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Q7RM49 (CDC2H_PLAYO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:CRK2
ORF Names:PY02339
OrganismPlasmodium yoelii yoelii [Reference proteome]
Taxonomic identifier73239 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-159 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Cell division control protein 2 homolog
PRO_0000232672

Regions

Domain4 – 285282Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1261Proton acceptor By similarity
Binding site321ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1591Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7RM49 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 701FCFCEEA4F5CA3

FASTA28933,121
        10         20         30         40         50         60 
MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTVSIR EISILKELRH 

        70         80         90        100        110        120 
SNIVKLYDVI HAKKRLILVF EHLDQDLKKL IDVCDGGLES VTAKSFLLQL LNGIAYCHEH 

       130        140        150        160        170        180 
RVLHRDLKPQ NLLINREGEL KIADFGLARA FGIPARRYTH EVVTLWYRAP DILMGSKKYS 

       190        200        210        220        230        240 
TPIDIWSVGC IFAEMVNGRP LFPGVSETDQ LMRIFKILGT PNSQNWPDVF KLPKYDPNFP 

       250        260        270        280 
VYEPLPWETF IKGLDDTGID LLSKMLKLDP NQRITAKQAI EHPYFKETN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABL01000639 Genomic DNA. Translation: EAA21777.1.
RefSeqXP_730212.1. XM_725119.1.

3D structure databases

ProteinModelPortalQ7RM49.
SMRQ7RM49. Positions 1-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING73239.Q7RM49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3807518.
KEGGpyo:PY02339.

Organism-specific databases

EuPathDBPlasmoDB:PY17X_1134700.

Phylogenomic databases

eggNOGCOG0515.
KOK04563.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2H_PLAYO
AccessionPrimary (citable) accession number: Q7RM49
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families