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Q7RTT5

- SSX7_HUMAN

UniProt

Q7RTT5 - SSX7_HUMAN

Protein

Protein SSX7

Gene

SSX7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Could act as a modulator of transcription.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SSX7
    Gene namesi
    Name:SSX7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:19653. SSX7.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Protein SSX7PRO_0000227811Add
    BLAST

    Proteomic databases

    PaxDbiQ7RTT5.
    PRIDEiQ7RTT5.

    PTM databases

    PhosphoSiteiQ7RTT5.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed in a melanoma cell line.1 Publication

    Gene expression databases

    CleanExiHS_SSX7.
    GenevestigatoriQ7RTT5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298181.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTT5.
    SMRiQ7RTT5. Positions 20-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 8364KRAB-relatedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SSX family.Curated
    Contains 1 KRAB-related domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG136451.
    HOGENOMiHOG000231461.
    HOVERGENiHBG002056.
    InParanoidiQ7RTT5.
    OMAiNESEYYV.
    OrthoDBiEOG7DNNX1.
    PhylomeDBiQ7RTT5.
    TreeFamiTF338517.

    Family and domain databases

    InterProiIPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR028804. SSX.
    IPR019041. SSXRD_motif.
    [Graphical view]
    PANTHERiPTHR14112. PTHR14112. 1 hit.
    PfamiPF09514. SSXRD. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50806. KRAB_RELATED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RTT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGDDAFARR PRAGAQIPEK IQKSFDDIAK YFSKKEWEKM KSLEKISYVY    50
    MKRKYEAMTK LGFKATLPPF MHNTGATDLQ GNDFDNDRNQ GNQVERPQMT 100
    FCRLQRIFPK IMPKKPAEEG NDSKGVPEAS GSQNDGKHLC PPGKPSTSEK 150
    INKTSGPKRG KHAWTHRLRE RKQLVIYEEI SDPEEDDE 188
    Length:188
    Mass (Da):21,591
    Last modified:December 15, 2003 - v1
    Checksum:i3871D4FAA13DC78E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431L → S.
    Corresponds to variant rs3122210 [ dbSNP | Ensembl ].
    VAR_053694

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL450023 Genomic DNA. Translation: CAI41147.1.
    BK000687 Genomic DNA. Translation: DAA00374.1.
    CCDSiCCDS14343.1.
    RefSeqiNP_775494.1. NM_173358.2.
    UniGeneiHs.558712.

    Genome annotation databases

    EnsembliENST00000298181; ENSP00000298181; ENSG00000187754.
    GeneIDi280658.
    KEGGihsa:280658.
    UCSCiuc004dqx.1. human.

    Polymorphism databases

    DMDMi74749937.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL450023 Genomic DNA. Translation: CAI41147.1 .
    BK000687 Genomic DNA. Translation: DAA00374.1 .
    CCDSi CCDS14343.1.
    RefSeqi NP_775494.1. NM_173358.2.
    UniGenei Hs.558712.

    3D structure databases

    ProteinModelPortali Q7RTT5.
    SMRi Q7RTT5. Positions 20-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298181.

    PTM databases

    PhosphoSitei Q7RTT5.

    Polymorphism databases

    DMDMi 74749937.

    Proteomic databases

    PaxDbi Q7RTT5.
    PRIDEi Q7RTT5.

    Protocols and materials databases

    DNASUi 280658.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298181 ; ENSP00000298181 ; ENSG00000187754 .
    GeneIDi 280658.
    KEGGi hsa:280658.
    UCSCi uc004dqx.1. human.

    Organism-specific databases

    CTDi 280658.
    GeneCardsi GC0XM052674.
    HGNCi HGNC:19653. SSX7.
    MIMi 300542. gene.
    neXtProti NX_Q7RTT5.
    PharmGKBi PA134879420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136451.
    HOGENOMi HOG000231461.
    HOVERGENi HBG002056.
    InParanoidi Q7RTT5.
    OMAi NESEYYV.
    OrthoDBi EOG7DNNX1.
    PhylomeDBi Q7RTT5.
    TreeFami TF338517.

    Miscellaneous databases

    GenomeRNAii 280658.
    NextBioi 93431.
    PROi Q7RTT5.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_SSX7.
    Genevestigatori Q7RTT5.

    Family and domain databases

    InterProi IPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR028804. SSX.
    IPR019041. SSXRD_motif.
    [Graphical view ]
    PANTHERi PTHR14112. PTHR14112. 1 hit.
    Pfami PF09514. SSXRD. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50806. KRAB_RELATED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The SSX gene family: characterization of 9 complete genes."
      Gure A.O., Wei I.J., Old L.J., Chen Y.-T.
      Int. J. Cancer 101:448-453(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSSX7_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3