Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor 24

Gene

TCF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 24
Short name:
TCF-24
Gene namesi
Name:TCF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32275. TCF24.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi408360247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Transcription factor 24PRO_0000405315Add
BLAST

Proteomic databases

PaxDbiQ7RTU0.
PRIDEiQ7RTU0.

PTM databases

iPTMnetiQ7RTU0.
PhosphoSiteiQ7RTU0.

Expressioni

Gene expression databases

GenevisibleiQ7RTU0. HS.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Protein-protein interaction databases

BioGridi934215. 2 interactions.
STRINGi9606.ENSP00000455444.

Structurei

3D structure databases

ProteinModelPortaliQ7RTU0.
SMRiQ7RTU0. Positions 56-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 10153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000206610.
InParanoidiQ7RTU0.
OMAiQFLKHSV.
OrthoDBiEOG74R1V2.
TreeFamiTF350742.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGRPAGSP LSASAEPAPL AAAIRDSRPG RTGPGPAGPG GGSRSGSGRP
60 70 80 90 100
AAANAARERS RVQTLRHAFL ELQRTLPSVP PDTKLSKLDV LLLATTYIAH
110 120 130 140 150
LTRSLQDDAE APADAGLGAL RGDGYLHPVK KWPMRSRLYI GATGQFLKHS
160
VSGEKTNHDN TPTDSQP
Length:167
Mass (Da):17,516
Last modified:October 3, 2012 - v3
Checksum:iB1637A24221E6A59
GO

Sequence cautioni

The sequence DAA00306.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110998 Genomic DNA. No translation available.
BK000144 Genomic DNA. Translation: DAA00306.1. Sequence problems.
CCDSiCCDS59103.1.
RefSeqiNP_001180431.1. NM_001193502.1.
XP_011515735.1. XM_011517433.1.
UniGeneiHs.120040.

Genome annotation databases

EnsembliENST00000563496; ENSP00000455444; ENSG00000261787.
GeneIDi100129654.
KEGGihsa:100129654.
UCSCiuc022avl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110998 Genomic DNA. No translation available.
BK000144 Genomic DNA. Translation: DAA00306.1. Sequence problems.
CCDSiCCDS59103.1.
RefSeqiNP_001180431.1. NM_001193502.1.
XP_011515735.1. XM_011517433.1.
UniGeneiHs.120040.

3D structure databases

ProteinModelPortaliQ7RTU0.
SMRiQ7RTU0. Positions 56-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi934215. 2 interactions.
STRINGi9606.ENSP00000455444.

PTM databases

iPTMnetiQ7RTU0.
PhosphoSiteiQ7RTU0.

Polymorphism and mutation databases

DMDMi408360247.

Proteomic databases

PaxDbiQ7RTU0.
PRIDEiQ7RTU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000563496; ENSP00000455444; ENSG00000261787.
GeneIDi100129654.
KEGGihsa:100129654.
UCSCiuc022avl.1. human.

Organism-specific databases

CTDi100129654.
GeneCardsiTCF24.
HGNCiHGNC:32275. TCF24.
neXtProtiNX_Q7RTU0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000206610.
InParanoidiQ7RTU0.
OMAiQFLKHSV.
OrthoDBiEOG74R1V2.
TreeFamiTF350742.

Miscellaneous databases

GenomeRNAii100129654.
PROiQ7RTU0.

Gene expression databases

GenevisibleiQ7RTU0. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
    McLellan A.S., Langlands K., Kealey T.
    Mech. Dev. 119:S285-S291(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiTCF24_HUMAN
AccessioniPrimary (citable) accession number: Q7RTU0
Secondary accession number(s): H3BPR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.