Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7QHW5 (ARM_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Armadillo segment polarity protein
Gene names
Name:arm
ORF Names:AGAP001043
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length850 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity. UniProtKB P18824

Subcellular location

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity. Note: Inner surface of cell membrane and adherens junction By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 9 ARM repeats.

Ontologies

Keywords
   Biological processCell adhesion
Wnt signaling pathway
   Cellular componentCell junction
Cell membrane
Cytoplasm
Membrane
   DomainRepeat
   Molecular functionDevelopmental protein
Segmentation polarity protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoskeletal anchoring at plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

gastrulation

Inferred from Biological aspect of Ancestor. Source: RefGenome

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

morphogenesis of embryonic epithelium

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of heart induction by canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

nervous system development

Inferred from Biological aspect of Ancestor. Source: RefGenome

oocyte development

Inferred from Biological aspect of Ancestor. Source: RefGenome

segment polarity determination

Inferred from electronic annotation. Source: UniProtKB-KW

single organismal cell-cell adhesion

Inferred from Biological aspect of Ancestor. Source: RefGenome

vesicle-mediated transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentZ disc

Inferred from Biological aspect of Ancestor. Source: RefGenome

basolateral plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

catenin complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic side of plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

desmosome

Inferred from Biological aspect of Ancestor. Source: RefGenome

fascia adherens

Inferred from Biological aspect of Ancestor. Source: RefGenome

membrane coat

Inferred from electronic annotation. Source: InterPro

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

zonula adherens

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionalpha-catenin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

cadherin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein kinase binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

structural molecule activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription coactivator activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 850850Armadillo segment polarity protein
PRO_0000064291

Regions

Repeat146 – 18540ARM 1
Repeat188 – 22841ARM 2
Repeat230 – 26940ARM 3
Repeat272 – 31140ARM 4
Repeat356 – 39540ARM 5
Repeat397 – 43438ARM 6
Repeat483 – 52442ARM 7
Repeat594 – 63441ARM 8
Repeat636 – 67540ARM 9
Compositional bias724 – 80481Gly-rich

Sequences

Sequence LengthMass (Da)Tools
Q7QHW5 [UniParc].

Last modified May 16, 2012. Version 5.
Checksum: 44233E955FCB41CB

FASTA85091,665
        10         20         30         40         50         60 
MSYQMPQNRS MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT QVPSLSGKDD 

        70         80         90        100        110        120 
DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR AAMFPETLEE GIEIPSTQFD 

       130        140        150        160        170        180 
PQQPTAVQRL AEPSQMLKHA VVNLINYQDD ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV 

       190        200        210        220        230        240 
HQLSKKEASR HAIMNSPQMV AALVRALSNS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG 

       250        260        270        280        290        300 
GIPALVKLLS SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 

       310        320        330        340        350        360 
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK VLSVCSSNKP 

       370        380        390        400        410        420 
AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV DGLETLLSGL VTVLGSSDVN 

       430        440        450        460        470        480 
VVTCAAGILS NLTCNNQRNK VTVCQVGGVE ALVGTIINAG DREEITEPAV CALRHLTSRH 

       490        500        510        520        530        540 
PESESAQNVV RNGYGLPVIV KLLNPPSRWP LIKAVIGLIR NLALCPANAA PLREHGAIHL 

       550        560        570        580        590        600 
LVRLLFKAFQ DTQRQRSSVA SNGSQPPGAY ADGVRMEEIV EGTVGALHIL AKEEYNRQVI 

       610        620        630        640        650        660 
RSQNVIPIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP LTELLNSANE 

       670        680        690        700        710        720 
GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDSM WNNGELGIGP DLQDILSPEQ 

       730        740        750        760        770        780 
AYEGLYGQGP ASVHSSHGGR AFQQGYDTLP IDSMQGLEIG GGGGSSNGGA TGNGGMGGQQ 

       790        800        810        820        830        840 
QQSGGGPGSV VMGGGGASGM SSSGQPTSPY GMDMDVGEME ASELTFDHLD VMPSPPQDNN 

       850 
QVAAWYDTDL 

« Hide

References

[1]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAAB01008811 Genomic DNA. Translation: EAA04913.5.
RefSeqXP_309245.5. XM_309245.5.

3D structure databases

ProteinModelPortalQ7QHW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7165.AGAP001043-PA.

Proteomic databases

PRIDEQ7QHW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP001043-RA; AGAP001043-PA; AGAP001043.
GeneID1270538.
KEGGaga:AgaP_AGAP001043.
VectorBaseAGAP001043. Anopheles gambiae.

Phylogenomic databases

eggNOGNOG297695.
HOGENOMHOG000230958.
InParanoidQ7QHW5.
OrthoDBEOG7X9G6B.
PhylomeDBQ7QHW5.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSPR01869. BCATNINFAMLY.
SMARTSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARM_ANOGA
AccessionPrimary (citable) accession number: Q7QHW5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 16, 2012
Last modified: July 9, 2014
This is version 87 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families