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Protein

Armadillo segment polarity protein

Gene

arm

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity).By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: GO_Central
  2. cadherin binding Source: GO_Central
  3. nuclear hormone receptor binding Source: GO_Central
  4. protein phosphatase binding Source: GO_Central
  5. signal transducer activity Source: InterPro
  6. transcription coactivator activity Source: GO_Central

GO - Biological processi

  1. adherens junction assembly Source: InterPro
  2. cell adhesion Source: UniProtKB-KW
  3. intracellular protein transport Source: InterPro
  4. positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  5. regulation of cell fate specification Source: GO_Central
  6. segment polarity determination Source: UniProtKB-KW
  7. vesicle-mediated transport Source: InterPro
  8. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
ORF Names:AGAP001043
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Chromosome X

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction.By similarity

GO - Cellular componenti

  1. catenin complex Source: GO_Central
  2. cell-cell adherens junction Source: GO_Central
  3. cytoplasm Source: GO_Central
  4. membrane coat Source: InterPro
  5. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 850850Armadillo segment polarity proteinPRO_0000064291Add
BLAST

Proteomic databases

PRIDEiQ7QHW5.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP001043-PA.

Structurei

3D structure databases

ProteinModelPortaliQ7QHW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 18540ARM 1Add
BLAST
Repeati188 – 22841ARM 2Add
BLAST
Repeati230 – 26940ARM 3Add
BLAST
Repeati272 – 31140ARM 4Add
BLAST
Repeati356 – 39540ARM 5Add
BLAST
Repeati397 – 43438ARM 6Add
BLAST
Repeati483 – 52442ARM 7Add
BLAST
Repeati594 – 63441ARM 8Add
BLAST
Repeati636 – 67540ARM 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi724 – 80481Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence Analysis
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ7QHW5.
KOiK02105.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ7QHW5.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7QHW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQMPQNRS MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT
60 70 80 90 100
QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR
110 120 130 140 150
AAMFPETLEE GIEIPSTQFD PQQPTAVQRL AEPSQMLKHA VVNLINYQDD
160 170 180 190 200
ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV
210 220 230 240 250
AALVRALSNS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS
260 270 280 290 300
SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
310 320 330 340 350
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK
360 370 380 390 400
VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV
410 420 430 440 450
DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE
460 470 480 490 500
ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNVV RNGYGLPVIV
510 520 530 540 550
KLLNPPSRWP LIKAVIGLIR NLALCPANAA PLREHGAIHL LVRLLFKAFQ
560 570 580 590 600
DTQRQRSSVA SNGSQPPGAY ADGVRMEEIV EGTVGALHIL AKEEYNRQVI
610 620 630 640 650
RSQNVIPIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP
660 670 680 690 700
LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDSM
710 720 730 740 750
WNNGELGIGP DLQDILSPEQ AYEGLYGQGP ASVHSSHGGR AFQQGYDTLP
760 770 780 790 800
IDSMQGLEIG GGGGSSNGGA TGNGGMGGQQ QQSGGGPGSV VMGGGGASGM
810 820 830 840 850
SSSGQPTSPY GMDMDVGEME ASELTFDHLD VMPSPPQDNN QVAAWYDTDL
Length:850
Mass (Da):91,665
Last modified:May 15, 2012 - v5
Checksum:i44233E955FCB41CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008811 Genomic DNA. Translation: EAA04913.5.
RefSeqiXP_309245.5. XM_309245.5.

Genome annotation databases

EnsemblMetazoaiAGAP001043-RA; AGAP001043-PA; AGAP001043.
GeneIDi1270538.
KEGGiaga:AgaP_AGAP001043.
VectorBaseiAGAP001043. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008811 Genomic DNA. Translation: EAA04913.5.
RefSeqiXP_309245.5. XM_309245.5.

3D structure databases

ProteinModelPortaliQ7QHW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP001043-PA.

Proteomic databases

PRIDEiQ7QHW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP001043-RA; AGAP001043-PA; AGAP001043.
GeneIDi1270538.
KEGGiaga:AgaP_AGAP001043.
VectorBaseiAGAP001043. Anopheles gambiae.

Organism-specific databases

CTDi1270538.

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ7QHW5.
KOiK02105.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ7QHW5.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiARM_ANOGA
AccessioniPrimary (citable) accession number: Q7QHW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: May 15, 2012
Last modified: March 3, 2015
This is version 92 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.