Q7RTR8 (T2R42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 42
Short name=T2R42

Alternative name(s):
Taste receptor type 2 member 55
Short name=T2R55

Gene names

Name:	TAS2R42
Synonyms:	TAS2R55

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of taste Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Taste receptor type 2 member 42		PRO_0000082344
Regions
	Topological domain	1 – 7	7	Extracellular Potential
	Transmembrane	8 – 28	21	Helical; Name=1; Potential
	Topological domain	29 – 50	22	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Name=2; Potential
	Topological domain	72 – 101	30	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=4; Potential
	Topological domain	123 – 127	5	Cytoplasmic Potential
	Transmembrane	128 – 148	21	Helical; Name=3; Potential
	Topological domain	149 – 187	39	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 238	30	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 265	6	Extracellular Potential
	Transmembrane	266 – 286	21	Helical; Name=7; Potential
	Topological domain	287 – 314	28	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	175	1	Y → F. Ref.2 Corresponds to variant rs35969491 [ dbSNP | Ensembl ].		VAR_062086
	Natural variant	196	1	F → S. Ref.2 Corresponds to variant rs5020531 [ dbSNP | Ensembl ].		VAR_053352
	Natural variant	255	1	G → W. Ref.2 Corresponds to variant rs1669413 [ dbSNP | Ensembl ].		VAR_062087
	Natural variant	265	1	Y → C. Corresponds to variant rs1451772 [ dbSNP | Ensembl ].		VAR_053353
	Natural variant	292	1	R → Q. Corresponds to variant rs1669412 [ dbSNP | Ensembl ].		VAR_062088
	Natural variant	311	1	A → P. Ref.2 Corresponds to variant rs1650017 [ dbSNP | Ensembl ].		VAR_062089

Sequences

	Sequence		Length	Mass (Da)
	Q7RTR8 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 0A49C39889F8CFA4	FASTA	314	36,195
	10 20 30 40 50 60 MATELDKIFL ILAIAEFIIS MLGNVFIGLV NCSEGIKNQK VFSADFILTC LAISTIGQLL 70 80 90 100 110 120 VILFDSFLVG LASHLYTTYR LGKTVIMLWH MTNHLTTWLA TCLSIFYFFK IAHFPHSLFL 130 140 150 160 170 180 WLRWRMNGMI VMLLILSLFL LIFDSLVLEI FIDISLNIID KSNLTLYLDE SKTLYDKLSI 190 200 210 220 230 240 LKTLLSLTSF IPFSLFLTSL LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSFL 250 260 270 280 290 300 FLFIVHFFSL QVANGIFFML WNNKYIKFVM LALNAFPSCH SFILILGNSK LRQTAVRLLW 310 HLRNYTKTPN ALPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-175; SER-196; TRP-255 AND PRO-311.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Adaptive diversification of bitter taste receptor genes in mammalian evolution." Shi P., Zhang J., Yang H., Zhang Y.-P. Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY724953 Genomic DNA. Translation: AAU21149.1. AC010176 Genomic DNA. No translation available. BC131742 mRNA. Translation: AAI31743.1. BK001099 Genomic DNA. Translation: DAA01206.1.
IPI	IPI00375371.
RefSeq	NP_852094.1. NM_181429.1.
UniGene	Hs.553716.
3D structure databases
ProteinModelPortal	Q7RTR8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334050.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	55976719.
Proteomic databases
PaxDb	Q7RTR8.
PRIDE	Q7RTR8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334266; ENSP00000334050; ENSG00000186136.
GeneID	353164.
KEGG	hsa:353164.
UCSC	uc001qzr.1. human.
Organism-specific databases
CTD	353164.
GeneCards	GC12M011338.
HGNC	HGNC:18888. TAS2R42.
HPA	HPA036149.
MIM	613966. gene.
neXtProt	NX_Q7RTR8.
PharmGKB	PA38741.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43990.
HOGENOM	HOG000234595.
HOVERGEN	HBG060698.
InParanoid	Q7RTR8.
KO	K08474.
OMA	HRRAMKM.
OrthoDB	EOG4VDQ0B.
PhylomeDB	Q7RTR8.
Gene expression databases
ArrayExpress	Q7RTR8.
CleanEx	HS_TAS2R42.
Genevestigator	Q7RTR8.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
PROSITE	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	353164.
NextBio	99726.
SOURCE	Search...

Entry information

Entry name

T2R42_HUMAN

Accession

Primary (citable) accession number: Q7RTR8
Secondary accession number(s): A2RRP4, Q645X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.