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Q7RTT5

- SSX7_HUMAN

UniProt

Q7RTT5 - SSX7_HUMAN

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Protein
Protein SSX7
Gene
SSX7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Could act as a modulator of transcription.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSX7
Gene namesi
Name:SSX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:19653. SSX7.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Protein SSX7
PRO_0000227811Add
BLAST

Proteomic databases

PaxDbiQ7RTT5.
PRIDEiQ7RTT5.

PTM databases

PhosphoSiteiQ7RTT5.

Expressioni

Tissue specificityi

Testis-specific. Expressed in a melanoma cell line.1 Publication

Gene expression databases

CleanExiHS_SSX7.
GenevestigatoriQ7RTT5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298181.

Structurei

3D structure databases

ProteinModelPortaliQ7RTT5.
SMRiQ7RTT5. Positions 20-70.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8364KRAB-related
Add
BLAST

Sequence similaritiesi

Belongs to the SSX family.

Phylogenomic databases

eggNOGiNOG136451.
HOGENOMiHOG000231461.
HOVERGENiHBG002056.
InParanoidiQ7RTT5.
OMAiNESEYYV.
OrthoDBiEOG7DNNX1.
PhylomeDBiQ7RTT5.
TreeFamiTF338517.

Family and domain databases

InterProiIPR001909. Krueppel-associated_box.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view]
PANTHERiPTHR14112. PTHR14112. 1 hit.
PfamiPF09514. SSXRD. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50806. KRAB_RELATED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RTT5-1 [UniParc]FASTAAdd to Basket

« Hide

MNGDDAFARR PRAGAQIPEK IQKSFDDIAK YFSKKEWEKM KSLEKISYVY    50
MKRKYEAMTK LGFKATLPPF MHNTGATDLQ GNDFDNDRNQ GNQVERPQMT 100
FCRLQRIFPK IMPKKPAEEG NDSKGVPEAS GSQNDGKHLC PPGKPSTSEK 150
INKTSGPKRG KHAWTHRLRE RKQLVIYEEI SDPEEDDE 188
Length:188
Mass (Da):21,591
Last modified:December 15, 2003 - v1
Checksum:i3871D4FAA13DC78E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431L → S.
Corresponds to variant rs3122210 [ dbSNP | Ensembl ].
VAR_053694

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL450023 Genomic DNA. Translation: CAI41147.1.
BK000687 Genomic DNA. Translation: DAA00374.1.
CCDSiCCDS14343.1.
RefSeqiNP_775494.1. NM_173358.2.
UniGeneiHs.558712.

Genome annotation databases

EnsembliENST00000298181; ENSP00000298181; ENSG00000187754.
ENST00000598733; ENSP00000471753; ENSG00000267995.
GeneIDi280658.
KEGGihsa:280658.
UCSCiuc004dqx.1. human.

Polymorphism databases

DMDMi74749937.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL450023 Genomic DNA. Translation: CAI41147.1 .
BK000687 Genomic DNA. Translation: DAA00374.1 .
CCDSi CCDS14343.1.
RefSeqi NP_775494.1. NM_173358.2.
UniGenei Hs.558712.

3D structure databases

ProteinModelPortali Q7RTT5.
SMRi Q7RTT5. Positions 20-70.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000298181.

PTM databases

PhosphoSitei Q7RTT5.

Polymorphism databases

DMDMi 74749937.

Proteomic databases

PaxDbi Q7RTT5.
PRIDEi Q7RTT5.

Protocols and materials databases

DNASUi 280658.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298181 ; ENSP00000298181 ; ENSG00000187754 .
ENST00000598733 ; ENSP00000471753 ; ENSG00000267995 .
GeneIDi 280658.
KEGGi hsa:280658.
UCSCi uc004dqx.1. human.

Organism-specific databases

CTDi 280658.
GeneCardsi GC0XM052674.
HGNCi HGNC:19653. SSX7.
MIMi 300542. gene.
neXtProti NX_Q7RTT5.
PharmGKBi PA134879420.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136451.
HOGENOMi HOG000231461.
HOVERGENi HBG002056.
InParanoidi Q7RTT5.
OMAi NESEYYV.
OrthoDBi EOG7DNNX1.
PhylomeDBi Q7RTT5.
TreeFami TF338517.

Miscellaneous databases

GenomeRNAii 280658.
NextBioi 93431.
PROi Q7RTT5.
SOURCEi Search...

Gene expression databases

CleanExi HS_SSX7.
Genevestigatori Q7RTT5.

Family and domain databases

InterProi IPR001909. Krueppel-associated_box.
IPR003655. Krueppel-associated_box-rel.
IPR028804. SSX.
IPR019041. SSXRD_motif.
[Graphical view ]
PANTHERi PTHR14112. PTHR14112. 1 hit.
Pfami PF09514. SSXRD. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50806. KRAB_RELATED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The SSX gene family: characterization of 9 complete genes."
    Gure A.O., Wei I.J., Old L.J., Chen Y.-T.
    Int. J. Cancer 101:448-453(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSSX7_HUMAN
AccessioniPrimary (citable) accession number: Q7RTT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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