Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ornithine aminotransferase

Gene

OAT

Organism
Plasmodium yoelii yoelii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase (OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:OAT
ORF Names:PY00104
OrganismiPlasmodium yoelii yoelii
Taxonomic identifieri73239 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)
Proteomesi
  • UP000008553 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PY00104.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Ornithine aminotransferasePRO_0000233396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi352914.XP_728979.1.

Structurei

Secondary structure

1
414
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2011Combined sources
Beta strandi28 – 3710Combined sources
Beta strandi39 – 424Combined sources
Beta strandi47 – 526Combined sources
Helixi53 – 564Combined sources
Turni57 – 604Combined sources
Helixi65 – 7511Combined sources
Beta strandi85 – 873Combined sources
Helixi88 – 10114Combined sources
Beta strandi104 – 1118Combined sources
Helixi112 – 12918Combined sources
Beta strandi139 – 1435Combined sources
Beta strandi174 – 1774Combined sources
Helixi182 – 1898Combined sources
Beta strandi194 – 1996Combined sources
Beta strandi201 – 2044Combined sources
Turni205 – 2073Combined sources
Helixi215 – 22511Combined sources
Beta strandi229 – 2335Combined sources
Turni235 – 2428Combined sources
Beta strandi243 – 2464Combined sources
Helixi247 – 2515Combined sources
Beta strandi256 – 2605Combined sources
Helixi262 – 2654Combined sources
Beta strandi272 – 2765Combined sources
Helixi278 – 2814Combined sources
Turni292 – 2954Combined sources
Helixi297 – 31216Combined sources
Helixi315 – 33420Combined sources
Beta strandi340 – 3467Combined sources
Beta strandi349 – 3546Combined sources
Turni356 – 3583Combined sources
Helixi361 – 37010Combined sources
Turni379 – 3813Combined sources
Beta strandi382 – 3854Combined sources
Helixi393 – 41018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z7DX-ray2.10A/B/C/D/E/F1-414[»]
ProteinModelPortaliQ7RT90.
SMRiQ7RT90. Positions 8-411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7RT90.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
InParanoidiQ7RT90.
KOiK00819.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RT90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVKDLKTP EDYINNELKY GAHNYDPIPV VLKRAKGVFV YDVNDKRYYD
60 70 80 90 100
FLSAYSSVNQ GHCHPNILNA MINQAKNLTI CSRAFFSVPL GICERYLTNL
110 120 130 140 150
LGYDKVLMMN TGAEANETAY KLCRKWGYEV KKIPENMAKI VVCKNNFSGR
160 170 180 190 200
TLGCISASTT KKCTSNFGPF APQFSKVPYD DLEALEEELK DPNVCAFIVE
210 220 230 240 250
PIQGEAGVIV PSDNYLQGVY DICKKYNVLF VADEVQTGLG RTGKLLCVHH
260 270 280 290 300
YNVKPDVILL GKALSGGHYP ISAVLANDDI MLVIKPGEHG STYGGNPLAA
310 320 330 340 350
SICVEALNVL INEKLCENAE KLGGPFLENL KRELKDSKIV RDVRGKGLLC
360 370 380 390 400
AIEFKNELVN VLDICLKLKE NGLITRDVHD KTIRLTPPLC ITKEQLDECT
410
EIIVKTVKFF DERF
Length:414
Mass (Da):46,267
Last modified:December 15, 2003 - v1
Checksum:i65800F4730BD8B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01000033 Genomic DNA. Translation: EAA20544.1.
RefSeqiXP_728979.1. XM_723886.1.

Genome annotation databases

EnsemblProtistsiEAA20544; EAA20544; EAA20544.
GeneIDi3801528.
KEGGipyo:PY00104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01000033 Genomic DNA. Translation: EAA20544.1.
RefSeqiXP_728979.1. XM_723886.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z7DX-ray2.10A/B/C/D/E/F1-414[»]
ProteinModelPortaliQ7RT90.
SMRiQ7RT90. Positions 8-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi352914.XP_728979.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAA20544; EAA20544; EAA20544.
GeneIDi3801528.
KEGGipyo:PY00104.

Organism-specific databases

EuPathDBiPlasmoDB:PY00104.

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
InParanoidiQ7RT90.
KOiK00819.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Miscellaneous databases

EvolutionaryTraceiQ7RT90.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17XNL.

Entry informationi

Entry nameiOAT_PLAYO
AccessioniPrimary (citable) accession number: Q7RT90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.