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Q7RTR8

- T2R42_HUMAN

UniProt

Q7RTR8 - T2R42_HUMAN

Protein

Taste receptor type 2 member 42

Gene

TAS2R42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 42
    Short name:
    T2R42
    Alternative name(s):
    Taste receptor type 2 member 55
    Short name:
    T2R55
    Gene namesi
    Name:TAS2R42
    Synonyms:TAS2R55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18888. TAS2R42.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Taste receptor type 2 member 42PRO_0000082344Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7RTR8.
    PRIDEiQ7RTR8.

    Expressioni

    Gene expression databases

    CleanExiHS_TAS2R42.
    GenevestigatoriQ7RTR8.

    Organism-specific databases

    HPAiHPA036149.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RTR8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 5022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 10130ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 1275CytoplasmicSequence Analysis
    Topological domaini149 – 18739ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2656ExtracellularSequence Analysis
    Topological domaini287 – 31428CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43990.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ7RTR8.
    KOiK08474.
    OMAiEIFIDIS.
    OrthoDBiEOG72C512.
    PhylomeDBiQ7RTR8.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7RTR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATELDKIFL ILAIAEFIIS MLGNVFIGLV NCSEGIKNQK VFSADFILTC    50
    LAISTIGQLL VILFDSFLVG LASHLYTTYR LGKTVIMLWH MTNHLTTWLA 100
    TCLSIFYFFK IAHFPHSLFL WLRWRMNGMI VMLLILSLFL LIFDSLVLEI 150
    FIDISLNIID KSNLTLYLDE SKTLYDKLSI LKTLLSLTSF IPFSLFLTSL 200
    LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSFL FLFIVHFFSL 250
    QVANGIFFML WNNKYIKFVM LALNAFPSCH SFILILGNSK LRQTAVRLLW 300
    HLRNYTKTPN ALPL 314
    Length:314
    Mass (Da):36,195
    Last modified:December 15, 2003 - v1
    Checksum:i0A49C39889F8CFA4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti175 – 1751Y → F.1 Publication
    Corresponds to variant rs35969491 [ dbSNP | Ensembl ].
    VAR_062086
    Natural varianti196 – 1961F → S.1 Publication
    Corresponds to variant rs5020531 [ dbSNP | Ensembl ].
    VAR_053352
    Natural varianti255 – 2551G → W.1 Publication
    Corresponds to variant rs1669413 [ dbSNP | Ensembl ].
    VAR_062087
    Natural varianti265 – 2651Y → C.
    Corresponds to variant rs1451772 [ dbSNP | Ensembl ].
    VAR_053353
    Natural varianti292 – 2921R → Q.
    Corresponds to variant rs1669412 [ dbSNP | Ensembl ].
    VAR_062088
    Natural varianti311 – 3111A → P.1 Publication
    Corresponds to variant rs1650017 [ dbSNP | Ensembl ].
    VAR_062089

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY724953 Genomic DNA. Translation: AAU21149.1.
    AC010176 Genomic DNA. No translation available.
    BC131742 mRNA. Translation: AAI31743.1.
    BK001099 Genomic DNA. Translation: DAA01206.1.
    CCDSiCCDS31747.1.
    UniGeneiHs.553716.

    Genome annotation databases

    EnsembliENST00000334266; ENSP00000334050; ENSG00000186136.
    KEGGihsa:353164.
    UCSCiuc001qzr.1. human.

    Polymorphism databases

    DMDMi55976719.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY724953 Genomic DNA. Translation: AAU21149.1 .
    AC010176 Genomic DNA. No translation available.
    BC131742 mRNA. Translation: AAI31743.1 .
    BK001099 Genomic DNA. Translation: DAA01206.1 .
    CCDSi CCDS31747.1.
    UniGenei Hs.553716.

    3D structure databases

    ProteinModelPortali Q7RTR8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334050.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 55976719.

    Proteomic databases

    PaxDbi Q7RTR8.
    PRIDEi Q7RTR8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334266 ; ENSP00000334050 ; ENSG00000186136 .
    KEGGi hsa:353164.
    UCSCi uc001qzr.1. human.

    Organism-specific databases

    GeneCardsi GC12M011338.
    HGNCi HGNC:18888. TAS2R42.
    HPAi HPA036149.
    MIMi 613966. gene.
    neXtProti NX_Q7RTR8.
    PharmGKBi PA38741.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43990.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q7RTR8.
    KOi K08474.
    OMAi EIFIDIS.
    OrthoDBi EOG72C512.
    PhylomeDBi Q7RTR8.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 353164.
    NextBioi 99726.
    PROi Q7RTR8.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS2R42.
    Genevestigatori Q7RTR8.

    Family and domain databases

    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-175; SER-196; TRP-255 AND PRO-311.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiT2R42_HUMAN
    AccessioniPrimary (citable) accession number: Q7RTR8
    Secondary accession number(s): A2RRP4, Q645X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3