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Q7QIL8

- EIF3E_ANOGA

UniProt

Q7QIL8 - EIF3E_ANOGA

Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eIF3-S6

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit EUniRule annotation
    Short name:
    eIF3eUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
    Gene namesi
    Name:eIF3-S6
    ORF Names:AGAP006944
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2L

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Eukaryotic translation initiation factor 3 subunit EPRO_0000365960Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi7165.AGAP006944-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7QIL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 387106PCIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit E family.UniRule annotation
    Contains 1 PCI domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG324642.
    HOGENOMiHOG000036697.
    KOiK03250.
    OMAiHNASEED.
    OrthoDBiEOG7QNVKP.
    PhylomeDBiQ7QIL8.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_03004. eIF3e.
    InterProiIPR016650. eIF3e.
    IPR019010. eIF3e_N.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10317. PTHR10317. 1 hit.
    PfamiPF09440. eIF3_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
    SMARTiSM00088. PINT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7QIL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKFDLTAKN CQYLDRHLTF PLLEFLLQKK VFDQTSLLKF ILETVSKTNM    50
    VDYKHDIRER LAMDKVHPDE LAQGRANVLA TLKELQAEVA PLMKCMEELK 100
    NPDSTKDSKS VIHALQQTLD YDIILSAQKL AKYLYECGNY NDSLSYLYVC 150
    MLVMEPNDKN YLGVLWGKLA VEILTLNWQT ALEDLTRLRD FIENYNFSPI 200
    QVLQQRAWLI HWSVLVFFNH GKGRDLIIDM FLYKPQYLNA IQTMCPHILR 250
    YLATAVIINR GRRNALKDLI KVIQQESYTY RDPITEFLEH LYVNFDFEGA 300
    RKKLHECQTV IVNDFFIIGC LTEFVENARL MIFETFCRIH QCITIGMLAD 350
    KLNMKPDEAE CWIVNLIRNA RLDAKIDSKL GHVVMGTQPL SPYQQLVEKI 400
    DSLSVRSEAL TLLVERKHKA KTQEAGEGHW KYY 433
    Length:433
    Mass (Da):50,489
    Last modified:December 7, 2004 - v2
    Checksum:i675D52209410A7F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008807 Genomic DNA. Translation: EAA04727.2.
    RefSeqiXP_308812.2. XM_308812.4.

    Genome annotation databases

    EnsemblMetazoaiAGAP006944-RA; AGAP006944-PA; AGAP006944.
    GeneIDi1270140.
    KEGGiaga:AgaP_AGAP006944.
    VectorBaseiAGAP006944. Anopheles gambiae.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008807 Genomic DNA. Translation: EAA04727.2 .
    RefSeqi XP_308812.2. XM_308812.4.

    3D structure databases

    ProteinModelPortali Q7QIL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7165.AGAP006944-PA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP006944-RA ; AGAP006944-PA ; AGAP006944 .
    GeneIDi 1270140.
    KEGGi aga:AgaP_AGAP006944.
    VectorBasei AGAP006944. Anopheles gambiae.

    Organism-specific databases

    CTDi 1270140.

    Phylogenomic databases

    eggNOGi NOG324642.
    HOGENOMi HOG000036697.
    KOi K03250.
    OMAi HNASEED.
    OrthoDBi EOG7QNVKP.
    PhylomeDBi Q7QIL8.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_03004. eIF3e.
    InterProi IPR016650. eIF3e.
    IPR019010. eIF3e_N.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10317. PTHR10317. 1 hit.
    Pfami PF09440. eIF3_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
    SMARTi SM00088. PINT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PEST.

    Entry informationi

    Entry nameiEIF3E_ANOGA
    AccessioniPrimary (citable) accession number: Q7QIL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3