-23
Alternative name(s):
Class A basic helix-loop-helix protein 24
Short name:
bHLHa24
Gene namesi
Name:TCF23
Synonyms:BHLHA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18602. TCF23.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163792.
PharmGKBiPA38359.

Polymorphism and mutation databases

BioMutaiTCF23.
DMDMi74749939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158201 – 214Transcription factor 23Add BLAST214

Proteomic databases

PaxDbiQ7RTU1.
PeptideAtlasiQ7RTU1.
PRIDEiQ7RTU1.

PTM databases

iPTMnetiQ7RTU1.
PhosphoSitePlusiQ7RTU1.

Expressioni

Tissue specificityi

Expressed in liver, kidney and spleen.1 Publication

Gene expression databases

BgeeiENSG00000163792.
CleanExiHS_TCF23.

Organism-specific databases

HPAiHPA044596.

Interactioni

Subunit structurei

Forms inactive heterodimeric complexes with TCF3.By similarity

Protein-protein interaction databases

BioGridi127330. 1 interactor.
IntActiQ7RTU1. 2 interactors.
STRINGi9606.ENSP00000296096.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU1.
SMRiQ7RTU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 128bHLHPROSITE-ProRule annotationAdd BLAST53

Domaini

Both the bHLH region and the C-terminal portion are essential for inhibitory function.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000154520.
HOVERGENiHBG096612.
InParanoidiQ7RTU1.
OMAiRTRQDLW.
OrthoDBiEOG091G0MGD.
PhylomeDBiQ7RTU1.
TreeFamiTF350742.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRKARGPP AMPGVGHSQT QAKARLLPGA DRKRSRLSRT RQDPWEERSW
60 70 80 90 100
SNQRWSRATP GPRGTRAGGL ALGRSEASPE NAARERSRVR TLRQAFLALQ
110 120 130 140 150
AALPAVPPDT KLSKLDVLVL AASYIAHLTR TLGHELPGPA WPPFLRGLRY
160 170 180 190 200
LHPLKKWPMR SRLYAGGLGY SDLDSTTAST PSQRTRDAEV GSQVPGEADA
210
LLSTTPLSPA LGDK
Length:214
Mass (Da):23,309
Last modified:December 15, 2003 - v1
Checksum:i5D1408A9BFFEE339
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03832525R → Q.Corresponds to variant rs11126879dbSNPEnsembl.1
Natural variantiVAR_03832640T → S.Corresponds to variant rs4502371dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013403 Genomic DNA. No translation available.
BC137191 mRNA. Translation: AAI37192.1.
BC137192 mRNA. Translation: AAI37193.1.
BK000143 Genomic DNA. Translation: DAA00305.1.
CCDSiCCDS33163.1.
RefSeqiNP_786951.1. NM_175769.2.
UniGeneiHs.591583.

Genome annotation databases

EnsembliENST00000296096; ENSP00000296096; ENSG00000163792.
GeneIDi150921.
KEGGihsa:150921.
UCSCiuc010ylg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013403 Genomic DNA. No translation available.
BC137191 mRNA. Translation: AAI37192.1.
BC137192 mRNA. Translation: AAI37193.1.
BK000143 Genomic DNA. Translation: DAA00305.1.
CCDSiCCDS33163.1.
RefSeqiNP_786951.1. NM_175769.2.
UniGeneiHs.591583.

3D structure databases

ProteinModelPortaliQ7RTU1.
SMRiQ7RTU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127330. 1 interactor.
IntActiQ7RTU1. 2 interactors.
STRINGi9606.ENSP00000296096.

PTM databases

iPTMnetiQ7RTU1.
PhosphoSitePlusiQ7RTU1.

Polymorphism and mutation databases

BioMutaiTCF23.
DMDMi74749939.

Proteomic databases

PaxDbiQ7RTU1.
PeptideAtlasiQ7RTU1.
PRIDEiQ7RTU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296096; ENSP00000296096; ENSG00000163792.
GeneIDi150921.
KEGGihsa:150921.
UCSCiuc010ylg.3. human.

Organism-specific databases

CTDi150921.
GeneCardsiTCF23.
HGNCiHGNC:18602. TCF23.
HPAiHPA044596.
MIMi609635. gene.
neXtProtiNX_Q7RTU1.
OpenTargetsiENSG00000163792.
PharmGKBiPA38359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000154520.
HOVERGENiHBG096612.
InParanoidiQ7RTU1.
OMAiRTRQDLW.
OrthoDBiEOG091G0MGD.
PhylomeDBiQ7RTU1.
TreeFamiTF350742.

Miscellaneous databases

GenomeRNAii150921.
PROiQ7RTU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163792.
CleanExiHS_TCF23.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCF23_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU1
Secondary accession number(s): B2RNZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 15, 2003
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.