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Q7RBD6

- LIPA_PLAYO

UniProt

Q7RBD6 - LIPA_PLAYO

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Protein

Lipoyl synthase, apicoplast

Gene

lipA

Organism
Plasmodium yoelii yoelii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi192 – 1921Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi197 – 1971Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi203 – 2031Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi218 – 2181Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi222 – 2221Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi225 – 2251Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, apicoplastUniRule annotation (EC:2.8.1.8UniRule annotation)
Alternative name(s):
Lipoate synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lip-synUniRule annotation
Lipoic acid synthaseUniRule annotation
Gene namesi
Name:lipAUniRule annotation
ORF Names:PY06208
OrganismiPlasmodium yoelii yoelii
Taxonomic identifieri73239 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)
ProteomesiUP000008553: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PY06208.

Subcellular locationi

Plastidapicoplast UniRule annotation

GO - Cellular componenti

  1. apicoplast Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Apicoplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 502486Lipoyl synthase, apicoplastPRO_0000398233Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi73239.Q7RBD6.

Structurei

3D structure databases

ProteinModelPortaliQ7RBD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0320.
InParanoidiQ7RBD6.
KOiK03644.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7RBD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFLVLFFSY SIFVLPYSIL VYGISKDRKC CEYGNSVDSS KILYIAGSVR
60 70 80 90 100
KRRKTFEKKI NVSNFEREGN ANGYKHIDNK GIYATKQNLE FDEARNKEAN
110 120 130 140 150
ENNKNDATTV NRKIIIESEN KNNHNNQEQN IKDCYTNENA QNDEKNKKVK
160 170 180 190 200
IPKVGNAMPE KKPDWFHVPA PNGEKYKKLK SDLGKLKLHT VCEEAQCPNI
210 220 230 240 250
GECWNIGTAT IMLLGDTCTR GCKFCSIKTS SKPPPPDINE PFNTAKAICE
260 270 280 290 300
WDINYIVITS VDRDDLPDGG ADHFAKTVEL IKFSKPSILI ECLVSDFQGN
310 320 330 340 350
IDSIKRLALS GLDVYAHNIE TVKRLQKYVR DKRANYEQSL YVLKKAKEIN
360 370 380 390 400
PNLYTKTSIM LGLGETQDEV LQTMKDARSN DIDVITFGQY LRPTKNHLNV
410 420 430 440 450
VEYISPQMFN YYKDVGLKMG FKYIASGPLV RSSYMAGEYF MKNMVEKGRN
460 470 480 490 500
QKNQQIKPVE LKLVTELDKL TECIQKEIKH REISVFIQVH AFLVNVFVLV

RA
Length:502
Mass (Da):57,463
Last modified:December 15, 2003 - v1
Checksum:i77AD72396A80E94D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01002075 Genomic DNA. Translation: EAA18375.1.
RefSeqiXP_726810.1. XM_721717.1.

Genome annotation databases

GeneIDi3792150.
KEGGipyo:PY06208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABL01002075 Genomic DNA. Translation: EAA18375.1 .
RefSeqi XP_726810.1. XM_721717.1.

3D structure databases

ProteinModelPortali Q7RBD6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 73239.Q7RBD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3792150.
KEGGi pyo:PY06208.

Organism-specific databases

EuPathDBi PlasmoDB:PY06208.

Phylogenomic databases

eggNOGi COG0320.
InParanoidi Q7RBD6.
KOi K03644.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17XNL.

Entry informationi

Entry nameiLIPA_PLAYO
AccessioniPrimary (citable) accession number: Q7RBD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3