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Q7QIL8

- EIF3E_ANOGA

UniProt

Q7QIL8 - EIF3E_ANOGA

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Protein
Eukaryotic translation initiation factor 3 subunit E
Gene
eIF3-S6, AGAP006944
Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit E
Short name:
eIF3e
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6
Gene namesi
Name:eIF3-S6
ORF Names:AGAP006944
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2L

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Eukaryotic translation initiation factor 3 subunit EUniRule annotation
PRO_0000365960Add
BLAST

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.

Protein-protein interaction databases

STRINGi7165.AGAP006944-PA.

Structurei

3D structure databases

ProteinModelPortaliQ7QIL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 387106PCI
Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.
Contains 1 PCI domain.

Phylogenomic databases

eggNOGiNOG324642.
HOGENOMiHOG000036697.
KOiK03250.
OMAiHNASEED.
OrthoDBiEOG7QNVKP.
PhylomeDBiQ7QIL8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7QIL8-1 [UniParc]FASTAAdd to Basket

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MAKFDLTAKN CQYLDRHLTF PLLEFLLQKK VFDQTSLLKF ILETVSKTNM    50
VDYKHDIRER LAMDKVHPDE LAQGRANVLA TLKELQAEVA PLMKCMEELK 100
NPDSTKDSKS VIHALQQTLD YDIILSAQKL AKYLYECGNY NDSLSYLYVC 150
MLVMEPNDKN YLGVLWGKLA VEILTLNWQT ALEDLTRLRD FIENYNFSPI 200
QVLQQRAWLI HWSVLVFFNH GKGRDLIIDM FLYKPQYLNA IQTMCPHILR 250
YLATAVIINR GRRNALKDLI KVIQQESYTY RDPITEFLEH LYVNFDFEGA 300
RKKLHECQTV IVNDFFIIGC LTEFVENARL MIFETFCRIH QCITIGMLAD 350
KLNMKPDEAE CWIVNLIRNA RLDAKIDSKL GHVVMGTQPL SPYQQLVEKI 400
DSLSVRSEAL TLLVERKHKA KTQEAGEGHW KYY 433
Length:433
Mass (Da):50,489
Last modified:December 7, 2004 - v2
Checksum:i675D52209410A7F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008807 Genomic DNA. Translation: EAA04727.2.
RefSeqiXP_308812.2. XM_308812.4.

Genome annotation databases

EnsemblMetazoaiAGAP006944-RA; AGAP006944-PA; AGAP006944.
GeneIDi1270140.
KEGGiaga:AgaP_AGAP006944.
VectorBaseiAGAP006944. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008807 Genomic DNA. Translation: EAA04727.2 .
RefSeqi XP_308812.2. XM_308812.4.

3D structure databases

ProteinModelPortali Q7QIL8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7165.AGAP006944-PA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP006944-RA ; AGAP006944-PA ; AGAP006944 .
GeneIDi 1270140.
KEGGi aga:AgaP_AGAP006944.
VectorBasei AGAP006944. Anopheles gambiae.

Organism-specific databases

CTDi 1270140.

Phylogenomic databases

eggNOGi NOG324642.
HOGENOMi HOG000036697.
KOi K03250.
OMAi HNASEED.
OrthoDBi EOG7QNVKP.
PhylomeDBi Q7QIL8.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03004. eIF3e.
InterProi IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10317. PTHR10317. 1 hit.
Pfami PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiEIF3E_ANOGA
AccessioniPrimary (citable) accession number: Q7QIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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