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Protein

Putative protein SSX6

Gene

SSX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Could act as a modulator of transcription.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-33246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein SSX6
Gene namesi
Name:SSX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:19652. SSX6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74759050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002278101 – 188Putative protein SSX6Add BLAST188

Proteomic databases

PaxDbiQ7RTT6.
PRIDEiQ7RTT6.

PTM databases

iPTMnetiQ7RTT6.
PhosphoSitePlusiQ7RTT6.

Expressioni

Tissue specificityi

Not detected in any normal tissues. Expressed in a melanoma cell line.1 Publication

Gene expression databases

CleanExiHS_SSX6.

Organism-specific databases

HPAiHPA045683.

Structurei

3D structure databases

ProteinModelPortaliQ7RTT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 83KRAB-relatedPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the SSX family.Curated
Contains 1 KRAB-related domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JCMU. Eukaryota.
ENOG4111A52. LUCA.
HOGENOMiHOG000231461.
HOVERGENiHBG002056.
InParanoidiQ7RTT6.
PhylomeDBiQ7RTT6.
TreeFamiTF338517.

Family and domain databases

InterProiIPR001909. KRAB.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERiPTHR14112. PTHR14112. 1 hit.
PfamiPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50806. KRAB_RELATED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDDAFAKR PRDDAKASEK RSKAFDDIAK YFSKEEWEKM KFSEKISCVH
60 70 80 90 100
MKRKYEAMTK LGFNVTLSLF MRNKRATDSQ RNDSDNDRNR GNEVERPQMT
110 120 130 140 150
FGRLQRIIPK IMPEKPAEEG SDSKGVPEAS GPQNDGKKLC PPGKASSSEK
160 170 180
IHERSGPKRG KHAWTHRLRE RKQLVIYEEI SDPEEDDK
Length:188
Mass (Da):21,688
Last modified:December 15, 2003 - v1
Checksum:iBBAB5A4F7BA879C8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05369290R → C.Corresponds to variant rs5952474dbSNPEnsembl.1
Natural variantiVAR_053693138K → Q.Corresponds to variant rs17327911dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356464, Z98304 Genomic DNA. Translation: CAI40525.1.
Z98304, AL356464 Genomic DNA. Translation: CAI42940.1.
BK000686 Genomic DNA. Translation: DAA00373.1.
UniGeneiHs.511998.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356464, Z98304 Genomic DNA. Translation: CAI40525.1.
Z98304, AL356464 Genomic DNA. Translation: CAI42940.1.
BK000686 Genomic DNA. Translation: DAA00373.1.
UniGeneiHs.511998.

3D structure databases

ProteinModelPortaliQ7RTT6.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ7RTT6.
PhosphoSitePlusiQ7RTT6.

Polymorphism and mutation databases

DMDMi74759050.

Proteomic databases

PaxDbiQ7RTT6.
PRIDEiQ7RTT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiSSX6.
HGNCiHGNC:19652. SSX6.
HPAiHPA045683.
MIMi300541. gene.
neXtProtiNX_Q7RTT6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCMU. Eukaryota.
ENOG4111A52. LUCA.
HOGENOMiHOG000231461.
HOVERGENiHBG002056.
InParanoidiQ7RTT6.
PhylomeDBiQ7RTT6.
TreeFamiTF338517.

Enzyme and pathway databases

BioCyciZFISH:G66-33246-MONOMER.

Miscellaneous databases

PROiQ7RTT6.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SSX6.

Family and domain databases

InterProiIPR001909. KRAB.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERiPTHR14112. PTHR14112. 1 hit.
PfamiPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50806. KRAB_RELATED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSX6_HUMAN
AccessioniPrimary (citable) accession number: Q7RTT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.