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Q7QHW5

- ARM_ANOGA

UniProt

Q7QHW5 - ARM_ANOGA

Protein

Armadillo segment polarity protein

Gene

arm

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 5 (16 May 2012)
      Previous versions | rss
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    Functioni

    May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis By similarity.By similarity

    GO - Molecular functioni

    1. alpha-catenin binding Source: RefGenome
    2. cadherin binding Source: RefGenome
    3. protein kinase binding Source: RefGenome
    4. structural molecule activity Source: RefGenome
    5. transcription coactivator activity Source: RefGenome

    GO - Biological processi

    1. cell morphogenesis Source: RefGenome
    2. cytoskeletal anchoring at plasma membrane Source: RefGenome
    3. gastrulation Source: RefGenome
    4. intracellular protein transport Source: InterPro
    5. morphogenesis of embryonic epithelium Source: RefGenome
    6. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
    7. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
    8. nervous system development Source: RefGenome
    9. oocyte development Source: RefGenome
    10. segment polarity determination Source: UniProtKB-KW
    11. single organismal cell-cell adhesion Source: RefGenome
    12. vesicle-mediated transport Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Segmentation polarity protein

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo segment polarity protein
    Gene namesi
    Name:arm
    ORF Names:AGAP001043
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome X

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctionadherens junction By similarity
    Note: Inner surface of cell membrane and adherens junction.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RefGenome
    2. catenin complex Source: RefGenome
    3. cytoplasmic side of plasma membrane Source: RefGenome
    4. cytosol Source: RefGenome
    5. desmosome Source: RefGenome
    6. fascia adherens Source: RefGenome
    7. membrane coat Source: InterPro
    8. transcription factor complex Source: RefGenome
    9. Z disc Source: RefGenome
    10. zonula adherens Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 850850Armadillo segment polarity proteinPRO_0000064291Add
    BLAST

    Proteomic databases

    PRIDEiQ7QHW5.

    Interactioni

    Protein-protein interaction databases

    STRINGi7165.AGAP001043-PA.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7QHW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati146 – 18540ARM 1Add
    BLAST
    Repeati188 – 22841ARM 2Add
    BLAST
    Repeati230 – 26940ARM 3Add
    BLAST
    Repeati272 – 31140ARM 4Add
    BLAST
    Repeati356 – 39540ARM 5Add
    BLAST
    Repeati397 – 43438ARM 6Add
    BLAST
    Repeati483 – 52442ARM 7Add
    BLAST
    Repeati594 – 63441ARM 8Add
    BLAST
    Repeati636 – 67540ARM 9Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi724 – 80481Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-catenin family.Sequence Analysis
    Contains 9 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    HOGENOMiHOG000230958.
    InParanoidiQ7QHW5.
    KOiK02105.
    OrthoDBiEOG7X9G6B.
    PhylomeDBiQ7QHW5.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 11 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7QHW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYQMPQNRS MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT    50
    QVPSLSGKDD DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR 100
    AAMFPETLEE GIEIPSTQFD PQQPTAVQRL AEPSQMLKHA VVNLINYQDD 150
    ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV HQLSKKEASR HAIMNSPQMV 200
    AALVRALSNS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG GIPALVKLLS 250
    SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA 300
    IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK 350
    VLSVCSSNKP AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV 400
    DGLETLLSGL VTVLGSSDVN VVTCAAGILS NLTCNNQRNK VTVCQVGGVE 450
    ALVGTIINAG DREEITEPAV CALRHLTSRH PESESAQNVV RNGYGLPVIV 500
    KLLNPPSRWP LIKAVIGLIR NLALCPANAA PLREHGAIHL LVRLLFKAFQ 550
    DTQRQRSSVA SNGSQPPGAY ADGVRMEEIV EGTVGALHIL AKEEYNRQVI 600
    RSQNVIPIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP 650
    LTELLNSANE GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDSM 700
    WNNGELGIGP DLQDILSPEQ AYEGLYGQGP ASVHSSHGGR AFQQGYDTLP 750
    IDSMQGLEIG GGGGSSNGGA TGNGGMGGQQ QQSGGGPGSV VMGGGGASGM 800
    SSSGQPTSPY GMDMDVGEME ASELTFDHLD VMPSPPQDNN QVAAWYDTDL 850
    Length:850
    Mass (Da):91,665
    Last modified:May 16, 2012 - v5
    Checksum:i44233E955FCB41CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008811 Genomic DNA. Translation: EAA04913.5.
    RefSeqiXP_309245.5. XM_309245.5.

    Genome annotation databases

    EnsemblMetazoaiAGAP001043-RA; AGAP001043-PA; AGAP001043.
    GeneIDi1270538.
    KEGGiaga:AgaP_AGAP001043.
    VectorBaseiAGAP001043. Anopheles gambiae.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008811 Genomic DNA. Translation: EAA04913.5 .
    RefSeqi XP_309245.5. XM_309245.5.

    3D structure databases

    ProteinModelPortali Q7QHW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7165.AGAP001043-PA.

    Proteomic databases

    PRIDEi Q7QHW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP001043-RA ; AGAP001043-PA ; AGAP001043 .
    GeneIDi 1270538.
    KEGGi aga:AgaP_AGAP001043.
    VectorBasei AGAP001043. Anopheles gambiae.

    Organism-specific databases

    CTDi 1270538.

    Phylogenomic databases

    eggNOGi NOG297695.
    HOGENOMi HOG000230958.
    InParanoidi Q7QHW5.
    KOi K02105.
    OrthoDBi EOG7X9G6B.
    PhylomeDBi Q7QHW5.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF00514. Arm. 3 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 11 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PEST.

    Entry informationi

    Entry nameiARM_ANOGA
    AccessioniPrimary (citable) accession number: Q7QHW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 89 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3