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Q7RBD6

- LIPA_PLAYO

UniProt

Q7RBD6 - LIPA_PLAYO

Protein

Lipoyl synthase, apicoplast

Gene

lipA

Organism
Plasmodium yoelii yoelii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

    Catalytic activityi

    Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.

    Cofactori

    Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi192 – 1921Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi197 – 1971Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi203 – 2031Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi222 – 2221Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi225 – 2251Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. lipoate synthase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein lipoylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00538; UER00593.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoyl synthase, apicoplastUniRule annotation (EC:2.8.1.8UniRule annotation)
    Alternative name(s):
    Lipoate synthaseUniRule annotation
    Short name:
    LSUniRule annotation
    Short name:
    Lip-synUniRule annotation
    Lipoic acid synthaseUniRule annotation
    Gene namesi
    Name:lipAUniRule annotation
    ORF Names:PY06208
    OrganismiPlasmodium yoelii yoelii
    Taxonomic identifieri73239 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)
    ProteomesiUP000008553: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiPlasmoDB:PY06208.

    Subcellular locationi

    Plastidapicoplast UniRule annotation

    GO - Cellular componenti

    1. apicoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apicoplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616UniRule annotationAdd
    BLAST
    Chaini17 – 502486Lipoyl synthase, apicoplastPRO_0000398233Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi73239.Q7RBD6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7RBD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0320.
    KOiK03644.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00206. Lipoyl_synth.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view]
    PANTHERiPTHR10949. PTHR10949. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00510. lipA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7RBD6-1 [UniParc]FASTAAdd to Basket

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    MNFLVLFFSY SIFVLPYSIL VYGISKDRKC CEYGNSVDSS KILYIAGSVR    50
    KRRKTFEKKI NVSNFEREGN ANGYKHIDNK GIYATKQNLE FDEARNKEAN 100
    ENNKNDATTV NRKIIIESEN KNNHNNQEQN IKDCYTNENA QNDEKNKKVK 150
    IPKVGNAMPE KKPDWFHVPA PNGEKYKKLK SDLGKLKLHT VCEEAQCPNI 200
    GECWNIGTAT IMLLGDTCTR GCKFCSIKTS SKPPPPDINE PFNTAKAICE 250
    WDINYIVITS VDRDDLPDGG ADHFAKTVEL IKFSKPSILI ECLVSDFQGN 300
    IDSIKRLALS GLDVYAHNIE TVKRLQKYVR DKRANYEQSL YVLKKAKEIN 350
    PNLYTKTSIM LGLGETQDEV LQTMKDARSN DIDVITFGQY LRPTKNHLNV 400
    VEYISPQMFN YYKDVGLKMG FKYIASGPLV RSSYMAGEYF MKNMVEKGRN 450
    QKNQQIKPVE LKLVTELDKL TECIQKEIKH REISVFIQVH AFLVNVFVLV 500
    RA 502
    Length:502
    Mass (Da):57,463
    Last modified:December 15, 2003 - v1
    Checksum:i77AD72396A80E94D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABL01002075 Genomic DNA. Translation: EAA18375.1.
    RefSeqiXP_726810.1. XM_721717.1.

    Genome annotation databases

    GeneIDi3792150.
    KEGGipyo:PY06208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABL01002075 Genomic DNA. Translation: EAA18375.1 .
    RefSeqi XP_726810.1. XM_721717.1.

    3D structure databases

    ProteinModelPortali Q7RBD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 73239.Q7RBD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3792150.
    KEGGi pyo:PY06208.

    Organism-specific databases

    EuPathDBi PlasmoDB:PY06208.

    Phylogenomic databases

    eggNOGi COG0320.
    KOi K03644.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00593 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00206. Lipoyl_synth.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view ]
    PANTHERi PTHR10949. PTHR10949. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00510. lipA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17XNL.

    Entry informationi

    Entry nameiLIPA_PLAYO
    AccessioniPrimary (citable) accession number: Q7RBD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3