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Protein

Proton channel OTOP2

Gene

OTOP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processHydrogen ion transport, Ion transport, Transport

Protein family/group databases

TCDBi1.A.110.1.3 the channel-forming otopetrin (otop) family

Names & Taxonomyi

Protein namesi
Recommended name:
Proton channel OTOP2Curated
Alternative name(s):
Otopetrin-21 Publication
Gene namesi
Name:OTOP21 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183034.12
HGNCiHGNC:19657 OTOP2
MIMi607827 gene
neXtProtiNX_Q7RTS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183034
PharmGKBiPA134930692

Polymorphism and mutation databases

BioMutaiOTOP2
DMDMi296439281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138201 – 562Proton channel OTOP2Add BLAST562

Proteomic databases

PaxDbiQ7RTS6
PeptideAtlasiQ7RTS6
PRIDEiQ7RTS6

PTM databases

iPTMnetiQ7RTS6
PhosphoSitePlusiQ7RTS6

Expressioni

Gene expression databases

BgeeiENSG00000183034
CleanExiHS_OTOP2

Organism-specific databases

HPAiHPA024524
HPA053090

Interactioni

Protein-protein interaction databases

IntActiQ7RTS6, 3 interactors
MINTiQ7RTS6
STRINGi9606.ENSP00000332528

Structurei

3D structure databases

ProteinModelPortaliQ7RTS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the otopetrin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4740 Eukaryota
ENOG410XVS5 LUCA
GeneTreeiENSGT00530000063198
HOGENOMiHOG000090257
HOVERGENiHBG056633
InParanoidiQ7RTS6
OMAiCIHTHLD
OrthoDBiEOG091G03VC
PhylomeDBiQ7RTS6
TreeFamiTF313428

Family and domain databases

InterProiView protein in InterPro
IPR004878 Otopetrin
PANTHERiPTHR21522 PTHR21522, 1 hit
PfamiView protein in Pfam
PF03189 Otopetrin, 3 hits

Sequencei

Sequence statusi: Complete.

Q7RTS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEELAQGPK ESPPAPRAGP REVWKKGGRL LSVLLAVNVL LLACTLISGG
60 70 80 90 100
AFNKVAVYDT DVFALLTAMM LLATLWILFY LLRTVRCPCA VPYRDAHAGP
110 120 130 140 150
IWLRGGLVLF GICTLIMDVF KTGYYSSFFE CQSAIKILHP LIQAVFVIIQ
160 170 180 190 200
TYFLWVSAKD CVHVHLDLTW CGLMFTLTTN LAIWMAAVVD ESVHQSHSYS
210 220 230 240 250
SSHSNASHAR LISDQHADNP VGGDSCLCST AVCQIFQQGY FYLYPFNIEY
260 270 280 290 300
SLFASTMLYV MWKNVGRFLA STPGHSHTPT PVSLFRETFF AGPVLGLLLF
310 320 330 340 350
VVGLAVFIIY EVQVSGDGSR TRQALVIYYS FNIVCLGLTT LVSLSGSIIY
360 370 380 390 400
RFDRRAMDHH KNPTRTLDVA LLMGAALGQY AISYYSIVAV VAGTPQDLLA
410 420 430 440 450
GLNLTHALLM IAQHTFQNMF IIESLHRGPP GAEPHSTHPK EPCQDLTFTN
460 470 480 490 500
LDALHTLSAC PPNPGLVSPS PSDQREAVAI VSTPRSQWRR QCLKDISLFL
510 520 530 540 550
LLCNVILWIM PAFGARPHFS NTVEVDFYGY SLWAVIVNIC LPFGIFYRMH
560
AVSSLLEVYV LS
Length:562
Mass (Da):62,236
Last modified:May 18, 2010 - v3
Checksum:i07B46C4A06C655D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037760392A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs148548570Ensembl.1
Natural variantiVAR_037761465G → W. Corresponds to variant dbSNP:rs6501741Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068874 Genomic DNA No translation available.
AC087651 Genomic DNA No translation available.
BK000567 mRNA Translation: DAA00895.1
CCDSiCCDS11708.1
RefSeqiNP_835454.1, NM_178160.2
XP_011523781.1, XM_011525479.1
UniGeneiHs.352515

Genome annotation databases

EnsembliENST00000331427; ENSP00000332528; ENSG00000183034
ENST00000580223; ENSP00000463837; ENSG00000183034
GeneIDi92736
KEGGihsa:92736
UCSCiuc010wrp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOTOP2_HUMAN
AccessioniPrimary (citable) accession number: Q7RTS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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