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Protein

Glutathione S-transferase

Gene

GST

Organism
Plasmodium yoelii yoelii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei5 – 51GlutathioneBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 4895.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Gene namesi
Name:GST
ORF Names:PY05088
OrganismiPlasmodium yoelii yoelii
Taxonomic identifieri73239 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)
ProteomesiUP000008553 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PY05088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Glutathione S-transferasePRO_0000259969Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi352914.XP_725489.1.

Structurei

3D structure databases

ProteinModelPortaliQ7REH6.
SMRiQ7REH6. Positions 11-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9185GST N-terminalAdd
BLAST
Domaini93 – 209117GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 632Glutathione bindingBy similarity
Regioni75 – 762Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
InParanoidiQ7REH6.
KOiK00799.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7REH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYLYNFFFF FFFFFSRGKA ELIRLIFAYL QVKYTDIRFG VNGDAFAEFN
60 70 80 90 100
NFKKEKEIPF NQVPILEIGG LILAQSQAIV RYLSKKYNIS GNGELNEFYA
110 120 130 140 150
DMIFCGVQDI HYKFNNTNLF KQNETTFLNE ELPKWSGYFE KLLQKNNTNY
160 170 180 190 200
FVGDTITYAD LAVFNLYDDI ESKYPNCLKN FPLLKAHIEL ISNIPNIKHY

IANRKESVY
Length:209
Mass (Da):24,693
Last modified:December 15, 2003 - v1
Checksum:iA4A7FAB3AC69CF6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01001592 Genomic DNA. Translation: EAA17054.1.
RefSeqiXP_725489.1. XM_720396.1.

Genome annotation databases

GeneIDi3790828.
KEGGipyo:PY05088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01001592 Genomic DNA. Translation: EAA17054.1.
RefSeqiXP_725489.1. XM_720396.1.

3D structure databases

ProteinModelPortaliQ7REH6.
SMRiQ7REH6. Positions 11-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi352914.XP_725489.1.

Chemistry

ChEMBLiCHEMBL1741263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3790828.
KEGGipyo:PY05088.

Organism-specific databases

EuPathDBiPlasmoDB:PY05088.

Phylogenomic databases

eggNOGiNOG05174.
InParanoidiQ7REH6.
KOiK00799.

Enzyme and pathway databases

BRENDAi2.5.1.18. 4895.

Miscellaneous databases

PROiQ7REH6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17XNL.

Entry informationi

Entry nameiGST_PLAYO
AccessioniPrimary (citable) accession number: Q7REH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 15, 2003
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.