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Q7QHW5

- ARM_ANOGA

UniProt

Q7QHW5 - ARM_ANOGA

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Protein

Armadillo segment polarity protein

Gene
arm, AGAP001043
Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: RefGenome
  2. cadherin binding Source: RefGenome
  3. protein kinase binding Source: RefGenome
  4. structural molecule activity Source: RefGenome
  5. transcription coactivator activity Source: RefGenome

GO - Biological processi

  1. cell morphogenesis Source: RefGenome
  2. cytoskeletal anchoring at plasma membrane Source: RefGenome
  3. gastrulation Source: RefGenome
  4. intracellular protein transport Source: InterPro
  5. morphogenesis of embryonic epithelium Source: RefGenome
  6. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  7. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  8. nervous system development Source: RefGenome
  9. oocyte development Source: RefGenome
  10. segment polarity determination Source: UniProtKB-KW
  11. single organismal cell-cell adhesion Source: RefGenome
  12. vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Segmentation polarity protein

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo segment polarity protein
Gene namesi
Name:arm
ORF Names:AGAP001043
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome X

Subcellular locationi

Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
Note: Inner surface of cell membrane and adherens junction By similarity.

GO - Cellular componenti

  1. basolateral plasma membrane Source: RefGenome
  2. catenin complex Source: RefGenome
  3. cytoplasmic side of plasma membrane Source: RefGenome
  4. cytosol Source: RefGenome
  5. desmosome Source: RefGenome
  6. fascia adherens Source: RefGenome
  7. membrane coat Source: InterPro
  8. transcription factor complex Source: RefGenome
  9. Z disc Source: RefGenome
  10. zonula adherens Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 850850Armadillo segment polarity proteinPRO_0000064291Add
BLAST

Proteomic databases

PRIDEiQ7QHW5.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP001043-PA.

Structurei

3D structure databases

ProteinModelPortaliQ7QHW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 18540ARM 1Add
BLAST
Repeati188 – 22841ARM 2Add
BLAST
Repeati230 – 26940ARM 3Add
BLAST
Repeati272 – 31140ARM 4Add
BLAST
Repeati356 – 39540ARM 5Add
BLAST
Repeati397 – 43438ARM 6Add
BLAST
Repeati483 – 52442ARM 7Add
BLAST
Repeati594 – 63441ARM 8Add
BLAST
Repeati636 – 67540ARM 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi724 – 80481Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
HOGENOMiHOG000230958.
InParanoidiQ7QHW5.
KOiK02105.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ7QHW5.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 11 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7QHW5-1 [UniParc]FASTAAdd to Basket

« Hide

MSYQMPQNRS MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT    50
QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR 100
AAMFPETLEE GIEIPSTQFD PQQPTAVQRL AEPSQMLKHA VVNLINYQDD 150
ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV 200
AALVRALSNS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS 250
SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 300
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK 350
VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV 400
DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE 450
ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNVV RNGYGLPVIV 500
KLLNPPSRWP LIKAVIGLIR NLALCPANAA PLREHGAIHL LVRLLFKAFQ 550
DTQRQRSSVA SNGSQPPGAY ADGVRMEEIV EGTVGALHIL AKEEYNRQVI 600
RSQNVIPIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP 650
LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDSM 700
WNNGELGIGP DLQDILSPEQ AYEGLYGQGP ASVHSSHGGR AFQQGYDTLP 750
IDSMQGLEIG GGGGSSNGGA TGNGGMGGQQ QQSGGGPGSV VMGGGGASGM 800
SSSGQPTSPY GMDMDVGEME ASELTFDHLD VMPSPPQDNN QVAAWYDTDL 850
Length:850
Mass (Da):91,665
Last modified:May 16, 2012 - v5
Checksum:i44233E955FCB41CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008811 Genomic DNA. Translation: EAA04913.5.
RefSeqiXP_309245.5. XM_309245.5.

Genome annotation databases

EnsemblMetazoaiAGAP001043-RA; AGAP001043-PA; AGAP001043.
GeneIDi1270538.
KEGGiaga:AgaP_AGAP001043.
VectorBaseiAGAP001043. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAAB01008811 Genomic DNA. Translation: EAA04913.5 .
RefSeqi XP_309245.5. XM_309245.5.

3D structure databases

ProteinModelPortali Q7QHW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7165.AGAP001043-PA.

Proteomic databases

PRIDEi Q7QHW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP001043-RA ; AGAP001043-PA ; AGAP001043 .
GeneIDi 1270538.
KEGGi aga:AgaP_AGAP001043.
VectorBasei AGAP001043. Anopheles gambiae.

Organism-specific databases

CTDi 1270538.

Phylogenomic databases

eggNOGi NOG297695.
HOGENOMi HOG000230958.
InParanoidi Q7QHW5.
KOi K02105.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q7QHW5.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 11 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiARM_ANOGA
AccessioniPrimary (citable) accession number: Q7QHW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 88 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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