Q7REH6 (GST_PLAYO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase
EC=2.5.1.18

Gene names

Name:	GST
ORF Names:	PY05088

Organism

Plasmodium yoelii yoelii [Reference proteome]

Taxonomic identifier

73239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Vinckeia) › Plasmodium yoelii

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Glutathione S-transferase		PRO_0000259969
Regions
	Domain	7 – 91	85	GST N-terminal
	Domain	93 – 209	117	GST C-terminal
	Region	62 – 63	2	Glutathione binding By similarity
	Region	75 – 76	2	Glutathione binding By similarity
Sites
	Binding site	5	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7REH6 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: A4A7FAB3AC69CF6D	FASTA	209	24,693
	10 20 30 40 50 60 MTYLYNFFFF FFFFFSRGKA ELIRLIFAYL QVKYTDIRFG VNGDAFAEFN NFKKEKEIPF 70 80 90 100 110 120 NQVPILEIGG LILAQSQAIV RYLSKKYNIS GNGELNEFYA DMIFCGVQDI HYKFNNTNLF 130 140 150 160 170 180 KQNETTFLNE ELPKWSGYFE KLLQKNNTNY FVGDTITYAD LAVFNLYDDI ESKYPNCLKN 190 200 FPLLKAHIEL ISNIPNIKHY IANRKESVY

References

[1]

"Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii." Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C., Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M., Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E., Riedmuller S.B. , Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M., Shoaibi A., Cummings L.M., Florens L., Yates J.R. III, Raine J.D., Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W., Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R., Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J., Carucci D.J. Nature 419:512-519(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17XNL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABL01001592 Genomic DNA. Translation: EAA17054.1.
RefSeq	XP_725489.1. XM_720396.1.
3D structure databases
ProteinModelPortal	Q7REH6.
SMR	Q7REH6. Positions 11-209.
ModBase	Search...
Protein-protein interaction databases
STRING	73239.Q7REH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3790828.
KEGG	pyo:PY05088.
Organism-specific databases
EuPathDB	PlasmoDB:PY05088.
Phylogenomic databases
eggNOG	NOG05174.
KO	K00799.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1741263.

Entry information

Entry name

GST_PLAYO

Accession

Primary (citable) accession number: Q7REH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	December 15, 2003
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)