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Protein
Submitted name:

AGAP010442-PA

Gene

GPRFZ2

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, ReceptorSAAS annotation
Biological processWnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
AGAP010442-PAImported
Submitted name:
Frizzled 2 transmembrane receptorImported
Gene namesi
Name:GPRFZ2Imported
Synonyms:1272596Imported
ORF Names:AgaP_AGAP010442Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3L

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei314 – 336HelicalSequence analysisAdd BLAST23
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei392 – 421HelicalSequence analysisAdd BLAST30
Transmembranei433 – 452HelicalSequence analysisAdd BLAST20
Transmembranei483 – 505HelicalSequence analysisAdd BLAST23
Transmembranei526 – 550HelicalSequence analysisAdd BLAST25
Transmembranei577 – 600HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 127PROSITE-ProRule annotation
Disulfide bondi74 ↔ 120PROSITE-ProRule annotation
Disulfide bondi111 ↔ 149PROSITE-ProRule annotation
Disulfide bondi138 ↔ 179PROSITE-ProRule annotation
Disulfide bondi142 ↔ 166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ7QDV6.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7165.AGAP010442-PA.

Structurei

3D structure databases

ProteinModelPortaliQ7QDV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 182FZInterPro annotationAdd BLAST122
Domaini312 – 607G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233236.
InParanoidiQ7QDV6.
KOiK02375.
OMAiGKNSKNC.
OrthoDBiEOG091G0J14.
PhylomeDBiQ7QDV6.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR036790. Frizzled_dom_sf.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7QDV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALARSKHRR HTVRSTLQQT VGVRCAVSVL PILLLMISGV AECSYHSGVS
60 70 80 90 100
PMPHVPAVPK DPNSRCEEIT IPMCRGIGYN LTSFPNEMNH ETQEEAGLEV
110 120 130 140 150
HQFWPLVEIK CSPDLKFFLC SMYTPICIED YHKPLPVCRS VCERARAGCA
160 170 180 190 200
PIMESYSFNW PERMACENLP VSGDSDNLCM EMPREEEHGE DRGAGGSSGG
210 220 230 240 250
GSGSSGHSGK PTRKSHGGSG GQSSGGGNQQ NNKCKGKNSK NCQNPPGERT
260 270 280 290 300
KECMCRCREP LVTLGRESST TTLLHHHGSL SSNQSVERVG DVQNCAIPCR
310 320 330 340 350
GAFFTQEEKD FAGIWIALWS GLCGISTLMT LTTFLIDTER FKYPERPIVF
360 370 380 390 400
LSACYFIVSC GYLTRIFLGH DEIACDGKSI KYPSTGQSSC TMIFIMIYFF
410 420 430 440 450
GMASSIWWVI LSFTWFLAAG LKWGNEAISK HSQYFHLAAW LIPTVQTVSV
460 470 480 490 500
LLRPAVDGDP VAGICYVGNT SVENLKNFVL APLFMYLVVG TTFLMAGFVS
510 520 530 540 550
LFRIRSVIKQ QGGIGAGSKA DKLEKLMIRI GIFSVLYTVP ATIVIGCHLY
560 570 580 590 600
EASYFEDWMT GLTCPCKVAP GLRQKPLYSV LMLKYFMALA VGITSGVWIW
610 620 630 640 650
SGKTVDSWRR LWRRLFGSPD PTGAGQVLIK PRPPLPQPYA TSGIGVPGSA
660 670 680
AASLLATPYT QTVGSVASTS HHHLHHHVLK QAPLSHV
Length:687
Mass (Da):75,286
Last modified:December 15, 2003 - v1
Checksum:i5F5C4A19D71AEF87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008849 Genomic DNA. Translation: EAA07210.1.
RefSeqiXP_311505.1. XM_311505.1.

Genome annotation databases

EnsemblMetazoaiAGAP010442-RA; AGAP010442-PA; AGAP010442.
GeneIDi1272596.
KEGGiaga:AgaP_AGAP010442.
VectorBaseiAGAP010442-RA; AGAP010442-PA; AGAP010442.

Similar proteinsi

Entry informationi

Entry nameiQ7QDV6_ANOGA
AccessioniPrimary (citable) accession number: Q7QDV6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported