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Protein

Ornithine aminotransferase

Gene

OAT

Organism
Plasmodium yoelii yoelii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase (OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:OAT
ORF Names:PY00104
OrganismiPlasmodium yoelii yoelii
Taxonomic identifieri73239 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)
Proteomesi
  • UP000008553 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PY00104.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333961 – 414Ornithine aminotransferaseAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi352914.XP_728979.1.

Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Beta strandi28 – 37Combined sources10
Beta strandi39 – 42Combined sources4
Beta strandi47 – 52Combined sources6
Helixi53 – 56Combined sources4
Turni57 – 60Combined sources4
Helixi65 – 75Combined sources11
Beta strandi85 – 87Combined sources3
Helixi88 – 101Combined sources14
Beta strandi104 – 111Combined sources8
Helixi112 – 129Combined sources18
Beta strandi139 – 143Combined sources5
Beta strandi174 – 177Combined sources4
Helixi182 – 189Combined sources8
Beta strandi194 – 199Combined sources6
Beta strandi201 – 204Combined sources4
Turni205 – 207Combined sources3
Helixi215 – 225Combined sources11
Beta strandi229 – 233Combined sources5
Turni235 – 242Combined sources8
Beta strandi243 – 246Combined sources4
Helixi247 – 251Combined sources5
Beta strandi256 – 260Combined sources5
Helixi262 – 265Combined sources4
Beta strandi272 – 276Combined sources5
Helixi278 – 281Combined sources4
Turni292 – 295Combined sources4
Helixi297 – 312Combined sources16
Helixi315 – 334Combined sources20
Beta strandi340 – 346Combined sources7
Beta strandi349 – 354Combined sources6
Turni356 – 358Combined sources3
Helixi361 – 370Combined sources10
Turni379 – 381Combined sources3
Beta strandi382 – 385Combined sources4
Helixi393 – 410Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z7DX-ray2.10A/B/C/D/E/F1-414[»]
ProteinModelPortaliQ7RT90.
SMRiQ7RT90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7RT90.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
InParanoidiQ7RT90.
KOiK00819.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7RT90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVKDLKTP EDYINNELKY GAHNYDPIPV VLKRAKGVFV YDVNDKRYYD
60 70 80 90 100
FLSAYSSVNQ GHCHPNILNA MINQAKNLTI CSRAFFSVPL GICERYLTNL
110 120 130 140 150
LGYDKVLMMN TGAEANETAY KLCRKWGYEV KKIPENMAKI VVCKNNFSGR
160 170 180 190 200
TLGCISASTT KKCTSNFGPF APQFSKVPYD DLEALEEELK DPNVCAFIVE
210 220 230 240 250
PIQGEAGVIV PSDNYLQGVY DICKKYNVLF VADEVQTGLG RTGKLLCVHH
260 270 280 290 300
YNVKPDVILL GKALSGGHYP ISAVLANDDI MLVIKPGEHG STYGGNPLAA
310 320 330 340 350
SICVEALNVL INEKLCENAE KLGGPFLENL KRELKDSKIV RDVRGKGLLC
360 370 380 390 400
AIEFKNELVN VLDICLKLKE NGLITRDVHD KTIRLTPPLC ITKEQLDECT
410
EIIVKTVKFF DERF
Length:414
Mass (Da):46,267
Last modified:December 15, 2003 - v1
Checksum:i65800F4730BD8B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01000033 Genomic DNA. Translation: EAA20544.1.
RefSeqiXP_728979.1. XM_723886.1.

Genome annotation databases

EnsemblProtistsiEAA20544; EAA20544; EAA20544.
GeneIDi3801528.
KEGGipyo:PY00104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01000033 Genomic DNA. Translation: EAA20544.1.
RefSeqiXP_728979.1. XM_723886.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z7DX-ray2.10A/B/C/D/E/F1-414[»]
ProteinModelPortaliQ7RT90.
SMRiQ7RT90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi352914.XP_728979.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAA20544; EAA20544; EAA20544.
GeneIDi3801528.
KEGGipyo:PY00104.

Organism-specific databases

EuPathDBiPlasmoDB:PY00104.

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
InParanoidiQ7RT90.
KOiK00819.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Miscellaneous databases

EvolutionaryTraceiQ7RT90.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAT_PLAYO
AccessioniPrimary (citable) accession number: Q7RT90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.