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Q7RTR8 (T2R42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 42

Short name=T2R42
Alternative name(s):
Taste receptor type 2 member 55
Short name=T2R55
Gene names
Name:TAS2R42
Synonyms:TAS2R55
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from direct assay PubMed 20022913. Source: UniProt

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Taste receptor type 2 member 42
PRO_0000082344

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 5022Cytoplasmic Potential
Transmembrane51 – 7121Helical; Name=2; Potential
Topological domain72 – 10130Extracellular Potential
Transmembrane102 – 12221Helical; Name=4; Potential
Topological domain123 – 1275Cytoplasmic Potential
Transmembrane128 – 14821Helical; Name=3; Potential
Topological domain149 – 18739Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23830Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 2656Extracellular Potential
Transmembrane266 – 28621Helical; Name=7; Potential
Topological domain287 – 31428Cytoplasmic Potential

Amino acid modifications

Glycosylation1631N-linked (GlcNAc...) Potential

Natural variations

Natural variant1751Y → F. Ref.2
Corresponds to variant rs35969491 [ dbSNP | Ensembl ].
VAR_062086
Natural variant1961F → S. Ref.2
Corresponds to variant rs5020531 [ dbSNP | Ensembl ].
VAR_053352
Natural variant2551G → W. Ref.2
Corresponds to variant rs1669413 [ dbSNP | Ensembl ].
VAR_062087
Natural variant2651Y → C.
Corresponds to variant rs1451772 [ dbSNP | Ensembl ].
VAR_053353
Natural variant2921R → Q.
Corresponds to variant rs1669412 [ dbSNP | Ensembl ].
VAR_062088
Natural variant3111A → P. Ref.2
Corresponds to variant rs1650017 [ dbSNP | Ensembl ].
VAR_062089

Sequences

Sequence LengthMass (Da)Tools
Q7RTR8 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 0A49C39889F8CFA4

FASTA31436,195
        10         20         30         40         50         60 
MATELDKIFL ILAIAEFIIS MLGNVFIGLV NCSEGIKNQK VFSADFILTC LAISTIGQLL 

        70         80         90        100        110        120 
VILFDSFLVG LASHLYTTYR LGKTVIMLWH MTNHLTTWLA TCLSIFYFFK IAHFPHSLFL 

       130        140        150        160        170        180 
WLRWRMNGMI VMLLILSLFL LIFDSLVLEI FIDISLNIID KSNLTLYLDE SKTLYDKLSI 

       190        200        210        220        230        240 
LKTLLSLTSF IPFSLFLTSL LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSFL 

       250        260        270        280        290        300 
FLFIVHFFSL QVANGIFFML WNNKYIKFVM LALNAFPSCH SFILILGNSK LRQTAVRLLW 

       310 
HLRNYTKTPN ALPL 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-175; SER-196; TRP-255 AND PRO-311.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY724953 Genomic DNA. Translation: AAU21149.1.
AC010176 Genomic DNA. No translation available.
BC131742 mRNA. Translation: AAI31743.1.
BK001099 Genomic DNA. Translation: DAA01206.1.
UniGeneHs.553716.

3D structure databases

ProteinModelPortalQ7RTR8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334050.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM55976719.

Proteomic databases

PaxDbQ7RTR8.
PRIDEQ7RTR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334266; ENSP00000334050; ENSG00000186136.
KEGGhsa:353164.
UCSCuc001qzr.1. human.

Organism-specific databases

CTD353164.
GeneCardsGC12M011338.
HGNCHGNC:18888. TAS2R42.
HPAHPA036149.
MIM613966. gene.
neXtProtNX_Q7RTR8.
PharmGKBPA38741.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43990.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ7RTR8.
KOK08474.
OMAEIFIDIS.
OrthoDBEOG72C512.
PhylomeDBQ7RTR8.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_TAS2R42.
GenevestigatorQ7RTR8.

Family and domain databases

InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R42.
GenomeRNAi353164.
NextBio99726.
PROQ7RTR8.
SOURCESearch...

Entry information

Entry nameT2R42_HUMAN
AccessionPrimary (citable) accession number: Q7RTR8
Secondary accession number(s): A2RRP4, Q645X0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries