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Protein

Histone deacetylase

Gene

1271834

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi601ZincUniRule annotation1
Metal bindingi603ZincUniRule annotation1
Metal bindingi609ZincUniRule annotation1
Active sitei717UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:1271834Imported
ORF Names:AgaP_AGAP000410Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP000410-PA

Structurei

3D structure databases

ProteinModelPortaliQ7QFC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini609 – 907Hist_deacetylInterPro annotationAdd BLAST299

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 93Sequence analysisAdd BLAST28
Coiled coili357 – 377Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
InParanoidiQ7QFC8
KOiK11406
OrthoDBiEOG091G0EQO
PhylomeDBiQ7QFC8

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 3 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q7QFC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMARDSTMG RDRVLVVPNT GIALNSSSSS SQIAAPADIS QQILELQKEQ
60 70 80 90 100
ELEKQKLWHA FQEKNKELEM QHRQQLEHKF QELRDQRIAE EAAQQRERRE
110 120 130 140 150
REAIKRKEKH ECCANASSEV KQKLQTFLIQ KKQAAASNGL SSPLPYRNWG
160 170 180 190 200
VVKSSSGESL PGGAVAAAVS SHPYKIPPPP SSIAKYDPDF PLRKTASEPN
210 220 230 240 250
LLKIRLKQRV IEKRSLNGPL AARRQERLRR LQKQQHNQAL AQTNCAASAS
260 270 280 290 300
VATTDSGPNS PPTVGSRASP TNAPIQEENE DPQYGSVTSR ASINDLSLFS
310 320 330 340 350
SPSMPNISLG RPHLGSSAAA SVAHLALNAT RPTHLGVGAG IGGQAGSVPF
360 370 380 390 400
GSPMLDLSEQ QQRSQNVAAE RQAYEQHMLM KQKIRQTALT RAANCVNREP
410 420 430 440 450
QLREEVESNE VIDLTDKKQP PKTVLASSVI KSTSQSHLLS SSSHGVDGEP
460 470 480 490 500
PTAQQQQQQQ QQHLSELIHQ QQHYHREREL FMRRSIQLSV LEDPYSHHAG
510 520 530 540 550
SAGGSGGAAA AAAAAAAAAN LLRPLSRTSS SPLVHLSSIG GGGGGGKRFG
560 570 580 590 600
RRPSDGPSKA CSPTLGRGRA VTTICHRHRE QKLRPATTGL AFDSLMLKHV
610 620 630 640 650
CACGDNANHP EHSGRLQSIW ARLLGTGLAI RCDKLRSRKA TQEELQTVHT
660 670 680 690 700
EGHALLFGTS QLNRQKVDTS RVSFVRLAII PAAAARMAAG CVIDLSYKVA
710 720 730 740 750
RGENRNGFAV VRPPGHHAEA DAAMGFCFFN SIALAARLLR HRMPHEMRRI
760 770 780 790 800
LIVDWDVHHG NGTQQAFYDD ASVLYLSVHR HDDGNFFPGT GGPAECGVGT
810 820 830 840 850
GLGYNVNVAW SGGVNPPLGD AEYLAAFRTV VMPIARDFAP DIVLVSAGFD
860 870 880 890 900
AAVGHPAPLG GYVVSPACFG HLTRELMQLA NGKIVLALEG GYDLPAICDS
910 920 930 940 950
AEECVRALLG ESTSSIAPSE LARPPCQAAV ETLQKTIAIQ VSHWPCVKRL
960 970 980 990 1000
AHTVGLSALQ AHSSEREESD TVTAMAGLSM QPLKRTSDVS CEDSEEPMDQ

DESK
Length:1,004
Mass (Da):108,483
Last modified:July 27, 2011 - v5
Checksum:iA4E8ED41EE612317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008846 Genomic DNA Translation: EAA06252.5
RefSeqiXP_310688.5, XM_310688.5

Genome annotation databases

EnsemblMetazoaiAGAP000410-RA; AGAP000410-PA; AGAP000410
GeneIDi1271834
KEGGiaga:AgaP_AGAP000410
VectorBaseiAGAP000410-RA; AGAP000410-PA; AGAP000410

Similar proteinsi

Entry informationi

Entry nameiQ7QFC8_ANOGA
AccessioniPrimary (citable) accession number: Q7QFC8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 103 of the entry and version 5 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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